메뉴 건너뛰기




Volumn 18, Issue 4, 1999, Pages 893-903

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at ser579

Author keywords

Cyclic AMP phosphodiesterase; ERK2; MAP kinase; Phosphorylation; Protein kinase A

Indexed keywords

CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 1;

EID: 0033558010     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.4.893     Document Type: Article
Times cited : (233)

References (60)
  • 1
    • 0025871767 scopus 로고
    • Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase
    • Alvarez, E., Northwood, I.C., Gonzalez, F.A., Latour, D.A., Seth, A., Abate, C., Curran, T. and Davis, R.J. (1991) Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem., 266, 15277-15285.
    • (1991) J. Biol. Chem. , vol.266 , pp. 15277-15285
    • Alvarez, E.1    Northwood, I.C.2    Gonzalez, F.A.3    Latour, D.A.4    Seth, A.5    Abate, C.6    Curran, T.7    Davis, R.J.8
  • 2
    • 0028839684 scopus 로고
    • Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3
    • Alvarez, R., Sette, C., Yang, D., Eglen, R.M., Wilhelm, R., Shelton, E.R. and Conti, M. (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol. Pharmacol., 48, 616-622.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 616-622
    • Alvarez, R.1    Sette, C.2    Yang, D.3    Eglen, R.M.4    Wilhelm, R.5    Shelton, E.R.6    Conti, M.7
  • 4
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • Beavo, J.A. (1995) Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physiol. Rev., 75, 725-748.
    • (1995) Physiol. Rev. , vol.75 , pp. 725-748
    • Beavo, J.A.1
  • 5
    • 0028136159 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterases
    • Beavo, J.A., Conti, M. and Heaslip, R.J. (1994) Multiple cyclic nucleotide phosphodiesterases. Mol. Pharmacol., 46, 399-405.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 399-405
    • Beavo, J.A.1    Conti, M.2    Heaslip, R.J.3
  • 6
    • 0028358806 scopus 로고
    • Diversity in function and regulation of MAP kinase pathways
    • Blumer, K.J. and Johnson, G.L. (1994) Diversity in function and regulation of MAP kinase pathways. Trends Biochem. Sci., 19, 236-240.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 236-240
    • Blumer, K.J.1    Johnson, G.L.2
  • 7
    • 0028574848 scopus 로고
    • Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes. Cell
    • Bolger, G. (1994) Molecular Biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. Cell. Signal., 6, 851-859.
    • (1994) Signal. , vol.6 , pp. 851-859
    • Bolger, G.1
  • 8
    • 0027454556 scopus 로고
    • A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
    • Bolger, G., Michaeli, T., Martins, T., St John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M. and Ferguson, K. (1993) A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol. Cell. Biol., 13, 6558-6571.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6558-6571
    • Bolger, G.1    Michaeli, T.2    Martins, T.3    St John, T.4    Steiner, B.5    Rodgers, L.6    Riggs, M.7    Wigler, M.8    Ferguson, K.9
  • 9
    • 0030665303 scopus 로고    scopus 로고
    • Characterisation of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene
    • Bolger, G.B., Erdogan, S., Jones, R.E., Loughney, K., Scotland, G., Hoffmann, R., Wilkinson, I., Farrell, C. and Houslay, M.D. (1997) Characterisation of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene. Biochem. J., 328, 539-548.
    • (1997) Biochem. J. , vol.328 , pp. 539-548
    • Bolger, G.B.1    Erdogan, S.2    Jones, R.E.3    Loughney, K.4    Scotland, G.5    Hoffmann, R.6    Wilkinson, I.7    Farrell, C.8    Houslay, M.D.9
  • 10
    • 0030047931 scopus 로고    scopus 로고
    • Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8
    • Bolger, G.B., McPhee, I. and Houslay, M.D. (1996) Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8. J. Biol. Chem., 271, 1065-1071.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1065-1071
    • Bolger, G.B.1    McPhee, I.2    Houslay, M.D.3
  • 11
    • 0017184389 scopus 로고
    • Protein determination in biological samples
    • Bradford, M. (1976) Protein determination in biological samples. Anal. Biochem., 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.1
  • 12
    • 0028867206 scopus 로고
    • Expression of type V adenylyl cyclase is required for epidermal growth factor-mediated stimulation of cAMP accumulation
    • Chen, Z., Nield, H.S., Sun, H., Barbier, A. and Patel, T.B. (1995) Expression of type V adenylyl cyclase is required for epidermal growth factor-mediated stimulation of cAMP accumulation. J. Biol. Chem., 270, 27525-27530.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27525-27530
    • Chen, Z.1    Nield, H.S.2    Sun, H.3    Barbier, A.4    Patel, T.B.5
  • 13
    • 0025248571 scopus 로고
    • Inhibition of forskolin-induced neunte outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
    • Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., Hayashi, K., Inoue, T., Naito, K., Toshioka, T. and Hidaka, H. (1990) Inhibition of forskolin-induced neunte outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem., 265, 5267-5272.
