Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B: Consequences for rolipram inhibition

Journal of Biological Chemistry

Volumn 274, Issue 17, 1999, Pages 11796-11810

  McPhee, Ian ^a   Yarwood, Stephen J ^a   Scotland, Grant ^a   Huston, Elaine ^a   Beard, Matthew B ^a   Ross, Annette H ^a   Houslay, Emma S ^a   Houslay, Miles D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP PHOSPHODIESTERASE; DNA; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; PHOSPHODIESTERASE INHIBITOR; PROTEIN TYROSINE KINASE; ROLIPRAM;

ANIMAL CELL; ARTICLE; CATALYSIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; COS CELLS; DNA PRIMERS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHODIESTERASE INHIBITORS; PROTEIN CONFORMATION; PYRROLIDINONES; ROLIPRAM; SRC-FAMILY KINASES;

EID: 0033597139     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.17.11796     Document Type: Article

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