The free radical scavenger α-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis

Journal of Infectious Diseases

Volumn 183, Issue 2, 2001, Pages 247-252

  Loeffler, J M ^a   Ringer, R ^a   Hablutzel M ^a   Tauber M G ^a   Leib, S L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

N TERT BUTYL ALPHA PHENYLNITRONE; SCAVENGER; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL MENINGITIS; BRAIN CORTEX LESION; BRAIN INJURY; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; HISTOPATHOLOGY; LEARNING DISORDER; MAZE TEST; NERVE CELL; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOCOCCUS AGALACTIAE; TASK PERFORMANCE;

ANIMALS; APOPTOSIS; CEREBRAL CORTEX; DENTATE GYRUS; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; LEARNING; MAZE LEARNING; MENINGITIS, PNEUMOCOCCAL; NEURONS; NITROGEN OXIDES; RATS; RATS, SPRAGUE-DAWLEY; STREPTOCOCCUS PNEUMONIAE;

EID: 0035863578     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/317921     Document Type: Article

References (42)

1. Adverse outcomes of bacterial meningitis in school-age survivors
2. Neurological sequelae and fatality as prognostic measures in 875 cases of bacterial meningitis
3. Outcomes of bacterial meningitis in children: A meta-analysis
4. Risk factors for adverse outcomes of bacterial meningitis
5. Place navigation impaired in rats with hippocampal lesions
6. A behavioural analysis of spatial localization following electrolytic, kainate-, or colchicine-induced damage to the hippocampal formation in the rat
7. Knowing where and getting there: A human navigation network
8. Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis
9. Bilateral hippocampal volume loss in patients with a history of encephalitis or meningitis
10. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
11. Tumor necrosis factor-α contributes to apoptosis in hippocampal neurons during experimental group B streptococcal meningitis
12. Neuronal injury in experimental meningo-encephalitis due to Listeria monocytogenes: Early apoptosis of neuron in the hippocampus
13. Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats
14. Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis
15. Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis
16. Pyruvate oxidase as a determinant of virulence in Streptococcus pneumoniae
17. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
18. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B
19. Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats
20. Oxygen free radicals and the cerebral anteriolar response to group B streptococci
21. HPLC procedure for the pharmacokinetic study of the spin-trapping agent, alpha-phenyl-N-tert-butyl nitrone (PBN)
22. Blood chemistry changes in the rat induced by high doses of nitronyl free radical spin traps
23. Effects of clinically used antioxidants in experimental pneumococcal meningitis
24. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis
25. Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis
26. Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo
27. Direct evidence of free radical production after ischaemia and reperfusion and protective effect of desferrioxamine: ESR and vitamin E studies
28. α-phenyl-tert-butyl nitrone inhibits free radical release in brain concussion
29. Involvement of free radicals in excitotoxicity in vivo
30. Oxygen radical scavengers prevent impairment of microvascular autoregulation in H. influenzae type b meningitis in rats
31. Experimental pneumococcal meningitis: Cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide
32. Interference with the oxidative response of neutrophils by Streptococcus pneumoniae
33. Characterisation of an oxidative response inhibitor produced by Streptococcus pneumoniae
34. Oxidative inactivation of pneumolysin by the myeloperoxidase system and stimulated human neutrophils
35. Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae
36. Gene expression and thiol redox state
37. Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system
38. Cutting edge: Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via toll-like receptor 2
39. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
40. Spin trap salvage from endotoxemia: The role of cytokine down-regulation
41. Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl-N-tert-butylnitrone (PBN)
42. Haemophilus influenzae and Streptococcus pneumoniae induce different intracerebral mRNA cytokine patterns during the course of experimental bacterial meningitis