Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

Cellular Signalling

Volumn 18, Issue 11, 2006, Pages 2056-2069

  Hill, Elaine V ^a   Sheppard, Catherine L ^a   Cheung, York Fong ^a   Gall, Irene ^a   Krause, Eberhard ^b   Houslay, Miles D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

cAMP; cAMP phosphodiesterase; ERK; Macrophage; MAP kinase; Multi site phosphorylation; Oxidative stress; PDE4; PDE4D3; Phosphatidyl inositol 3 kinase; Rolipram

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC AMP PHOSPHODIESTERASE 4D3; HYDROGEN PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; S6 KINASE; SERINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WORTMANNIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL STRAIN COS1; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MOLECULAR INTERACTION; MOUSE; MUTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3',5'-CYCLIC-AMP PHOSPHODIESTERASES; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; BINDING SITES; CELL LINE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; OXIDANTS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; SERINE; SIGNAL TRANSDUCTION;

EID: 33749342971     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2006.07.018     Document Type: Article

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