메뉴 건너뛰기




Volumn 173, Issue 12, 2004, Pages 7531-7538

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; CD18 ANTIGEN; CELL ADHESION MOLECULE; CYCLIC AMP; ENDOTOXIN; MACROPHAGE INFLAMMATORY PROTEIN 2; PHOSPHODIESTERASE 4B; PHOSPHODIESTERASE 4D; PHOSPHODIESTERASE IV; ROLIPRAM; UNCLASSIFIED DRUG;

EID: 10344242415     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.12.7531     Document Type: Article
Times cited : (156)

References (58)
  • 1
    • 0023938335 scopus 로고
    • The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response
    • Kammer, G. M. 1988. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol. Today 9:222.
    • (1988) Immunol. Today , vol.9 , pp. 222
    • Kammer, G.M.1
  • 2
    • 0026736043 scopus 로고
    • Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3′,5′-cyclic adenosine monophosphate on cell replication in human T lymphocytes
    • Skalhegg, B. S., B. F. Landmark, S. O. Doskeland, V. Hansson, T. Lea, and T. Jahnsen. 1992. Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3′,5′-cyclic adenosine monophosphate on cell replication in human T lymphocytes. J. Biol. Chem. 267:15707.
    • (1992) J. Biol. Chem. , vol.267 , pp. 15707
    • Skalhegg, B.S.1    Landmark, B.F.2    Doskeland, S.O.3    Hansson, V.4    Lea, T.5    Jahnsen, T.6
  • 3
    • 0031914520 scopus 로고    scopus 로고
    • Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents
    • Torphy, T. J. 1998. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. Am. J. Respir. Crit. Care Med. 157:351.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 351
    • Torphy, T.J.1
  • 4
    • 0024501727 scopus 로고
    • Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP
    • Tannenbaum, C. S., and T. A. Hamilton. 1989. Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP. J. Immunol. 142:1274.
    • (1989) J. Immunol. , vol.142 , pp. 1274
    • Tannenbaum, C.S.1    Hamilton, T.A.2
  • 5
    • 0027170699 scopus 로고
    • Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate
    • Parhami, F., Z. T. Fang, A. M. Fogelman, A. Andalibi, M. C. Territo, and J. A. Berliner. 1993. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J. Clin. Invest. 92:471.
    • (1993) J. Clin. Invest. , vol.92 , pp. 471
    • Parhami, F.1    Fang, Z.T.2    Fogelman, A.M.3    Andalibi, A.4    Territo, M.C.5    Berliner, J.A.6
  • 6
    • 0035067974 scopus 로고    scopus 로고
    • Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis
    • Fine, J. S., H. D. Byrnes, P. J. Zavodny, and R. W. Hipkin. 2001. Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis. Inflammation 25:61.
    • (2001) Inflammation , vol.25 , pp. 61
    • Fine, J.S.1    Byrnes, H.D.2    Zavodny, P.J.3    Hipkin, R.W.4
  • 9
    • 0025225659 scopus 로고
    • Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst
    • Nielson, C. P., R. E. Vestal, R. J. Sturm, and R. Heaslip. 1990. Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst. J. Allergy Clin. Immunol. 86:801.
    • (1990) J. Allergy Clin. Immunol. , vol.86 , pp. 801
    • Nielson, C.P.1    Vestal, R.E.2    Sturm, R.J.3    Heaslip, R.4
  • 10
    • 0022967477 scopus 로고
    • Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells
    • Bessler, H., R. Gilgal, M. Djaldetti, and I. Zahavi. 1986. Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells. J. Leukocyte Biol. 40:747.
    • (1986) J. Leukocyte Biol. , vol.40 , pp. 747
    • Bessler, H.1    Gilgal, R.2    Djaldetti, M.3    Zahavi, I.4
  • 11
    • 0031935312 scopus 로고    scopus 로고
    • Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: Synergism with prostanoids and salbutamol
    • Au, B. T., M. M. Teixeira, P. D. Collins, and T. J. Williams. 1998. Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol. Br. J. Pharmacol. 123:1260.
    • (1998) Br. J. Pharmacol. , vol.123 , pp. 1260
    • Au, B.T.1    Teixeira, M.M.2    Collins, P.D.3    Williams, T.J.4
  • 12
    • 0028800523 scopus 로고
    • Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators
    • Derian, C. K., R. J. Santulli, P. E. Rao, H. F. Solomon, and J. A. Barrett. 1995. Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators. J. Immunol. 154:308.
    • (1995) J. Immunol. , vol.154 , pp. 308
    • Derian, C.K.1    Santulli, R.J.2    Rao, P.E.3    Solomon, H.F.4    Barrett, J.A.5
  • 13
    • 0025977903 scopus 로고
    • cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness
    • Harvath, L., J. D. Robbins, A. A. Russell, and K. B. Seamon. 1991. cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness. J. Immunol. 146:224.
