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Volumn 66, Issue 22, 2006, Pages 10691-10700

Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEIN P16INK4A; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

EID: 33845294825     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-0979     Document Type: Article
Times cited : (13)

References (50)
  • 1
    • 0028856794 scopus 로고
    • Telomere length and replicative aging in human vascular tissues
    • Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci U S A 1995;92:11190-4.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11190-11194
    • Chang, E.1    Harley, C.B.2
  • 2
    • 0013462065 scopus 로고
    • A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    • Moyzis RK, Buckingham JM, Cram LS, et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A 1988;85:6622-26.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 6622-6626
    • Moyzis, R.K.1    Buckingham, J.M.2    Cram, L.S.3
  • 3
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith JD, Comeau L, Rosenfleld S, et al. Mammalian telomeres end in a large duplex loop. Cell 1999;97:503-14.
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1    Comeau, L.2    Rosenfleld, S.3
  • 4
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter CM, Avilion AA, LeFeuvre CE, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992;11:1921-29.
    • (1992) EMBO J , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3
  • 5
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi SE, Chang S, Lee SL, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000;406:641-5.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3
  • 6
    • 0033593814 scopus 로고    scopus 로고
    • Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
    • Hande MP, Samper E, Lansdorp P, Blasco MA. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol 1999;144:589-601.
    • (1999) J Cell Biol , vol.144 , pp. 589-601
    • Hande, M.P.1    Samper, E.2    Lansdorp, P.3    Blasco, M.A.4
  • 7
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph KL, Millard M, Bosenberg MW, DePinho RA. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 2001;28:155-9.
    • (2001) Nat Genet , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    DePinho, R.A.4
  • 8
    • 0000839280 scopus 로고    scopus 로고
    • Telomere dysfunction provokes regional amplification and deletion in cancer genomes
    • O'Hagan RC, Chang S, Maser RS, et al. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2002;2:149-55.
    • (2002) Cancer Cell , vol.2 , pp. 149-155
    • O'Hagan, R.C.1    Chang, S.2    Maser, R.S.3
  • 9
    • 18644370262 scopus 로고    scopus 로고
    • Chromosomal instability in ulcerative colitis is related to telomere shortening
    • O'Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet 2002;32:280-4.
    • (2002) Nat Genet , vol.32 , pp. 280-284
    • O'Sullivan, J.N.1    Bronner, M.P.2    Brentnall, T.A.3
  • 10
    • 4444345401 scopus 로고    scopus 로고
    • In situ analyses of genome instability in breast cancer
    • Chin K, de Solorzano CO, Knowles D, et al. In situ analyses of genome instability in breast cancer. Nat Genet 2004;36:984-8.
    • (2004) Nat Genet , vol.36 , pp. 984-988
    • Chin, K.1    De Solorzano, C.O.2    Knowles, D.3
  • 11
    • 0037301996 scopus 로고    scopus 로고
    • Endothelial cell tumors
    • Bell CD. Endothelial cell tumors. Microsc Res Tech 2003;60:165-70.
    • (2003) Microsc Res Tech , vol.60 , pp. 165-170
    • Bell, C.D.1
  • 12
    • 0031973789 scopus 로고    scopus 로고
    • Cytogenetic analysis of four angiosarcomas from deep and superficial soft tissue
    • Schuborg C, Mertens F, Rydholm A, et al. Cytogenetic analysis of four angiosarcomas from deep and superficial soft tissue. Cancer Genet Cytogenet 1998;100:52-6.
    • (1998) Cancer Genet Cytogenet , vol.100 , pp. 52-56
    • Schuborg, C.1    Mertens, F.2    Rydholm, A.3
  • 13
    • 0034904062 scopus 로고    scopus 로고
    • Sinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: Cytogenetic analysis using multiple techniques
    • Wong KF, So CC, Wong N, et al. Sinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: cytogenetic analysis using multiple techniques. Cancer Genet Cytogenet 2001;129:64-8.
    • (2001) Cancer Genet Cytogenet , vol.129 , pp. 64-68
    • Wong, K.F.1    So, C.C.2    Wong, N.3
  • 14
    • 0033605145 scopus 로고    scopus 로고
    • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999;283:1321-5.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 15
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003;426:194-8.
    • (2003) Nature , vol.426 , pp. 194-198
    • D'Adda Di Fagagna, F.1    Reaper, P.M.2    Clay-Farrace, L.3
  • 16
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    • Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 2004;14:501-13.
    • (2004) Mol Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.M.5
  • 17
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L, Artandi SE, Shen Q, et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999;97:527-38.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3
  • 18
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 2005;37:961-76.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 19
    • 11144268164 scopus 로고    scopus 로고
    • Significant role for p16INK4a in p53-independent telomere-directed senescence
    • Jacobs JJ, de Lange T. Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol 2004;14:2302-8.
