메뉴 건너뛰기




Volumn 24, Issue 3, 2004, Pages 401-416

Iron and α-synuclein in the substantia nigra of MPTP-treated mice: Effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate

Author keywords

Synuclein; AD; Iron chelator; Iron regulatory protein; MPTP; Neurodegeneration; Neuroprotection; PD; R apomorphine, epigallocatechin 3 gallate

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; APOMORPHINE; DOPAMINE; EPIGALLOCATECHIN GALLATE; GREEN TEA EXTRACT; IRON; IRON CHELATING AGENT; LIPID; NEUROFILAMENT PROTEIN; NEUROMELANIN; NEUROTOXIN; NITRIC OXIDE; OXIDOPAMINE; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VK 28; CATECHIN; DRUG DERIVATIVE; FREE RADICAL; NERVE PROTEIN; NEUROPROTECTIVE AGENT; SNCA PROTEIN, MOUSE; SYNUCLEIN; UBIQUITIN;

EID: 1842621154     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:24:3:401     Document Type: Article
Times cited : (171)

References (100)
  • 1
    • 0038222577 scopus 로고    scopus 로고
    • Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: Preclinical experience
    • Aronowski J., Strong R., Shirzadi A., and Grotta J. C. (2003) Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience. Stroke 34, 1246-1251.
    • (2003) Stroke , vol.34 , pp. 1246-1251
    • Aronowski, J.1    Strong, R.2    Shirzadi, A.3    Grotta, J.C.4
  • 2
    • 1542317394 scopus 로고    scopus 로고
    • Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline
    • Bar Am O., Amit T., and Youdim M. B. H. (2004a) Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline. Neurosci. Lett., 355, 169-172.
    • (2004) Neurosci. Lett. , vol.355 , pp. 169-172
    • Bar Am, O.1    Amit, T.2    Youdim, M.B.H.3
  • 3
    • 2642529309 scopus 로고    scopus 로고
    • Regulation of protein kinase C by the MAO-B inhibitor anti-Parkinson drug rasagiline and its anti-Alzheimer cholinesterase inhibitor derivatives in vivo
    • Bar Am O., Yogev-Falach M., Amit T., Sagi Y., and Youdim M. B. H. (2004b) Regulation of protein kinase C by the MAO-B inhibitor anti-Parkinson drug rasagiline and its anti-Alzheimer cholinesterase inhibitor derivatives in vivo. J. Neurochem., 89, 1119-1125.
    • (2004) J. Neurochem. , vol.89 , pp. 1119-1125
    • Bar Am, O.1    Yogev-Falach, M.2    Amit, T.3    Sagi, Y.4    Youdim, M.B.H.5
  • 4
    • 0036118114 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice
    • Battaglia G., Busceti C. L., Cuomo L., Giorgi F. S., Orzi F., De Blasi A., et al. (2002a) Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice. Neuropharmacology 42, 367-373.
    • (2002) Neuropharmacology , vol.42 , pp. 367-373
    • Battaglia, G.1    Busceti, C.L.2    Cuomo, L.3    Giorgi, F.S.4    Orzi, F.5    De Blasi, A.6
  • 5
    • 0036296950 scopus 로고    scopus 로고
    • Morphological and biochemical evidence that apomorphine rescues striatal dopamine terminals and prevents methamphetamine toxicity
    • Battaglia G., Gesi M., Lenzi P., Busceti C. L., Soldani P., Orzi F., et al. (2002b) Morphological and biochemical evidence that apomorphine rescues striatal dopamine terminals and prevents methamphetamine toxicity. Ann. N. Y. Acad. Sci. 965, 254-266.
    • (2002) Ann. N. Y. Acad. Sci. , vol.965 , pp. 254-266
    • Battaglia, G.1    Gesi, M.2    Lenzi, P.3    Busceti, C.L.4    Soldani, P.5    Orzi, F.6
  • 6
    • 0025980955 scopus 로고
    • The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine- induced degeneration of nigrostriatal dopamine neurons
    • Ben-Shachar D., Eshel G., Finberg J. P., and Youdim M. B. (1991) The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J. Neurochem. 56, 1441-1444.
    • (1991) J. Neurochem. , vol.56 , pp. 1441-1444
    • Ben-Shachar, D.1    Eshel, G.2    Finberg, J.P.3    Youdim, M.B.4
  • 8
    • 0030792007 scopus 로고    scopus 로고
    • Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade
    • Berra E., Municio M. M., Sanz L., Frutos S., Diaz-Meco M. T., and Moscat J. (1997) Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol. Cell. Biol. 17, 4346-4354.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4346-4354
    • Berra, E.1    Municio, M.M.2    Sanz, L.3    Frutos, S.4    Diaz-Meco, M.T.5    Moscat, J.6
  • 9
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D., Torch S., Lambeng N., Nissou M., Benabid A. L., Sadoul R., and Verna J. M. (2001) Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog. Neurobiol. 65, 135-172.
