Preliminary characterization of the role of protein serine/threonine phosphatases in the regulation of human lung mast cell function

British Journal of Pharmacology

Volumn 120, Issue 2, 1997, Pages 239-246

  Peirce, Matthew J ^a   Cox, Sarah E ^b   Munday, Michael R ^b   Peachell, Peter T ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Dephosphorylation; Mast cells; Mediator release; Okadaic acid; Phosphatases

Indexed keywords

CASEIN; GLYCOGEN PHOSPHORYLASE; HISTAMINE; IMMUNOGLOBULIN E; LEUKOTRIENE; OKADAIC ACID; OKADOL; OKADONE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PHOSPHORUS 32; PROSTAGLANDIN D2; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; HISTAMINE RELEASE; HUMAN; HUMAN CELL; LUNG; MAST CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

HISTAMINE RELEASE; HUMANS; LUNG; MAST CELLS; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION;

EID: 0031023947     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700915     Document Type: Article

References (37)

1. AGOSTINIS, P., GORIS, J., WAELKENS, E., PINNA, L.A., MARCHIORI, F. & MERLEVEDE, W. (1987). Dephosphorylation of phosphoproteins and synthetic phosphopeptides - study of the specificity of the polycation-stimulated and MgATP-dependent phosphorylase phosphatases. J. Biol. Chem., 262, 1060-1064.
2. ALI, H. & PEARCE, F.L. (1985). Isolation and properties of cardiac and other mast cells from the rat and guinea-pig. Agents Actions, 16, 138-140.
3. BENHAMOU, M. & SIRAGANIAN, R.P. (1992). Protein-tyrosine phosphorylation: an essential component of Fc epsilon RI signalling. Immunol. Today, 13, 195-197.
4. BIALOJAN, C. & TAKAI, A. (1988). Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases - specificity and kinetics. Biochem. J., 256, 283-290.
5. BOTANA, L.M. & MACGLASHAN, D.W. JR. (1993). Effect of okadaic acid on human basophil secretion. Biochem. Pharmacol., 45, 2311-2315.
6. BREWIS, N.D., STREET, A.J., PRESCOTT, A.R. & COHEN, P.T. (1993). PPX, a novel protein serine/threonine phosphatase localised to centrosomes. EMBO J., 12, 987-996.
7. CHEN, M.X., MCPARTLIN, A.E., BROWN, L., CHEN, Y.H., BARKER, H.M. & COHEN, P.T. (1994). A novel human protein serine/ threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localises to the nucleus. EMBO J., 13, 4278-4290.
8. COHEN, P. (1989). The structure and regulation of protein phosphatases. Ann. Rev. Biochem., 58, 453-508.
9. COHEN, P. & COHEN, P.T.W. (1989). Protein phosphatases come of age. J. Biol. Chem., 264, 21435-21438.
10. COHEN, P., HOLMES, C.F. & TSUKITANI, Y. (1990). Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci., 15, 98-102.
11. COHEN, P., KLUMPP, S. & SCHELLING, D.L. (1989). An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues. FEBS Lett., 250, 596-600.
12. DE PAULIS, A., CIRILLO, R., CICCARELLI, A., DE CRESCENZO, G., ORIENTE, A. & MARONE, G. (1991). Characterisation of the antiinflammatory effect of FK-506 on human mast cells. J. Immunol., 147, 4278-4285.
13. ENNIS, M. (1991). Current techniques of histamine determination: automated fluorometric assays. Handbook Exp. Pharmacol., 97, 31-38.
14. ESTEVEZ, M.D., VIEYTES, M.R., LOUZAO, M.C. & BOTANA, L.M. (1994). Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells. Biochem. Pharmacol., 47, 591-593.
15. FRUMAN, D.A., KLEE, C.B., BIERER, B.E. & BURAKOFF, S.J. (1992). Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc. Natl. Acad. Sci. U.S.A., 89, 3686-3690.
16. GILBERT, H.S. & ORNSTEIN, L. (1975). Basophil counting with a new staining method using alcian blue. Blood, 46, 279-282.
17. HAMAWY, M.M., MERGENHAGEN, S.E. & SIRAGANIAN, R.P. (1995). Protein tyrosine phosphorylation as a mechanism of signalling in mast cells and basophils. Cell. Signalling, 7, 535-544.