    • (2004) Curr Biol , vol.14 , pp. 2302-2308
    • Jacobs, J.J.1    De Lange, T.2
  • 20
    • 0017219962 scopus 로고
    • Transformation of cultured human vascular endothelium by SV40 DNA
    • Gimbrone MA, Jr., Fareed GC. Transformation of cultured human vascular endothelium by SV40 DNA. Cell 1976;9:685-93.
    • (1976) Cell , vol.9 , pp. 685-693
    • Gimbrone Jr., M.A.1    Fareed, G.C.2
  • 21
    • 0028910237 scopus 로고
    • Maintenance of vascular endothelial cell-specific properties after immortalization with an amphotrophic replication-deficient retrovirus containing human papilloma virus 16 E6/E7 DNA
    • Fontijn R, Hop C, Brinkman H-J, et al. Maintenance of vascular endothelial cell-specific properties after immortalization with an amphotrophic replication-deficient retrovirus containing human papilloma virus 16 E6/E7 DNA. Exp Cell Res 1995;216:199-207.
    • (1995) Exp Cell Res , vol.216 , pp. 199-207
    • Fontijn, R.1    Hop, C.2    Brinkman, H.-J.3
  • 22
    • 0002889389 scopus 로고
    • SV40-induced transformation of human diploid cells: Crisis and recovery
    • Girardi AJ, Jensen FC, Koprowski H. SV40-induced transformation of human diploid cells: crisis and recovery. J Cell Comp Physiol 1965;65:69-84.
    • (1965) J Cell Comp Physiol , vol.65 , pp. 69-84
    • Girardi, A.J.1    Jensen, F.C.2    Koprowski, H.3
  • 23
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-4.
    • (1994) Science , vol.266 , pp. 2011-2014
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 24
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Oullette M, Froklis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-52.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Oullette, M.2    Froklis, M.3
  • 25
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono T, Foster SA, Koop JI, et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998;396:84-8.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3
  • 26
    • 0033979731 scopus 로고    scopus 로고
    • Human keratinocytes that express hTERT and also bypass a p16INK4a-enforced mechanism that limits lifespan become immortal yet retain normal growth and differentiation characteristics
    • Dickson MA, Hahn WC, Ino Y, et al. Human keratinocytes that express hTERT and also bypass a p16INK4a-enforced mechanism that limits lifespan become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 2000;20:1436-47.
    • (2000) Mol Cell Biol , vol.20 , pp. 1436-1447
    • Dickson, M.A.1    Hahn, W.C.2    Ino, Y.3
  • 27
    • 0036954835 scopus 로고    scopus 로고
    • Association of p16(INK4a) and pRb inactivation with immortalization of human cells
    • Tsutsui T, Kumakura S, Yamamoto A, et al. Association of p16(INK4a) and pRb inactivation with immortalization of human cells. Carcinogenesis 2002;23:2111-7.
    • (2002) Carcinogenesis , vol.23 , pp. 2111-2117
    • Tsutsui, T.1    Kumakura, S.2    Yamamoto, A.3
  • 28
    • 10744219897 scopus 로고    scopus 로고
    • Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype
    • Milyavsky M, Shats I, Erez N, et al. Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res 2003;63:7147-57.
    • (2003) Cancer Res , vol.63 , pp. 7147-7157
    • Milyavsky, M.1    Shats, I.2    Erez, N.3
  • 29
    • 2442612651 scopus 로고    scopus 로고
    • Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts
    • Noble JR, Zhong ZH, Neumann AA, et al. Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts. Oncogene 2004;23:3116-21.
    • (2004) Oncogene , vol.23 , pp. 3116-3121
    • Noble, J.R.1    Zhong, Z.H.2    Neumann, A.A.3
  • 30
    • 6344265743 scopus 로고    scopus 로고
    • Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization
    • Taylor LM, James A, Schuller CE, et al. Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization. J Biol Chem 2004;279:43634-45.
    • (2004) J Biol Chem , vol.279 , pp. 43634-43645
    • Taylor, L.M.1    James, A.2    Schuller, C.E.3
  • 31
    • 0033543760 scopus 로고    scopus 로고
    • Human endothelial cell lifespan extension by telomerase expression
    • Yang J, Chang E, Cherry AM, et al. Human endothelial cell lifespan extension by telomerase expression. J Biol Chem 1999;274:26141-8.
    • (1999) J Biol Chem , vol.274 , pp. 26141-26148
    • Yang, J.1    Chang, E.2    Cherry, A.M.3
  • 32
    • 85047700179 scopus 로고    scopus 로고
    • Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras
    • MacKenzie KL, Franco S, Naiyer AJ, et al. Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras. Oncogene 2002;21:4200-11.