    • (2001) Prog. Neurobiol. , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.L.5    Sadoul, R.6    Verna, J.M.7
  • 11
    • 0033677879 scopus 로고    scopus 로고
    • Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism
    • Chase T. N. and Oh J. D. (2000) Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism. Trends Neurosci. 23, S86-S91.
    • (2000) Trends Neurosci. , vol.23
    • Chase, T.N.1    Oh, J.D.2
  • 12
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: A family of proteins involved in synaptic function, plasticity neurodegeneration and disease
    • Clayton D. F. and George J. M. (1998) The synucleins: a family of proteins involved in synaptic function, plasticity neurodegeneration and disease. Trends Neurosci. 21, 249-254.
    • (1998) Trends Neurosci. , vol.21 , pp. 249-254
    • Clayton, D.F.1    George, J.M.2
  • 13
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: Regulators of the cellular life-or-death switch
    • Cory S. and Adams J. M. (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 14
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W. and Przedborski S. (2003) Parkinson's disease: mechanisms and models. Neuron 39, 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 17
    • 0025374307 scopus 로고
    • MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate
    • Elsworth J. D., Deutch A. Y., Redmond D. E., Jr., Sladek J. R., Jr., and Roth R. H. (1990) MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neurosci. Lett. 114, 316-322.
    • (1990) Neurosci. Lett. , vol.114 , pp. 316-322
    • Elsworth, J.D.1    Deutch, A.Y.2    Redmond Jr., D.E.3    Sladek Jr., J.R.4    Roth, R.H.5
  • 18
    • 10744232522 scopus 로고    scopus 로고
    • Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    • Felletschin B., Bauer P., Walter U., Behnke S., Spiegel J., Csoti L, et al. (2003) Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Neurosci. Lett. 352, 53-56.
    • (2003) Neurosci. Lett. , vol.352 , pp. 53-56
    • Felletschin, B.1    Bauer, P.2    Walter, U.3    Behnke, S.4    Spiegel, J.5    Csoti, L.6
  • 19
    • 0030592141 scopus 로고    scopus 로고
    • Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction
    • Gassen M., Glinka Y., Pinchasi B., and Youdim M. B. H. (1996) Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction. Eur. J. Pharmacol. 308, 219-225.
    • (1996) Eur. J. Pharmacol. , vol.308 , pp. 219-225
    • Gassen, M.1    Glinka, Y.2    Pinchasi, B.3    Youdim, M.B.H.4
  • 20
    • 0031857636 scopus 로고    scopus 로고
    • Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine
    • Gassen M., Gross A., and Youdim M. B. (1998). Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine. Mov, Disord, 13, 242-248.
    • (1998) Mov. Disord. , vol.13 , pp. 242-248
    • Gassen, M.1    Gross, A.2    Youdim, M.B.3
  • 21
    • 0032609803 scopus 로고    scopus 로고
    • Apomorphine, a dopamine receptor agonist with remarkable antioxidant and cytoprotective properties
    • Gassen M., Gross A., and Youdim M. B. H. (1999) Apomorphine, a dopamine receptor agonist with remarkable antioxidant and cytoprotective properties. Adv. Neurol. 80, 297-302.
    • (1999) Adv. Neurol. , vol.80 , pp. 297-302
    • Gassen, M.1    Gross, A.2    Youdim, M.B.H.3
  • 22
    • 0028000825 scopus 로고
    • Altered brain metabolism of iron as a cause of neurodegenerative diseases?
    • Gerlach M., Ben-Shachar D., Riederer P., and Youdim M. B. (1994) Altered brain metabolism of iron as a cause of neurodegenerative diseases? J. Neurochem. 63, 793-807.
    • (1994) J. Neurochem. , vol.63 , pp. 793-807
    • Gerlach, M.1    Ben-Shachar, D.2    Riederer, P.3    Youdim, M.B.4
  • 24
    • 0036894795 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in early Parkinson disease: The TEMPO Study
    • Group P. S. (2002) A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch. Neurol. 59, 1937-1943.
    • (2002) Arch. Neurol. , vol.59 , pp. 1937-1943
    • Group, P.S.1
  • 25
    • 19944428747 scopus 로고    scopus 로고
    • Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes
    • Grunblatt E., Mandel S., Jacob-Hirsch J., Zeligson S., Amariglo N., Rechavi G., et al. (2004) Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. J. Neural. Transm. 111, 1435-1463.
    • (2004) J. Neural. Transm. , vol.111 , pp. 1435-1463
    • Grunblatt, E.1    Mandel, S.2    Jacob-Hirsch, J.3    Zeligson, S.4    Amariglo, N.5    Rechavi, G.6
  • 26
    • 0034043595 scopus 로고    scopus 로고
    • Neuroprotective strategies in Parkinson's disease using the models of 6-hydroxydopamine and MPTP
    • Grunblatt E., Mandel S., and Youdim M. B. H. (2000) Neuroprotective strategies in Parkinson's disease using the models of 6-hydroxydopamine and MPTP. Ann. N. Y. Acad. Sci. 899, 262-273.