18. HARDIE, D.G. (1993). Use of protein phosphatase inhibitors in intact cells. In Protein Phosphorylation-a Practical Approach, ed. Hardie D.G. pp. 109-119. Oxford: Oxford University Press.
19. HARDIE, D.G., HAYSTEAD, T.A. & SIM, A.T. (1991). Use of okadaic acid to inhibit protein phosphatases in intact cells. Methods Enzymol., 201, 469-476.
20. HAYSTEAD, T.A.J., SIM, A.T.R., CARLING, D., HONNOR, R.C., TSUKITANI, Y. & COHEN, P. (1989). Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature, 337, 78-81.
21. HONKANEN, R.E., ZWILLER, J., DAILY, S.L., KHATRA, B.S., DUKELOW, M. & BOYNTON, A.L. (1991). Identification, purification, and characterisation of a novel serine/threonine protein phosphatase from bovine brain. J. Biol. Chem., 266, 6614-6619.
22. ISHIZAKA, T., CONRAD, D.H., SCHULMAN, E.S., STERK, A.R. & ISHIZAKA, K. (1983). Biochemical analysis of initial triggering events of IgE-mediated histamine release from human lung mast cells. J. Immunol., 130, 2357-2362.
23. LAVENS, S.E., PEACHELL, P.T. & WARNER, J.A. (1992). Role of tyrosine kinases in IgE-mediated signal transduction in human lung mast cells and basophils. Am. J. Respir. Cell Mol. Biol., 7, 637-644.
24. LIU, J., FARMER, J.D., LANE, W.S., FRIEDMAN, J., WEISSMAN, I. & SCHREIBER, S.L. (1991). Calcineurin is a common target of cyclophilin-cyclosporin-A and FKBP-FK506 complexes. Cell, 66, 807-815.
25. MASSEY, W.A., COHAN, V.L., MACGLASHAN, D.W. JR., GITTLEN, S.W., KAGEY-SOBOTKA, A., LICHTENSTEIN, L.M. & WARNER, J.A. (1991). Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition. J. Pharmacol. Exp. Ther., 258, 824-829.
26. NISHIWAKI, S., FUJIKI, H., SUGANUMA, M., FURUYA-SUGURI, H., MATSUSHIMA, R., IIDA, Y., OJIKA, M., YAMADA, K., UEMURA, D., YASUMOTO, T., SCHMITZ, F.J. & SUGIMURA, T. (1990). Structure-activity relationship within a series of okadaic acid derivatives. Carcinogenesis, 11, 1837-1841.
27. PAOLINI, R., JOUVIN, M.H. & KINET, J-P. (1991). Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement. Nature, 353, 855-858.
28. PEACHELL, P.T. & MUNDAY, M.R. (1993). Regulation of human lung mast cell function by phosphatase inhibitors. J. Immunol., 151, 3808-3816.
29. PEIRCE, M.J., WARNER, J.A., MUNDAY, M.R. & PEACHELL, P.T. (1996). Regulation of human basophil function by phosphatase inhibitors. Br. J. Pharmacol., 119, 446-453.
30. RESINK, T.J., HEMMINGS, B.A., LIM TUNG, H.Y. & COHEN, P. (1983). Characterisation of a reconstituted Mg-ATP-dependent protein phosphatase. Eur. J. Biochem., 133, 455-461.
31. SAKAMOTO, N., SHUNTOH, H. & TANAKA, C. (1994). Protein phosphatase inhibitors induce the release of serotonin from rat basophilic leukemia cells (RBL-2H3). Biochem. Biophys. Acta, 1221, 291-296.
32. SCHULMAN, E.S., MACGLASHAN, D.W., PETERS, S.P., SCHLEIMER, R.P., NEWBALL, H.H. & LICHTENSTEIN, L.M. (1982). Human lung mast cells: purification and characterisation. J. Immunol., 129, 2662-2667.
33. SHENOLIKAR, S. (1994). Protein serine/threonine phosphatases-new avenues for cell regulation. Ann. Rev. Cell Biol., 10, 55-86.
34. SIRAGANIAN, R.P. (1974). An automated continuous-flow system for the extraction and fluorometric analysis of histamine. Anal. Biochem., 57, 383.
35. TAKEI, M., MITSUI, H. & ENDO, K. (1993). Effect of okadaic acid on histamine release from rat peritoneal mast cells activated by anti-IgE. J. Pharm. Pharmacol., 45, 750-752.
36. 2 release from human lung mast cells by cyclosporin-A. Int. Arch. Allergy Appl. Immunol., 88, 253-255.
37. TUNG, H.Y.L., PELECH, S., FISHER, M.J., POGSON, C.I. & COHEN, P. (1985). The protein phosphatases involved in cellular regulation. Influence of polyamines on the activities of protein phosphatase-1 and protein phosphatase-2A. Eur. J. Biochem., 149, 305-313.