Mast cell function: Regulation of degranulation by serine/threonine phosphatases

Pharmacology and Therapeutics

Volumn 112, Issue 2, 2006, Pages 425-439

  Sim, Alistair T R ^a   Ludowyke, Russell I ^b   Verrills, Nicole M ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Degranulation; Exocytosis; Mast cells; PP2A; Protein phosphatase; Protein phosphorylation

Indexed keywords

CALCIMYCIN; CALCINEURIN; CALYCULIN A; FOSTRIECIN; MARINE TOXIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PHOSPHOSERINE; PHOSPHOTHREONINE; TACROLIMUS;

AMINO ACID SEQUENCE; CELL ACTIVATION; CELL FUNCTION; CELL MEMBRANE; CHEMICAL STRUCTURE; DOWNSTREAM PROCESSING; DRUG RECEPTOR BINDING; DRUG TARGETING; EXOCYTOSIS; HUMAN; MAST CELL DEGRANULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ASTHMA; CELL DEGRANULATION; EXOCYTOSIS; HUMANS; MAST CELLS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 33749266374     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2006.04.011     Document Type: Review

References (185)

1. Alto N., Carlisle Michel J.J., Dodge K.L., Langeberg L.K., and Scott J.D. Intracellular targeting of protein kinases and phosphatases. Diabetes 51 Suppl. 3 (2002) S385-S388
2. Andreassen P.R., Lacroix F.B., Villa-Moruzzi E., and Margolis R.L. Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells. J Cell Biol 141 (1998) 1207-1215
3. Apgar J.R. Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C. J Cell Biol 112 (1991) 1157-1163
4. Aramburu J., Rao A., and Klee C.B. Calcineurin: from structure to function. Curr Top Cell Regul 36 (2002) 237-295
5. Artuc M., Steckelings U.M., and Henz B.M. Mast cell-fibroblast interactions: human mast cells as source and inducers of fibroblast and epithelial growth factors. J Invest Dermatol 118 3 (2002) 391-395
6. Bairoch A., Apweiler R., Wu C.H., Barker W.C., Boeckmann B., Ferro S., et al. The universal protein resource (UniProt). Nucleic Acids Res 33 (2005) D154-D159
7. Baldwin M.L., Rostas J.A., and Sim A.T. Two modes of exocytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B. J Neurochem 85 (2003) 1190-1199
8. Banzet S., Koulmann N., Simler N., Birot O., Sanchez H., Chapot R., et al. Fibre-type specificity of interleukin-6 gene transcription during muscle contraction in rat: association with calcineurin activity. J Physiol 566 (2005) 839-847
9. Barford D. Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem Sci 21 (1996) 407-412
10. Bastan R., Peirce M.J., and Peachell P.T. Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung. Eur J Pharmacol 430 (2001) 135-141
11. Beaven M.A., and Baumgartner R.A. Downstream signals initiated in mast cells by Fc epsilon RI and other receptors. Curr Opin Immunol 8 (1996) 766-772
12. Begum N., and Ragolia L. cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells. J Biol Chem 271 (1996) 31166-31171
13. Benoist M., Gaillard S., and Castets F. The striatin family: a new signaling platform in dendritic spines. J Physiol 99 (2006) 146-158 (Paris)
14. Berger P., Perng D.W., Thabrew H., Compton S.J., Cairns J.A., McEuen A.R., et al. Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells. J Appl Physiol 91 3 (2001) 1372-1379
15. Blank U., and Rivera J. The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol 25 (2004) 266-273
16. Blank U., Cyprien B., Martin-Verdeaux S., Paumet F., Pombo I., Rivera J., et al. SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line. Mol Immunol 38 (2002) 1341-1345
17. Bochner B.S., and Busse W.W. Allergy and asthma. J Allergy Clin Immunol 115 (2005) 953-959
18. Bollen M. Combinatorial control of protein phosphatase-1. Trends Biochem Sci 26 (2001) 426-431
