Accelerated metabolite identification by "Extraction-NMR"

Journal of Pharmaceutical and Biomedical Analysis

Volumn 32, Issue 3, 2003, Pages 531-538

  Gerhard, Ute ^a   Thomas, Steven ^a   Mortishire Smith, Russell ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

1D proton and fluorine NMR; 2D NMR; Drug discovery; Drug metabolism; In vitro and in vivo samples; Metabolite structure determination; Mixture analysis

Indexed keywords

ACETIC ACID ETHYL ESTER; CRUDE ETHYL ACETATE EXTRACT; FLUORINE; METHYL GROUP; NICOTINAMIDE; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; DRUG; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; SOLVENT;

ACCELERATION; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; EXTRACTION; HYDROXYLATION; IN VITRO STUDY; INCUBATION TIME; METABOLITE; MICROSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; RAT; SIGNAL PROCESSING; STRUCTURE ANALYSIS; TECHNIQUE; ANIMAL; BILE; BIOTRANSFORMATION; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLISM; METHODOLOGY;

ACETATES; ANIMALS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; RATS; SOLVENTS;

EID: 0142186274     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00218-8     Document Type: Article

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