    • (2002) Oncogene , vol.21 , pp. 4200-4211
    • MacKenzie, K.L.1    Franco, S.2    Naiyer, A.J.3
  • 33
    • 0035895269 scopus 로고    scopus 로고
    • Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells
    • O'Hare MJ, Bond J, Clarke C, et al. Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci U S A 2001;98:646-51.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 646-651
    • O'Hare, M.J.1    Bond, J.2    Clarke, C.3
  • 34
    • 0035383807 scopus 로고    scopus 로고
    • Increased expression of the INK4a/ ARF locus in polycythemia vera
    • Dai C, Krantz SB. Increased expression of the INK4a/ ARF locus in polycythemia vera. Blood 2001;97:3424-32.
    • (2001) Blood , vol.97 , pp. 3424-3432
    • Dai, C.1    Krantz, S.B.2
  • 35
    • 0032528623 scopus 로고    scopus 로고
    • Loss of P16(INK4) expression by methylation is associated with lifespan extension of human mammary epithelial cells
    • Huschtscha LI, Noble JR, Neumann AA, et al. Loss of P16(INK4) expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res 1998;58:3508-12.
    • (1998) Cancer Res , vol.58 , pp. 3508-3512
    • Huschtscha, L.I.1    Noble, J.R.2    Neumann, A.A.3
  • 37
    • 0034616215 scopus 로고    scopus 로고
    • Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase
    • Ouellette MM, Liao M, Herbet BS, et al. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem 2000;275:10072-6.
    • (2000) J Biol Chem , vol.275 , pp. 10072-10076
    • Ouellette, M.M.1    Liao, M.2    Herbet, B.S.3
  • 38
    • 0037133668 scopus 로고    scopus 로고
    • Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert
    • Liu Y, Kha H, Ungrin M, Robinson MO, Harrington L. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc Natl Acad Sci U S A 2002;99:3597-602.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3597-3602
    • Liu, Y.1    Kha, H.2    Ungrin, M.3    Robinson, M.O.4    Harrington, L.5
  • 39
    • 12944329959 scopus 로고    scopus 로고
    • Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
    • Gisselsson D, Pettersson L, Hoglund M, et al. Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity. Proc Natl Acad Sci U S A 2000;97:5357-62.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5357-5362
    • Gisselsson, D.1    Pettersson, L.2    Hoglund, M.3
  • 40
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • Romanov SR, Kozakiewicz BK, Holst CR, et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001;409:633-7.
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1    Kozakiewicz, B.K.2    Holst, C.R.3
  • 41
    • 26944472376 scopus 로고    scopus 로고
    • Telomere dysfunction drives chromosomal instability in human mammary epithelial cells
    • Soler D, Genesca A, Arnedo G, Egozcue J, Tusell L. Telomere dysfunction drives chromosomal instability in human mammary epithelial cells. Genes Chromosomes Cancer 2005;44:339-50.
    • (2005) Genes Chromosomes Cancer , vol.44 , pp. 339-350
    • Soler, D.1    Genesca, A.2    Arnedo, G.3    Egozcue, J.4    Tusell, L.5
  • 44
    • 0026528828 scopus 로고
    • Karyotypic and phenotypic changes during in vitro aging of human endothelial cells
    • Johnson TE, Umbenhauer DR, Hill R, et al. Karyotypic and phenotypic changes during in vitro aging of human endothelial cells. J Cell Physiol 1992;150:17-27.
    • (1992) J Cell Physiol , vol.150 , pp. 17-27
    • Johnson, T.E.1    Umbenhauer, D.R.2    Hill, R.3
  • 45
    • 0034329383 scopus 로고    scopus 로고
    • Loss of chromosome 13 in cultured human vascular endothelial cells
    • Zhang L, Aviv H, Gardner JP, et al. Loss of chromosome 13 in cultured human vascular endothelial cells. Exp Cell Res 2000;260:357-64.
    • (2000) Exp Cell Res , vol.260 , pp. 357-364
    • Zhang, L.1    Aviv, H.2    Gardner, J.P.3
  • 47
    • 0032923742 scopus 로고    scopus 로고
    • Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
    • Jiang XR, Jimenez G, Chang E, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 1999;21:111-4.
    • (1999) Nat Genet , vol.21 , pp. 111-114
    • Jiang, X.R.1    Jimenez, G.2    Chang, E.3
  • 48
    • 0034666057 scopus 로고    scopus 로고
    • Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation
    • MacKenzie KL, Franco S, May C, Sadelain M, Moore MAS. Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation. Exp Cell Res 2000;259:336-50.
    • (2000) Exp Cell Res , vol.259 , pp. 336-350
    • MacKenzie, K.L.1    Franco, S.2    May, C.3    Sadelain, M.4    Moore, M.A.S.5
  • 49
    • 3042591085 scopus 로고    scopus 로고
    • Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
    • Kurz DJ, Decary S, Hong Y, et al. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004;117:2417-26.
    • (2004) J Cell Sci , vol.117 , pp. 2417-2426
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3
  • 50
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001;107:67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.