    • (1991) J. Immunol. , vol.146 , pp. 224
    • Harvath, L.1    Robbins, J.D.2    Russell, A.A.3    Seamon, K.B.4
  • 14
    • 0028171972 scopus 로고
    • β-adrenoceptors, cAMP and airway smooth muscle relaxation: Challenges to the dogma
    • Torphy, T. J. 1994. β-Adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma. Trends Pharmacol. Sci. 15:370.
    • (1994) Trends Pharmacol. Sci. , vol.15 , pp. 370
    • Torphy, T.J.1
  • 15
    • 0032531841 scopus 로고    scopus 로고
    • Interaction of cyclic GMP and cyclic AMP during neutrophil migration: Involvement of phosphodiesterase type III
    • VanUffelen, B. E., B. M. de Koster, and J. G. Elferink. 1998. Interaction of cyclic GMP and cyclic AMP during neutrophil migration: involvement of phosphodiesterase type III. Biochem. Pharmacol. 56:1061.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 1061
    • VanUffelen, B.E.1    De Koster, B.M.2    Elferink, J.G.3
  • 16
    • 0033524977 scopus 로고    scopus 로고
    • CD3- and CD28-dependent induction of PDE7 required for T cell activation
    • Li, L., C. Yee, and J. A. Beavo. 1999. CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science 283:848.
    • (1999) Science , vol.283 , pp. 848
    • Li, L.1    Yee, C.2    Beavo, J.A.3
  • 18
    • 0037188511 scopus 로고    scopus 로고
    • Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
    • Jin, S. L., and M. Conti. 2002. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses. Proc. Natl. Acad. Sci. USA 99:7628.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7628
    • Jin, S.L.1    Conti, M.2
  • 19
    • 0033033913 scopus 로고    scopus 로고
    • Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils
    • Wang, P., P. Wu, K. M. Ohleth, R. W. Egan, and M. M. Billah. 1999. Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils. Mol. Pharmacol. 56:170.
    • (1999) Mol. Pharmacol. , vol.56 , pp. 170
    • Wang, P.1    Wu, P.2    Ohleth, K.M.3    Egan, R.W.4    Billah, M.M.5
  • 20
    • 0034846480 scopus 로고    scopus 로고
    • Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: Role of interleukin-10
    • Seldon, P. M., and M. A. Giembycz. 2001. Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: role of interleukin-10. Br. J. Pharmacol. 134:58.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 58
    • Seldon, P.M.1    Giembycz, M.A.2
  • 21
    • 0032605044 scopus 로고    scopus 로고
    • The molecular biology of cyclic nucleotide phosphodiesterases
    • Conti, M., and S. L. Jin. 1999. The molecular biology of cyclic nucleotide phosphodiesterases. Prog. Nucleic Acid Res. Mol. Biol. 63:1.
    • (1999) Prog. Nucleic Acid Res. Mol. Biol. , vol.63 , pp. 1
    • Conti, M.1    Jin, S.L.2
  • 23
    • 0028145823 scopus 로고
    • Expression and regulation of human and rat phosphodiesterase type IV isogenes
    • Engels, P., K. Fichtel, and H. Lubbert. 1994. Expression and regulation of human and rat phosphodiesterase type IV isogenes. FEBS Lett. 350:291.
    • (1994) FEBS Lett. , vol.350 , pp. 291
    • Engels, P.1    Fichtel, K.2    Lubbert, H.3
  • 24
    • 0031601339 scopus 로고    scopus 로고
    • The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: Intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions
    • Houslay, M. D., M. Sullivan, and G. B. Bolger. 1998. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. Adv. Pharmacol. 44:225.
    • (1998) Adv. Pharmacol. , vol.44 , pp. 225
    • Houslay, M.D.1    Sullivan, M.2    Bolger, G.B.3
  • 25
    • 0034024182 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitors and the treatment of asthma: Where are we now and where do we go from here?
    • Giembycz, M. A. 2000. Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here? Drugs 59:193.
    • (2000) Drugs , vol.59 , pp. 193
    • Giembycz, M.A.1
  • 26
    • 0030876492 scopus 로고    scopus 로고
    • Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study
    • Gantner, F., H. Tenor, V. Gekeler, C. Schudt, A. Wendel, and A. Hatzelmann. 1997. Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study. J. Allergy Clin. Immunol. 100:527.
    • (1997) J. Allergy Clin. Immunol. , vol.100 , pp. 527
    • Gantner, F.1    Tenor, H.2    Gekeler, V.3    Schudt, C.4    Wendel, A.5    Hatzelmann, A.6
  • 27
    • 0029101862 scopus 로고
    • Identification of phosphodiesterase IV activity and its cyclic adenosine monophosphate-dependent up-regulation in a human keratinocyte cell line (HaCaT)
    • Tenor, H., A. Hatzelmann, A. Wendel, and C. Schudt. 1995. Identification of phosphodiesterase IV activity and its cyclic adenosine monophosphate- dependent up-regulation in a human keratinocyte cell line (HaCaT). J. Invest. Dermatol. 105:70.