    • (1990) J. Biol. Chem. , vol.265 , pp. 5267-5272
    • Chijiwa, T.1    Mishima, A.2    Hagiwara, M.3    Sano, M.4    Hayashi, K.5    Inoue, T.6    Naito, K.7    Toshioka, T.8    Hidaka, H.9
  • 14
    • 0029009878 scopus 로고
    • Recent progress in understanding the hormonal regulation of phosphodiesterases
    • Conti, M., Nemoz, G., Sette, C. and Vicini, E. (1995) Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr. Rev., 16, 370-389.
    • (1995) Endocr. Rev. , vol.16 , pp. 370-389
    • Conti, M.1    Nemoz, G.2    Sette, C.3    Vicini, E.4
  • 15
    • 0027716596 scopus 로고
    • Inhibition by cAMP of ras-dependent activation of raf
    • Cook, S.J. and McCormick, F. (1993) Inhibition by cAMP of ras-dependent activation of raf. Science, 262, 1069-1072.
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 16
    • 0027170176 scopus 로고
    • RapV12 antagonizes ras-dependent activation of ERK1 and ERK2 by LPA and EGF in rat-1 fibroblasts
    • Cook, S.J., Rubinfeld, B., Albert, I. and McCormick, F. (1993) RapV12 antagonizes ras-dependent activation of ERK1 and ERK2 by LPA and EGF in rat-1 fibroblasts. EMBO J., 12, 3475-3485.
    • (1993) EMBO J. , vol.12 , pp. 3475-3485
    • Cook, S.J.1    Rubinfeld, B.2    Albert, I.3    McCormick, F.4
  • 17
    • 0029040541 scopus 로고
    • Selective phosphodiesterase inhibitors in the therapy of asthma
    • Dent, G. and Giembycz, M.A. (1995) Selective phosphodiesterase inhibitors in the therapy of asthma. Clin. Immunother., 3, 423-437.
    • (1995) Clin. Immunother. , vol.3 , pp. 423-437
    • Dent, G.1    Giembycz, M.A.2
  • 18
    • 0030875602 scopus 로고    scopus 로고
    • MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
    • Fanger, G.R., Johnson, N.L. and Johnson, G.L. (1997) MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J., 16, 4961-4972.
    • (1997) EMBO J. , vol.16 , pp. 4961-4972
    • Fanger, G.R.1    Johnson, N.L.2    Johnson, G.L.3
  • 19
    • 0030219389 scopus 로고    scopus 로고
    • More on target with protein phosphorylation: Conferring specificity by location
    • Faux, M.C. and Scott, J.D. (1996) More on target with protein phosphorylation: conferring specificity by location. Trends Biochem. Sci., 21, 312-318.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 312-318
    • Faux, M.C.1    Scott, J.D.2
  • 20
    • 0025888298 scopus 로고
    • Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases
    • Gonzalez, F.A., Raden, D.L. and Davis, R.J. (1991) Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem., 266, 22159-22163.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22159-22163
    • Gonzalez, F.A.1    Raden, D.L.2    Davis, R.J.3
  • 21
    • 0020609348 scopus 로고
    • Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes
    • Heyworth, C.M. and Houslay, M.D. (1983) Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes. Biochem. J., 214, 93-98.
