High-throughput purification of compound libraries

Drug Discovery Today

Volumn 6, Issue 9, 2001, Pages 471-477

  Ripka, William C ^a   Barker, Geoffrey ^a   Krakover, Jonathan ^a  

^a Ontogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REAGENT; SOLVENT;

AUTOMATION; COMBINATORIAL LIBRARY; DRUG RESEARCH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT TECHNIQUE; INSTRUMENTATION; LIQUID LIQUID EXTRACTION; PURIFICATION; REVIEW; SCREENING; SOLID PHASE EXTRACTION; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYNTHESIS; TECHNIQUE;

EID: 0035339061     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01751-2     Document Type: Review

References (36)

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5. Libraries of N-alkylaminoheterocycles from nucleophilic aromatic substitution with purification by solid supported liquid extraction
6. Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands
7. Automated high-throughput liquid-liquid extraction for initial purification of combinatorial libraries
8. Fluorous synthesis: a fluorous-phase strategy for improving separation efficiency in organic synthesis
9. A strategic alternative to solid phase synthesis: preparation of a small isoxazoline library by fluorous synthesis
10. Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries
11. Solid-phase extraction on C18 silica as a purification strategy in the solution synthesis of a 1-thio-beta-D-galactopyranoside library
12. Chemoselective high-throughput purification mediated by solid supported reagents: Its application to the first 6,9-disubstituted purine library synthesis
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14. Rapid purification of small molecule libraries by ion exchange chromatography
15. The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents
16. The application of high-throughput synthesis and purification to the preparation of ethanolamines
17. Mixed-mode anion-cation exchange/hydrophilic interaction liquid chromatography-electrospray mass spectrometry as an alternative to reversed phase for small molecule drug discovery
18. Solid-phase extraction for combinatorial libraries
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23. High throughput purification of combinatorial libraries
24. High throughput analysis and purification in support of automated parallel synthesis
25. Automated analytical/preparative high-performance liquid chromatography-mass spectrometry system for the rapid characterization and purification of compound libraries
26. New developments in automated PrepLCMS extends the robustness and utility of the method for compound library analysis and purification
27. An automated system for the purification of combinatorial libraries by preparative LC/MS
28. The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries
29. High-throughput preparative separations from combinatorial libraries
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31. Semipreparative separation and fractionation of sulfonamides via supercritical fluid chromatography