Regulation of Telomere Elongation by the Cyclin-Dependent Kinase CDK1

Molecular Cell

Volumn 24, Issue 3, 2006, Pages 423-432

  Frank, Christopher J ^a   Hyde, Molly ^a   Greider, Carol W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CELLCYCLE; DNA

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE 1; DNA DIRECTED DNA POLYMERASE ALPHA; PROTEIN; PROTEIN RIF2; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELL ELONGATION; CHROMOSOME; DNA STRAND BREAKAGE; ENZYME ACTIVITY; MUTATION; NONHUMAN; TELOMERE;

CARRIER PROTEINS; CDC2 PROTEIN KINASE; DNA BREAKS, DOUBLE-STRANDED; DNA POLYMERASE I; DNA, SINGLE-STRANDED; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEIC ACID CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERE;

EID: 33750431337     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.10.020     Document Type: Article

References (67)

1. Assenmacher N., and Hopfner K.P. MRE11/RAD50/NBS1: complex activities. Chromosoma 113 (2004) 157-166
2. Baumann P., and Cech T.R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292 (2001) 1171-1175
3. Bishop A.C., Ubersax J.A., Petsch D.T., Matheos D.P., Gray N.S., Blethrow J., Shimizu E., Tsien J.Z., Schultz P.G., Rose M.D., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 (2000) 395-401
4. Blackburn E.H. Switching and signaling at the telomere. Cell 106 (2001) 661-673
5. Blasco M.A., Lee H.W., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., and Greider C.W. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91 (1997) 25-34
6. Brachmann C.B., Davies A., Cost G.J., Caputo E., Li J., Hieter P., and Boeke J.D. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14 (1998) 115-132
7. Bressan D.A., Olivares H.A., Nelms B.E., and Petrini J.H. Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics 150 (1998) 591-600
8. Carson M.J., and Hartwell L. CDC17: an essential gene that prevents telomere elongation in yeast. Cell 42 (1985) 249-257
9. Chan S.W., Chang J., Prescott J., and Blackburn E.H. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr. Biol. 11 (2001) 1240-1250
10. d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., Von Zglinicki T., Saretzki G., Carter N.P., and Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 (2003) 194-198
11. Desdouets C., Santocanale C., Drury L.S., Perkins G., Foiani M., Plevani P., and Diffley J.F. Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha. EMBO J. 17 (1998) 4139-4146
12. Diede S.J., and Gottschling D.E. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell 99 (1999) 723-733
13. Diede S.J., and Gottschling D.E. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere. Curr. Biol. 11 (2001) 1336-1340
14. Dionne I., and Wellinger R.J. Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc. Natl. Acad. Sci. USA 93 (1996) 13902-13907
15. Enomoto S., Glowczewski L., and Berman J. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol. Biol. Cell 13 (2002) 2626-2638
16. Foiani M., Marini F., Gamba D., Lucchini G., and Plevani P. The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol. Cell. Biol. 14 (1994) 923-933
17. Garvik B., Carson M., and Hartwell L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15 (1995) 6128-6138
18. Gottschling D.E., and Zakian V.A. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell 47 (1986) 195-205
19. Grandin N., and Charbonneau M. Mitotic cyclins regulate telomeric recombination in telomerase-deficient yeast cells. Mol. Cell. Biol. 23 (2003) 9162-9177
20. Greider C.W., and Blackburn E.H. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51 (1987) 887-898
21. Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., and de Lange T. Mammalian telomeres end in a large duplex loop. Cell 97 (1999) 503-514
22. Haase S.B., and Lew D.J. Flow cytometric analysis of DNA content in budding yeast. Methods Enzymol. 283 (1997) 322-332
23. Hackett J.A., Feldser D.M., and Greider C.W. Telomere dysfunction increases mutation rate and genomic instability. Cell 106 (2001) 275-286
24. Hao L.Y., Strong M.A., and Greider C.W. Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J. Biol. Chem. 279 (2004) 45148-45154
25. Hardy C.F., Sussel L., and Shore D. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 6 (1992) 801-814
26. Henderson E.R., and Blackburn E.H. An overhanging 3′ terminus is a conserved feature of telomeres. Mol. Cell. Biol. 9 (1989) 345-348
27. Hopfner K.P., Karcher A., Craig L., Woo T.T., Carney J.P., and Tainer J.A. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell 105 (2001) 473-485
28. IJpma A.S., and Greider C.W. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae. Mol Biol Cell 14 (2003) 987-1001
29. Ira G., Pellicioli A., Balijja A., Wang X., Fiorani S., Carotenuto W., Liberi G., Bressan D., Wan L., Hollingsworth N.M., et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431 (2004) 1011-1017
30. Ivanov E.L., Sugawara N., White C.I., Fabre F., and Haber J.E. Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol. Cell. Biol. 14 (1994) 3414-3425
