Does the integrin αA domain act as a ligand for its βA domain?

Current Biology

Volumn 12, Issue 10, 2002, Pages R340-R342

  Alonso, José Luis ^a   Essafi, Makram ^a   Xiong, Jian Ping ^a   Stehle, Thilo ^a   Arnaout, M Amin ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; LIGAND;

AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; LETTER; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; HUMANS; INTEGRINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 0037076494     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00852-7     Document Type: Note

References (20)

1. Integrin structure
2. A novel divalent cation-binding site in the A domain of the β2 integrin CR3 (CD11b/CD18) is essential for ligand binding
3. Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand
4. Crystal structure of the A-domain from the α-subunit of β2 integrin complement receptor type 3 (CR3, CD11b/CD18)
5. Structural basis of collagen recognition by integrin α2β1
6. Two functional states of the CD11b A-domain: Correlations with key features of two Mn2+-complexed crystal structures
7. NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding
8. An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain
9. Locking in alternate conformations of the integrin alpha Lbeta 2 I domain with disulfide bonds reveals functional relationships among integrin domains
10. Identifying the putative metal ion-dependent adhesion site in the beta2 (CD18) subunit required for alphaLbeta2 and alphaMbeta2 ligand interactions
11. Critical residues for ligand binding in an I domain-like structure of the integrin β1 subunit
12. Cation binding to CD11b I domain and activation model assessment
13. Two conformations of the integrin A-domain (I-domain): A pathway for activation?
14. Antibodies that selectively inhibit leukocyte function-associated antigen 1 binding to intercellular adhesion molecule-3 recognize a unique epitope within the CD11a I domain
15. Epitope mapping of antibodies to the C-terminal region of the integrin beta(2) subunit reveals regions that become exposed upon receptor activation
16. Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events
17. Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b
18. 2+binding epitope on leukocyte integrin α subunits
19. Crystal structure of the extracellular segment of integrin alpha V beta3
20. Comparative protein modeling by satisfaction of spatial restraints