-
1
-
-
0033835996
-
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T. 2000. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916-919.
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
2
-
-
0034704198
-
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
-
Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. 2000. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 290:2302-2303.
-
(2000)
Science
, vol.290
, pp. 2302-2303
-
-
Bertram, L.1
Blacker, D.2
Mullin, K.3
Keeney, D.4
Jones, J.5
Basu, S.6
Yhu, S.7
McInnis, M.G.8
Go, R.C.9
Vekrellis, K.10
Selkoe, D.J.11
Saunders, A.J.12
Tanzi, R.E.13
-
3
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS. 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17:1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
4
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. 1998. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 273:3205-3211.
-
(1998)
J Biol Chem
, vol.273
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
Nixon, R.6
Beyreuther, K.7
Selkoe, D.J.8
Haass, C.9
-
5
-
-
0033783140
-
Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
-
Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C. 2000. Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch. Nat Cell Biol 2:205-211.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 205-211
-
-
Capell, A.1
Steiner, H.2
Romig, H.3
Keck, S.4
Baader, M.5
Grim, M.G.6
Baumeister, R.7
Haass, C.8
-
6
-
-
0030823756
-
Acceleration of amyloid fibril formation by specific binding of Aβ-(1-40) peptide to ganglioside-containing membrane vesicles
-
Choo-Smith LP, Garzon-Rodriguez W, Glabe CG, Surewicz WK. 1997. Acceleration of amyloid fibril formation by specific binding of Aβ-(1-40) peptide to ganglioside-containing membrane vesicles. J Biol Chem 272:22987-22990.
-
(1997)
J Biol Chem
, vol.272
, pp. 22987-22990
-
-
Choo-Smith, L.P.1
Garzon-Rodriguez, W.2
Glabe, C.G.3
Surewicz, W.K.4
-
7
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onsetfamilies
-
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onsetfamilies. Science 261:921-923.
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
8
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, VanLeuven F. 1998. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391:387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
VanLeuven, F.8
-
9
-
-
0033535504
-
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. 1999. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
10
-
-
0035902619
-
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance anddecreases brain Aβ burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. 2001. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance anddecreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98:8850-8855.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.C.4
Paul, S.M.5
Holtzman, D.M.6
-
11
-
-
0035979234
-
Presenilin-dependent γ-secretase activity modulates thymocyte development
-
Doerfler P, Shearman MS, Perlmutter RM. 2001. Presenilin-dependent γ-secretase activity modulates thymocyte development. Proc Natl Acad Sci USA 98:9312-9317.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9312-9317
-
-
Doerfler, P.1
Shearman, M.S.2
Perlmutter, R.M.3
-
12
-
-
0034703979
-
Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG. 2000. Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 290:2303-2304.
-
(2000)
Science
, vol.290
, pp. 2303-2304
-
-
Ertekin-Taner, N.1
Graff-Radford, N.2
Younkin, L.H.3
Eckman, C.4
Baker, M.5
Adamson, J.6
Ronald, J.7
Blangero, J.8
Hutton, M.9
Younkin, S.G.10
-
13
-
-
0033780472
-
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
-
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. 2000. Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1. Nat Cell Biol 2:428-434.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 428-434
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
Tsai, J.Y.6
Rahmati, T.7
Xia, W.8
Selkoe, D.J.9
Wolfe, M.S.10
-
14
-
-
0031781795
-
Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease
-
Funato H, Yoshimura M, Kusui K, Tamaoka A, Ishikawa K, Ohkoshi N, Namekata K, Okeda R, Ihara Y. 1998. Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease. Am J Pathol 152:1633-1640.
-
(1998)
Am J Pathol
, vol.152
, pp. 1633-1640
-
-
Funato, H.1
Yoshimura, M.2
Kusui, K.3
Tamaoka, A.4
Ishikawa, K.5
Ohkoshi, N.6
Namekata, K.7
Okeda, R.8
Ihara, Y.9
-
15
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner GG, Wong CW. 1984. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885-890.
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
16
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
17
-
-
0029907548
-
Assembly of microtubule-associated protein tau into Alzheimer-like filamentsinduced by sulphated glycosaminoglycans
-
Goedert M, Jakes R, Spillantini MG, Hasegawa M, Smith MJ, Crowther RA. 1996. Assembly of microtubule-associated protein tau into Alzheimer-like filamentsinduced by sulphated glycosaminoglycans. Nature 383:550-553.
