Purification of HTOS libraries by supercritical fluid chromatography

Journal of Liquid Chromatography and Related Technologies

Volumn 26, Issue 3, 2003, Pages 333-354

  Hochlowski, Jill ^a   Olson, Jeff ^a   Pan, Jeff ^a   Sauer, Daryl ^a   Searle, Philip ^a   Sowin, Thomas ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

High throughput organic synthesis (HTOS); Preparative chromatography; Supercritical fluid chromatography (SFC)

Indexed keywords

PURIFICATION; STANDARDIZATION; SUPERCRITICAL FLUIDS;

PILOT REACTIONS;

CHROMATOGRAPHIC ANALYSIS;

ARTICLE; DESICCATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIBRARY; ORGANIC CHEMISTRY; PURIFICATION; SAMPLE; STANDARD; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYNTHESIS;

EID: 0037282918     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120017174     Document Type: Article

References (7)

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2. Maiefski, R.; Wendell, D.; Ripka, W.D.; Krakover, J.D. Apparatus and Method for Multiple Channel High Throughput Purification, PCT Int. Appl. WO 0026662, 2000.
3. Wang, T.; Barber, M.; Hardt, I.; Kassel, D.B. Mass-directed fractionation and isolation of pharmaceutical compounds by packed-column supercritical fluid chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 2001, 15, 2067-2075.
4. Farrell, W.; Ventura, M.; Aurigemma, C.; Tran, P.; Fiori, K.; Xiong, X.; Lopez, R.; Osbonubi, M. Analytical and Semi-Preparative SFC for Combinatorial Chemistry. Supercritical Fluid Chromatography, Extraction, and Processing, Myrtle Beach, SC. August 2001.
5. Kassel, D. Possibilities and Potential Pitfalls of SFC/MS as a Complementary Tool to HPLC/MS for High Throughput Drug Discovery. Supercritical Fluid Chromatography, Extraction, and Processing, Myrtle Beach, SC. August 2001.
6. Ripka, W.C.; Barker, G.; Krakover, J. High-throughput purification of compound libraries. Drug Discov. Today 2001, 6 (9), 471-477.
7. Olson, J.; Pan, J.; Hochlowski, J.; Searle, P.; Blanchard, D. Customization of a commercially available prep scale SFC system to enhance capabilities. JALA 2002, 7 (4), 69-74.