Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 21, 2003, Pages 12498-12503

  Khan, Qasim A ^a   Kohlhagen, Glenda ^a   Marshall, Richard ^c   Austin, Caroline A ^c   Kalena, Govind P ^b   Kroth, Heiko ^b   Sayer, Jane M ^b   Jerina, Donald M ^b   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; ANTINEOPLASTIC AGENT; BENZO[A]PYRENE 7,8 DIOL 9,10 EPOXIDE DEOXYADENOSINE ADDUCT; DIHYDROXYBENZO[A]PYRENE OXIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; HYDROCARBON; INTERCALATING AGENT; OLIGODEOXYNUCLEOTIDE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BASE PAIRING; BINDING SITE; CARCINOGENESIS; DNA CLEAVAGE; DNA CONFORMATION; DNA FLANKING REGION; DNA STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; INTERCALATION COMPLEX; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BINDING SITES; DNA ADDUCTS; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; HUMANS; INTERCALATING AGENTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0142123054     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2032456100     Document Type: Article

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