-
(1996)
Nature
, vol.383
, pp. 550-553
-
-
Goedert, M.1
Jakes, R.2
Spillantini, M.G.3
Hasegawa, M.4
Smith, M.J.5
Crowther, R.A.6
-
18
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. 2001. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ42 fibrils. Science 293:1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
19
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. 1986. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261:6084-6089.
-
(1986)
J Biol Chem
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
Tung, Y.C.4
Zaidi, M.S.5
Wisniewski, H.M.6
-
20
-
-
0035929554
-
Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling γ-secretase-like cleavage of Notch
-
Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y. 2001. Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling γ-secretase-like cleavage of Notch. J Biol Chem 276:35235-35238.
-
(2001)
J Biol Chem
, vol.276
, pp. 35235-35238
-
-
Gu, Y.1
Misonou, H.2
Sato, T.3
Dohmae, N.4
Takio, K.5
Ihara, Y.6
-
21
-
-
0026646604
-
Amyloid β-peptide is produced by cultured cells during normal metabolism
-
Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, Selkoe DJ. 1992. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359:322-325.
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
Selkoe, D.J.11
-
22
-
-
0031741247
-
New phosphorylation sites identified in hyperphosphorylated tau (paired helicalfilament-tau) from Alzheimer's disease brain using nanoelectrospray massspectrometry
-
Hanger DP, Betts JC, Loviny TL, Blackstock WP, Anderton BH. 1998. New phosphorylation sites identified in hyperphosphorylated tau (paired helicalfilament-tau) from Alzheimer's disease brain using nanoelectrospray massspectrometry. J Neurochem 71:2465-2476.
-
(1998)
J Neurochem
, vol.71
, pp. 2465-2476
-
-
Hanger, D.P.1
Betts, J.C.2
Loviny, T.L.3
Blackstock, W.P.4
Anderton, B.H.5
-
23
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA. 1992. Alzheimer's disease: The amyloid cascade hypothesis. Science 256:184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
24
-
-
0032561415
-
Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
-
Hasegawa M, Smith MJ, Goedert M. 1998. Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly. FEBS Lett 437:207-210.
-
(1998)
FEBS Lett
, vol.437
, pp. 207-210
-
-
Hasegawa, M.1
Smith, M.J.2
Goedert, M.3
-
25
-
-
0033775709
-
Total inactivation of γ-secretase activity in presenilin-deficient embryonic stem cells
-
Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B. 2000. Total inactivation of γ-secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol 2:461-462.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 461-462
-
-
Herreman, A.1
Serneels, L.2
Annaert, W.3
Collen, D.4
Schoonjans, L.5
De Strooper, B.6
-
26
-
-
0032484089
-
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
-
Hong M, Zhukareva V, Vogelsberg-Ragaglia V, Wszolek Z, Reed L, Miller BI, Geschwind DH, Bird TD, McKeel D, Goate A, Morris JC, Wilhelmsen KC, Schellenberg GD, Trojanowski JQ, Lee VM. 1998. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282:1914-1917.
-
(1998)
Science
, vol.282
, pp. 1914-1917
-
-
Hong, M.1
Zhukareva, V.2
Vogelsberg-Ragaglia, V.3
Wszolek, Z.4
Reed, L.5
Miller, B.I.6
Geschwind, D.H.7
Bird, T.D.8
McKeel, D.9
Goate, A.10
Morris, J.C.11
Wilhelmsen, K.C.12
Schellenberg, G.D.13
Trojanowski, J.Q.14
Lee, V.M.15
-
27
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as β-secretase
-
Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G. 1999. Identification of a novel aspartic protease (Asp 2) as β-secretase. Mol Cell Neurosci 14:419-427.
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
28
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowsky J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JBJ, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P. 1998. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393:702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
Pickering-Brown, S.7
Chakraverty, S.8
Isaacs, A.9
Grover, A.10
Hackett, J.11
Adamson, J.12
Lincoln, S.13
Dickson, D.14
Davies, P.15
Petersen, R.C.16
Stevens, M.17
De Graaff, E.18
Wauters, E.19
Van Baren, J.20
Hillebrand, M.21
Joosse, M.22
Kwon, J.M.23
Nowotny, P.24
Che, L.K.25
Norton, J.26
Morris, J.C.27
Reed, L.A.28
Trojanowsky, J.29
Basun, H.30
Lannfelt, L.31
Neystat, M.32
Fahn, S.33
Dark, F.34
Tannenberg, T.35
Dodd, P.R.36
Hayward, N.37
Kwok, J.B.J.38
Schofield, P.R.39
Andreadis, A.40
Snowden, J.41
Craufurd, D.42
Neary, D.43
Owen, F.44
Oostra, B.A.45
Hardy, J.46
Goate, A.47
Van Swieten, J.48
Mann, D.49
Lynch, T.50
Heutink, P.51
more..