    • (1995) J. Invest. Dermatol. , vol.105 , pp. 70
    • Tenor, H.1    Hatzelmann, A.2    Wendel, A.3    Schudt, C.4
  • 28
    • 0025136872 scopus 로고
    • Mechanism for the emetic side effect of xanthine bronchodilators
    • Howell, R. E., W. T. Muehsam, and W. J. Kinnier. 1990. Mechanism for the emetic side effect of xanthine bronchodilators. Life Sci. 46:563.
    • (1990) Life Sci. , vol.46 , pp. 563
    • Howell, R.E.1    Muehsam, W.T.2    Kinnier, W.J.3
  • 29
    • 0034130633 scopus 로고    scopus 로고
    • Immumosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors
    • Souness, J. E., D. Aldous, and C. Sargent. 2000. Immumosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors. Immunopharmacology 47:127.
    • (2000) Immunopharmacology , vol.47 , pp. 127
    • Souness, J.E.1    Aldous, D.2    Sargent, C.3
  • 30
    • 0032692936 scopus 로고    scopus 로고
    • Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice
    • Jin, S. L., F. J. Richard, W. P. Kuo, A. J. D'Ercole, and M. Conti. 1999. Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. USA 96:11998.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11998
    • Jin, S.L.1    Richard, F.J.2    Kuo, W.P.3    D'Ercole, A.J.4    Conti, M.5
  • 31
    • 0015231739 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterase activities from rat brain
    • Thompson, W. J., and M. M. Appleman. 1971. Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochemistry 10:311.
    • (1971) Biochemistry , vol.10 , pp. 311
    • Thompson, W.J.1    Appleman, M.M.2
  • 32
    • 0028989596 scopus 로고
    • Biologic activities of the β-chemokine TCA3 on neutrophils and macrophages
    • Devi, S., J. Laning, Y. Luo, and M. E. Dorf. 1995. Biologic activities of the β-chemokine TCA3 on neutrophils and macrophages. J. Immunol. 154:5376.
    • (1995) J. Immunol. , vol.154 , pp. 5376
    • Devi, S.1    Laning, J.2    Luo, Y.3    Dorf, M.E.4
  • 33
    • 0030720773 scopus 로고    scopus 로고
    • Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration
    • Campbell, J. J., E. F. Foxman, and E. C. Butcher. 1997. Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration. Eur. J. Immunol. 27:2571.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2571
    • Campbell, J.J.1    Foxman, E.F.2    Butcher, E.C.3
  • 34
    • 0028809048 scopus 로고
    • Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation
    • Frevert, C. W., S. Huang, H. Danaee, J. D. Paulauskis, and L. Kobzik. 1995. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J. Immunol. 154:335.
    • (1995) J. Immunol. , vol.154 , pp. 335
    • Frevert, C.W.1    Huang, S.2    Danaee, H.3    Paulauskis, J.D.4    Kobzik, L.5
  • 37
    • 0347359224 scopus 로고    scopus 로고
    • Localized effects of cAMP mediated by distinct routes of protein kinase A
    • Tasken, K., and E. M. Aandahl. 2004. Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol. Rev. 84:137.
    • (2004) Physiol. Rev. , vol.84 , pp. 137
    • Tasken, K.1    Aandahl, E.M.2
  • 38
    • 0016915716 scopus 로고
    • Effect of exogenous cyclic AMP and other adenine nucleotides on neutrophil chemotaxis and motility
    • Rivkin, I., and E. L. Becker. 1976. Effect of exogenous cyclic AMP and other adenine nucleotides on neutrophil chemotaxis and motility. Int. Arch. Allergy Appl. Immunol. 50:95.
    • (1976) Int. Arch. Allergy Appl. Immunol. , vol.50 , pp. 95
    • Rivkin, I.1    Becker, E.L.2
  • 39
    • 0034635513 scopus 로고    scopus 로고
    • Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
    • Servant, G., O. D. Weiner, P. Herzmark, T. Balla, J. W. Sedat, and H. R. Bourne. 2000. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287:1037.
    • (2000) Science , vol.287 , pp. 1037
    • Servant, G.1    Weiner, O.D.2    Herzmark, P.3    Balla, T.4    Sedat, J.W.5    Bourne, H.R.6
  • 40
    • 0030813029 scopus 로고    scopus 로고
    • Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants
    • Laudanna, C., J. J. Campbell, and E. C. Butcher. 1997. Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants. J. Biol. Chem. 272:24141.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24141
    • Laudanna, C.1    Campbell, J.J.2    Butcher, E.C.3
  • 41
    • 0036622712 scopus 로고    scopus 로고
    • 2 integrin avidity in neutrophils
    • 2 integrin avidity in neutrophils. J. Leukocyte Biol. 71:1042.
