Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides

Journal of Biological Chemistry

Volumn 279, Issue 11, 2004, Pages 10215-10221

  Luo, Bing Hao ^a   Takagi, Junichi ^a,b   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; CELLS; CHEMICAL ACTIVATION; CHEMICAL BONDS; CONFORMATIONS; SULFUR COMPOUNDS;

CELL ADHESION;

BIOCHEMISTRY;

BETA3 INTEGRIN; DISULFIDE; DITHIOTHREITOL; METAL ION; EPITOPE; FIBRINOGEN; LIGAND;

ALPHA HELIX; ARTICLE; BETA CHAIN; BETA3 INTEGRIN I LIKE DOMAIN; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ELECTRON MICROSCOPY; GLYCOSYLATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FAMILY; RECEPTOR AFFINITY; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DOSE RESPONSE; GENETIC TRANSFECTION; HAMSTER; HUMAN; METABOLISM; MUTATION; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHO CELLS; CRICETINAE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; FIBRINOGEN; HUMANS; INTEGRIN BETA3; LIGANDS; MODELS, MOLECULAR; MUTATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

EID: 1642305349     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312732200     Document Type: Article

References (29)

1. Hynes, R. O. (2002) Cell 110, 673-687
2. Shimaoka, M., Takagi, J., and Springer, T. A. (2002) Annu. Rev. Biophys. Biomol. Struct. 31, 485-516
3. Kim, M., Carman, C. V., and Springer, T. A. (2003) Science 301, 1720-1725
4. Takagi, J., Petre, B. M., Walz, T., and Springer, T. A. (2002) Cell 110, 599-611
5. Xiong, J. P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L., and Arnaout, M. A. (2002) Science 296, 151-155
6. Xiong, J.-P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Goodman, S. L., and Arnaout, M. A. (2001) Science 294, 339-345
7. Beglova, N., Blacklow, S. C., Takagi, J., and Springer, T. A. (2002) Nat. Struct. Biol. 9, 282-287
8. Takagi, J., Strokovich, K., Springer, T. A., and Walz, T. (2003) EMBO J. 22, 4607-4615
9. Luo, B.-H., Springer, T. A., and Takagi, J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2403-2408
10. Mould, A. P., Askari, J. A., Barton, S., Kline, A. D., McEwan, P. A., Craig, S. E., and Humphries, M. J. (2002) J. Biol. Chem. 277, 19800-19805
11. Mould, A. P., Barton, S. J., Askari, J. A., McEwan, P. A., Buckley, P. A., Craig, S. E., and Humphries, M. J. (2003) J. Biol. Chem. 278, 17028-17035
12. Mould, A. P., Barton, S. J., Askari, J. A., Craig, S. E., and Humphries, M. J. (2003) J. Biol. Chem. 278, 51622-51629
13. Lu, C., Shimaoka, M., Ferzly, M., Oxvig, C., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2387-2392
14. Lu, C., Shimaoka, M., Zang, Q., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2393-2398
15. Shimaoka, M., Lu, C., Palframan, R., von Andrian, U. H., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 6009-6014
16. Shimaoka, M., Xiao, T., Liu, J.-H., Yang, Y., Dong, Y., Jun, C.-D., McCormack, A., Zhang, R., Joachimiak, A., Takagi, J., Wang, J., and Springer, T. A. (2003) Cell 112, 99-111
17. Shimaoka, M., Lu, C., Salas, A., Xiao, T., Takagi, J., and Springer, T. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16737-16741
18. Lee, J.-O., Rieu, P., Arnaout, M. A., and Liddington, R. (1995) Cell 80, 631-638
19. Emsley, J., Knight, C. G., Farndale, R. W., Barnes, M. J., and Liddington, R. C. (2000) Cell 101, 47-56
20. Levitt, M. (1992) J. Mol. Biol. 226, 507-533
21. DuBridge, R. B., Tang, P., Hsia, H. C., Leong, P. M., Miller, J. H., and Calos, M. P. (1987) Mol. Cell Biol. 7, 379-387
22. Huang, C., and Springer, T. A. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3162-3167
23. Lu, C., and Springer, T. A. (1997) J. Immunol. 159, 268-278
24. Puzon-McLaughlin, W., Kamata, T., and Takada, Y. (2000) J. Biol. Chem. 275, 7795-7802
25. Yan, B., and Smith, J. W. (2000) J. Biol. Chem. 275, 39964-39972
26. Eirin, M. T., Calvete, J. J., and Gonzalez-Rodriguez, J. (1986) Biochem. J. 240, 147-153
27. Kalomiris, E. L., and Coller, B. S. (1985) Biochemistry 24, 5430-5436
28. Guex, N., and Peitsch, M. C. (1997) Electrophoresis 18, 2714-2723
29. Carson, M. (1997) Methods Enzymol. 277, 493-505