    • (2000) Ann. N. Y. Acad. Sci. , vol.899 , pp. 262-273
    • Grunblatt, E.1    Mandel, S.2    Youdim, M.B.H.3
  • 27
    • 0343550312 scopus 로고    scopus 로고
    • Apomorphine protects against MPTP-induced neurotoxicity in mice
    • Grunblatt E., Mandel S., Berkuzki T., and Youdim M. B. H. (1999) Apomorphine protects against MPTP-induced neurotoxicity in mice. Mov. Disord. 14, 612-618.
    • (1999) Mov. Disord. , vol.14 , pp. 612-618
    • Grunblatt, E.1    Mandel, S.2    Berkuzki, T.3    Youdim, M.B.H.4
  • 28
    • 0035085603 scopus 로고    scopus 로고
    • Effects of R-apomorphine and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss
    • Grunblatt E., Mandel S., Maor G., and Youdim M. B. H. (2001a) Effects of R-apomorphine and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss. J. Neurochem. 77, 146-156.
    • (2001) J. Neurochem. , vol.77 , pp. 146-156
    • Grunblatt, E.1    Mandel, S.2    Maor, G.3    Youdim, M.B.H.4
  • 29
    • 0034941949 scopus 로고    scopus 로고
    • Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: Effect of R-apomorphine
    • Grunblatt E., Mandel S., Maor G., and Youdim M. B. H. (2001b) Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine. J. Neurochem. 78, 1-12.
    • (2001) J. Neurochem. , vol.78 , pp. 1-12
    • Grunblatt, E.1    Mandel, S.2    Maor, G.3    Youdim, M.B.H.4
  • 30
    • 0030755366 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    • Gunshin H., Mackenzie B., Berger U. V., Gunshin Y., Romero M. F., Boron W. F., et al. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388, 482-488.
    • (1997) Nature , vol.388 , pp. 482-488
    • Gunshin, H.1    Mackenzie, B.2    Berger, U.V.3    Gunshin, Y.4    Romero, M.F.5    Boron, W.F.6
  • 31
    • 0036835002 scopus 로고    scopus 로고
    • Apomorphine induces trophic factors that support fetal rat mesencephalic dopaminergic neurons in cultures
    • Guo H., Tang Z., Yu Y., Xu L., Jin G., and Zhou J. (2002) Apomorphine induces trophic factors that support fetal rat mesencephalic dopaminergic neurons in cultures. Eur. J. Neurosci. 16, 1861-1870.
    • (2002) Eur. J. Neurosci. , vol.16 , pp. 1861-1870
    • Guo, H.1    Tang, Z.2    Yu, Y.3    Xu, L.4    Jin, G.5    Zhou, J.6
  • 32
    • 0030582664 scopus 로고    scopus 로고
    • Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes
    • Guo Q., Zhao B., Li M., Shen S., and Xin W. (1996) Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim. Biophys. Acta 1304, 210-222.
    • (1996) Biochim. Biophys. Acta , vol.1304 , pp. 210-222
    • Guo, Q.1    Zhao, B.2    Li, M.3    Shen, S.4    Xin, W.5
  • 33
    • 0032812762 scopus 로고    scopus 로고
    • Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species
    • Hanson E. S. and Leibold E. A. (1999) Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species. Gene Expr. 7, 367-376.
    • (1999) Gene Expr. , vol.7 , pp. 367-376
    • Hanson, E.S.1    Leibold, E.A.2
  • 34
    • 0035103294 scopus 로고    scopus 로고
    • Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?
    • Hartmann A., Michel P. P., Troadec J. D., Mouatt-Prigent A., Faucheux B. A., Ruberg M., et al. (2001) Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease? J. Neurochem. 76, 1785-1793.
    • (2001) J. Neurochem. , vol.76 , pp. 1785-1793
    • Hartmann, A.1    Michel, P.P.2    Troadec, J.D.3    Mouatt-Prigent, A.4    Faucheux, B.A.5    Ruberg, M.6
  • 35
    • 0032879452 scopus 로고    scopus 로고
    • Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease
    • Hashimoto M., Takeda A., Hsu L. J., Takenouchi T., and Masliah E. (1999) Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease. J. Biol. Chem. 274, 28849-28852.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28849-28852
    • Hashimoto, M.1    Takeda, A.2    Hsu, L.J.3    Takenouchi, T.4    Masliah, E.5
  • 36
    • 0029670980 scopus 로고    scopus 로고
    • Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of mice
    • Hassouna I., Wickert H., Zimmermann M., and Gillardon F. (1996) Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment of mice. Neurosci. Lett. 204, 85-88.
    • (1996) Neurosci. Lett. , vol.204 , pp. 85-88
    • Hassouna, I.1    Wickert, H.2    Zimmermann, M.3    Gillardon, F.4
  • 37
    • 0029758487 scopus 로고    scopus 로고
    • Molecular control of vertebrate iron metabolism: MRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
    • Hentze M. W. and Kuhn L. C. (1996) Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. USA 93, 8175-8182.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8175-8182
    • Hentze, M.W.1    Kuhn, L.C.2
  • 38
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
    • Hirsch E. C., Hunot S., Damier P., and Faucheux B. (1998) Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann. Neurol. 44, S115-S120.