-
29
-
-
0035816709
-
Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, anendogenous seed for Alzheimer amyloid
-
Kakio A, Nishimoto SI, Yanagisawa K, Kozutsumi Y, Matsuzaki K. 2001. Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, anendogenous seed for Alzheimer amyloid. J Biol Chem 276:24985-24990.
-
(2001)
J Biol Chem
, vol.276
, pp. 24985-24990
-
-
Kakio, A.1
Nishimoto, S.I.2
Yanagisawa, K.3
Kozutsumi, Y.4
Matsuzaki, K.5
-
30
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
31
-
-
0024109663
-
The carboxyl third of tau is tightly bound to paired helical filaments
-
Kondo J, Honda T, Mori H, Hamada Y, Miura R, Ogawara M, Ihara Y. 1988. The carboxyl third of tau is tightly bound to paired helical filaments. Neuron 1:827-834.
-
(1988)
Neuron
, vol.1
, pp. 827-834
-
-
Kondo, J.1
Honda, T.2
Mori, H.3
Hamada, Y.4
Miura, R.5
Ogawara, M.6
Ihara, Y.7
-
32
-
-
0031746979
-
A detergent-insoluble membrane compartment contains Aβ in vivo
-
Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT Jr, Kosik KS. 1998. A detergent-insoluble membrane compartment contains Aβ in vivo. Nat Med 4:730-734.
-
(1998)
Nat Med
, vol.4
, pp. 730-734
-
-
Lee, S.J.1
Liyanage, U.2
Bickel, P.E.3
Xia, W.4
Lansbury P.T., Jr.5
Kosik, K.S.6
-
33
-
-
0025904444
-
A68: A major subunit of paired helical filaments and derivatized forms of normal tau
-
Lee VM, Balin BJ, Otvos L Jr, Trojanowski JQ. 1991. A68: A major subunit of paired helical filaments and derivatized forms of normal tau. Science 251:675-678.
-
(1991)
Science
, vol.251
, pp. 675-678
-
-
Lee, V.M.1
Balin, B.J.2
Otvos L., Jr.3
Trojanowski, J.Q.4
-
34
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, Crowly AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wijsman EM, Bird TD, Schellenberg GD, Tanzi RE. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.E.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
Crowly, A.C.11
Fu, Y.-H.12
Guenette, S.Y.13
Galas, D.14
Nemens, E.15
Wijsman, E.M.16
Bird, T.D.17
Schellenberg, G.D.18
Tanzi, R.E.19
-
35
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E. 2001. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293:1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
36
-
-
0034621824
-
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ. 2000. Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405:689-694.
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzio-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelil, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.P.15
Yin, K.C.16
Shafer, J.A.17
Gardell, S.J.18
-
37
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. 1985. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82:4245-4249.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
38
-
-
0033055359
-
Stable expression in Chinese hamster ovary cells of mutated tau genes causingfrontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
-
Matsumura N, Yamazaki T, Ihara Y. 1999. Stable expression in Chinese hamster ovary cells of mutated tau genes causingfrontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Am J Pathol 154:1649-1656.
-
(1999)
Am J Pathol
, vol.154
, pp. 1649-1656
-
-
Matsumura, N.1
Yamazaki, T.2
Ihara, Y.3
-
39
-
-
0035131614
-
Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation
-
Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y. 2001a. Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation. Am J Pathol 158:373-379.
-
(2001)
Am J Pathol
, vol.158
, pp. 373-379
-
-
Miyasaka, T.1
Morishima-Kawashima, M.2
Ravid, R.3
Heutink, P.4
Van Swieten, J.C.5
Nagashima, K.6
Ihara, Y.7
-
40
-
-
0034823184
-
Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation
-
Miyasaka T, Morishima-Kawashima M, Ravid R, Kamphorst W, Nagashima K, Ihara Y. 2001b. Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation. J Neuropathol Exp Neurol 60:872-884.
