Pharmacologic interference with NF-κB activation attenuates central nervous system complications in experimental pneumococcal meningitis

Journal of Infectious Diseases

Volumn 182, Issue 5, 2000, Pages 1437-1445

  Koedel, U ^a   Bayerlein, I ^a   Paul, R ^a   Sporer, B ^a   Pfister, H W ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BAY 117085; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; N ACETYLLEUCYLLEUCYLNORLEUCINAL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL MENINGITIS; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INTRACRANIAL PRESSURE; MALE; NEUROLOGICAL COMPLICATION; NONHUMAN; PLEOCYTOSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; STREPTOCOCCUS INFECTION; SYMPTOMATOLOGY; WESTERN BLOTTING;

ANIMAL; ANTI-INFECTIVE AGENTS; BLOOD-BRAIN BARRIER; BRAIN; CEREBROVASCULAR CIRCULATION; CYSTEINE PROTEINASE INHIBITORS; GLYCOPROTEINS; INTRACRANIAL PRESSURE; MALE; MENINGITIS, PNEUMOCOCCAL; NF-KAPPA B; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T;

EID: 0033790833     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315877     Document Type: Article

References (74)

1. Bacterial meningitis in the United States in 1995. Active Surveillance Team
2. Acute bacterial meningitis in adults: A review of 493 episodes
3. Spectrum of complications during bacterial meningitis in adults: Results of a prospective clinical study
4. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat: Temporal sequence and role of encapsulation
5. Loss of cerebrovascular autoregulation in experimental meningitis in rabbits
6. Protective effect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat
7. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
8. Experimental pneumococcal meningitis: Cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide
9. Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats
10. The role of cytokines in the generation of inflammation and tissue damage in experimental pneumococcal meningitis
11. Neutralization of macrophage inflammatory protein 2 (MIP-2) and MIP-1α attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis
12. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes
13. The NF-κB and IκB proteins: New discoveries and insights
14. NF-κ B: A crucial transcription factor for glial and neuronal cell function
15. Function and activation of NF-κB in the immune system
16. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
17. Oxidative stress in bacterial meningitis
18. Brain injury in bacterial meningitis
19. Activators and target genes of Rel/NF-κB transcription factors
20. The NF-κ B activation pathway: Its regulation and role in inflammation and cell survival
21. Signal transduction through NF-κB
22. IκB-NF-κB structures: At the interface of inflammation control
23. Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
24. Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis
25. Role of NFκB in the mortality of sepsis
26. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice
27. Transcription factor NF-κB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease
28. Activation of NF-κB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology
29. Prolonged activation of NF-κB following traumatic brain injury in rats
30. Traumatic spinal cord injury induces nuclear factor-κB activation
31. NF-κB is activated and promotes cell death in focal cerebral ischemia
32. Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis
33. Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence
34. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis
35. 2 reactivity and heterogeneity of cerebral blood flow in ischemic, border zone, and normal cortex
36. Selective recognition of the activated form of transcription factor NF-κB by a monoclonal antibody
37. Inhibition of IκB-α and IκB-β proteolysis by calpain inhibitor I blocks nitric oxide synthesis
38. N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-κB activation and prevents TNF and IL-6 synthesis in vivo
39. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
40. Constitutive NF-κB activity in neurons
41. High concentrations of intrathecal interleukin-6 in human bacterial and nonbacterial meningitis
42. Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis
43. Stimulatory effect of ouabain on VCAM-1 and iNOS expression in murine endothelial cells: Involvement of NF-κB
44. Brain synapses contain inducible forms of the transcription factor NF-κB
45. Activation of transcription factor NF-κB by phagocytic stimuli in human neutrophils
46. DNA binding and IκB inhibition of the cloned p65 subunit of NFκB, a rel-related polypeptide
47. The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the re1 oncogene product
48. Transcription factor NF-κB is activated in microglia during experimental autoimmune encephalomyelitis
49. Pneumococcal cell wall activates NF-κ B in human monocytes: Aspects distinct from endotoxin
50. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via toll-like receptor 2
51. Identification of hydrogen peroxide as a Streptococcus pneumoniae toxin for rat alveolar epithelial cells
52. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
53. Is NF-κB the sensor of oxidative stress?
54. Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis
55. Detection of brain free radical generated photons in vivo: Preliminary results
56. Superoxide production by primary rat cerebral endothelial cells in response to pneumococci
57. Nuclear factor-κB: A pivotal role in the systemic inflammatory response syndrome and new target for therapy
58. New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases
59. Nuclear factor-κB: Important transcription factor and therapeutic target
60. Effect of calpain inhibitor I, and inhibitor of the proteolysis of IκB, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat
61. Predominant role of NF-κB p65 in the pathogenesis of chronic intestinal inflammation
62. Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis
63. Microvascular changes during the early phase of experimental bacterial meningitis
64. Methylprednisolone attenuates inflammation, increase of brain water content and intracranial pressure, but does not influence cerebral blood flow changes in experimental pneumococcal meningitis
65. Tumor necrosis factor-α contributes to apoptosis in hippocampal neurons during experimental group B streptococcal meningitis
66. Dexamethasone attenuates NF-κ B DNA binding activity without inducing IκB levels in rat brain in vivo
67. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors
68. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
69. Interleukin (IL)-10 inhibits nuclear factor-κB (NFκB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
70. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
71. Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-κB
72. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
73. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
74. Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: Roles of NF-κB in the activation and differentiation of autoreactive T cells