19. Bollen M., and Beullens M. Signaling by protein phosphatases in the nucleus. Trends Cell Biol 12 (2002) 138-145
20. Borish L.C., Nelson H.S., Corren J., Bensch G., Busse W.W., Whitmore J.B., et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol 107 (2001) 963-970
21. Boudreau R.T., and Hoskin D.W. The use of okadaic acid to elucidate the intracellular role(s) of protein phosphatase 2A: lessons from the mast cell model system. Int Immunopharmacol 5 (2005) 1507-1518
22. Boudreau R.T., Garduno R., and Lin T.J. Protein phosphatase 2A and protein kinase Calpha are physically associated and are involved in Pseudomonas aeruginosa-induced interleukin 6 production by mast cells. J Biol Chem 277 (2002) 5322-5329
23. Boudreau R.T., Hoskin D.W., and Lin T.J. Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK. J Leukoc Biol 76 (2004) 1075-1081
24. Bradding P. The role of the mast cell in asthma: a reassessment. Curr Opin Allergy Clin Immunol 3 1 (2003) 45-50
25. Brady M.J., and Saltiel A.R. The role of protein phosphatase-1 in insulin action. Recent Prog Horm Res 56 (2001) 157-173
26. Brightling C.E., and Bradding P. The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis. Curr Allergy Asthma Rep 5 (2005) 130-135
27. Brightling C.E., Bradding P., Pavord I.D., and Wardlaw A.J. New insights into the role of the mast cell in asthma. Clin Exp Allergy 33 5 (2003) 550-556
28. Brightling C.E., Bradding P., Symon F.A., Holgate S.T., Wardlaw A.J., and Pavord I.D. Mast-cell infiltration of airway smooth muscle in asthma. (see comment). N Engl J Med 346 22 (2002) 1699-1705
29. Broide D.H., Gleich G.J., Cuomo A.J., Coburn D.A., Federman E.C., Schwartz L.B., et al. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol 88 (1991) 637-648
30. Browne G.J., Delibegovic M., Keppens S., Stalmans W., and Cohen P.T. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Biochem J 360 (2001) 449-459
31. Brush M.H., Weiser D.C., and Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol 23 (2003) 1292-1303
32. Butland B.K., Strachan D.P., Crawley-Boevey E.E., and Anderson H.R. Childhood asthma in South London: trends in prevalence and use of medical services 1991-2002. Thorax 61 (2006) 383-387
33. 2+ flux. Cell 83 (1995) 463-472
34. Cameron A.M., Steiner J.P., Sabatini D.M., Kaplin A.I., Walensky L.D., and Snyder S.H. Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proc Natl Acad Sci U S A 92 (1995) 1784-1788
35. Cantani A., and Micera M. A prospective study of asthma desensitization in 1182 children, 592 asthmatic children and 590 nonatopic controls. Eur Rev Med Pharmacol Sci 9 (2005) 325-329
36. Carroll N.G., Mutavdzic S., and James A.L. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 19 (2002) 879-885
37. Carroll N.G., Mutavdzic S., and James A.L. Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma. Thorax 57 (2002) 677-682
38. Ceulemans H., Stalmans W., and Bollen M. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. Bioessays 24 (2002) 371-381
39. Chen J., Martin B.L., and Brautigan D.L. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257 (1992) 1261-1264
40. Chen W., Possemato R., Campbell K.T., Plattner C.A., Pallas D.C., and Hahn W.C. Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell 5 (2004) 127-136
41. Chheda M.G., Ashery U., Thakur P., Rettig J., and Sheng Z.H. Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nat Cell Biol 3 (2001) 331-338
42. Chinkers M. Protein phosphatase 5 in signal transduction. Trends Endocrinol Metab 12 (2001) 28-32
43. Choi O.H., Adelstein R.S., and Beaven M.A. Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C. J Biol Chem 269 (1994) 536-541
