Protective effect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat

Neuroscience Letters

Volumn 225, Issue 1, 1997, Pages 33-36

  Koedel, Uwe ^a   Pfister, Hans Walter ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Antioxidant; Meningitis; N Acetyl L cysteine; Nitric oxide; Pneumococci; Rat; Reactive oxygen species; S Methylisothiourea

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; S METHYLPSEUDOTHIOUREA; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; CONTROLLED STUDY; INFECTION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MENINGITIS; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PNEUMONIAE;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HOMEOSTASIS; MALE; MENINGITIS, PNEUMOCOCCAL; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 0030901966     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00177-8     Document Type: Article

References (17)

1. Araoma, O.I., Halliwell, B., Hoey, B.M. and Butler, J., The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid, Free Radical Biol. Med., 6 (1989) 593-597.
2. Beckman, J.S., Ischaemic injury mediators, Nature, 345 (1990) 27-28.
3. Berkowitz, I.D., Hayden, W.R., Traystman, R.J. and Jones, M.D.J., Haemophilus influenzae type b impairment of pial vessel autoregulation in rats, Pediatr. Res., 33 (1993) 48-51.
4. Bernard, G.R., Lucht, W.D., Niedermeyer, M.E., Snapper, J.R., Ogletree, M.L. and Brigham, K.L., Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function, J. Clin. Invest., 73 (1984) 1772-1784.
5. Buster, B.L., Weintrob, A.C., Townsend, G.C. and Scheld, W.M., Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats, Infect. Immunol., 63 (1995) 3835-3839.
6. Dirnagl, U. and Pulsinelli, W., Autoregulation of cerebral blood flow in experimental focal brain ischemia, J. Cerebral Blood Flow Metab., 10 (1990) 327-336.
7. Harrison, P.M., Wendon, J.A., Gimson, A.E.S., Alexander, G.J.M. and Williams, R., Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure, N. Engl. J. Med., 324 (1991) 1852-1857.
8. Koedel, U., Bernatowicz, A., Paul, R., Frei, K., Fontana, A. and Pfister, H.-W., Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide, Ann. Neurol., 37 (1995) 313-323.
9. Kontos, H.A., Oxygen radicals in CNS damage, Chem. Biol. Interact, 72 (1989) 229-255.
10. Leib, S.L., Kim, Y.S., Black, S.M., Ferriero, D.M. and Täuber, M.G., Detrimental effect of nitric oxide inhibition in experimental bacterial meningitis, Ann. Neurol., 39 (1996) 555.
11. Mayer, M. and Noble, M., N-Acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro, Proc. Natl. Acad. Sci. USA, 91 (1994) 7496-7500.
12. Paulson, O.B., Brodersen, P., Hansen, E.L. and Kristensen, H.S., Regional cerebral blood flow, cerebral metabolic rate of oxygen, and cerebrospinal fluid acid-base variables in patient with acute meningitis and with acute encephalitis, Acta Med. Scand., 196 (1974) 191-198.
13. Pfister, H.W., Koedel, U., Dirnagl, U., Haberl, R.L., Ruckdeschel, G. and Einhäupl, K.M., Effect of catalase on regional cerebral blood flow and brain edema during the early phase of experimental pneumococcal meningitis, J. Infect. Dis., 166 (1992) 1442-1445.
14. Quagliarello, V.J. and Scheld, W.M., New perspectives on bacterial meningitis, Clin. Infect. Dis., 17 (1993) 603-610.
15. Szabo, C., Southan, G.J. and Thiemermann, C., Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea, a potent and selective inhibitor of inducible nitric oxide synthase, Proc. Natl. Acad. Sci. USA, 91 (1995) 12472-12476.
16. Tureen, J.H., Dworkin, R.J., Kennedy, S.L., Sachdeva, M. and Sande, M.A., Loss of cerebrovascular autoregulation in experimental meningitis in rabbits, J. Clin. Invest., 85 (1990) 577-581.
17. Weber, J.R., Angstwurm, K., Bürger, W., Einhäupl, K.M. and Dirnagl, U., Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis, J. Neuroimmunol., 63 (1995) 63-68.