The role of toll-like receptors (TLR) in innate and adaptive immune responses and their function in immune response regulation;Rola receptorów toll-podobnych (TLR) w odpornos̈ci wrodzonej i nabytej oraz ich funkcja w regulacji odpowiedzi immunologicznej

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 60, Issue , 2006, Pages 52-63

  Majewska, Monika ^a   Szczepanik, Marian ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Contrasuppression; Innate immune response; Pathogen associated molecular patterns (PAMP); T regulatory cell (Treg); Toll like receptors (TLR)

Indexed keywords

CYTOKINE; TOLL LIKE RECEPTOR;

ADAPTATION; ANIMAL; ANTIGEN PRESENTATION; BIOSYNTHESIS; CELLULAR IMMUNITY; HUMAN; IMMUNOLOGY; INFECTION; REGULATORY T LYMPHOCYTE; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIGEN PRESENTATION; CYTOKINES; ENGLISH ABSTRACT; HUMANS; IMMUNITY, CELLULAR; INFECTION; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTORS;

EID: 33846063490     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: None     Document Type: Review

References (91)

1. Akira S., Hoshino K.: Myeloid differentiation factor 88-dependent and-independent pathways in toll-like receptor signaling. J. Infect. Dis., 2003; 187(Suppl.2): S356-S363
2. Akira S., Sato S.: Toll-like receptors and their signaling mechanisms. Scand. J. Infect. Dis., 2003; 35: 555-562
3. Akira S., Takeda K.: Toll-like receptor signalling. Nat. Rev. Immunol., 2004; 4: 499-511
4. Akira S., Takeda K., Kaisho T.: Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol., 2001; 2: 675-680
5. Akira S., Yamamoto M., Takeda K.: Role of adapters in Toll-like receptor signaling. Biochem, Soc. Trans., 2003; 31: 637-642
6. Alonzi T., Fattori E., Lazzaro D., Costa P., Probert L., Kollias G., De Benedetti F., Poli V., Ciliberto G.: Interleukin 6 is required for the development of collagen-induced arthritis. J. Exp. Med., 1998; 187: 461-468
7. Applequist S.E., Wallin R.P., Ljunggren H.G.: Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. Int. Immunol., 2002; 14: 1065-1074
8. Askenase P.W., Itakura A., Leite-de-Moraes M.C., Lisbonne M., Roongapinun S., Goldstein D.R., Szczepanik M.: TLR-4 dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J. Immunol., 2005; 175: 6390-6401
9. Blander J.M., Medzhitov R.: Regulation of phagosome maturation by signals from toll-like receptors. Science, 2004; 304: 1014-1018
10. Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., Wilkinson J.E., Galas D., Ziegler S.F., Ramsdell F.: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet., 2001; 27: 68-73
11. Campos R.A., Szczepanik M., Itakura A., Akahira-Azuma M., Sidobre S., Kronenberg M., Askenase P.W.: Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J. Exp. Med., 2003; 198: 1785-1796
12. Caramalho I., Lopes-Carvalho T., Ostler D., Zelenay S., Haury M., Demengeot J.: Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med., 2003; 197: 403-411
13. Dieli F., Sireci G., Scire E., Salerno A., Bellavia A.: Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice. Immunology, 1999; 98: 71-79
14. Eisenbarth S.C., Piggott D.A., Huleatt J.W., Visintin I., Herrick C.A., Bottomly K.: Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med., 2002; 196: 1645-1651
15. Fitzgerald K.A., Rowe D.C., Golenbock D.T.: Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect., 2004; 6: 1361-1367
16. Flohe S.B., Bruggemann J., Lendemans S., Nikulina M., Meierhoff G., Flohe S., Kolb H.: Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype. J. Immunol., 2003; 170: 2340-2348
17. Gao B., Tsan M.F.: Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages. J. Biol. Chem., 2003; 278: 22523-22529
18. Hallman M., Ramet M., Ezekowitz R.A.: Toll-like receptors as sensors of patogens. Pediatr. Res., 2001; 50: 315-321
19. Hasan U., Chaffois C., Gaillard C., Saulnier V., Merck E., Tancredi S., Guiet C., Briere F., Vlach J., Lebecque S., Trinchieri G., Bates E.E.: Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J. Immunol., 2005; 174: 2942-2950
20. Herrick C.A., MacLeod H., Glusac E., Tigelaar R.E., Bottomly K.: Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J. Clin. Invest., 2000; 105: 765-775
