Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: Role of DNA backbone flexibility and an open catalytic site

Journal of Biological Chemistry

Volumn 281, Issue 43, 2006, Pages 32428-32438

  Johnson, Allison A ^a   Sayer, Jane M ^b   Yagi, Haruhiko ^b   Patil, Sachindra S ^c   Debart, Françoise ^d   Maier, Martin A ^e   Corey, David R ^f   Vasseur, Jean Jacques ^d   Burke Jr , Terrence R ^c   Marquez, Victor E ^c   Jerina, Donald M ^b   Pommier, Yves ^a,g  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d CNRS   (France)

^e ISIS PHARMACEUTICALS   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSTS; CHROMOSOMES; CRYSTAL STRUCTURE; ENZYMES; REACTION KINETICS;

INTEGRASE CATALYSIS; OLIGONUCLEOTIDES; POSITION-SPECIFIC EFFECTS; VIRAL REPLICATION;

DNA;

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; ENDONUCLEASE; INTEGRASE; OLIGONUCLEOTIDE; PHOSPHODIESTERASE; SUGAR;

ANIMAL CELL; ARTICLE; CATALYSIS; DNA MODIFICATION; DRUG BINDING SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; BINDING SITES; CATALYSIS; DIHYDROXYDIHYDROBENZOPYRENES; DNA; DNA ADDUCTS; DNA, VIRAL; EPOXY COMPOUNDS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PLIABILITY; SUBSTRATE SPECIFICITY; VIRUS INTEGRATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33845949994     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605101200     Document Type: Article

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