Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: The PNEUMOREA prospective multicenter study

Critical Care Medicine

Volumn 34, Issue 11, 2006, Pages 2758-2765

  Auburtin, Marc ^a   Wolff, Michel ^a   Charpentier, Julien ^b   Varon, Emmanuelle ^c   Le Tulzo, Yves ^d   Girault, Christophe ^e   Mohammedi, Ismaël ^f   Renard, Benoît ^g   Mourvillier, Bruno ^a   Bruneel, Fabrice ^h   Ricard, Jean Damien ⁱ   Timsit, Jean François ^a,j  

^a BICHAT HOSPITAL   (France)

^b Hôpital Pontchaillou ^*  (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^e HÔPITAL CHARLES NICOLLE   (France)

^f EDOUARD HERRIOT HOSPITAL   (France)

^g HÔTEL DIEU   (France)

^h CENTRE HOSPITALIER DE VERSAILLES   (France)

ⁱ HÔPITAL LOUIS MOURIER   (France)

^j HÔPITAL MICHALLON   (France)

more..

Author keywords

Intensive care unit; Penicillin nonsusceptible Streptococcus pneumoniae; Pneumococcal meningitis

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; CEFOTAXIME; CEFTRIAXONE; CEPHALOSPORIN; CORTICOSTEROID; DEXAMETHASONE; PENICILLIN G; RIFAMPICIN; STEROID; VANCOMYCIN;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL MENINGITIS; BACTERIAL STRAIN; BACTERIUM ISOLATION; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CYTOLOGY; CHRONOTHERAPY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FRANCE; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE UNIT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL PARAMETERS; MORBIDITY; MORTALITY; MULTIVARIATE ANALYSIS; NEUROLOGIC DISEASE; NEUROLOGICAL COMPLICATION; NEUROPROTECTION; OBSERVATIONAL STUDY; PENICILLIN RESISTANCE; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SURVIVAL TIME; THERAPY DELAY;

ADULT; AGED; ANTI-BACTERIAL AGENTS; CENTRAL NERVOUS SYSTEM DISEASES; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; FRANCE; HUMANS; INTENSIVE CARE UNITS; MALE; MENINGITIS, PNEUMOCOCCAL; MIDDLE AGED; MULTIVARIATE ANALYSIS; PENICILLIN RESISTANCE; PROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 33750275276     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000239434.26669.65     Document Type: Article

References (39)

