Hyphenated Techniques in Drug Discovery: Purity Assessment, Purification, Quantitative Analysis and Metabolite Identification

Sample Preparation for Hyphenated Analytical Techniques

Volumn , Issue , 2009, Pages 114-149

  Kingston, Jenny ^a   O'Connor, Desmond ^a   Sparey, Tim ^a   Thomas, Steven ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Challenges associated with sample analysis in support of early drug discovery; Column considerations; Evaporative light scattering detection (ELSD); Hyphenated techniques in drug discovery; Mass spectrometer robustness; Metabolite identification; Purification of reaction mixtures; Quantitative bioanalysis; Supercritical fluid chromatography (SFC) complementary separation technique

Indexed keywords

COLUMN CHROMATOGRAPHY; EFFLUENT TREATMENT; GAS CHROMATOGRAPHY; LIGHT SCATTERING; PURIFICATION; SUPERCRITICAL FLUIDS;

DRUG DISCOVERY; EVAPORATIVE LIGHT SCATTERING DETECTION; METABOLITE IDENTIFICATION; QUANTITATIVE BIO-ANALYSIS; REACTION MIXTURE; SEPARATION TECHNIQUES;

METABOLITES;

EID: 33846043762     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444305500.ch6     Document Type: Chapter

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