Automated analytical/preparative high-performance liquid chromatography- mass spectrometry system for the rapid characterization and purification of compound libraries

Journal of Chromatography A

Volumn 794, Issue 1-2, 1998, Pages 3-13

  Zeng, L ^a   Burton, L ^b   Yung, K ^b   Shushan, B ^b   Kassel, D B ^a  

^a Formerly CombiChem Inc   (United States)

^b MDS SCIEX   (Canada)

Author keywords

Combinatorial chemistry; Mass spectrometry; Parallel synthesis; Preparative chromatography

Indexed keywords

ARTICLE; AUTOANALYSIS; AUTOANALYZER; BIOTECHNOLOGY; DIAGNOSTIC VALUE; DRUG DETERMINATION; DRUG PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 0032559294     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(97)01008-X     Document Type: Article

References (32)

1. Cheng S., Tarby C.M., Comer D.D., Williams J.P., Caproale L.H., Myers P.L., Boger D.L. Bioorg. Med. Chem. 4(5):1996;727-737.
2. Gordon E.M., Barrett R.W., Dower W.J., Fodor S.P.A., Gordon E.M. J. Med. Chem. 37(4):1994;1233-1236.
3. Furka A., Sobestyen F., Asgedom M., Dibo G. Intl. J. Pept. Prot. Res. 37:1991;487-493.
4. Lam K.S., Salmon S.E., Hersh E.M., Hraby V.J., Kazmierski W.M., Knapp R.J. Nature. 354:1991;82-84.
5. Houghten R.A. Proc. Natl. Acad. Sci. USA. 82:1985;5131-5135.
6. Houghten R.A., DeGraw S.T., Bray M.K., Hoffman S.R., Frizzell N.D. Biotechniques. 4:1900;522-528.
7. Geysen H.M., Meloen R.M., Barteling S.J. Proc. Natl. Acad. Sci. USA. 88:1984;3998-4002.
8. Geysen H.M., Rodda S.J., Macon T.J., Tribbick G., Schoofs P.G. J. Immunol. Methods. 102:1987;259-274.
9. Carell T., Wintner E.A., Sutherland A.J., Rebek J., Dunayevskiy Y.M., Vouros P. Chem. Biol. 2:1995;171-183.
10. Brummel C.Z., Lee I.N.W., Zhous Y., Bentovic S.J., Winograd N. Science. 264:1994;399-402.
11. Dunayevskiy Y., Vouros P., Carell T., Wintner E.A., Rebek J. Anal. Chem. 67(17):1995;2906-2915.
12. Metzger J.W., Wiesmuller K.-H., Gnau V., Granges J., Jung G. Angew. Chem. Intl. Ed. Engl. 32:1993;894-897.
13. Metzger J.W., Kempter C., Wiesmuller K.-H., Jung G. Anal. Biochem. 219:1994;261-277.
14. Houghten R.A., Pinilla C., Blondelle S.E., Appel J.R., Dooley C.T., Cuerro J.H. Nature. 354:1991;84-86.
15. Pinilla C., Appel J.R., Blanc P., Houghten R.A. Biotechniques. 13:1992;901-905.
16. Lam K.S., Lake D., Salmon S.E., Smith J., Chen M.L., Wade S., Adbul-Latif F., Knapp R.J., Leblova Z., Ferguson R.D., Krchnak V., Sepetov N.F., Lebl M. Methods. 9(3):1996;482-493.
17. Nestler H.P., Bartlett P.A., Still W.C. J. Org. Chem. 59:1994;4723-4724.
18. Nielsen J., Brenner S., Janda K.D. J. Amer. Chem. Soc. 115:1993;9812-9813.
19. Moran E.J., Sepehr S., Cargill J.F., Shahbaz M., Lio A., Mjalli A.M.M., Armstrong R.W. J. Amer. Chem. Soc. 117:1995;10787-10790.
20. Brenner S., Lerner R.A. Proc. Natl. Acad. Sci. USA. 89:1992;5381-5385.
21. Ohlmeyer M.H., Swanson R.N., Dillard L.W., Reader J.C., Asouline G., Kobayashi R., Wigler N., Still W.C. Proc. Natl. Acad. Sci. USA. 90:1993;10922-10925.
22. Janda K.D. Proc. Natl. Acad. Sci. USA. 91(23):1994;10779-10785.
23. Taylor L.C.E., Johnson R.L., Roso R. J. Amer. Soc. Mass Spectrom. 6:1995;387-393.
24. Pullen F.S., Perkins G.L., Burton K.J., Ware R.S., Teague M.S., Kiplinger J.P. J. Amer. Soc. Mass Spectrom. 6:1995;394-400.
25. R.C. Spreen, L.M. Schoffler, Analyt. Chem. News and Features (1996) 414A-418A.
26. Chapeaurouge A., Bigler L., Schafer A., Brevz S. J. Amer. Soc. Mass Spectrom. 6:1995;207-211.
27. D.S. Wagner, W. Bodnar, H.M. Geysen, Proceedings of the 44th ASMS Conference on Mass Spectrometry and Allied Topics, Portland, OR, USA, 1996.
28. Kassel D.B., Green M.D., Wehbie R., Swanstrom R., Berman J. Anal. Biochem. 228:1995;259-266.
29. Berman J., Green M., Sugg E., Anderegg R., Millington D.S., Norwood D.L., McGeehan J., Wiseman J. J. Biol. Chem. 267:1993;1434-1437.
30. C. Garr, The Use of Evaporative Light Scattering in Quality Control of Combinatorial Libraries, Proceedings of the Conference on Solid and Solution Phase Combinatorial Synthesis, New Orleans, 1997.
31. H.N. Weller et al., Molec. Div. (1997) in press.
32. D.B. Kassel, K. Yung, B. Shushan, R. Bonner, L. Burton, Proceedings of the 44th ASMS Conference on Mass Spectrometry and Allied Topics, Portland, OR, USA, 1996.