31. Karlseder J., Broccoli D., Dai Y., Hardy S., and de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283 (1999) 1321-1325
32. Larrivee M., LeBel C., and Wellinger R.J. The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev. 18 (2004) 1391-1396
33. Lee S.E., Moore J.K., Holmes A., Umezu K., Kolodner R.D., and Haber J.E. Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94 (1998) 399-409
34. Lee S.E., Bressan D.A., Petrini J.H., and Haber J.E. Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst.) 1 (2002) 27-40
35. Lingner J., Hughes T.R., Shevchenko A., Mann M., Lundblad V., and Cech T.R. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276 (1997) 561-567
36. Lisby M., Barlow J.H., Burgess R.C., and Rothstein R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118 (2004) 699-713
37. Lundblad V. Budding yeast telomeres. In: De Lange T., Lundblad V., and Blackburn E. (Eds). Telomeres (2006), Cold Spring Harbor Laboratory Press, Cold Spring Harbor 345-386
38. Makarov V.L., Hirose Y., and Langmore J.P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88 (1997) 657-666
39. Marcand S., Brevet V., Mann C., and Gilson E. Cell cycle restriction of telomere elongation. Curr. Biol. 10 (2000) 487-490
40. Moreau S., Ferguson J.R., and Symington L.S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19 (1999) 556-566
41. Nakada D., Matsumoto K., and Sugimoto K. ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev. 17 (2003) 1957-1962
42. Nikitina T., and Woodcock C.L. Closed chromatin loops at the ends of chromosomes. J. Cell Biol. 166 (2004) 161-165
43. Paull T.T., and Gellert M. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1 (1998) 969-979
44. Pellicioli A., Lucca C., Liberi G., Marini F., Lopes M., Plevani P., Romano A., Di Fiore P.P., and Foiani M. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J. 18 (1999) 6561-6572
45. Pennock E., Buckley K., and Lundblad V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104 (2001) 387-396
46. Ptacek J., Devgan G., Michaud G., Zhu H., Zhu X., Fasolo J., Guo H., Jona G., Breitkreutz A., Sopko R., et al. Global analysis of protein phosphorylation in yeast. Nature 438 (2005) 679-684
47. Reed S.I., and Wittenberg C. Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87 (1990) 5697-5701
48. Ritchie K.B., and Petes T.D. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155 (2000) 475-479
49. Rothkamm K., Kruger I., Thompson L.H., and Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23 (2003) 5706-5715
50. Schramke V., Luciano P., Brevet V., Guillot S., Corda Y., Longhese M.P., Gilson E., and Geli V. RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat. Genet. 36 (2004) 46-54
51. Seto A.G., Livengood A.J., Tzfati Y., Blackburn E.H., and Cech T.R. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev. 16 (2002) 2800-2812
52. Stellwagen A.E., Haimberger Z.W., Veatch J.R., and Gottschling D.E. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev. 17 (2003) 2384-2395
53. Stewart G.S., Maser R.S., Stankovic T., Bressan D.A., Kaplan M.I., Jaspers N.G., Raams A., Byrd P.J., Petrini J.H., and Taylor A.M. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99 (1999) 577-587
54. Taggart A.K., Teng S.C., and Zakian V.A. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science 297 (2002) 1023-1026
55. Takata H., Kanoh Y., Gunge N., Shirahige K., and Matsuura A. Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol. Cell 14 (2004) 515-522
56. Takata H., Tanaka Y., and Matsuura A. Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol. Cell 17 (2005) 573-583
57. Teixeira M.T., Arneric M., Sperisen P., and Lingner J. Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 117 (2004) 323-335
58. Tomita K., Kibe T., Kang H.Y., Seo Y.S., Uritani M., Ushimaru T., and Ueno M. Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Mol. Cell. Biol. 24 (2004) 9557-9567
59. Tsubouchi H., and Ogawa H. A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis. Mol. Cell. Biol. 18 (1998) 260-268
60. Tsukamoto Y., Mitsuoka C., Terasawa M., Ogawa H., and Ogawa T. Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination. Mol. Biol. Cell 16 (2005) 597-608
61. Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K., Shokat K.M., and Morgan D.O. Targets of the cyclin-dependent kinase Cdk1. Nature 425 (2003) 859-864
62. Usui T., Ohta T., Oshiumi H., Tomizawa J., Ogawa H., and Ogawa T. Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95 (1998) 705-716
63. van Steensel B., Smogorzewska A., and de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 (1998) 401-413
64. Verdun R.E., Crabbe L., Haggblom C., and Karlseder J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol. Cell 20 (2005) 551-561
65. Wellinger R.J., Wolf A.J., and Zakian V.A. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 72 (1993) 51-60
66. Wotton D., and Shore D. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev. 11 (1997) 748-760
67. Zou L., and Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300 (2003) 1542-1548