    • (1998) Ann. Neurol. , vol.44
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 39
    • 0030842085 scopus 로고    scopus 로고
    • Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease
    • Hunot S., Brugg B., Ricard D., Michel P. P., Muriel M. P., Ruberg M., et al. (1997) Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease. Proc. Natl. Acad. Sci. USA 94, 7531-7536.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7531-7536
    • Hunot, S.1    Brugg, B.2    Ricard, D.3    Michel, P.P.4    Muriel, M.P.5    Ruberg, M.6
  • 40
    • 0036260184 scopus 로고    scopus 로고
    • Striatal and extrastriatal dysfunction in Parkinson's disease with dementia: A 6-[18F]fluoro-L-dopa PET study
    • Ito K., Nagano-Saito A., Kato T., Arahata Y., Nakamura A., Kawasumi Y., et al. (2002) Striatal and extrastriatal dysfunction in Parkinson's disease with dementia: a 6-[18F]fluoro-L-dopa PET study. Brain 125, 1358-1365.
    • (2002) Brain , vol.125 , pp. 1358-1365
    • Ito, K.1    Nagano-Saito, A.2    Kato, T.3    Arahata, Y.4    Nakamura, A.5    Kawasumi, Y.6
  • 41
    • 0028985267 scopus 로고
    • The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H. A., et al. (1995) The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14, 467-475.
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3    Ge, N.4    Flanagan, L.5    De Silva, H.A.6
  • 43
    • 0141725659 scopus 로고    scopus 로고
    • Neuropathological spectrum of synucleinopathies
    • Jellinger K. A. (2003) Neuropathological spectrum of synucleinopathies. Mov. Dis. Suppl. 6, S2-S12.
    • (2003) Mov. Dis. Suppl. , vol.6
    • Jellinger, K.A.1
  • 44
    • 0035233512 scopus 로고    scopus 로고
    • The pathology of Parkinson's disease
    • Jellinger K. A. (2001) The pathology of Parkinson's disease. Adv. Neurol. 86, 55-72.
    • (2001) Adv. Neurol. , vol.86 , pp. 55-72
    • Jellinger, K.A.1
  • 45
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanisms in nigral cell death in Parkinson's disease
    • Jenner P. (1998) Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov. Disord. 13, 24-34.
    • (1998) Mov. Disord. , vol.13 , pp. 24-34
    • Jenner, P.1
  • 46
    • 17644438752 scopus 로고    scopus 로고
    • Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease
    • Kaasinen V., Nagren K., Hietala J., Oikonen V., Vilkman H., Farde L., et al. (2000) Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease. Neurology 54, 1482-1487.
    • (2000) Neurology , vol.54 , pp. 1482-1487
    • Kaasinen, V.1    Nagren, K.2    Hietala, J.3    Oikonen, V.4    Vilkman, H.5    Farde, L.6
  • 47
    • 0242684415 scopus 로고    scopus 로고
    • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
    • Kaur D., Yantiri F., Rajagopalan S., Kumar J., MoJ. Q., Boonplueang R., et al. (2003) Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron 37, 899-909.
    • (2003) Neuron , vol.37 , pp. 899-909
    • Kaur, D.1    Yantiri, F.2    Rajagopalan, S.3    Kumar, J.4    Moj, Q.5    Boonplueang, R.6
  • 48
    • 0034089867 scopus 로고    scopus 로고
    • Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2
    • Kim S. and Ponka P. (2000) Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2. J. Biol. Chem. 275, 6220-6226.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6220-6226
    • Kim, S.1    Ponka, P.2
  • 49
    • 0030864433 scopus 로고    scopus 로고
    • Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice
    • Lan J. and Jiang D. H. (1997) Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. (Budapest) 104, 469-481.
    • (1997) J. Neural Transm. (Budapest) , vol.104 , pp. 469-481
    • Lan, J.1    Jiang, D.H.2
  • 50
    • 0035138456 scopus 로고    scopus 로고
    • Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
    • LaVaute T., Smith S., Cooperman S., Iwai K., Land W., Meyron-Holtz E., et al. (2001) Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat. Genet. 27, 209-214.
    • (2001) Nat. Genet. , vol.27 , pp. 209-214
    • LaVaute, T.1    Smith, S.2    Cooperman, S.3    Iwai, K.4    Land, W.5    Meyron-Holtz, E.6
  • 51
    • 0031763264 scopus 로고    scopus 로고
    • The synuclein family
    • Lavedan C. (1998) The synuclein family. Genome Res. 8, 871-880.
    • (1998) Genome Res. , vol.8 , pp. 871-880
    • Lavedan, C.1
  • 52
    • 0035087726 scopus 로고    scopus 로고
    • Immunolocalization of iron regulatory protein expression in the murine central nervous system
    • Leibold E. A., Gahring L. C., and Rogers S. W. (2001) Immunolocalization of iron regulatory protein expression in the murine central nervous system. Histochem. Cell Biol. 115, 195-203.