44. Church M.K., and Hiroi J. Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. Br J Pharmacol 90 (1987) 421-429
45. Cohen P. The structure and regulation of protein phosphatases. Annu Rev Biochem 58 (1989) 453-508
46. Cohen P.T. Protein phosphatase 1-targeted in many directions. J Cell Sci 115 (2002) 241-256
47. Cohen P.T., Philp A., and Vazquez-Martin C. Protein phosphatase 4-from obscurity to vital functions. FEBS Lett 579 (2005) 3278-3286
48. Crivellato E., Beltrami C.A., Mallardi F., and Ribatti D. The mast cell: an active participant or an innocent bystander?. Histol Hispathol (2004) 259-270
49. Csortos C., Zolnierowicz S., Bako E., Durbin S.D., and DePaoli-Roach A.A. High complexity in the expression of the B′ subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms. J Biol Chem 271 (1996) 2578-2588
50. 2+ ionophore. J Immunol 143 (1989) 2617-2625
51. de Vries K.J., Geijtenbeek A., Brian E.C., de Graan P.N., Ghijsen W.E., and Verhage M. Dynamics of munc18-1 phosphorylation/dephosphorylation in rat brain nerve terminals. Eur J Neurosci 12 (2000) 385-390
52. Dell'Acqua M.L., Dodge K.L., Tavalin S.J., and Scott J.D. Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem 277 (2002) 48796-48802
53. Ducruet A.P., Vogt A., Wipf P., Lazo J.S., Wang W.Q., Sun J.P., et al. Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease. An overview of the protein tyrosine phosphatase superfamily. Annu Rev Pharmacol Toxicol 45 (2005) 725-750
54. Dulubova I., Yamaguchi T., Arac D., Li H., Huryeva I., Min S.W., et al. Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proc Natl Acad Sci U S A 100 (2003) 32-37
55. Egloff M.P., Johnson D.F., Moorhead G., Cohen P.T., Cohen P., and Barford D. Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J 16 (1997) 1876-1887
56. Estevez M.D., Vieytes M.R., Louzao M.C., and Botana L.M. Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells. Biochem Pharmacol 47 (1994) 591-593
57. Fath S., Kobor M.S., Philippi A., Greenblatt J., and Tschochner H. Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis. J Biol Chem 279 (2004) 25251-25259
58. Favre B., Turowski P., and Hemmings B.A. Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J Biol Chem 272 (1997) 13856-13863
59. Fitzgerald M.L., and Reed G.L. Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. Biochem J 342 (1999) 353-360
60. Fletcher A.I., Shuang R., Giovannucci D.R., Zhang L., Bittner M.A., and Stuenkel E.L. Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. J Biol Chem 274 (1999) 4027-4035
61. Fruman D.A., Bierer B.E., Benes J.E., Burakoff S.J., Austen K.F., and Katz H.R. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. J Immunol 154 (1995) 1846-1851
62. Gaillard S., Bailly Y., Benoist M., Rakitina T., Kessler J.P., Fronzaroli-Molinieres L., et al. Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain. Traffic 7 (2006) 74-84
63. Gerst J.E. SNAREs and SNARE regulators in membrane fusion and exocytosis. Cell Mol Life Sci 55 (1999) 707-734
64. Gibson P.G., Allen C.J., Yang J.P., Wong B.J., Dolovich J., Denburg J., et al. Intraepithelial mast cells in allergic and nonallergic asthma. Assessment using bronchial brushings. Am Rev Respir Dis 148 (1993) 80-86
65. Gorina S., and Pavletich N.P. Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP20. Science 274 (1996) 1001-1005
66. Gotz J., and Schild A. Transgenic and knockout models of PP2A. Methods Enzymol 366 (2003) 390-403
67. Gotz J., Probst A., Ehler E., Hemmings B., and Kues W. Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A 95 (1998) 12370-12375
68. Guy G.R., Philp R., and Tan Y.H. Activation of protein kinases and the inactivation of protein phosphatase 2A in tumour necrosis factor and interleukin-1 signal-transduction pathways. Eur J Biochem 229 (1995) 503-511