21. Heyninck K., De Valck D., Vanden Berghe W., Van Criekinge W., Contreras R., Fiers W., Haegeman G., Beyaert R.: The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP-or TRAF-2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell. Biol., 1999; 145: 1471-1482
22. Higgins S.C., Lavelle E.C., McCann C., Keogh B., McNeela E., Byrne P., O'Gorman B., Jarnicki A., McGuirk P., Mills K.H.: Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J. Immunol., 2003; 171: 3119-3127
23. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., Akira S.: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol., 1999; 162:3749-3752
24. Itakura A., Szczepanik M., Campos R.A., Paliwal V., Majewska M., Matsuda H., Takatsu K., Askenase P.W.: An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within one day they produce IgM antibodies that initiate elicitation of contact sensitivity. J. Immunol., 2005; 175: 7170-7178
25. Kato A., Ogasawara T., Homma T., Saito H., Matsumoto K.: Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes. J. Immunol., 2004; 172: 6185-6194
26. Kimoto M., Nagasawa K., Miyake K.: Role of TLR4/MD-2 and RP105/MD-1 in innate recognition of lipopolysaccharide. Scand. J. Infect. Dis., 2003; 35: 568-572
27. Kobayashi H., Ohshima S., Nishioka K., Yamaguchi N., Umeshita-Sasai M., Ishii T., Mima T., Kishimoto T., Kawase I., Saeki Y.: Antigen induced arthritis (AIA) can be transferred by bone marrow transplantation: evidence that interleukin 6 is essential for induction of AIA. J. Rheumatol., 2002; 29: 1176-1182
28. Lammas D.A., Casanova J.L., Kumararatne D.S.: Clinical consequences of defects in the IL-12-dependent interferon-gamma (IFN-gamma) pathway. Clin. Exp. Immunol., 2000; 121: 417-425
29. Leadbetter E.A., Rifkin I.R., Hohlbaum A.M., Beaudette B.C., Shlomchik M.J., Marshak-Rothstein A.: Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature, 2002; 416: 603-607
30. Liew F.Y., Xu D., Brint E.K., O'Neill L.A.: Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol., 2005; 5: 446-458
31. Lobo F., Szczepanik M., Bryniarski K., Majewska M., Ptak M., Ptak W.: Toll-like receptor (TLR) ligands reverse suppression of delayed type hypersensitivity (DTH) reactions induced by epicutaneous (EC) immunization. FASEB J., 2004; 88: 21
32. Lobo F., Szczepanik M., Bryniarski K., Ptak M., Ptak W.: TCRab CD4/CD8 double-positive T cells mediate suppression of delayed type hypersensitivity (DTH) reactions induced by epicutaneous (EC) immunization. FASEB J., 2004; 88: 17
33. Marshall J.S.: Mast-cell responses to pathogens. Nat. Rev. Immunol., 2004; 4: 787-799
34. Matzinger P.: The danger model: A renewed sense of self. Science, 2002; 296: 301-305
35. Medzhitov R., Janeway C.A.Jr.: Decoding the patterns of self and nonself by innate immune system. Science, 2002; 296: 298-300
36. Meylan E. Burns K., Hofmann K., Blancheteau V., Martinon F., Kelliher M., Tschopp J.: RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat. Immunol., 2004; 5: 503-507
37. Miura Y., Shimazu R., Miyake K., Akashi S., Ogata H., Yamashita Y., Narisawa Y., Kimoto M.: RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood, 1998; 92: 2815-2822
38. Miyake K.: Innate recognition of lipopolysaccharide by CD14 and Tolllike receptor 4-MD-2: unique roles for MD-2. Int. Immunopharmacol., 2003; 3: 119-128
39. Moreno C., Merino J., Ramirez N., Echeverria A., Pastor F., Sanchez-Ibarrola A.: Lipopolysaccharide needs soluble CD14 to interact with TLR4 in human monocytes depleted of membrane CD14. Microbes Infect., 2004; 6: 990-995
40. Moudgil K.D., Kim E., Yun O.J., Chi H.H., Brahn E., Sercarz E.E.: Environmental modulation of autoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatory determinants within heat shock protein 65. J. Immunol., 2001; 166: 4237-4243
41. Nagai Y., Shimazu R., Ogata H., Akashi S., Sudo K., Yamasaki H., Hayashi S., Iwakura Y., Kimoto M., Miyake K.: Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood, 2002; 99: 1699-1705
42. Netea M.G., Sutmuller R., Hermann C., Van der Graaf C.A., Van der Meer J.W., van Krieken J.H., Hartung T., Adema G., Kullberg B.J.: Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J. Immunol., 2004; 172: 3712-3718
43. Nishiya T., DeFranco A.L.: Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem., 2004; 279: 19008-19017
44. Ogata H., Su I., Miyake K., Nagai Y., Akashi S., Mecklenbrauker I., Rajewsky K., Kimoto M., Tarakhovsky A.: The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med., 2000; 192: 23-29