    • (2001) Histochem. Cell Biol. , vol.115 , pp. 195-203
    • Leibold, E.A.1    Gahring, L.C.2    Rogers, S.W.3
  • 53
    • 0038661168 scopus 로고    scopus 로고
    • Neuroprotection and neurorescue against amyloid beta toxicity and PKC-dependent release of non-amyloidogenic soluble precusor protein by green tea polyphenol (-)-epigallocatechin-3-gallate
    • Levites Y., Amit T., Mandel S., and Youdim M. B. H. (2003) Neuroprotection and neurorescue against amyloid beta toxicity and PKC-dependent release of non-amyloidogenic soluble precusor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J. 17, 952-954.
    • (2003) FASEB J. , vol.17 , pp. 952-954
    • Levites, Y.1    Amit, T.2    Mandel, S.3    Youdim, M.B.H.4
  • 54
    • 0037163110 scopus 로고    scopus 로고
    • Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin-3-gallate neuroprotective action
    • Levites Y., Amit T., Youdim M. B. H., and Mandel S. (2002) Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin-3-gallate neuroprotective action. J. Biol. Chem. 277, 30,574-30,580.
    • (2002) J. Biol. Chem. , vol.277
    • Levites, Y.1    Amit, T.2    Youdim, M.B.H.3    Mandel, S.4
  • 55
    • 0034851553 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
    • Levites Y., Weinreb O., Maor G., Youdim M. B. H., and Mandel S. (2001) Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J. Neurochem. 78, 1073-1082.
    • (2001) J. Neurochem. , vol.78 , pp. 1073-1082
    • Levites, Y.1    Weinreb, O.2    Maor, G.3    Youdim, M.B.H.4    Mandel, S.5
  • 56
    • 0036285744 scopus 로고    scopus 로고
    • Neuroprotection in Parkinson's disease: Love story or mission impossible?
    • Linazasoro G. (2002) Neuroprotection in Parkinson's disease: love story or mission impossible? Expert Rev. Neurother. 2, 403-416.
    • (2002) Expert Rev. Neurother. , vol.2 , pp. 403-416
    • Linazasoro, G.1
  • 57
    • 0035341268 scopus 로고    scopus 로고
    • How protein kinase C activation protects nerve cells from oxidative stress-induced cell death
    • Maher P. (2001) How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. J. Neurosci. 21, 2929-2938.
    • (2001) J. Neurosci. , vol.21 , pp. 2929-2938
    • Maher, P.1
  • 58
    • 0034517802 scopus 로고    scopus 로고
    • cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: Implications for idiopathic Parkinson's disease
    • Mandel S., Grunblatt E., and Youdim M. B. H. (2000) cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson's disease. J. Neural Transm. Suppl. 60, 117-124.
    • (2000) J. Neural Transm. Suppl. , vol.60 , pp. 117-124
    • Mandel, S.1    Grunblatt, E.2    Youdim, M.B.H.3
  • 59
    • 0036808013 scopus 로고    scopus 로고
    • Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray
    • Mandel S., Grunblatt E., Maor G., and Youdim M. B. H. (2002a) Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray. Neurochem. Res. 27, 1231-1243.
    • (2002) Neurochem. Res. , vol.27 , pp. 1231-1243
    • Mandel, S.1    Grunblatt, E.2    Maor, G.3    Youdim, M.B.H.4
  • 61
    • 1642344739 scopus 로고    scopus 로고
    • Molecular events in dopaminergic neurodegeneration and neuroprotection in MPTP model of parkinson's disease employing cDNA microarray
    • Said, A. C. M., ed., Martin Dunitz, London
    • Mandel S., Grunblatt E., Royak-Levites Y., Maor G., and Youdim M. B. H. (2002b) Molecular events in dopaminergic neurodegeneration and neuroprotection in MPTP model of parkinson's disease employing cDNA microarray, in Brain DiseasE, Therapeutic Strategies and Repair, Vol. 34, Said, A. C. M., ed., Martin Dunitz, London, pp. 291-298.
    • (2002) Brain DiseasE, Therapeutic Strategies and Repair , vol.34 , pp. 291-298
    • Mandel, S.1    Grunblatt, E.2    Royak-Levites, Y.3    Maor, G.4    Youdim, M.B.H.5
  • 62
    • 1642382889 scopus 로고    scopus 로고
    • Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: Implications for neurodegenerative diseases
    • Mandel S. Weinreb O. Amit T., and Youdim, M.B.H. (2004) Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases. J. Neurochem., 88, 1555-1569.
    • (2004) J. Neurochem. , vol.88 , pp. 1555-1569
    • Mandel, S.1    Weinreb, O.2    Amit, T.3    Youdim, M.B.H.4
  • 63
    • 0037386720 scopus 로고    scopus 로고
    • Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs
    • Mandel S., Weinreb O., and Youdim M. B. (2003b) Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs. Trends Pharmacol. Sci. 24, 184-191.
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 184-191
    • Mandel, S.1    Weinreb, O.2    Youdim, M.B.3
  • 64
    • 0025943571 scopus 로고
    • The rat brain synucleins; family of proteins transiently associated with neuronal membrane
    • Maroteaux L. and Scheller R. H. (1991) The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res. Mol. Brain Res. 11, 335-343.