69. Hagmann W. Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line. Biochem J 299 Pt 2 (1994) 467-472
70. Hansra G., Bornancin F., Whelan R., Hemmings B.A., and Parker P.J. 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer. J Biol Chem 271 (1996) 32785-32788
71. Hardie D.G., Haystead T.A., and Sim A.T. Use of okadaic acid to inhibit protein phosphatases in intact cells. Methods Enzymol 201 (1991) 469-476
72. Hashimoto Y., Perrino B.A., and Soderling T.R. Identification of an autoinhibitory domain in calcineurin. J Biol Chem 265 (1990) 1924-1927
73. Hastie C.J., and Cohen P.T. Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett 431 (1998) 357-361
74. Heinrich R., Neel B.G., and Rapoport T.A. Mathematical models of protein kinase signal transduction. Mol Cell 9 (2002) 957-970
75. Hemmings B.A., Adams-Pearson C., Maurer F., Muller P., Goris J., Merlevede W., et al. alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry 29 (1990) 3166-3173
76. Hendrix P., Mayer-Jackel R.E., Cron P., Goris J., Hofsteenge J., Merlevede W., et al. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. J Biol Chem 268 (1993) 15267-15276
77. Heneberg P., and Draber P. Nonreceptor protein tyrosine and lipid phosphatases in type I fc(epsilon) receptor-mediated activation of mast cells and basophils. Int Arch Allergy Immunol 128 (2002) 253-263
78. Holst J., Sim A.T., and Ludowyke R.I. Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells. Mol Biol Cell 13 (2002) 1083-1098
79. Huang X., and Honkanen R.E. Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC). J Biol Chem 273 (1998) 1462-1468
80. Hubbard M.J., and Cohen P. On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem Sci 18 (1993) 172-177
81. Hubbard M.J., and Klee C.B. Characterization of a high-affinity monoclonal antibody to calcineurin whose epitope defines a new structural domain of calcineurin A. Eur J Biochem 185 (1989) 411-418
82. Hubbard M.J., and Klee C.B. Functional domain structure of calcineurin A: mapping by limited proteolysis. Biochemistry 28 (1989) 1868-1874
83. Hultsch T., Brand P., Lohmann S., Saloga J., Kincaid R.L., and Knop J. Direct evidence that FK506 inhibition of FcepsilonRI-mediated exocytosis from RBL mast cells involves calcineurin. Arch Dermatol Res 290 (1998) 258-263
84. Imai A., Sugiyama M., Furui T., and Tamaya T. Gi protein-mediated translocation of serine/threonine phosphatase to the plasma membrane and apoptosis of ovarian cancer cell in response to gonadotropin-releasing hormone antagonist cetrorelix. J Obstet Gynaecol 26 (2006) 37-41
85. Jahn R., and Sudhof T.C. Membrane fusion and exocytosis. Annu Rev Biochem 68 (1999) 863-911
86. Janssens V., and Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353 (2001) 417-439
87. Janssens V., Goris J., and Van Hoof C. PP2A: the expected tumor suppressor. Curr Opin Genet Dev 15 (2005) 34-41
88. Jayaraman T., Brillantes A.M., Timerman A.P., Fleischer S., Erdjument-Bromage H., Tempst P., et al. FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem 267 (1992) 9474-9477
89. Johnson E.N., Appelbaum E.R., Carpenter D.C., Cox R.F., Disa J., Foley J.J., et al. Neuromedin U elicits cytokine release in murine Th2-type T cell clone D10, G4.1. J Immunol 173 (2004) 7230-7238
90. Jones J.A., and Hannun Y.A. Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. J Biol Chem 277 (2002) 15530-15538
91. Jones J.A., Rawles R., and Hannun Y.A. Identification of a novel phosphatidic acid binding domain in protein phosphatase-1. Biochemistry 44 (2005) 13235-13245