45. Ohashi K., Burkart V., Flohe S., Kolb H.: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol., 2000; 164: 558-561
46. Ohshima S., Saeki Y., Mima T., Sasai M., Nishioka K., Nomura S., Kopf M., Katada Y., Tanaka T., Suemura M., Kishimoto T.: Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl. Acad. Sci. USA, 1998; 95: 8222-8226
47. O'Reilly S.M., Moynagh P.N.: Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein. Biochem. Biophys. Res. Commun., 2003; 303: 586-593
48. Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., Aderem A.: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. USA, 2000; 97: 13766-13771
49. Palsson-McDermott E.M., O'Neill L.A.: Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology., 2004; 113: 153-162
50. Pasare C., Medzhitov R.: Toll-dependent control mechanisms of CD4 T cell activation. Immunity, 2004; 21: 733-741
51. Pasare C., Medzhitov R.: Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science, 2003; 299: 1033-1036
52. Ptak W., Bryniarski K., Ptak M., Majewska M., Gamian A., Lobo F.M., Szczepanik M.: Toll-like receptor (TLR) ligands reverse suppression of contact hypersensitivity (CS) reaction induced by epicutaneous (EC) immunization with protein antigen. Int. Arch. Allergy Immunol., 2006 (w druku)
53. Ptak W., Szczepanik M., Bryniarski K., Tutaj M., Ptak M.: Epicutaneous application of protein antigens incorporated into cosmetic cream induces antigen-nonspecific unresponsiveness in mice and affects the cell-mediated immune response. Int. Arch. Allergy Immunol., 2002; 128: 8-14
54. Pulendran B., Kumar P., Cutler C.W., Mohamadzadeh M., Van Dyke T., Banchereau J.: Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J. Immunol., 2001; 167: 5067-5076
55. Richards H.B., Satoh M., Shaw M., Libert C., Poli V., Reeves W.H.: Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus. J. Exp. Med., 1998; 188: 985-990
56. Samoilova E.B., Horton J.L., Hilliard B., Liu T.S., Chen Y.: IL-6 deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol., 1998; 161: 6480-6486
57. Sasai M., Saeki Y., Ohshima S., Nishioka K., Mima T., Tanaka T., Katada Y., Yoshizaki K., Suemura M., Kishimoto T.: Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Reum., 1999; 42: 1635-1643
58. Shimizu H., Matsuguchi T., Fukuda Y., Nakano I., Hayakawa T., Takeuchi O., Akira S., Umemura M., Suda T., Yoshikai Y.: Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice. Gastroenterology, 2002; 123: 1265-1277
59. Shirai Y., Hashimoto M., Kato R., Kawamura Y.I., Kirikae T., Yano H., Takashima J., Kirihara Y., Saito Y., Fujino M.A., Dohi T.: Lipopolysaccharide induces CD25-positive, IL-10 producing lymphocytes without secretion of proinflammatory cytokines in the human colon: low MD-2 mRNA expression in colonic macrophages. J. Clin. Immunol., 2004; 24: 42-52
60. Smiley S.T., King J.A., Hancock W.W.: Fibrynogen stimulates macrophage chemokine secretion through toll-like receptor 4. J. Immunol., 2001; 167: 2887-2894
61. Stephens G.L., McHugh R.S., Whitters M.J., Young D.A., Luxenberg D., Carreno B.M., Collins M., Shevach E.M.: Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J. Immunol., 2004; 173: 5008-5020
62. Sudo N., Sawamura S., Tanaka K., Aiba Y., Kubo C., Koga Y.: The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol., 1997; 159: 1739-1745
63. Szczepanik M.: Regulation of contact hypersensitivity responses by different populations of T suppressor cells. Skin induced tolerance and its clinical implications. Recent Res. Devel. Immunology., 2002; 4: 641-667
64. Szczepanik M.: Skin induced tolerance and its clinical implication. Modern Asp. Immunobiol., 2002; 2: 265-268
65. Szczepanik M., Bryniarski K., Ptak M., Tutaj M., Ptak W.: Epicutaneous (e.c.) application of TNP-coupled protein induces TCRa CD4+ CD8+ Ts cells that inhibit Th1 mediated immune response. Centr. Eur. J. Immunol., 2002; 27: 126
66. Szczepanik M., Bryniarski K., Tutaj M., Ptak M., Skrzeczynska J., Askenase P.W., Ptak W.: Epicutaneous immunization induces alphabetaT-cell receptor CD4 CD8 double-positive non-specific suppressor T cells that inhibit contact sensitivity via transforming growth factorbeta. Immunology, 2005; 115: 42-54