    • (1983) Biochem. J. , vol.214 , pp. 93-98
    • Heyworth, C.M.1    Houslay, M.D.2
  • 22
    • 0032127768 scopus 로고    scopus 로고
    • CAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: Generation of a molecular model
    • Hoffmann, R., Wilkinson, I.R., McCallum, J.F., Engels, P. and Houslay, M.D. (1998) cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: Generation of a molecular model. Biochem. J., 333, 139-149.
    • (1998) Biochem. J. , vol.333 , pp. 139-149
    • Hoffmann, R.1    Wilkinson, I.R.2    McCallum, J.F.3    Engels, P.4    Houslay, M.D.5
  • 23
    • 0028169702 scopus 로고
    • CAMP abrogates the p21 (ras)-mitogen-activated protein kinase pathway in fibroblasts
    • Hordijk, P.L., Verlaan, I., Jalink, K., Van Corven, E.J. and Moolenaar, W.H. (1994) cAMP abrogates the p21 (ras)-mitogen-activated protein kinase pathway in fibroblasts. J. Biol. Chem., 269, 3534-3538.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3534-3538
    • Hordijk, P.L.1    Verlaan, I.2    Jalink, K.3    Van Corven, E.J.4    Moolenaar, W.H.5
  • 24
    • 0025019549 scopus 로고
    • The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocytes intracellular cyclic AMP concentrations
    • Houslay, M.D. (1990) The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocytes intracellular cyclic AMP concentrations. Cell. Signal., 2, 85-98.
    • (1990) Cell. Signal. , vol.2 , pp. 85-98
    • Houslay, M.D.1
  • 25
    • 0030974622 scopus 로고    scopus 로고
    • Tailoring cAMP signalling responses through isoform multiplicity
    • Houslay, M.D. and Milligan, G. (1997) Tailoring cAMP signalling responses through isoform multiplicity. Trends Biochem. Sci., 22, 217-224.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 217-224
    • Houslay, M.D.1    Milligan, G.2
  • 26
    • 0031601339 scopus 로고    scopus 로고
    • The multi-enzyme PDE4 cyclic AMP specific phosphodiesterase family: Intracellular targeting, regulation and selective inhibition by compounds exerting anti-inflammatory and anti-depressant actions
    • Houslay, M.D., Sullivan, M. and Bolger, G.B. (1997) The multi-enzyme PDE4 cyclic AMP specific phosphodiesterase family: intracellular targeting, regulation and selective inhibition by compounds exerting anti-inflammatory and anti-depressant actions. Adv. Pharmarol., 44, 225-342.
    • (1997) Adv. Pharmarol. , vol.44 , pp. 225-342
    • Houslay, M.D.1    Sullivan, M.2    Bolger, G.B.3
  • 27
    • 0031104328 scopus 로고    scopus 로고
    • PDE 4 inhibitors: The use of molecular cloning in the design and development of novel drugs
    • Hughes, B., Owens, R., Perry, M., Warrellow, G. and Allen, R. (1997) PDE 4 inhibitors: The use of molecular cloning in the design and development of novel drugs. Drug Discov. Today, 2, 89-101.
    • (1997) Drug Discov. Today , vol.2 , pp. 89-101
    • Hughes, B.1    Owens, R.2    Perry, M.3    Warrellow, G.4    Allen, R.5
  • 28
    • 0029826758 scopus 로고    scopus 로고
    • Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding
    • Kolch, W., Philipp, A., Mischak, H., Dutil, E.M., Mullen, T.M., Feramisco, J.R., Meinkoth, J.L. and Rose, D.W. (1996) Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding. Oncogene, 13, 1305-1314.
    • (1996) Oncogene , vol.13 , pp. 1305-1314
    • Kolch, W.1    Philipp, A.2    Mischak, H.3    Dutil, E.M.4    Mullen, T.M.5    Feramisco, J.R.6    Meinkoth, J.L.7    Rose, D.W.8
  • 29
    • 0022550932 scopus 로고
    • Oligomerization is essential for transport of vesicular stomatitis viral glycoprotein to the cell surface
    • Kreis, T.E. and Lodish, H.F. (1986) Oligomerization is essential for transport of vesicular stomatitis viral glycoprotein to the cell surface. Cell, 46, 929-937.