92. Keranen L.M., Dutil E.M., and Newton A.C. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 5 (1995) 1394-1403
93. Khew-Goodall Y., Mayer R.E., Maurer F., Stone S.R., and Hemmings B.A. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (erratum appears in Biochemistry 1991 May 28;30(21): 5328). Biochemistry 30 (1991) 89-97
94. Kim M.J., Jo D.G., Hong G.S., Kim B.J., Lai M., Cho D.H., et al. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proc Natl Acad Sci U S A 99 (2002) 9870-9875
95. Kitani S., Teshima R., Nonomura Y., Morita Y., and Ito K. The effect of okadaic acid on histamine release, cell morphology and phosphorylation in rat basophilic leukemia (RBL-2H3) cells, human basophils and rat peritoneal mast cells. Int Arch Allergy Immunol 110 (1996) 339-347
96. Klenchin V.A., and Martin T.F. Priming in exocytosis: attaining fusion-competence after vesicle docking. Biochimie 82 (2000) 399-407
97. Kobayashi T., Miura T., Haba T., Sato M., Serizawa I., Nagai H., et al. An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J Immunol 164 (2000) 3855-3861
98. Krishna M.T., Chauhan A., Little L., Sampson K., Hawksworth R., Mant T., et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol 107 (2001) 1039-1045
99. Krishnaswamy G., Ajitawi O., and Chi D.S. The human mast cell: an overview. Methods Mol Biol 315 (2006) 13-34
100. Kumar R.K., and Foster P.S. Modeling allergic asthma in mice: pitfalls and opportunities. Am J Respir Cell Mol Biol 27 (2002) 267-272
101. Kuno T., Mukai H., Ito A., Chang C.D., Kishima K., Saito N., et al. Distinct cellular expression of calcineurin A alpha and A beta in rat brain. J Neurochem 58 (1992) 1643-1651
102. Lai M.M., Luo H.R., Burnett P.E., Hong J.J., and Snyder S.H. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. J Biol Chem 275 (2000) 34017-34020
103. Lang T., Wacker I., Wunderlich I., Rohrbach A., Giese G., Soldati T., et al. Role of actin cortex in the subplasmalemmal transport of secretory granules in PC-12 cells. Biophys J 78 (2000) 2863-2877
104. Langeberg L.K., and Scott J.D. A-kinase-anchoring proteins. J Cell Sci 118 (2005) 3217-3220
105. Lee J., and Stock J. Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase. J Biol Chem 268 (1993) 19192-19195
106. Letourneux C., Rocher G., and Porteu F. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J 25 (2006) 727-738
107. Li X., and Virshup D.M. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem 269 (2002) 546-552
108. Li M., Stefansson B., Wang W., Schaefer E.M., and Brautigan D.L. Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle. Cell Signal (2005)
109. Lu Q., Pallas D.C., Surks H.K., Baur W.E., Mendelsohn M.E., and Karas R.H. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. Proc Natl Acad Sci U S A 101 (2004) 17126-17131
110. Ludowyke R.I., and Scurr L.L. Calcium-independent secretion by ATP gamma S from a permeabilized rat basophilic leukaemia cell line (RBL-2H3). Cell Signal 6 (1994) 223-231
111. Ludowyke R.I., Peleg I., Beaven M.A., and Adelstein R.S. Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells. J Biol Chem 264 (1989) 12492-12501
112. Ludowyke R.I., Scurr L.L., and McNally C.M. Calcium ionophore-induced secretion from mast cells correlates with myosin light chain phosphorylation by protein kinase C. J Immunol 157 (1996) 5130-5138
113. Ludowyke R.I., Warton K., and Scurr L.L. Inhibition of antigen and calcium ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors. Cell Biol Int 22 (1998) 855-865
114. Ludowyke R.I., Holst J., Mudge L.M., and Sim A.T. Transient translocation and activation of protein phosphatase 2A during mast cell secretion. J Biol Chem 275 (2000) 6144-6152