67. Szczepanik M., Tutaj M.: Epicutaneous immunization with myelin basic protein (MBP) protects from experimental autoimmune encephalomyelitis (EAE) in mice. Centr. Eur. J. Immunol., 2002; 27: 128
68. Szczepanik M., Tutaj M., Bryniarski K., Dittel B.N.: Epicutaneously induced TGF-beta-dependent tolerance inhibits experimental autoimmune encephalomyelitis. J. Neuroimmunol., 2005; 164: 105-114
69. Szczepański J.M., Góralski M., Mozer-Lisewska I., Samara H., Zeromski J.: Rola receptorów Toll-podobnych w odpornos̈ci. Postępy Biologii Komórki, 2004; 3: 543-561
70. Takahashi M., Ogasawara K., Takeda K., Hashimoto W., Sakihara H., Kumagai K., Anzai R., Satoh M., Seki S.: LPS induces NK1.1+ alpha beta T cells with potent cytotoxicity in the liver of mice via produktion of IL-12 from Kupffer cells. J. Immunol., 1996; 156: 2436-2442
71. Takeda K., Akira S.: Microbial recognition by Toll-like receptors. J. Dermatol. Sci., 2004; 34: 73-82
72. Takeda K., Akira S.: TLR signaling pathways. Semin. Immunol., 2004; 16: 3-9
73. Takeda K., Akira S.: Toll-like receptors in innate immunity. Int. Immunol., 2005; 17: 1-14
74. Tapping R.I., Tobias P.S.: Soluble CD14-mediated cellular responses to lipopolysaccharide. Chem. Immunol., 2000; 74: 108-121
75. Triantafilou M., Triantafilou K.: Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol., 2002; 23: 301-304
76. Tsuji R.F., Szczepanik M., Kawikova I., Paliwal V., Campos R.A., Itakura A., Akahira-Azuma M., Baumgarth N., Herzenberg L.A., Askenase P.W.: B-cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity. J. Exp. Med., 2002; 196: 1277-1290
77. Vabulas R.M., Ahmad-Nejad P., Ghose S., Kirschning C.J., Issels R.D., Wagner H.: HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J. Biol. Chem., 2002; 277: 15107-15112
78. Vabulas R.M., Braedel S., Hilf N., Singh-Jasuja H., Herter S., Ahmad-Nejad P., Kirschning C.J., Da Costa C., Rammensee H.G., Wagner H., Schild H.: The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J. Biol. Chem., 2002; 277: 20847-20853
79. van den Biggelaar A.H., van Ree R., Rodrigues L.C., Lell B., Deelder A.M., Kremsner P.G., Yazdanbakhsh M.: Decreased atopy in children infected with Schistosoma haematobium: A role for parasite-induced interleukin-10. Lancet., 2000; 356: 1723-1727
80. von Boehmer H.: Mechanisms of suppression by suppressor T cells. Nat. Immunol., 2005; 6: 338-344
81. Wildin R.S., Ramsdell F., Peake J. Faravelli F., Casanova J.L., Buist N., Levy-Lahad E., Mazzella M., Goulet O., Perroni L., Bricarelli F.D., Byrne G., McEuen M., Proll S., Appleby M., Brunkow M.E.: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet., 2001; 27: 18-20
82. Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., Hoshino K., Takeuchi O., Kobayashi M., Fujita T., Takeda K., Akira S.: Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature, 2002; 420: 324-329
83. Yamamoto M., Sato S., Hemmi H., Uematsu S., Hoshino K., Kaisho T., Takeuchi O., Takeda K., Akira S.: TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat.Immunol., 2003; 4: 1144-1150
84. Yamamoto M., Takeda K., Akira S.: TIR domain-containing adaptors define the specificity of TLR signaling. Mol. Immunol., 2004; 40: 861-868
85. Yang R.B., Mark M.R., Gray A., Huang A., Xie M.H., Zhang M., Goddard A., Wood W.I., Gurney A.L., Godowski P.J.: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature, 1998; 395: 284-288
86. Yang Y., Huang C.T., Huang X., Pardoll D.M.: Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat. Immunol., 2004; 5: 508-515
87. Yarovinsky F., Zhang D., Andersen J.F., Bannenberg G.L., Serhan C.N., Hayden M.S., Hieny S., Sutterwala F.S., Flavell R.A., Ghosh S., Sher A.: TLR 11 activation of dendritic cells by a protozoan profilin-like protein. Science, 2005; 308: 1626-1629
88. Young S.L., Lyddon T.D., Jorgenson R.L., Misfeldt M.L.: Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. Am. J. Reprod. Immunol., 2004; 52: 67-73
89. Zhang D., Zhang G., Hayden M.S., Greenblatt M.B., Bussey C., Flavell R.A., Ghosh S.: A toll-like receptor that prevents infection by uropathogenic bacteria. Science, 2004; 303: 1522-1526
90. Zhang G., Ghosh S.: Negative regulation of Toll-like receptor-mediated signaling by Tollip. J. Biol. Chem., 2002; 277: 7059-7065
91. Zhang H., Tay P.N., Cao W., Li W., Lu J.: Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling. FEBS Lett., 2002; 532: 171-176