    • (1986) Cell , vol.46 , pp. 929-937
    • Kreis, T.E.1    Lodish, H.F.2
  • 30
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature, 227, 680-682.
    • (1970) Nature , vol.227 , pp. 680-682
    • Laemmli, U.K.1
  • 31
    • 0027215820 scopus 로고
    • A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
    • Lange-Carter, C.A., Pleiman, C.M., Gardner, A.M., Blumer, K.J. and Johnson, G.L. (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 260, 315-319.
    • (1993) Science , vol.260 , pp. 315-319
    • Lange-Carter, C.A.1    Pleiman, C.M.2    Gardner, A.M.3    Blumer, K.J.4    Johnson, G.L.5
  • 33
    • 0028036970 scopus 로고
    • Identification of two splice variant forms of type-IV (B) cyclic AMP phosphodiesterase. DPD (rPDE-IV (B1)) and PDE-4 (rPDE-IV (B2)) in brain: Selective localization in membrane and cytosolic compartments and differential expression in various brain regions
    • Lobban, M., Shakur, Y., Beattie, J. and Houslay, M.D. (1994) Identification of two splice variant forms of type-IV (B) cyclic AMP phosphodiesterase. DPD (rPDE-IV (B1)) and PDE-4 (rPDE-IV (B2)) in brain: Selective localization in membrane and cytosolic compartments and differential expression in various brain regions. Biochem. J., 304, 399-406.
    • (1994) Biochem. J. , vol.304 , pp. 399-406
    • Lobban, M.1    Shakur, Y.2    Beattie, J.3    Houslay, M.D.4
  • 34
    • 0030941373 scopus 로고    scopus 로고
    • Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells
    • MacKenzie, S., Fleming, I., Houslay, M.D., Anderson, N.G. and Kilgour, E. (1997) Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells. Biochem. J., 324, 159-165.
    • (1997) Biochem. J. , vol.324 , pp. 159-165
    • MacKenzie, S.1    Fleming, I.2    Houslay, M.D.3    Anderson, N.G.4    Kilgour, E.5
  • 35
    • 0032584089 scopus 로고    scopus 로고
    • Stimulation of p70s6 kinase via a growth hormone controlled PI-3 kinase pathway leads to the activation of a PDE4 cAMP specific phosphodiesterases in 3T3-F442A preadipocytes
    • MacKenzie, S.J., Yarwood, S.J., Peden, A.H., Bolger, G.B., Vernon, R.J. and Houslay, M.D. (1998) Stimulation of p70S6 kinase via a growth hormone controlled PI-3 kinase pathway leads to the activation of a PDE4 cAMP specific phosphodiesterases in 3T3-F442A preadipocytes. Proc. Natl Acad. Sci. USA, 95, 3549-3554.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 3549-3554
    • MacKenzie, S.J.1    Yarwood, S.J.2    Peden, A.H.3    Bolger, G.B.4    Vernon, R.J.5    Houslay, M.D.6
  • 36
    • 0029075805 scopus 로고
    • Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE 3 gene family)
    • Manganiello, V.C., Taira, M., Degerman, E. and Belfrage, P. (1995) Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE 3 gene family). Cell. Signal., 7, 445-455.
    • (1995) Cell. Signal. , vol.7 , pp. 445-455
    • Manganiello, V.C.1    Taira, M.2    Degerman, E.3    Belfrage, P.4
  • 37
    • 0019015257 scopus 로고
    • An intrinsic and a peripheral protein constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes
    • Marchmont, R.J. and Houslay, M.D. (1980) An intrinsic and a peripheral protein constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes. Biochem. J., 187, 381-392.
    • (1980) Biochem. J. , vol.187 , pp. 381-392
    • Marchmont, R.J.1    Houslay, M.D.2
  • 38
    • 0029151222 scopus 로고
    • Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family
    • McPhee, I., Pooley, L., Lobban, M., Bolger, G. and Houslay, M.D. (1995) Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family. Biochem. J., 310, 965-974.
    • (1995) Biochem. J. , vol.310 , pp. 965-974
    • McPhee, I.1    Pooley, L.2    Lobban, M.3    Bolger, G.4    Houslay, M.D.5
  • 40
    • 0025572744 scopus 로고
    • Gsα mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cycla
    • Nair, B.G., Parikh, B., Milligan, G. and Patel, T.B. (1990) Gsα mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cycla. J. Biol. Chem., 265, 21317-21322.
