The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity

Biochemistry

Volumn 38, Issue 28, 1999, Pages 8892-8898

  Greenwald, Jason ^a,b   Le, Vincent ^a,b   Butler, Scott L ^a   Bushman, Frederic D ^a   Choe, Senyon ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; COMPLEMENTARY DNA; INTEGRASE; VIRUS DNA; VIRUS ENZYME;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; GENETIC ENGINEERING; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

ALANINE; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DNA; GLYCINE; HIV INTEGRASE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 0033551443     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9907173     Document Type: Article

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