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, pp. 872-884
-
-
Miyasaka, T.1
Morishima-Kawashima, M.2
Ravid, R.3
Kamphorst, W.4
Nagashima, K.5
Ihara, Y.6
-
41
-
-
0023140474
-
Ubiquitin is a component of paired helical filaments in Alzheimer's disease
-
Mori H, Kondo J, Ihara Y. 1987. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 235:1641-1644.
-
(1987)
Science
, vol.235
, pp. 1641-1644
-
-
Mori, H.1
Kondo, J.2
Ihara, Y.3
-
42
-
-
0032480771
-
The presence of amyloid betaprotein in the detergent-insoluble membranecompartment of human neuroblastoma cells
-
Morishima-Kawashima M, Ihara Y. 1998. The presence of amyloid betaprotein in the detergent-insoluble membranecompartment of human neuroblastoma cells. Biochemistry 37:15247-15253.
-
(1998)
Biochemistry
, vol.37
, pp. 15247-15253
-
-
Morishima-Kawashima, M.1
Ihara, Y.2
-
43
-
-
0027193036
-
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
-
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Titani K, Ihara Y. 1993. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments. Neuron 10:1151-1160.
-
(1993)
Neuron
, vol.10
, pp. 1151-1160
-
-
Morishima-Kawashima, M.1
Hasegawa, M.2
Takio, K.3
Suzuki, M.4
Titani, K.5
Ihara, Y.6
-
44
-
-
0028899714
-
Proline-directed and non-proline-directed phosphorylation of PHF-tau
-
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Titani K, Ihara Y. 1995. Proline-directed and non-proline-directed phosphorylation of PHF-tau. J Biol Chem 270:823-829.
-
(1995)
J Biol Chem
, vol.270
, pp. 823-829
-
-
Morishima-Kawashima, M.1
Hasegawa, M.2
Takio, K.3
Suzuki, M.4
Yoshida, H.5
Titani, K.6
Ihara, Y.7
-
45
-
-
0033635302
-
Effect of apolipoprotein E allele ε4 on the initial phase of amyloid β-protein accumulation in the human brain
-
Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, Ihara Y. 2000. Effect of apolipoprotein E allele ε4 on the initial phase of amyloid β-protein accumulation in the human brain. Am J Pathol 157:2093-2099.
-
(2000)
Am J Pathol
, vol.157
, pp. 2093-2099
-
-
Morishima-Kawashima, M.1
Oshima, N.2
Ogata, H.3
Yamaguchi, H.4
Yoshimura, M.5
Sugihara, S.6
Ihara, Y.7
-
46
-
-
0034704197
-
Susceptibility locus for Alzheimer's disease on chromosome 10
-
Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290:2304-2305.
-
(2000)
Science
, vol.290
, pp. 2304-2305
-
-
Myers, A.1
Holmans, P.2
Marshall, H.3
Kwon, J.4
Meyer, D.5
Ramic, D.6
Shears, S.7
Booth, J.8
DeVrieze, F.W.9
Crook, R.10
Hamshere, M.11
Abraham, R.12
Tunstall, N.13
Rice, F.14
Carty, S.15
Lillystone, S.16
Kehoe, P.17
Rudrasingham, V.18
Jones, L.19
Lovestone, S.20
Perez-Tur, J.21
Williams, J.22
Owen, M.J.23
Hardy, J.24
Goate, A.M.25
more..
-
47
-
-
0035824391
-
γ-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
-
Ni CY, Murphy MP, Golde TE, Carpenter G. 2001. γ-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294:2179-2181.
-
(2001)
Science
, vol.294
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
Carpenter, G.4
-
48
-
-
0022723508
-
One of the antigenic determinants of paired helical filaments is related to tau protein
-
Nukina N, Ihara Y. 1986. One of the antigenic determinants of paired helical filaments is related to tau protein. J Biochem (Tokyo) 99:1541-1544.
-
(1986)
J Biochem (Tokyo)
, vol.99
, pp. 1541-1544
-
-
Nukina, N.1
Ihara, Y.2
-
49
-
-
0035956428
-
Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway
-
Okamoto I, Kawano Y, Murakami D, Sasayama T, Araki N, Miki T, Wong AJ, Saya H. 2001. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J Cell Biol 155:755-762.
