Dexamethasone in adults with bacterial meningitis

New England Journal of Medicine

Volumn 347, Issue 20, 2002, Pages 1549-1556

  De Gans, Jan ^a,b   Van Beek, Diederik ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; CORTICOSTEROID; DEXAMETHASONE; PLACEBO;

ADJUVANT THERAPY; ADULT; AGITATION; ARTICLE; BACTERIAL MENINGITIS; BRAIN ABSCESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HERPES ZOSTER; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; MULTICENTER STUDY; MYCOSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH PERFORATION; TREATMENT OUTCOME;

ACUTE DISEASE; ADULT; ANTI-BACTERIAL AGENTS; CHEMOTHERAPY, ADJUVANT; DEXAMETHASONE; DOUBLE-BLIND METHOD; FEMALE; GASTROINTESTINAL HEMORRHAGE; GLUCOCORTICOIDS; HUMANS; MALE; MENINGITIS, BACTERIAL; MENINGITIS, MENINGOCOCCAL; MENINGITIS, PNEUMOCOCCAL; MIDDLE AGED; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0037079004     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa021334     Document Type: Article

References (26)

1. Bohr V, Hansen B, Jessen O, et al. Eight hundred and seventy-five cases of bacterial meningitis. I. Clinical data, prognosis, and the role of specialized hospital departments. J Infect 1983;7:21-30.
2. Durand ML, Calderwood SB, Weber DJ, et al. Acute bacterial meningitis in adults: A review of 493 episodes. N Engl J Med 1993;328:21-8.
3. Quagliarello V, Scheld WM. Bacterial meningitis: Pathogenesis, pathophysiology, and progress. N Engl J Med 1992;327:864-72.
4. Scheld WM, Dacey RG, Winn HR, Welsh JE, Jane JA, Sande MA. Cerebrospinal fluid outflow resistance in rabbits with experimental meningitis: Alterations with penicillin and methylprednisolone. J Clin Invest 1980;66:243-53.
5. Tauber MG, Khayam-Bashi H, Sande MA. Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis. J Infect Dis 1985;151:528-34.
6. McIntyre PB, Berkey CS, King SM, et al. Dexamethasone as adjunctive therapy in bacterial meningitis: A meta-analysis of randomized clinical trials since 1988. JAMA 1997;278:925-31.
7. Girgis NI, Farid Z, Mikhail IA, Farrag I, Sultan Y, Kilpatrick ME. Dexamethasone treatment for bacterial meningitis in children and adults. Pediatr Infect Dis J 1989;8:848-51.
8. Quagliarello VJ, Scheld WM. Treatment of bacterial meningitis. N Engl J Med 1997;336:708-16.
9. Saez-Llorens X, McCracken GH Jr. Antimicrobial and anti-inflammatory treatment of bacterial meningitis. Infect Dis Clin North Am 1999;13:619-36.
10. Enting RH, Spanjaard L, van de Beek D, Hensen EF, de Gans J, Dankert J. Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in the Netherlands, 1993-1994. J Antimicrob Chemother 1996;38:777-86.
11. van de Beek D, de Gans J, Spanjaard L, Vermeulen M, Dankert J. Antibiotic guidelines and antibiotic use in adult bacterial meningitis in the Netherlands. J Antimicrob Chemother 2002;49:661-6.
12. Jennett B, Teasdale G. Management of Head Injuries. Vol. 20 of Contemporary Neurology. Philadelphia: F.A. Davis, 1981.
13. Wilson JTL, Pettigrew LEI, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: Guidelines for their use. J Neurotrauma 1998;15:573-85.
14. Wade DT. Measurement in Neurological Rehabilitation. Oxford, England: Oxford University Press, 1992.
15. Gardner MJ, Altman DG. Confidence intervals rather than P values: Estimation rather than hypothesis testing. Br Med J (Clin Res Ed) 1986;292:746-50.
16. Spanos A, Harrell FE Jr, Durack DT. Differential diagnosis of acute meningitis: An analysis of the predictive value of initial observations. JAMA 1989;262:2700-7.
17. Aronin SI, Peduzzi P, Quagliarello VJ. Community-acquired bacterial meningitis: Risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med 1998;129:862-9.
18. van Crevel H, Hijdra A, de Gans J. Lumbar puncture and the risk of herniation: When should we first perform CT? J Neurol 2002;249:129-37.
19. Hasbun R, Abrahams J, Jekel J, Quagliarello VJ. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 2001;345:1727-33.
20. Syrogiannopoulos GA, Lourida AN, Theodoridou MC, et al. Dexamethasone therapy for bacterial meningitis in children: 2- versus 4-day regimen. J Infect Dis 1994;169:853-8.
21. Schaad UB, Lips U, Gnehin HE, Blumberg A, Heinzer I, Wedgwood J. Dexamethasone therapy for bacterial meningitis in children. Lancet 1993;342:457-61.
22. Coyle PK. Glucocorticoids in central nervous system bacterial infection. Arch Neurol 1999;56:796-801.
23. Klugman KP, Friedland IR, Bradley JS. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrob Agents Chemother 1995;39:1988-92.
24. Viladrich PF, Gudiol F, Linares J, et al. Evaluation of vancomycin for therapy of adult pneumococcal meningitis. Antimicrob Agents Chemother 1991;35:2467-72.
25. van de Beek D, Schmand B, de Gans J, et al. Cognitive impairment in adults with good recovery after bacterial meningitis. J Infect Dis 2002;186:1047-52.
26. Sapolsky RM, Pulsinelli WA. Glucocorticoids potentiate ischemic injury to neurons: Therapeutic implications. Science 1985;229:1397-400.