115. Machado D.C., Horton D., Harrop R., Peachell P.T., and Helm B.A. Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen-specific IgE. Eur J Immunol 26 (1996) 2972-2980
116. Machado J.D., Morales A., Gomez J.F., and Borges R. cAmp modulates exocytotic kinetics and increases quantal size in chromaffin cells. Mol Pharmacol 60 (2001) 514-520
117. Matveeva E.A., Whiteheart S.W., Vanaman T.C., and Slevin J.T. Phosphorylation of the N-ethylmaleimide-sensitive factor is associated with depolarization-dependent neurotransmitter release from synaptosomes. J Biol Chem 276 (2001) 12174-12181
118. Mayer R.E., Khew-Goodall Y., Stone S.R., and Hemmings B.A. Expression and organization of protein phosphatase 2A catalytic subunit genes. Adv Second Messenger Phosphoprotein Res 24 (1990) 236-241
119. McAvoy T., Allen P.B., Obaishi H., Nakanishi H., Takai Y., Greengard P., et al. Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. Biochemistry 38 (1999) 12943-12949
120. McCright B., Brothman A.R., and Virshup D.M. Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 → p12. Genomics 36 (1996) 168-170
121. McCright B., Rivers A.M., Audlin S., and Virshup D.M. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem 271 (1996) 22081-22089
122. Meiselbach H., Sticht H., and Enz R. Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem Biol 13 (2006) 49-59
123. Moreno C.S., Park S., Nelson K., Ashby D., Hubalek F., Lane W.S., et al. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J Biol Chem 275 (2000) 5257-5263
124. Mumby M.C., and Walter G. Protein phosphatases and DNA tumor viruses: transformation through the back door?. Cell Regul 2 (1991) 589-598
125. Nagata M., Shijubo N., Walls A.F., Ichimiya S., Abe S., and Sato N. Chymase-positive mast cells in small sized adenocarcinoma of the lung. Virchows Archiv 443 (2003) 565-573
126. Nunbhakdi-Craig V., Machleidt T., Ogris E., Bellotto D., White III C.L., and Sontag E. Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. J Cell Biol 158 (2002) 967-978
127. Ogris E., Du X., Nelson K.C., Mak E.K., Yu X.X., Lane W.S., et al. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J Biol Chem 274 (1999) 14382-14391
128. Ogris E., Gibson D.M., and Pallas D.C. Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen. Oncogene 15 (1997) 911-917
129. Oh C.K. Mast cell mediators in airway remodeling. Chem Immunol Allergy 87 (2005) 85-100
130. Oliver J.M., Seagrave J., Stump R.F., Pfeiffer J.R., and Deanin G.G. Signal transduction and cellular response in RBL-2H3 mast cells. Prog Allergy 42 (1988) 185-245
131. Oliveria S.F., Gomez L.L., and Dell'Acqua M.L. Imaging kinase-AKAP79-phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol 160 (2003) 101-112
132. Pawankar R. Mast cells in allergic airway disease and chronic rhinosinusitis. Chem Immunol Allergy 87 (2005) 111-129
133. Peachell P. Targeting the mast cell in asthma. Curr Opin Pharmacol 5 (2005) 251-256
134. Peachell P.T., and Munday M.R. Regulation of human lung mast cell function by phosphatase inhibitors. J Immunol 151 (1993) 3808-3816
135. Peirce M.J., Warner J.A., Munday M.R., and Peachell P.T. Regulation of human basophil function by phosphatase inhibitors. Br J Pharmacol 119 (1996) 446-453
136. Peirce M.J., Cox S.E., Munday M.R., and Peachell P.T. Preliminary characterization of the role of protein serine/threonine phosphatases in the regulation of human lung mast cell function. Br J Pharmacol 120 (1997) 239-246
137. Perrino B.A., and Martin B.A. Ca(2+)- and myristoylation-dependent association of calcineurin with phosphatidylserine. J Biochem 129 (2001) 835-841
