-
1
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik G, Klippel A, Weber MJ. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 1997;17:1595-606.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
2
-
-
0032189381
-
Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
-
Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 1998;335:1-13.
-
(1998)
Biochem J
, vol.335
, pp. 1-13
-
-
Coffer, P.J.1
Jin, J.2
Woodgett, J.R.3
-
3
-
-
0141994820
-
PTEN: Tumor suppressor, multifunctional growth regulator and more
-
Goberdhan DC, Wilson C. PTEN: tumor suppressor, multifunctional growth regulator and more. Hum Mol Genet 2003;12 Suppl 2:R239-48.
-
(2003)
Hum Mol Genet
, vol.12
, Issue.2 SUPPL.
-
-
Goberdhan, D.C.1
Wilson, C.2
-
4
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998;282:1318-21.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
-
5
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999;96:857-68.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
-
7
-
-
0032491579
-
Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase Akt-dependent pathway
-
Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN, Rosen N. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase Akt-dependent pathway. J Biol Chem 1998;273:29864-72.
-
(1998)
J Biol Chem
, vol.273
, pp. 29864-29872
-
-
Muise-Helmericks, R.C.1
Grimes, H.L.2
Bellacosa, A.3
Malstrom, S.E.4
Tsichlis, P.N.5
Rosen, N.6
-
8
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
-
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601-5.
-
(1999)
Nature
, vol.399
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
9
-
-
0037093274
-
Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer
-
Nakanishi K, Sakamoto M, Yasuda J, et al. Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer. Cancer Res 2002;62:2971-5.
-
(2002)
Cancer Res
, vol.62
, pp. 2971-2975
-
-
Nakanishi, K.1
Sakamoto, M.2
Yasuda, J.3
-
10
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A 1987;84:5034-7.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
11
-
-
0031936947
-
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
-
Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog 1998;21:81-6.
-
(1998)
Mol Carcinog
, vol.21
, pp. 81-86
-
-
Ruggeri, B.A.1
Huang, L.2
Wood, M.3
Cheng, J.Q.4
Testa, J.R.5
-
12
-
-
0036094711
-
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
-
Ermoian RP, Furniss CS, Lamborn KR, et al. Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin Cancer Res 2002;8:1100-6.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1100-1106
-
-
Ermoian, R.P.1
Furniss, C.S.2
Lamborn, K.R.3
-
13
-
-
0036554734
-
Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer
-
Malik SN, Brattain M, Ghosh PM, et al. Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. Clin Cancer Res 2002;8:1168-71.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1168-1171
-
-
Malik, S.N.1
Brattain, M.2
Ghosh, P.M.3
-
14
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999;96:4240-5.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
15
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu YL, Kuo WL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999;21:99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.L.2
Kuo, W.L.3
-
16
-
-
0035913188
-
Oncogenic transformation induced by membrane-targeted akt2 and Akt3
-
Mende I, Malstrom S, Tsichlis PN, Vogt PK, Aoki M. Oncogenic transformation induced by membrane-targeted akt2 and Akt3. Oncogene 2001;20:4419-23.
-
(2001)
Oncogene
, vol.20
, pp. 4419-4423
-
-
Mende, I.1
Malstrom, S.2
Tsichlis, P.N.3
Vogt, P.K.4
Aoki, M.5
-
17
-
-
0037251810
-
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
-
West KA, Brognard J, Clark AS, et al. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003;111:81-90.
-
(2003)
J Clin Invest
, vol.111
, pp. 81-90
-
-
West, K.A.1
Brognard, J.2
Clark, A.S.3
-
18
-
-
0035872199
-
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
-
Brognard J, Clark AS, Ni YC, Dennis PA. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 2001;61:3986-97.
-
(2001)
Cancer Res
, vol.61
, pp. 3986-3997
-
-
Brognard, J.1
Clark, A.S.2
Ni, Y.C.3
Dennis, P.A.4
-
19
-
-
0037037374
-
A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis
-
Schmidt M, Hovelmann S, Beckers TL. A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis. Br J Cancer 2002;87:924-32.