    • (1991) Brain Res. Mol. Brain Res. , vol.11 , pp. 335-343
    • Maroteaux, L.1    Scheller, R.H.2
  • 65
    • 0142241356 scopus 로고    scopus 로고
    • Fe(III)-induced damage in α-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: Detection by the Comet assay
    • Martin F. L., Williamson S. J. M., Paleologou K. E., Hewitt R., El-Agnaf O. M. A., and Allsop D. (2003) Fe(III)-induced damage in α-synuclein- transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay. J. Neurochem. 87, 620.
    • (2003) J. Neurochem. , vol.87 , pp. 620
    • Martin, F.L.1    Williamson, S.J.M.2    Paleologou, K.E.3    Hewitt, R.4    El-Agnaf, O.M.A.5    Allsop, D.6
  • 66
    • 0030025635 scopus 로고    scopus 로고
    • Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease
    • Masliah E., Iwai A., Mallory M., Ueda K., and Saitoh T. (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol. 148, 201-210.
    • (1996) Am. J. Pathol. , vol.148 , pp. 201-210
    • Masliah, E.1    Iwai, A.2    Mallory, M.3    Ueda, K.4    Saitoh, T.5
  • 67
    • 0030726721 scopus 로고    scopus 로고
    • Involvement of iron in MPP+ toxicity in substantia nigra: Protection by desferrioxamine
    • Matarredona E. R., Santiago M., Cano J., and Machado A. (1997) Involvement of iron in MPP+ toxicity in substantia nigra: protection by desferrioxamine. Brain Res. 773, 76-81.
    • (1997) Brain Res. , vol.773 , pp. 76-81
    • Matarredona, E.R.1    Santiago, M.2    Cano, J.3    Machado, A.4
  • 68
    • 0037025111 scopus 로고    scopus 로고
    • Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease
    • McNaught K. S., Belizaire R., Jenner P., Olanow C. W., and Isacson O. (2002) Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease. Neurosci. Lett. 326, 155-158.
    • (2002) Neurosci. Lett. , vol.326 , pp. 155-158
    • McNaught, K.S.1    Belizaire, R.2    Jenner, P.3    Olanow, C.W.4    Isacson, O.5
  • 69
    • 0031057656 scopus 로고    scopus 로고
    • Bcl-2 gene family in the nervous system
    • Merry D. E. and Korsmeyer S. J. (1997) Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20, 245-267.
    • (1997) Annu. Rev. Neurosci. , vol.20 , pp. 245-267
    • Merry, D.E.1    Korsmeyer, S.J.2
  • 70
    • 0023922934 scopus 로고
    • Immunohistochemical evaluation of the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on dopaminergic nigrostriatal neurons of young adult mice using dopamine and tyrosine hydroxylase antibodies
    • Mori S., Fujitake J., Kuno S., and Sano Y. (1988) Immunohistochemical evaluation of the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) on dopaminergic nigrostriatal neurons of young adult mice using dopamine and tyrosine hydroxylase antibodies. Neurosci. Lett. 90, 57-62.
    • (1988) Neurosci. Lett. , vol.90 , pp. 57-62
    • Mori, S.1    Fujitake, J.2    Kuno, S.3    Sano, Y.4
  • 71
    • 0036324240 scopus 로고    scopus 로고
    • Parkinson's disease: Changes in apoptosis-related factors suggesting possible gene therapy
    • Nagatsu T. (2002) Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy. J. Neural Transm. 109, 731-745.
    • (2002) J. Neural Transm. , vol.109 , pp. 731-745
    • Nagatsu, T.1
  • 72
    • 0032510758 scopus 로고    scopus 로고
    • Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
    • Offen D., Beart P. M., Cheung N. S., Pascoe C. J., Hochman A., Gorodin S., et al. (1998) Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Proc. Natl. Acad. Sci. USA 95, 5789-5794.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5789-5794
    • Offen, D.1    Beart, P.M.2    Cheung, N.S.3    Pascoe, C.J.4    Hochman, A.5    Gorodin, S.6
  • 74
    • 0002563935 scopus 로고    scopus 로고
    • Iron and neurodegeneration: Prospects for neuroprotection
    • Olanow, C. W., Jenner, P., and Youdim, M. B., eds., Academic Press, London
    • Olanow C. W. and Youdim M. B. (1996) Iron and neurodegeneration: prospects for neuroprotection, in Neurodegeneration and Neuroprotection in Parkinson's Disease, Olanow, C. W., Jenner, P., and Youdim, M. B., eds., Academic Press, London, pp. 55-69.
    • (1996) Neurodegeneration and Neuroprotection in Parkinson's Disease , pp. 55-69
    • Olanow, C.W.1    Youdim, M.B.2
  • 75
    • 0034663039 scopus 로고    scopus 로고
    • The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity
    • Ostrerova-Golts N., Petrucelli L., Hardy J., Lee J. M., Farer M., and Wolozin B. (2000) The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. J. Neurosci. 20, 6048-6054.