    • (2002) J. Leukocyte Biol. , vol.71 , pp. 1042
    • Jones, S.L.1
  • 42
    • 0035933817 scopus 로고    scopus 로고
    • Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area
    • Tasken, K. A., P. Collas, W. A. Kemmner, O. Witczak, M. Conti, and K. Tasken. 2001. Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. J. Biol. Chem. 276:21999.
    • (2001) J. Biol. Chem. , vol.276 , pp. 21999
    • Tasken, K.A.1    Collas, P.2    Kemmner, W.A.3    Witczak, O.4    Conti, M.5    Tasken, K.6
  • 44
    • 0036473397 scopus 로고    scopus 로고
    • The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
    • Luttrell, L. M., and R. J. Lefkowitz. 2002. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 115:455.
    • (2002) J. Cell Sci. , vol.115 , pp. 455
    • Luttrell, L.M.1    Lefkowitz, R.J.2
  • 49
    • 0034612334 scopus 로고    scopus 로고
    • Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D
    • Hansen, G., S. Jin, D. T. Umetsu, and M. Conti. 2000. Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Proc. Natl. Acad. Sci. USA 97:6751.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6751
    • Hansen, G.1    Jin, S.2    Umetsu, D.T.3    Conti, M.4
  • 50
    • 0036200951 scopus 로고    scopus 로고
    • The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-β release during acute lung injury in mice: The role of the balance between tumor necrosis factor-α and interleukin-10
    • Corbel, M., N. Germain, J. Lanchou, S. Molet, P. M. R. e Silva, M. A. Martins, E. Boichot, and V. Lagente. 2002. The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-β release during acute lung injury in mice: the role of the balance between tumor necrosis factor-α and interleukin-10. J. Pharmacol. Exp. Ther. 301:258.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 258
    • Corbel, M.1    Germain, N.2    Lanchou, J.3    Molet, S.4    E Silva, P.M.R.5    Martins, M.A.6    Boichot, E.7    Lagente, V.8
  • 51
    • 0031989117 scopus 로고    scopus 로고
    • Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung
    • Goncalves de Moraes, V. L., M. Singer, B. B. Vargaftig, and M. Chignard. 1998. Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung. Br. J. Pharmacol. 123:631.
    • (1998) Br. J. Pharmacol. , vol.123 , pp. 631
    • Goncalves De Moraes, V.L.1    Singer, M.2    Vargaftig, B.B.3    Chignard, M.4
  • 52
    • 0036199266 scopus 로고    scopus 로고
    • Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities
    • Trifilief, A., D. Wyss, C. Walker, L. Mazzoni, and R. Hersperger. 2002. Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities. J. Pharmacol. Exp. Ther. 301:241.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 241
    • Trifilief, A.1    Wyss, D.2    Walker, C.3    Mazzoni, L.4    Hersperger, R.5
  • 55
    • 0036154530 scopus 로고    scopus 로고
    • Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-α) biosynthesis in alveolar epithelial cells
    • Haddad, J. J., S. C. Land, W. O. Tarnow-Mordi, M. Zembala, D. Kowalczyk, and R. Lauterbach. 2002. Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide- mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-α) biosynthesis in alveolar epithelial cells. J. Pharmacol. Exp. Ther. 300:559.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 559
    • Haddad, J.J.1    Land, S.C.2    Tarnow-Mordi, W.O.3    Zembala, M.4    Kowalczyk, D.5    Lauterbach, R.6
  • 56
    • 0025013980 scopus 로고
    • Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor α
    • Dubravec, D. B., D. R. Spriggs, J. A. Mannick, and M. L. Rodrick. 1990. Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor α. Proc. Natl. Acad. Sci. USA 87:6758.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6758
    • Dubravec, D.B.1    Spriggs, D.R.2    Mannick, J.A.3    Rodrick, M.L.4
  • 57
    • 0028216039 scopus 로고
    • Detection of cytokines and their cell sources in bronchial biopsy specimens from asthmatic patients: Relationship to atopic status, symptoms, and level of airway hyperresponsiveness
    • Ackerman, V., M. Marini, E. Vittori, A. Bellini, G. Vassali, and S. Mattoli. 1994. Detection of cytokines and their cell sources in bronchial biopsy specimens from asthmatic patients: relationship to atopic status, symptoms, and level of airway hyperresponsiveness. Chest 105:687.
    • (1994) Chest , vol.105 , pp. 687
    • Ackerman, V.1    Marini, M.2    Vittori, E.3    Bellini, A.4    Vassali, G.5    Mattoli, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.