-
(2002)
Br J Cancer
, vol.87
, pp. 924-932
-
-
Schmidt, M.1
Hovelmann, S.2
Beckers, T.L.3
-
20
-
-
0036278887
-
Cyclooxygenase-2 expression is a novel prognostic factor in malignant mesothelioma
-
Edwards JG, Faux SP, Plummer SM, et al. Cyclooxygenase-2 expression is a novel prognostic factor in malignant mesothelioma. Clin Cancer Res 2002;8:1857-62.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1857-1862
-
-
Edwards, J.G.1
Faux, S.P.2
Plummer, S.M.3
-
21
-
-
0036695853
-
Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study
-
Lee SH, Kim HS, Park WS, et al. Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study. APMIS 2002;110:587-92.
-
(2002)
APMIS
, vol.110
, pp. 587-592
-
-
Lee, S.H.1
Kim, H.S.2
Park, W.S.3
-
22
-
-
0035528774
-
Akt and PTEN: New diagnostic markers of non-small cell lung cancer?
-
David O. Akt and PTEN: new diagnostic markers of non-small cell lung cancer? J Cell Mol Med 2001;5:430-3.
-
(2001)
J Cell Mol Med
, vol.5
, pp. 430-433
-
-
David, O.1
-
23
-
-
18244391514
-
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
-
Perez-Tenorio G, Stal O. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer 2002;86:540-5.
-
(2002)
Br J Cancer
, vol.86
, pp. 540-545
-
-
Perez-Tenorio, G.1
Stal, O.2
-
24
-
-
0034976644
-
Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
-
Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas. Am J Pathol 2001;158:2097-106.
-
(2001)
Am J Pathol
, vol.158
, pp. 2097-2106
-
-
Kurose, K.1
Zhou, X.P.2
Araki, T.3
Cannistra, S.A.4
Maher, E.R.5
Eng, C.6
-
25
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
Andjelkovic M, Alessi DR, Meier R, et al. Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997;272:31515-24.
-
(1997)
J Biol Chem
, vol.272
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
-
26
-
-
0038505594
-
Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC)
-
Mukohara T, Kudoh S, Yamauchi S, et al. Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC). Lung Cancer 2003;41:123-30.
-
(2003)
Lung Cancer
, vol.41
, pp. 123-130
-
-
Mukohara, T.1
Kudoh, S.2
Yamauchi, S.3
-
27
-
-
13044305289
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
-
Sun H, Lesche R, Li DM, et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A 1999;96:6199-204.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6199-6204
-
-
Sun, H.1
Lesche, R.2
Li, D.M.3
-
29
-
-
0035253607
-
PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3- kinase/Akt-dependent and -independent pathways
-
Weng L, Brown J, Eng C. PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet 2001;10:237-42.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 237-242
-
-
Weng, L.1
Brown, J.2
Eng, C.3
-
31
-
-
0037728809
-
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
-
Grille SJ, Bellacosa A, Upson J, et al. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 2003;63:2172-8.
-
(2003)
Cancer Res
, vol.63
, pp. 2172-2178
-
-
Grille, S.J.1
Bellacosa, A.2
Upson, J.3
-
32
-
-
0037229714
-
Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
-
Arboleda MJ, Lyons JF, Kabbinavar FF, et al. Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 2003;63:196-206.
-
(2003)
Cancer Res
, vol.63
, pp. 196-206
-
-
Arboleda, M.J.1
Lyons, J.F.2
Kabbinavar, F.F.3
-
33
-
-
0037304479
-
Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma
-
Horiguchi A, Oya M, Uchida A, Marumo K, Murai M. Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. J Urol 2003;169:710-3.
-
(2003)
J Urol
, vol.169
, pp. 710-713
-
-
Horiguchi, A.1
Oya, M.2
Uchida, A.3
Marumo, K.4
Murai, M.5
-
34
-
-
0041846604
-
Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: Implications for lung cancer prevention studies
-
Tsao AS, McDonnell T, Lam S, et al. Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: implications for lung cancer prevention studies. Cancer Epidemiol Biomarkers Prev 2003;12:660-4.
-
(2003)
Cancer Epidemiol Biomarkers Prev
, vol.12
, pp. 660-664
-
-
Tsao, A.S.1
McDonnell, T.2
Lam, S.3
-
35
-
-
4444332925
-
Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
-
Cappuzzo F, Magrini E, Ceresoli GL, et al. Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2004;96:1133-41.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1133-1141
-
-
Cappuzzo, F.1
Magrini, E.2
Ceresoli, G.L.3
-
36
-
-
0036729372
-
Insulin-like growth factor-I inhibits cell growth in the A549 non-small cell lung cancer cell line
-
Kodama Y, Baxter RC, Martin JL. Insulin-like growth factor-I inhibits cell growth in the A549 non-small cell lung cancer cell line. Am J Respir Cell Mol Biol 2002;27:336-44.