    • (2000) J. Neurosci. , vol.20 , pp. 6048-6054
    • Ostrerova-Golts, N.1    Petrucelli, L.2    Hardy, J.3    Lee, J.M.4    Farer, M.5    Wolozin, B.6
  • 76
    • 0022538078 scopus 로고
    • Manipulation of glutathione contents fails to alter dopaminergic nigrostriatal neurotoxicity of N-methyl-4-phenyl-1,2,3,6- Tetrahydropyridine (MPTP) in the mouse
    • Perry T. L., Yong V. W., Jones K., and Wright J. M. (1986) Manipulation of glutathione contents fails to alter dopaminergic nigrostriatal neurotoxicity of N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in the mouse. Neurosci. Lett. 70, 261-265.
    • (1986) Neurosci. Lett. , vol.70 , pp. 261-265
    • Perry, T.L.1    Yong, V.W.2    Jones, K.3    Wright, J.M.4
  • 77
    • 0032960760 scopus 로고    scopus 로고
    • Developmental expression of alpha-synuclein in rat hippocampus and cerebral cortex
    • Petersen K., Diesen O. F., and Mikkelsen J. D. (1999) Developmental expression of alpha-synuclein in rat hippocampus and cerebral cortex. Neuroscience 91, 651-659.
    • (1999) Neuroscience , vol.91 , pp. 651-659
    • Petersen, K.1    Diesen, O.F.2    Mikkelsen, J.D.3
  • 78
    • 1842608738 scopus 로고    scopus 로고
    • Hereditary causes of distributed iron homeostasis in the central nervous system
    • Ponka P. (2004) Hereditary causes of distributed iron homeostasis in the central nervous system. Ann. NY Acad. Sci. 1012, 267-281.
    • (2004) Ann. NY Acad. Sci. , vol.1012 , pp. 267-281
    • Ponka, P.1
  • 79
    • 0037461309 scopus 로고    scopus 로고
    • Neuroprotective agents for clinical trials in Parkinson's disease: A systematic assessment
    • Ravina B. M., Fagan S. C., Hart R. G., Hovinga C. A., Murphy D. D., Dawson T. M., and Marler J. R. (2003) Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment. Neurology 60, 1234-1240.
    • (2003) Neurology , vol.60 , pp. 1234-1240
    • Ravina, B.M.1    Fagan, S.C.2    Hart, R.G.3    Hovinga, C.A.4    Murphy, D.D.5    Dawson, T.M.6    Marler, J.R.7
  • 81
    • 0038155162 scopus 로고    scopus 로고
    • Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor
    • Sagi Y., Weinstock M., and Youdim M. B. (2003) Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor. J. Neurochem. 86, 290-297.
    • (2003) J. Neurochem. , vol.86 , pp. 290-297
    • Sagi, Y.1    Weinstock, M.2    Youdim, M.B.3
  • 82
  • 83
    • 0032808086 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys
    • Schneider J. S., Tinker J. P., Van Velson M., Menzaghi F., and Lloyd G. K. (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J. Pharmacol. Exp. Ther. 290, 731-739.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 731-739
    • Schneider, J.S.1    Tinker, J.P.2    Van Velson, M.3    Menzaghi, F.4    Lloyd, G.K.5
  • 84
    • 0010382829 scopus 로고    scopus 로고
    • α-Synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway
    • Seo J. H., Rah J. C., Choi S. H., Shin J. K., Min K., Kim H. S., et al. (2002) α-Synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB J. 5, 5.
    • (2002) FASEB J. , vol.5 , pp. 5
    • Seo, J.H.1    Rah, J.C.2    Choi, S.H.3    Shin, J.K.4    Min, K.5    Kim, H.S.6
  • 85
    • 0346849912 scopus 로고    scopus 로고
    • Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats
    • Shachar D. B., Kahana N., Kampel V., Warshawsky A., and Youdim M. B. (2004) Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. Neuropharmacology 46, 254-263.
    • (2004) Neuropharmacology , vol.46 , pp. 254-263
    • Shachar, D.B.1    Kahana, N.2    Kampel, V.3    Warshawsky, A.4    Youdim, M.B.5
  • 86
    • 0025963530 scopus 로고
    • Selective increase of iron in substantia nigra zona compacta of parkinsonian brains
    • Sofic E., Paulus W., Jellinger K., Riederer P., and Youdim M. B. H. (1991) Selective increase of iron in substantia nigra zona compacta of parkinsonian brains. J. Neurochem. 56, 978-982.
    • (1991) J. Neurochem. , vol.56 , pp. 978-982
    • Sofic, E.1    Paulus, W.2    Jellinger, K.3    Riederer, P.4    Youdim, M.B.H.5
  • 87
    • 0028045734 scopus 로고
    • Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: Evidence from proton microprobe elemental microanalysis
    • Temlett J. A., Landsberg J. P., Watt F., Grime G. W. (1994) Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis. J. Neurochem. 62, 134-146.
    • (1994) J. Neurochem. , vol.62 , pp. 134-146
    • Temlett, J.A.1    Landsberg, J.P.2    Watt, F.3    Grime, G.W.4
  • 88
    • 0035873812 scopus 로고    scopus 로고
    • α-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro
    • Turnbull S., Tabner B. J., El-Agnaf O. M., Moore S., Davies Y., and Allsop D. (2001) α-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro. Free Radic. Biol. Med. 30, 1163-1170.