-
(2001)
J Cell Biol
, vol.155
, pp. 755-762
-
-
Okamoto, I.1
Kawano, Y.2
Murakami, D.3
Sasayama, T.4
Araki, N.5
Miki, T.6
Wong, A.J.7
Saya, H.8
-
50
-
-
0034975370
-
Accumulation of amyloid β-protein in the low-density membrane domain accuratelyreflects the extent of β-amyloid deposition in the brain
-
Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y. 2001. Accumulation of amyloid β-protein in the low-density membrane domain accuratelyreflects the extent of β-amyloid deposition in the brain. Am J Pathol 158:2209-2218.
-
(2001)
Am J Pathol
, vol.158
, pp. 2209-2218
-
-
Oshima, N.1
Morishima-Kawashima, M.2
Yamaguchi, H.3
Yoshimura, M.4
Sugihara, S.5
Khan, K.6
Games, D.7
Schenk, D.8
Ihara, Y.9
-
51
-
-
0030770726
-
Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
-
Pericak-Vance MA, Bass MP, Yamaoka LH, Gaskell PC, Scott WK, Terwedow HA, Menold MM, Conneally PM, Small GW, Vance JM, Saunders AM, Roses AD, Haines JL. 1997. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 278:1237-1241.
-
(1997)
JAMA
, vol.278
, pp. 1237-1241
-
-
Pericak-Vance, M.A.1
Bass, M.P.2
Yamaoka, L.H.3
Gaskell, P.C.4
Scott, W.K.5
Terwedow, H.A.6
Menold, M.M.7
Conneally, P.M.8
Small, G.W.9
Vance, J.M.10
Saunders, A.M.11
Roses, A.D.12
Haines, J.L.13
-
52
-
-
0035005101
-
New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage
-
Petit A, Bihel F, Alves da Costa C, Pourquie O, Checler F, Kraus JL. 2001. New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat Cell Biol 3:507-511.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 507-511
-
-
Petit, A.1
Bihel, F.2
Alves da Costa, C.3
Pourquie, O.4
Checler, F.5
Kraus, J.L.6
-
53
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD. 1998. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 43:815-825.
-
(1998)
Ann Neurol
, vol.43
, pp. 815-825
-
-
Poorkaj, P.1
Bird, T.D.2
Wijsman, E.3
Nemens, E.4
Garruto, R.M.5
Anderson, L.6
Andreadis, A.7
Wiederholt, W.C.8
Raskind, M.9
Schellenberg, G.D.10
-
54
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, Mar L, Sorbi S, Nacmias B, Placentini S, Amaducci L, Chumakov I, Cohen D, Lannfelt L, Fraser PE, Rommens JM, St. George-Hyslop PH. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
Mar, L.11
Sorbi, S.12
Nacmias, B.13
Placentini, S.14
Amaducci, L.15
Chumakov, I.16
Cohen, D.17
Lannfelt, L.18
Fraser, P.E.19
Rommens, J.M.20
St. George-Hyslop, P.H.21
more..
-
55
-
-
0034774969
-
Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
-
Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C. 2001. Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep 2:835-841.
-
(2001)
EMBO Rep
, vol.2
, pp. 835-841
-
-
Sastre, M.1
Steiner, H.2
Fuchs, K.3
Capell, A.4
Multhaup, G.5
Condron, M.M.6
Teplow, D.B.7
Haass, C.8
-
56
-
-
0034623284
-
Mutant presenilin 2 transgenic mice. A large increase in the levels of Aβ42 is presumablyassociated with the low density membrane domain that contains decreased levels of blycerophospholipids and sphingomyelin
-
Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. 2000. Mutant presenilin 2 transgenic mice. A large increase in the levels of Aβ42 is presumablyassociated with the low density membrane domain that contains decreased levels of blycerophospholipids and sphingomyelin. J Biol Chem 275:27901-27908.
-
(2000)
J Biol Chem
, vol.275
, pp. 27901-27908
-
-
Sawamura, N.1
Morishima-Kawashima, M.2
Waki, H.3
Kobayashi, K.4
Kuramochi, T.5
Frosch, M.P.6
Ding, K.7
Ito, M.8
Kim, T.W.9
Tanzi, R.E.10
Oyama, F.11
Tabira, T.12
Ando, S.13
Ihara, Y.14
-
57
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology inthe PDAPP mouse
-
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P. 1999. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology inthe PDAPP mouse. Nature 400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
58
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease isincreased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. 1996. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease isincreased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2:864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
59
-
-
0033966452
-
Notch and presenilins in vertebrates and invertebrates: Implications for neuronaldevelopment and degeneration
-
Selkoe DJ. 2000. Notch and presenilins in vertebrates and invertebrates: Implications for neuronaldevelopment and degeneration. Curr Opin Neurobiol 10:50-57.