1. Durand ML, Calderwood SB, Weber DJ, et al: Acute bacterial meningitis in adults: A review of 493 episodes. N Engl J Med 1993; 328:21-28
2. Hussein AS, Shafran SD: Acute bacterial meningitis in adults: A 12-year review. Medicine (Baltimore) 2000; 79:360-368
3. van de Beek D, de Gans J, Spanjaard L, et al: Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351:1849-1859
4. Mitchell L, Smith SH, Braun JS, et al: Dual phases of apoptosis in pneumococcal meningitis. J Infect Dis 2004; 190:2039-2046
5. Aronin SI, Pedruzzi P, Quagliarello VJ: Community-acquired meningitis: risk stratification for adverse outcome and effect of antibiotic timing. Ann Intern Med 1998; 129:862-869
6. Hoen B, Viel JF, Gerard A, et al: Mortality in pneumococcal meningitis: A multivariate analysis of prognostic factors. Eur J Med 1993; 2:28-32
7. Auburtin M, Porcher R, Bruneel F, et al: Pneumococcal meningitis in the intensive care unit: Prognostic factors of clinical outcome in a series of 80 cases. Am J Respir Crit Care Med 2002; 165:713-717
8. Miner JR, Heegaard W, Mapes A, et al: Presentation, time to antibiotics, and mortality of patients with bacterial meningitis at an urban county medical center. J Emerg Med 2001; 21:387-392
9. Proulx N, Frechette D, Toye B, et al: Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 2005; 98:291-298
10. McCabe WR, Jackson GG: Gram-negative bacteremia, etiology and ecology. Arch Intern Med 1962; 110:845-864
11. Teasdale G, Jennett B: Assessment of coma and impaired consciousness: A practical scale. Lancet 1974; 2:81-84
12. Le Gall JR, Lemeshow S, Saulnier F: A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 1993; 270:2957-2963
13. National Committee for Clinical Laboratory Standards: Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria Grown Aerobically. Fourth Edition. Approved Standard. NCCLS Document M7-A4. Villanova, PA, National Committee for Clinical Laboratory Standards, 1997
14. Quagliarello VJ, Scheld WM: Treatment of bacterial meningitis. N Engl J Med 1997; 336:708-716
15. de Gans J, van de Beck D: Dexamethasone in adults with bacterial meningitis. N Engl J Med 2002; 347:1549-1556
16. Roberts L, Counsell C: Assessment of clinical outcomes in acute stroke trials. Stroke 1998; 29:986-991
17. Harrell FE, Lee KL, Mark DB: Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996; 1:361-387
18. Akaike H: A new look at the statistical model identification. IEEE Trans Autom Control 1974; 19:716-723
19. Tunkel AR, Hartman BJ, Kaplan SL, et al: Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004; 39:1267-1284
20. Talan DA, Guterman JJ, Overturf GD, et al: Analysis of emergency department management of suspected bacterial meningitis. Ann Emerg Med 1989; 18:856-862
21. Meadow WL, Lantos J, Tanz RR, et al: Ought standard care be the standard of care? A study of the time to administration of antibiotics in children with meningitis. Am J Dis Child 1993; 147:40-44
22. Van de Beek D, de Gazns J, Tunkel AR, et al: Community acquired bacterial meningitis in adults. N Engl J Med 2006; 354:44-53
23. Yu VL, Chiu CCC, Feldman C, et al: An international prospective study of pneumococcal bacteremia: Correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin Infect Dis 2003; 37:230-237
24. Arditi M, Mason EO, Bradley JS, et al: Threeyear multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use. Pediatrics 1998; 102:1087-1097
25. Fiore AE, Moroney JF, Farley MM, et al: Clinical outcome of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance. Clin Infect Dis 2000; 30:71-77
26. Flores-Cordero JM, Amaya-Villar R, Rincon-Ferrari MD, et al: Acute community-acquired meningitis in adults admitted to the intensive care unit: clinical manifestations, management and prognostic factors. Intensive Care Med 2003; 29:1967-1973
27. Doit CP, Bonacorsi SP, Frémaux AJ, et al: In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis. Antimicrob Agents Chemother 1994; 38:2655-2659
28. Tauber MG, Burroughs M, Niemoller UM, et al: Differences of physiopathology in experimental meningitis caused by three strains of Streptococcus pneumoniae. J Infect Dis 1991; 163:806-811
29. Engelhard D, Pomeranz S, Gallily R, et al: Serotype-related differences in inflammatory response to Streptococcus pneumoniae in experimental meningitis. J Infect Dis 1997; 175:979-982
30. Ostergaard C, Brandt C, Konradsen HB, et al: Differences in survival, brain damage, and cerebrospinal fluid cytokine kinetics due to meningitis caused by 3 different Streptococcus pneumoniae serotypes: Evaluation in humans and in 2 experimental models. J Infect Dis 2004; 190:1212-1220
31. Azoulay-Dupuis E, Rieux V, Muffat-Jolly M, et al: Relationship between capsular type, penicillin susceptibility, and virulence of human Streptococcus pneumoniae in mice. Antimicrob Agents Chemother 2000; 44:1575-1577
32. Rieux V, Carbon C, Azoulay-Dupuis E: Complex relationship between acquisition of β-lactam resistance and loss of virulence in Streptococcus pneumoniae. J Infect Dis 2001; 184:66-72
33. Castillo EM, Rickman LS, Brodine SK, et al: Streptococcus pneumoniae bacteremia in an era of penicillin resistance. Am J Infect Control 2000; 28:239-243
34. Kastenbauer S, Pfister HW: Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 2003; 126:1015-1025
35. Mc Millan DA, Lin CY, Aronin SI, et al: Community-acquired bacterial meningitis in adults: Categorization of causes and timing of death. Clin Infect Dis 2001; 33:969-975
36. Koedel U, Scheld WM, Pfister HW: Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect Dis 2002; 2:721-736
37. Tauber MG, Kennedy SL, Tureen JH, et al: Experimental pneumococcal meningitis causes central nervous system pathology without inducing the 72-kd heat shock protein. Am J Pathol 1992; 141:53-60
38. van de Beek D, de Gans J: Dexamethasone and pneumococcal meningitis. Ann Intern Med 2004; 141:327
39. Hasbun R, Abrahams J, Jekel J, et al: Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 2001; 345:1727-1733