Toll-like receptors as sensors of pathogens

Pediatric Research

Volumn 50, Issue 3, 2001, Pages 315-321

  Hallman, Mikko ^a,b   RÄmet, Mika ^a,b,c   Ezekowitz, R Alan ^b,c  

^a UNIVERSITY OF OULU   (Finland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c GRJ 1402 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; TOLL LIKE RECEPTOR;

ACTIVE IMMUNIZATION; AUTOIMMUNE DISEASE; DNA BINDING; DROSOPHILA; GENE EXPRESSION; GERM LINE; GRAM POSITIVE BACTERIUM; INFLAMMATION; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATTERN RECOGNITION; PRIORITY JOURNAL; REVIEW; SENSOR; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; YEAST;

EID: 0034868267     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200109000-00004     Document Type: Review

References (59)

1. Innate immunity: The virtues of a nonclonal system of recognition
2. Phylogenetic perspectives in innate immunity
3. The mannose receptor is a pattern recognition receptor involved in host defense
4. Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product
5. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
6. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
7. A family of human receptors structurally related to Drosophila Toll
8. Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
9. TLR6: A novel member of an expanding Toll-like receptor family
10. Three novel mammalian Toll-like receptors: Gene structure, expression, and evolution
11. Signalling mechanisms in the antimicrobial host defense of Drosophila
12. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as Lps gene product
13. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
14. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
15. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
16. The human Toll signaling pathway: Divergence of nuclear factor kappa B and JNK/SAPK activation upstream of tumor factor receptor-associated factor 6 (TRAF6)
17. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
18. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
19. IKK-γ is an essential regulatory subunit of the IκB kinase complex
20. Genetic control of leukocyte responses to endotoxin
21. C57BL/10/CR mice: Nonresponders to activation by the lipid A moiety of bacterial lipopolysaccharide
22. Defective LPS signalling in C3H/HeJ and C57/BL/10ScCr mice: Mutations in Tlr4 gene
23. Mutational analysis of Tlr4-mediated LPS signal transduction in macrophages
24. Tlr4: Central component of the sole mammalian LPS sensor
25. Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections
26. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
27. Signaling events induced by lipopolysaccharide-activated Toll-like receptor 2
28. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
29. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
30. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
31. Peptidoglycanand lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
32. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
33. Bacterial DNA as immune cell activator
34. A Toll-like receptor recognizes bacterial DNA
35. Toll (TLR4) expression in cardiac myocytes in normal and failing myocardium
36. Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes
37. Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
38. Collectins and pulmonary host defense
39. Surfactant proteins A and D bind CD14 by different mechanisms
40. Effects of endotoxin on surfactant protein A and D stimulation of NO production by alveolar macrophages
41. Surfactant protein A (SP-A) gene targeted mice
42. Cytokine, pulmonary surfactant and consequences of intrauterine infection
43. Surfactant proteins in the diagnosis of fetal lung maturity. I. Predictive accuracy of the 35 kD protein, the lecithin/sphingomyelin ratio, and phosphatidylglycerol
44. Surfactant proteins A (SP-A) and D (SP-D): Levels in human amniotic fluid and localization in the fetal membranes
45. Ontogeny of Toll-like receptors Tlr2 and Tlr4 in mouse
46. Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth
47. Degree of lung maturity determines the direction of the interleukin-1-induced effect on the expression of surfactant proteins
48. The new BPD: An arrest of lung development
49. Oxygen radicals, cytokines, adhesion molecules and lung injury in neonates
50. Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
51. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis
52. Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement
53. Immunodeficiency in diseases
54. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease
55. Association of familial deficiency of mannose-binding lectin and meningococcal disease
56. Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis
57. Surfactant protein-A gene locus associated with recurrent otitis media
58. Two edged role of mannose binding lectin in rheumatoid arthritis: A cross sectional study J Rheumatol
59. Lung surfactant proteins involved in innate immunity