Crystal structure of a blenzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 8, 2004, Pages 2265-2269

  Ling, Hong ^a,c   Sayer, Jane M ^a   Plosky, Brian S ^b   Yagi, Haruhiko ^a   Boudsocq, François ^b,d   Woodgate, Roger ^b   Jerina, Donald M ^a   Yang, Wei ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; BENZO[A]PYRENE; CARCINOGEN; COAL TAR; DIHYDROXYBENZO[A]PYRENE OXIDE; DNA POLYMERASE; DPO4 PROTEIN; NUCLEOTIDE; ORGANIC SOLVENT; POLYCYCLIC AROMATIC HYDROCARBON; PROTEIN; SOLVENT; UNCLASSIFIED DRUG; BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; DNA DIRECTED DNA POLYMERASE; MUTAGENIC AGENT;

ARTICLE; BASE PAIRING; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIELECTRIC CONSTANT; DNA ADDUCT; DNA REPLICATION; GENE MUTATION; INTERCALATION COMPLEX; OCCUPATIONAL CANCER; PRIORITY JOURNAL; SCROTUM CANCER; SCROTUM DISORDER; SKIN CANCER; SKIN TUMOR; STRUCTURE ANALYSIS; TUMOR GROWTH; BINDING SITE; CHEMISTRY; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALIA; MAMMALIA; NICOTIANA TABACUM;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BASE PAIRING; BASE SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA-DIRECTED DNA POLYMERASE; MUTAGENS; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION;

EID: 1442355023     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308332100     Document Type: Article

References (36)

1. Phillips, D. H. (1983) Nature 303, 468-472.
2. Phillips, D. H. (1999) Mutat. Res. 443, 139-147.
3. Sims, P., Grover, P. L., Swaisland, A., Pal, K. & Hewer, A. (1974) Nature 252, 326-328.
4. Jerina, D. M., Chadha, A., Cheh, A. M., Schurdak, M. E., Wood, A. W. & Sayer, J. M. (1991) Adv. Exp. Med. Biol. 283, 533-553.
5. Geacintov, N. E., Cosman, M., Hingerty, B. E., Amin, S., Broyde, S. & Patel, D. J. (1997) Chem. Res. Toxicol. 10, 111-146.
6. Volk, D. E., Thiviyanathan, V., Rice, J. S., Luxon, B. A., Shah, J. H., Yagi, H., Sayer, J. M., Yeh, H. J., Jerina, D. M. & Gorenstein, D. G. (2003) Biochemistry 42, 1410-1420.
7. Wei, S. J., Chang, R. L., Wong, C. Q., Bhachech, N., Cui, X. X., Hennig, E., Yagi, H., Sayer, J. M., Jerina, D. M., Preston, B. D., et al. (1991) Proc. Natl. Acad. Sci. USA 88, 11227-11230.
8. Friedberg, E. C., Wagner, R. & Radman, M. (2002) Science 296, 1627-1630.
9. Ogi, T., Shinkai, Y., Tanaka, K. & Ohmori, H. (2002) Proc. Natl. Acad. Sci. USA 99, 15548-15553.
10. Suzuki, N., Ohashi, E., Kolbanovskiy, A., Geacintov, N. E., Grollman, A. P., Ohmori, H. & Shibutani, S. (2002) Biochemistry 41, 6100-6106.
11. Rechkoblit, O., Zhang, Y., Guo, D., Wang, Z., Amin, S., Krzeminsky, J., Louneva, N. & Geacintov, N. E. (2002) J. Biol. Chem. 277, 30488-30494.
12. Chiapperino, D., Kroth, H., Kramarczuk, I. H., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina, D. M. & Cheh, A. M. (2002) J. Biol. Chem. 277, 11765-11771.
13. Frank, E. G., Sayer, J. M., Kroth, H., Ohashi, E., Ohmori, H., Jerina, D. M. & Woodgate, R. (2002) Nucleic Acids Res. 30, 5284-5292.
14. Buening, M. K., Wislocki, P. G., Levin, W., Yagi, H., Thakker, D. R., Akagi, H., Koreeda, M., Jerina, D. M. & Conney, A. H. (1978) Proc. Natl. Acad. Sci. USA 75, 5358-5361.
15. Kroth, H., Yagi, H., Sayer, J. M., Kumar, S. & Jerina, D. M. (2001) Chem. Res. Toxicol. 14, 708-719.
16. Page, J. E., Pilcher, A. S., Yugi, H., Sayer, J. M., Jerima, D. M. & Dipple, A. (1999) Chem. Res. Toxicol. 12, 258-263.
17. Ling, H., Boudsocq, F., Woodgate, R. & Yang, W. (2001) Cell 107, 91-102.
18. Otwinowski, Z. & Minor, W. (1997) Methods Enzymol. 276, 307-326.
19. Brünger, A. T., Adams, P. D., Clore, G. M., Delane, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
20. Jones, T. A., Zou, J.-Y. & Cowan, S. W. (1991) Acta Crystallogr. A 47, 110-119.
21. Tan, J., Geacintov, N. E. & Broyde, S. (2000) Chem. Res. Toxicol. 13, 811-822.
22. Mao, B., Gu, Z., Gorin, A., Chen, J., Hingerty, B. E., Amin, S., Broyde, S., Geacintov, N. E. & Patel, D. J. (1999) Biochemistry 38, 10831-10842.
23. Lavery, R. & Sklenar, H. (1989) J. Biomol. Struct. Dyn. 6, 655-667.
24. Pradhan, P., Tirumala, S., Liu, X., Sayer, J. M., Jerina, D. M. & Yeh, H. J. (2001) Biochemistry 40, 5870-5881.
25. Steitz, T. A. & Steitz, J. A. (1993) Proc. Natl. Acad. Sci. USA 90, 6498-6502.
26. Zhou, B. L., Pata, J. D. & Steitz, T. A. (2001) Mol. Cell 8, 427-437.
27. Trincao, J., Johnson, R. E., Escalante, C. R., Prakash, S., Prakash, L. & Aggarwal, A. K. (2001) Mol. Cell 8, 417-426.
28. Silvian, L. F., Toth, E. A., Pham, P., Goodman, M. F. & Ellenberger, T. (2001) Nat. Struct. Biol. 8, 984-989.
29. Yang, W. (2003) Curr. Opin. Struct. Biol. 13, 23-30.
30. Page, J. E., Zajc, B., Oh-hara, T., Lakshman, M. K., Sayer, J. M., Jerina, D. M. & Dipple, A. (1998) Biochemistry 37, 9127-9137.
31. Fernandes, A., Liu, T., Amin, S., Geacintov, N. E., Grollman, A. P. & Moriya, M. (1998) Biochemistry 37, 10164-10172.
32. Lenne-Samuel, N., Janel-Bintz, R., Kolbanovskiy, A., Geacintov, N. E. & Fuchs, R. P. (2000) Mol. Microbiol. 38, 299-307.
33. Feng, B., Gorin, A., Kolbanovskiy, A., Hingerty, B. E., Geacintov, N. E., Broyde, S. & Patel, D. J. (1997) Biochemistry 36, 13780-13790.
34. Potapova, O., Grindley, N. D. & Joyce, C. M. (2002) J. Biol. Chem. 277, 28157-28166.
35. Carson, M. (1987) J. Mol. Graphics 5, 103-106.
36. Nicholls, A., Sharp, K. A. & Honig, B. (1991) Proteins Struct. Funct. Genet. 11, 281-296.