    • (1990) J. Biol. Chem. , vol.265 , pp. 21317-21322
    • Nair, B.G.1    Parikh, B.2    Milligan, G.3    Patel, T.B.4
  • 41
    • 0029034774 scopus 로고
    • Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
    • Pang, L., Sawada, T., Decker, S.J. and Saltiel, A.R. (1995) Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol Chem., 270, 13585-13588.
    • (1995) J. Biol Chem. , vol.270 , pp. 13585-13588
    • Pang, L.1    Sawada, T.2    Decker, S.J.3    Saltiel, A.R.4
  • 42
    • 0029664393 scopus 로고    scopus 로고
    • Activation of Gsα by the epidermal growth factor receptor involves phosphorylation
    • Poppleton, H., Sun, H., Fulgham, D., Bertics, P. and Patel, T.B. (1996) Activation of Gsα by the epidermal growth factor receptor involves phosphorylation. J. Biol. Chem., 271, 6947-6951.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6947-6951
    • Poppleton, H.1    Sun, H.2    Fulgham, D.3    Bertics, P.4    Patel, T.B.5
  • 43
    • 0028588997 scopus 로고
    • A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP
    • Rubin, C.S. (1994) A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. Biochim. Biophys. Acta, 1224, 467-479.
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 467-479
    • Rubin, C.S.1
  • 44
    • 0029008078 scopus 로고
    • Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IV (A1)) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase
    • Scotland, G. and Houslay, M.D. (1995) Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IV (A1)) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase. Biochem. J., 308, 673-681.
    • (1995) Biochem. J. , vol.308 , pp. 673-681
    • Scotland, G.1    Houslay, M.D.2
  • 45
    • 0028009991 scopus 로고
    • Localization of A-kinase through anchoring proteins
    • Scott, J.D. and McCartney, S. (1994) Localization of A-kinase through anchoring proteins. Mol. Endocrinol., 8, 5-11.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 5-11
    • Scott, J.D.1    McCartney, S.2
  • 46
    • 0030006920 scopus 로고    scopus 로고
    • Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation
    • Sette, C. and Conti, M. (1996) Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation. J. Biol. Chem., 271, 16526-16534.
    • (1996) J. Biol. Chem. , vol.271 , pp. 16526-16534
    • Sette, C.1    Conti, M.2
  • 47
    • 0028243837 scopus 로고
    • The short-term activation of a Rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation
    • Sette, C., Iona, S. and Conti, M. (1994) The short-term activation of a Rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation. J. Biol. Chem., 269, 9245-9252.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9245-9252
    • Sette, C.1    Iona, S.2    Conti, M.3
  • 48
    • 0027295333 scopus 로고
    • Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram
    • Shakur, Y., Pryde, J.G. and Houslay, M.D. (1993) Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram. Biochem. J., 292, 677-686.
    • (1993) Biochem. J. , vol.292 , pp. 677-686
    • Shakur, Y.1    Pryde, J.G.2    Houslay, M.D.3
  • 49
    • 0028897835 scopus 로고
    • Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum
    • Shakur, Y., Wilson, M., Pooley, L. Lobban, M., Griffiths, S.L., Campbell, A.M., Beattie, J., Daly, C. and Houslay, M.D. (1995) Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum. Biochem. J., 306, 801-809.
    • (1995) Biochem. J. , vol.306 , pp. 801-809
    • Shakur, Y.1    Wilson, M.2    Pooley, L.3    Lobban, M.4    Griffiths, S.L.5    Campbell, A.M.6    Beattie, J.7    Daly, C.8    Houslay, M.D.9
  • 50
    • 0025917462 scopus 로고
    • Intracompartmental sorting of essential myosin light chains: Molecular dissection and in vivo monitoring by epitope tagging
    • Soldati, T. and Perriard, J.C. (1991) Intracompartmental sorting of essential myosin light chains: Molecular dissection and in vivo monitoring by epitope tagging. Cell, 66, 277-289.