138. Reinton N., Collas P., Haugen T.B., Skalhegg B.S., Hansson V., Jahnsen T., et al. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. Dev Biol 223 (2000) 194-204
139. Ricciarelli R., and Azzi A. Regulation of recombinant PKC alpha activity by protein phosphatase 1 and protein phosphatase 2A. Arch Biochem Biophys 355 (1998) 197-200
140. Roberge M., Tudan C., Hung S.M., Harder K.W., Jirik F.R., and Anderson H. Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A. Cancer Res 54 (1994) 6115-6121
141. Ruediger R., Hentz M., Fait J., Mumby M., and Walter G. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. J Virol 68 (1994) 123-129
142. Schillace R.V., Voltz J.W., Sim A.T., Shenolikar S., and Scott J.D. Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. J Biol Chem 276 (2001) 12128-12134
143. Scott J.D., Dell'Acqua M.L., Fraser I.D., Tavalin S.J., and Lester L.B. Coordination of cAMP signaling events through PKA anchoring. Adv Pharmacol 47 (2000) 175-207
144. Shenolikar S., and Nairn A.C. Protein phosphatases: recent progress. Adv Second Messenger Phosphoprotein Res 23 (1991) 1-121
145. Sim A.T., and Scott J.D. Targeting of PKA, PKC and protein phosphatases to cellular microdomains. Cell Calcium 26 (1999) 209-217
146. Sim A.T., Ratcliffe E., Mumby M.C., Villa-Moruzzi E., and Rostas J.A. Differential activities of protein phosphatase types 1 and 2A in cytosolic and particulate fractions from rat forebrain. J Neurochem 62 (1994) 1552-1559
147. Sim A.T., Baldwin M.L., Rostas J.A., Holst J., and Ludowyke R.I. The role of serine/threonine protein phosphatases in exocytosis. Biochem J 373 (2003) 641-659
148. Sontag E. Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell Signal 13 (2001) 7-16
149. Sontag E., Hladik C., Montgomery L., Luangpirom A., Mudrak I., Ogris E., et al. Down regulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 63 (2004) 1080-1091
150. Spudich A. Myosin reorganization in activated RBL cells correlates temporally with stimulated secretion. Cell Motil Cytoskeleton 29 (1994) 345-353
151. Steen R.L., Martins S.B., Tasken K., and Collas P. Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. J Cell Biol 150 (2000) 1251-1262
152. Stemmer P.M., and Klee C.B. Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B. (erratum appears in Biochemistry 1995 Dec 5;34(48): 15880). Biochemistry 33 (1994) 6859-6866
153. Stemmer P.M., Wang X., Krinks M.H., and Klee C.B. Factors responsible for the Ca(2+)-dependent inactivation of calcineurin in brain. FEBS Lett 374 (1995) 237-240
154. Strack S. Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade. J Biol Chem 277 (2002) 41525-41532
155. Strack S., Zaucha J.A., Ebner F.F., Colbran R.J., and Wadzinski B.E. Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. J Comp Neurol 392 (1998) 515-527
156. Strack S., Kini S., Ebner F.F., Wadzinski B.E., and Colbran R.J. Differential cellular and subcellular localization of protein phosphatase 1 isoforms in brain. J Comp Neurol 413 (1999) 373-384
157. Strack S., Ruediger R., Walter G., Dagda R.K., Barwacz C.A., and Cribbs J.T. Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. J Biol Chem 277 (2002) 20750-20755
158. Swystun V.A., Gordon J.R., Davis E.B., Zhang X., and Cockcroft D.W. Mast cell tryptase release and asthmatic responses to allergen increase with regular use of salbutamol. J Allergy Clin Immunol 106 (2000) 57-64
159. Takanami I., Takeuchi K., and Naruke M. Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma. Cancer 88 (2000) 2686-2692
160. Takei M., Mitsui H., and Endo K. Effect of okadaic acid on histamine release from rat peritoneal mast cells activated by anti-IgE. J Pharm Pharmacol 45 (1993) 750-752
