Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock

Archives of Orthopaedic and Trauma Surgery

Volumn 121, Issue 4, 2001, Pages 219-222

  Hierholzer, C ^a   Harbrecht, B G ^a   Billiar, T R ^a   Tweardy, D J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; FIBRINOGEN; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EARLY RESPONSE GENE; ENZYME INDUCTION; GENE EXPRESSION; HEMORRHAGIC SHOCK; HYPOXIA; INFLAMMATION; ISCHEMIA; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; REPERFUSION; TISSUE INJURY;

ANIMALS; CYCLOOXYGENASE 2; DNA-BINDING PROTEINS; ENZYME INDUCTION; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISOENZYMES; LUNG; MALE; NUCLEAR PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, MESSENGER; SHOCK, HEMORRHAGIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0035084074     PISSN: 09368051     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004020000211     Document Type: Article

References (12)

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2. The hypoxic response: Huffing and HIFing
3. Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase
4. Essential role of induced nitric oxide in the initiation of the inflammatory response following hemorrhagic shock
5. Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
6. Traumatic shock induces type 2 nitric oxide synthase mRNA expression in the human liver
7. Hemorrhage activates myocardial NF-kappaB and increases TNF-alpha in the heart
8. Interaction between inducible nitric oxide synthase and cyclo-oxygenase-2 after cerebral ischemia
9. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1
10. Hypoxia induces cyclo-oxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells
11. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
12. 2 tension