-
(2002)
Am J Respir Cell Mol Biol
, vol.27
, pp. 336-344
-
-
Kodama, Y.1
Baxter, R.C.2
Martin, J.L.3
-
37
-
-
0034462138
-
Insulin-like growth factor-mediated muscle cell survival: Central roles for Akt and cyclin-dependent kinase inhibitor p21
-
Lawlor MA, Rotwein P. Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21. Mol Cell Biol 2000;20:8983-95.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8983-8995
-
-
Lawlor, M.A.1
Rotwein, P.2
-
38
-
-
0023235725
-
Detection of human lung epithelial cell growth factors by a lung carcinoma cell line: Use in culture of primary solid lung tumors
-
Siegfried JM. Detection of human lung epithelial cell growth factors by a lung carcinoma cell line: use in culture of primary solid lung tumors. Cancer Res 1987;47:2903-10.
-
(1987)
Cancer Res
, vol.47
, pp. 2903-2910
-
-
Siegfried, J.M.1
-
39
-
-
0041343301
-
Role of Bcl-2 as a prognostic factor for survival in lung cancer: A systematic review of the literature with meta-analysis
-
Martin B, Paesmans M, Berghmans T, et al. Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis. Br J Cancer 2003;89:55-64.
-
(2003)
Br J Cancer
, vol.89
, pp. 55-64
-
-
Martin, B.1
Paesmans, M.2
Berghmans, T.3
-
40
-
-
0027186201
-
bcl-2 protein in non-small-cell lung carcinoma
-
Pezzella F, Turley H, Kuzu I, et al. bcl-2 protein in non-small-cell lung carcinoma. N Engl J Med 1993;329:690-4.
-
(1993)
N Engl J Med
, vol.329
, pp. 690-694
-
-
Pezzella, F.1
Turley, H.2
Kuzu, I.3
-
43
-
-
3543052060
-
Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues
-
Castillo SS, Brognard J, Petukhov PA, et al. Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. Cancer Res 2004;64:2782-92.
-
(2004)
Cancer Res
, vol.64
, pp. 2782-2792
-
-
Castillo, S.S.1
Brognard, J.2
Petukhov, P.A.3
-
44
-
-
4444223702
-
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling
-
Ihle NT, Williams R, Chow S, et al. Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther 2004;3:763-72.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 763-772
-
-
Ihle, N.T.1
Williams, R.2
Chow, S.3
-
45
-
-
3042743988
-
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt
-
Yang L, Dan HC, Sun M, et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 2004;64:4394-9.
-
(2004)
Cancer Res
, vol.64
, pp. 4394-4399
-
-
Yang, L.1
Dan, H.C.2
Sun, M.3
-
46
-
-
0037453909
-
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
-
Chun KH, Kosmeder JW II, Sun S, et al. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst 2003;95:291-302.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 291-302
-
-
Chun, K.H.1
Kosmeder II, J.W.2
Sun, S.3
-
47
-
-
4143078350
-
Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells
-
Lee HY. Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. Biochem Pharmacol 2004;68:1119-24.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1119-1124
-
-
Lee, H.Y.1
-
48
-
-
3042740812
-
Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells
-
Hovelmann S, Beckers TL, Schmidt M. Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells. Br J Cancer 2004;90:2370-7.
-
(2004)
Br J Cancer
, vol.90
, pp. 2370-2377
-
-
Hovelmann, S.1
Beckers, T.L.2
Schmidt, M.3
-
49
-
-
0043122940
-
AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2
-
Fahy BN, Schlieman M, Virudachalam S, Bold RJ. AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer 2003;89:391-7.
-
(2003)
Br J Cancer
, vol.89
, pp. 391-397
-
-
Fahy, B.N.1
Schlieman, M.2
Virudachalam, S.3
Bold, R.J.4
-
50
-
-
0036731976
-
Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells
-
Kandasamy K, Srivastava RK. Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells. Cancer Res 2002;62:4929-37.
-
(2002)
Cancer Res
, vol.62
, pp. 4929-4937
-
-
Kandasamy, K.1
Srivastava, R.K.2
|