-
(2000)
Curr Opin Neurobiol
, vol.10
, pp. 50-57
-
-
Selkoe, D.J.1
-
60
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin J-F, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HAR, Haines JL, Pericak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St. George-Hyslop PH. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsuda, T.11
Mar, L.12
Foncin, J.-F.13
Bruni, A.C.14
Montesi, M.P.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumakov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Polinsky, R.J.24
Wasco, W.25
Da Silva, H.A.R.26
Haines, J.L.27
Pericak-Vance, M.A.28
Tanzi, R.E.29
Roses, A.D.30
Fraser, P.E.31
Rommens, J.M.32
St. George-Hyslop, P.H.33
more..
-
61
-
-
0026760261
-
Production of the Alzheimer amyloid β protein by normal proteolytic processing
-
Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai XD, McKay DM, Tintner R, Frangione B, Younkin SG. 1992. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258:126-129.
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
Cheung, T.T.4
Estus, S.5
Shaffer, L.M.6
Cai, X.D.7
McKay, D.M.8
Tintner, R.9
Frangione, B.10
Younkin, S.G.11
-
62
-
-
0033518251
-
Purification and cloning of amyloid precursor protein β-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McCoulogue L, John V. 1999. Purification and cloning of amyloid precursor protein β-secretase from human brain. Nature 402:537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
Zhao, J.25
McCoulogue, L.26
John, V.27
more..
-
64
-
-
0025179972
-
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneousdisorder
-
FAD Collaborative Study Group
-
St. George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, McLachlan DR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin J-F, Pollen D, Cantu J-M, Tupler R, Voskresenskaya N, Mayeux R, Growdon J, Fried VA, Myers RH, Nee L, Backhovens H, Martin J-J, Rossor M, Owen MJ, Mullan M, Percy ME, Karlinsky H, et al. 1990. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneousdisorder. FAD Collaborative Study Group. Nature 347:194-197.
-
(1990)
Nature
, vol.347
, pp. 194-197
-
-
St. George-Hyslop, P.H.1
Haines, J.L.2
Farrer, L.A.3
Polinsky, R.4
Van Broeckhoven, C.5
Goate, A.6
McLachlan, D.R.7
Orr, H.8
Bruni, A.C.9
Sorbi, S.10
Rainero, I.11
Foncin, J.-F.12
Pollen, D.13
Cantu, J.-M.14
Tupler, R.15
Voskresenskaya, N.16
Mayeux, R.17
Growdon, J.18
Fried, V.A.19
Myers, R.H.20
Nee, L.21
Backhovens, H.22
Martin, J.-J.23
Rossor, M.24
Owen, M.J.25
Mullan, M.26
Percy, M.E.27
Karlinsky, H.28
more..
-
65
-
-
0033535508
-
Presenilin is required for activity and nuclear access of Notch in Drosophila
-
Struhl G, Greenwald I. 1999. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398:522-525.
-
(1999)
Nature
, vol.398
, pp. 522-525
-
-
Struhl, G.1
Greenwald, I.2
-
66
-
-
0028322017
-
An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants
-
Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, Eckman C, Golde TE, Younkin SG. 1994. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants. Science 264:1336-1340.
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
Odaka, A.4
Otvos L., Jr.5
Eckman, C.6
Golde, T.E.7
Younkin, S.G.8
-
67
-
-
0033595706
-
β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. 1999. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
68
-
-
0036180950
-
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
-
Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. 2002. Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9:11-23.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 11-23
-
-
Wahrle, S.1
Das, P.2
Nyborg, A.C.3
McLendon, C.4
Shoji, M.5
Kawarabayashi, T.6
Younkin, L.H.7
Younkin, S.G.8
Golde, T.E.9
-
69
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. 2001. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 414:212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
70
-
-
0037176727
-
A novel ε-cleavage within the transmembrane domain of the Alzheimer amyloid precursorprotein demonstrates homology with Notch processing
-
Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G. 2002. A novel ε-cleavage within the transmembrane domain of the Alzheimer amyloid precursorprotein demonstrates homology with Notch processing. Biochemistry 41:2825-2835.