161. Tautz L., Pellecchia M., and Mustelin T. Targeting the PTPome in human disease. Expert Opin Ther Targets 10 (2006) 157-177
162. Tolarova H., Draberova L., Heneberg P., and Draber P. Involvement of filamentous actin in setting the threshold for degranulation in mast cells. Eur J Immunol 34 (2004) 1627-1636
163. Tomita M., Matsuzaki Y., and Onitsuka T. Effect of mast cells on tumor angiogenesis in lung cancer. Ann Thorac Surg 69 (2000) 1686-1690
164. Trinkle-Mulcahy L., Sleeman J.E., and Lamond A.I. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. J Cell Sci 114 (2001) 4219-4228
165. Turowski P., Fernandez A., Favre B., Lamb N.J., and Hemmings B.A. Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression. J Cell Biol 129 (1995) 397-410
166. Ueki K., Muramatsu T., and Kincaid R.L. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). Biochem Biophys Res Commun 187 (1992) 537-543
167. Voorhoeve P.M., Hijmans E.M., and Bernards R. Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein. Oncogene 18 (1999) 515-524
168. Walsh G.M. Novel therapies for asthma-advances and problems. Curr Pharm Des 11 (2005) 3027-3038
169. Wang W.Q., Sun J.P., and Zhang Z.Y. An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem 3 (2003) 739-748
170. Wardlaw A.J., Dunnette S., Gleich G.J., Collins J.V., and Kay A.B. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 137 (1988) 62-69
171. Wei H., Ashby D.G., Moreno C.S., Ogris E., Yeong F.M., Corbett A.H., et al. Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. J Biol Chem 276 (2001) 1570-1577
172. Westphal R.S., Tavalin S.J., Lin J.W., Alto N.M., Fraser I.D., Langeberg L.K., et al. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285 (1999) 93-96
173. Williams C.M., and Galli S.J. The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 105 (2000) 847-859
174. Williams C.M., and Galli S.J. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 192 (2000) 455-462
175. Witczak O., Skalhegg B.S., Keryer G., Bornens M., Tasken K., Jahnsen T., et al. Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J 18 (1999) 1858-1868
176. Xie H., and Clarke S. Methyl esterification of C-terminal leucine residues in cytosolic 36-kDa polypeptides of bovine brain. A novel eucaryotic protein carboxyl methylation reaction. J Biol Chem 268 (1993) 13364-13371
177. Yan Z., Fedorov S.A., Mumby M.C., and Williams R.S. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol Cell Biol 20 (2000) 1021-1029
178. Yang J., Hurley T.D., and DePaoli-Roach A.A. Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif. J Biol Chem 275 (2000) 22635-22644
179. Yang J., Roe S.M., Cliff M.J., Williams M.A., Ladbury J.E., Cohen P.T., et al. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J 24 (2005) 1-10
180. Yu X.X., Du X., Moreno C.S., Green R.E., Ogris E., Feng Q., et al. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol Biol Cell 12 (2001) 185-199
181. Zhang W., and Shi L. Evolution of the PPM-family protein phosphatases in Streptomyces: duplication of catalytic domain and lateral recruitment of additional sensory domains. Microbiology 150 (2004) 4189-4197
182. Zhou J., Pham H.T., Ruediger R., and Walter G. Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution. Biochem J 369 (2003) 387-398
183. Zhu D., Cardenas M.E., and Heitman J. Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. J Biol Chem 270 (1995) 24831-24838
184. Zolnierowicz S. Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. Biochem Pharmacol 60 (2000) 1225-1235
185. Zolnierowicz S., Van Hoof C., Andjelkovic N., Cron P., Stevens I., Merlevede W., et al. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. Biochem J 317 (1996) 187-194