    • (1991) Cell , vol.66 , pp. 277-289
    • Soldati, T.1    Perriard, J.C.2
  • 51
    • 0030925148 scopus 로고    scopus 로고
    • Proposal for pharmacologically distinct conformers of PDE4
    • Souness, J.E. and Rao, S. (1997) Proposal for pharmacologically distinct conformers of PDE4. Cell. Signal., 9, 227-236.
    • (1997) Cell. Signal. , vol.9 , pp. 227-236
    • Souness, J.E.1    Rao, S.2
  • 52
    • 0031041588 scopus 로고    scopus 로고
    • The juxtamembrane, cytosolic region of the epidermal growth factor receptor is involved in association with α-subunit of Gs
    • Sun, H., Chen, Z., Poppleton, H., Scholich, K., Mullenix, J., Weipz, G.J., Fulgham, D.L., Bertics, P.J. and Patel, T.B. (1997) The juxtamembrane, cytosolic region of the epidermal growth factor receptor is involved in association with α-subunit of Gs. J. Biol. Chem., 272, 5413-5420.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5413-5420
    • Sun, H.1    Chen, Z.2    Poppleton, H.3    Scholich, K.4    Mullenix, J.5    Weipz, G.J.6    Fulgham, D.L.7    Bertics, P.J.8    Patel, T.B.9
  • 53
    • 0024405251 scopus 로고
    • Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: Evidence for a family of genes
    • Swinnen, J.V., Joseph, D.R. and Conti, M. (1989) Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: Evidence for a family of genes. Proc. Natl Acad. Sci. USA, 86, 5325-5329.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 5325-5329
    • Swinnen, J.V.1    Joseph, D.R.2    Conti, M.3
  • 54
    • 0026545286 scopus 로고
    • Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity
    • Tang, E.K.Y. and Houslay, M.D. (1992) Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity. Biochem. J., 283, 341-346.
    • (1992) Biochem. J. , vol.283 , pp. 341-346
    • Tang, E.K.Y.1    Houslay, M.D.2
  • 55
    • 0025999955 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function
    • Thompson, W.J. (1991) Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function. Pharmacol. Ther, 51, 13-33.
    • (1991) Pharmacol. Ther , vol.51 , pp. 13-33
    • Thompson, W.J.1
  • 56
    • 0015231739 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterase activities from rat brain
    • Thompson, W.J. and Appleman, M.M. (1971) Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochemistry, 10, 311-316.
    • (1971) Biochemistry , vol.10 , pp. 311-316
    • Thompson, W.J.1    Appleman, M.M.2
  • 57
    • 0031914520 scopus 로고    scopus 로고
    • Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents
    • Torphy, T.J. (1998) Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. Am. J. Resp. Crit. Care Med., 157, 351-370.
    • (1998) Am. J. Resp. Crit. Care Med. , vol.157 , pp. 351-370
    • Torphy, T.J.1
  • 58
    • 0027442594 scopus 로고
    • Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle
    • Torphy, T.J., Undem, B.J., Cieslinski, L.B., Luttmann, M.A., Reeves, M.L. and Hay, D.W.P. (1993) Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle. J. Pharmacol. Exp. Ther., 265, 1213-1223.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 1213-1223
    • Torphy, T.J.1    Undem, B.J.2    Cieslinski, L.B.3    Luttmann, M.A.4    Reeves, M.L.5    Hay, D.W.P.6
  • 59
    • 0030753479 scopus 로고    scopus 로고
    • Rolipram inhibition of the human cyclic AMP phosphodiesterase splice varinat HSPDE4D3 expressed in yeast (S.cerevisiae)
    • Wilkinson, I., Engels, P. and Houslay, M.D. (1997) Rolipram inhibition of the human cyclic AMP phosphodiesterase splice varinat HSPDE4D3 expressed in yeast (S.cerevisiae). Pharmacol. Rev. Commun., 9, 215-226.
    • (1997) Pharmacol. Rev. Commun. , vol.9 , pp. 215-226
    • Wilkinson, I.1    Engels, P.2    Houslay, M.D.3
  • 60
    • 0027772672 scopus 로고
    • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate
    • Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weber, M.J. and Sturgill, T.W. (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science, 262, 1065-1069.
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Jelinek, T.3    Wolfman, A.4    Weber, M.J.5    Sturgill, T.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.