-
(2002)
Biochemistry
, vol.41
, pp. 2825-2835
-
-
Weidemann, A.1
Eggert, S.2
Reinhard, F.B.3
Vogel, M.4
Paliga, K.5
Baier, G.6
Masters, C.L.7
Beyreuther, K.8
Evin, G.9
-
71
-
-
0003986552
-
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease
-
Wischik CM, Novak M, Thogersen HC, Edwards PC, Runswick MJ, Jakes R, Walker JE, Milstein C, Roth M, Klug A. 1988. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci USA 85:4506-4510.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4506-4510
-
-
Wischik, C.M.1
Novak, M.2
Thogersen, H.C.3
Edwards, P.C.4
Runswick, M.J.5
Jakes, R.6
Walker, J.E.7
Milstein, C.8
Roth, M.9
Klug, A.10
-
72
-
-
0031915681
-
A substrate-based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity
-
Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. 1998. A substrate-based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity. J Med Chem 41:6-9.
-
(1998)
J Med Chem
, vol.41
, pp. 6-9
-
-
Wolfe, M.S.1
Citron, M.2
Diehl, T.S.3
Xia, W.4
Donkor, I.O.5
Selkoe, D.J.6
-
73
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. 1999a. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398:513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
74
-
-
0033551099
-
Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease
-
Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. 1999b. Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 38:4720-4727.
-
(1999)
Biochemistry
, vol.38
, pp. 4720-4727
-
-
Wolfe, M.S.1
Xia, W.2
Moore, C.L.3
Leatherwood, D.D.4
Ostaszewski, B.5
Rahmati, T.6
Donkor, I.O.7
Selkoe, D.J.8
-
75
-
-
0035826795
-
A fluid connection: Cholesterol and Aβ
-
Wolozin B. 2001. A fluid connection: Cholesterol and Aβ. Proc Natl Acad Sci USA 98:5371-5373.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5371-5373
-
-
Wolozin, B.1
-
76
-
-
0033882638
-
Amyloid β protein (Aβ) starts to deposit as plasma membrane-bound form indiffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type. Alzheimer disease and nondemented aged subjects
-
Yamaguchi H, Maat-Schieman ML, van Duinen SG, Prins FA, Neeskens P, Natte R, Roos RA. 2000. Amyloid β protein (Aβ) starts to deposit as plasma membrane-bound form indiffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects. J Neuropathol Exp Neurol 59:723-732.
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, pp. 723-732
-
-
Yamaguchi, H.1
Maat-Schieman, M.L.2
Van Duinen, S.G.3
Prins, F.A.4
Neeskens, P.5
Natte, R.6
Roos, R.A.7
-
77
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME. 1999. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature 402:533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashier, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
Carter, D.B.11
Tomasselli, A.G.12
Parodi, L.A.13
Heinrikson, R.L.14
Gurney, M.E.15
-
78
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellularcomplex that contains β-catenin
-
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva E, Xu D, Liang Y, Duthie M, St. George-Hyslop PH, Fraser PE. 1998. The presenilin 1 protein is a component of a high molecular weight intracellularcomplex that contains β-catenin. J Biol Chem 273:16470-16475.
-
(1998)
J Biol Chem
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
Levesque, L.6
Rogaeva, E.7
Xu, D.8
Liang, Y.9
Duthie, M.10
St. George-Hyslop, P.H.11
Fraser, P.E.12
-
79
-
-
0037177826
-
Proteolysis of chimeric β-amyloid precursor proteins containing the Notchtransmembrane domain yields an amyloid β-like peptides
-
Zhang J, Ye W, Wang R, Wolfe MS, Greenberg BD, Selkoe DJ. 2002. Proteolysis of chimeric β-amyloid precursor proteins containing the Notchtransmembrane domain yields an amyloid β-like peptides. J Biol Chem 277:15069-15075.
-
(2002)
J Biol Chem
, vol.277
, pp. 15069-15075
-
-
Zhang, J.1
Ye, W.2
Wang, R.3
Wolfe, M.S.4
Greenberg, B.D.5
Selkoe, D.J.6
-
80
-
-
0033779635
-
Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1
-
Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. 2000. Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1. Nat Cell Biol 2:463-465.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 463-465
-
-
Zhang, Z.1
Nadeau, P.2
Song, W.3
Donoviel, D.4
Yuan, M.5
Bernstein, A.6
Yankner, B.A.7
|