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 1163-1170
    • Turnbull, S.1    Tabner, B.J.2    El-Agnaf, O.M.3    Moore, S.4    Davies, Y.5    Allsop, D.6
  • 89
    • 0038205745 scopus 로고    scopus 로고
    • Targeting programmed cell death in neurodegenerative diseases
    • Vila M. and Przedborski S. (2003) Targeting programmed cell death in neurodegenerative diseases. Nat. Rev. Neurosci. 4, 365-375.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 365-375
    • Vila, M.1    Przedborski, S.2
  • 90
    • 0035956874 scopus 로고    scopus 로고
    • Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Vila M., Jackson-Lewis V., Vukosavic S., Djaldetti R., Liberatore G., Offen D., et al. (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 98, 2837-2842.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 2837-2842
    • Vila, M.1    Jackson-Lewis, V.2    Vukosavic, S.3    Djaldetti, R.4    Liberatore, G.5    Offen, D.6
  • 91
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila M., Vukosavic S., Jackson-Lewis V., Neystat M., Jakowec M., and Przedborski S. (2000) Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem. 74, 721-729.
    • (2000) J. Neurochem. , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 92
    • 0038322479 scopus 로고    scopus 로고
    • cDNA gene expression profile homology of antioxidants and their anti-apoptotic and pro-apoptotic activities in human neuroblastoma cells
    • Weinreb O., Mandel S., and Youdim M. B. H. (2003a) cDNA gene expression profile homology of antioxidants and their anti-apoptotic and pro-apoptotic activities in human neuroblastoma cells. FASEB J. 17, 935-937.
    • (2003) FASEB J. , vol.17 , pp. 935-937
    • Weinreb, O.1    Mandel, S.2    Youdim, M.B.H.3
  • 93
    • 0038727646 scopus 로고    scopus 로고
    • Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3- gallate, and melatonin
    • Weinreb O., Mandel S., and Youdim M. B. (2003b) Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin. Ann. N. Y. Acad. Sci. 993, 351-361; discussion, 387-393.
    • (2003) Ann. N. Y. Acad. Sci. , vol.993 , pp. 351-361
    • Weinreb, O.1    Mandel, S.2    Youdim, M.B.3
  • 94
    • 0031051539 scopus 로고    scopus 로고
    • Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons
    • Withers G. S., George J. M., Banker G. A., and Clayton D. F. (1997) Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. Brain Res. Dev. Brain Res. 99, 87-94.
    • (1997) Brain Res. Dev. Brain Res. , vol.99 , pp. 87-94
    • Withers, G.S.1    George, J.M.2    Banker, G.A.3    Clayton, D.F.4
  • 95
    • 0032531886 scopus 로고    scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2
    • Yang L., Matthews R. T., Schulz J. B., Klockgether T., Liao A. W., Martinou J. C., et al. (1998) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. J. Neurosci. 18, 8145-8152.
    • (1998) J. Neurosci. , vol.18 , pp. 8145-8152
    • Yang, L.1    Matthews, R.T.2    Schulz, J.B.3    Klockgether, T.4    Liao, A.W.5    Martinou, J.C.6
  • 96
    • 0642303109 scopus 로고    scopus 로고
    • The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing
    • Yogev-Falach M., Amit T., Bar-Am O., and Youdim M. B. (2003) The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing. FASEB J. 17, 2325-2327.
    • (2003) FASEB J. , vol.17 , pp. 2325-2327
    • Yogev-Falach, M.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4
  • 97
    • 0345308381 scopus 로고    scopus 로고
    • Rasagiline: An anti-Parkinson drug with neuroprotective activity
    • Youdim M. B. H. (2003) Rasagiline: an anti-Parkinson drug with neuroprotective activity. Expert Rev. Neurother. 3, 737-749.
    • (2003) Expert Rev. Neurother. , vol.3 , pp. 737-749
    • Youdim, M.B.H.1
  • 98
    • 3042530369 scopus 로고    scopus 로고
    • Iron in the brain, normal and pathological
    • Smith, B., and Adelman, G., eds., Elsevier, Amsterdam, in press
    • Youdim M. B. H. and Riederer P. (2004) Iron in the brain, normal and pathological, in Encyclopedia of Neuroscience, Smith, B., and Adelman, G., eds., Elsevier, Amsterdam, in press.
    • (2004) Encyclopedia of Neuroscience
    • Youdim, M.B.H.1    Riederer, P.2
  • 99
    • 1842608744 scopus 로고    scopus 로고
    • Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators; a lesson from 6-hydroxydopamine and iron chelators desferal and vk-28
    • Youdim M. B. H., Stephenson G., and Ben-Shachar D. (2004) Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators; a lesson from 6-hydroxydopamine and iron chelators desferal and vk-28. Ann. N. Y. Acad. Sci., 1012, 306-325.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1012 , pp. 306-325
    • Youdim, M.B.H.1    Stephenson, G.2    Ben-Shachar, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.