The role of serine/threonine protein phosphatases in exocytosis

Biochemical Journal

Volumn 373, Issue 3, 2003, Pages 641-659

  Sim, Alistair T R ^a   Baldwin, Monique L ^a   Rostas, John A P ^a   Holst, Jeff ^b   Ludowyke, Russell I ^b,c  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c Proteome Systems Ltd   (Australia)

Author keywords

cell; Exocytosis; Mast cell; Neuron; Phosphatase; Signal transduction

Indexed keywords

ANTIGENS; CELLS; DISEASES; ENZYMES; INSULIN; PATHOLOGY;

CELLULAR SIGNALING;

BIOCHEMISTRY;

CALCINEURIN; CALMODULIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2C; PHOSPHOPROTEIN PHOSPHATASE 4; PHOSPHOPROTEIN PHOSPHATASE 5; PHOSPHOPROTEIN PHOSPHATASE 6; PHOSPHOPROTEIN PHOSPHATASE 7; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; SERINE; THREONINE; UNCLASSIFIED DRUG;

CELLULAR IMMUNITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; EXOCYTOSIS; INSULIN RELEASE; MAST CELL; METABOLIC REGULATION; NERVE CELL; NEUROTRANSMISSION; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EXOCYTOSIS; PHOSPHOPROTEIN PHOSPHATASE;

EID: 0042068295     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030484     Document Type: Review

References (297)

1. Burgoyne, R D., Fisher, R. J., Graham, M. E, Haynes, L. P. and Morgan, A. (2001) Control of membrane fusion dynamics during regulated exocytosis. Biochem. Soc. Trans. 29, 467-472
2. 2+-triggered exocytosis. Science 298, 781-785
3. Gerber, S. H. and Sudhof, T. C. (2002) Molecular determinants of regulated exocytosis. Diabetes 51 (Suppl. 1), S3-S11
4. Jahn, R. and Sudhof, T. C. (1999) Membrane fusion and exocytosis. Annu. Rev. Biochem. 68, 863-911
5. Gerst, J. E. (1999) SNAREs and SNARE regulators in membrane fusion and exocytosis. Cell. Mol. Life Sci. 55, 707-734
6. Klenchin, V. A. and Martin, T. F. (2000) Priming in exocytosis: attaining fusion-competence after vesicle docking. Biochimie 82, 399-407
7. Dulubova, I., Yamaguchi, T., Arac, D., Li, H., Huryeva, I., Min, S. W., Rizo, J. and Sudhof, T. C. (2003) Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proc. Natl. Acad. Sci. U.S.A. 100, 32-37
8. de Vries, K. J., Geijtenbeek, A., Brian, E. C., De Graan, P. N., Ghijsen, W. E. and Verhage, M. (2000) Dynamics of munc18-1 phosphorylation/dephosphorylation in rat brain nerve terminals. Eur. J. Neurosci. 12, 385-390
9. Chheda, M. G., Ashery, U., Thakur, P., Rettig, J. and Sheng, Z. H. (2001) Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nat. Cell Biol. 3, 331-338
10. Fitzgerald, M. L. and Reed, G. L. (1999) Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. Biochem. J 342, 353-360
11. Fletcher, A. I., Shuang, R., Giovannucci, D. R., Zhang, L., Bittner, M. A and Stuenkel, E. L. (1999) Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. J. Biol. Chem. 274, 4027-4035
12. Matveeva, E. A., Whiteheart, S. W., Vanaman, T. C. and Slevin, J. T. (2001) Phosphorylation of the N-ethylmaleimide-sensitive factor is associated with depolarization-dependent neurotransmitter release from synaptosomes. J. Biol. Chem. 276, 12174-12181
13. Ostenson, C. G., Sandberg-Nordqvist, A. C., Chen, J., Hallbrink, M., Rotin, D., Langel, U. and Efendic, S. (2002) Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochem. Biophys. Res. Commun. 291, 945-950
14. Roberts, C., Roberts, G. A., Lobner, K., Bearzatto, M., Clark, A., Bonifacio, E. and Christie, M. R. (2001) Expression of the protein tyrosine phosphatase-like protein IA-2 during pancreatic islet development. J Histochem. Cytochem. 49, 767-776
15. Hermel, J. M., Dirkx, Jr, R. and Solimena, M. (1999) Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules. Eur. J. Neurosci. 11, 2609-2620
16. 2+ channels involves tyrosine phosphorylation. Eur. J. Neurosci. 11, 279-292
17. Cohen, P. T. (2002) Protein phosphatase 1-targeted in many directions. J. Cell Sci. 115, 241-256
18. Heinrich, R., Neel, B. G. and Rapoport, T. A. (2002) Mathematical models of protein kinase signal transduction. Mol. Cell 9, 957-970
19. Bollen, M. and Beullens, M. (2002) Signaling by protein phosphatases in the nucleus. Trends Cell Biol. 12, 138-145
20. Cohen, P. T. (1997) Novel protein serine/threonine phosphatases: variety is the spice of life. Trends Biochem. Sci. 22, 245-251
21. Janssens, V. and Goris, J. (2001) Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-439
22. Mumby, M. (2001) A new role for protein methylation: switching partners at the phosphatase ball. Sci STKE. 2001 April 24, 2001 (79) PE1
23. Aramburu, J., Rao, A. and Klee, C. B. (2000) Calcineurin: from structure to function. Curr. Top. Cell Regul. 36, 237-295
24. 2+, calcineurin and the control of transcription. J Biol. Chem. 276, 2313-2316
25. Klee, C. B., Ren, H. and Wang, X. (1998) Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J. Biol. Chem. 273, 13367-13370
26. Shibasaki, F., Hallin, L., and Uchino, H. (2002) Calcineurin as a multifunctional regulator. J. Biochem. Tokyo 131, 1-15
27. Barford, D. (1996) Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem. Sci. 21, 407-412
28. Bollen, M. (2001) Combinatorial control of protein phosphatase-1. Trends Biochem. Sci. 26, 426-431
29. Sontag, E. (2001) Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell. Signalling 13, 7-16
30. Cohen, P. (1989) The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58, 453-508
31. Strack, S., Kini, S., Ebner, F. F., Wadzinski, B. E. and Colbran, R. J (1999) Differential cellular and subcellular localization of protein phosphatase 1 isoforms in brain. J. Comp. Neurol. 413, 373-384
32. da Cruz e Silva, E. F., Fox, C. A., Ouimet, C. C., Gustafson, E., Watson, S. J. and Greengard, P. (1995) Differential expression of protein phosphatase 1 isoforms in mammalian brain. J. Neurosci. 15, 3375-3389
33. Andreassen, P. R., Lacroix, F. B., Villa-Moruzzi, E. and Margolis, R. L. (1998) Differential subcellular localization of protein phosphatase-1α, γ1 and δ isoforms during both interphase and mitosis in mammalian cells. J. Cell Biol. 141, 1207-1215
34. Trinkle-Mulcahy, L., Sleeman, J. E. and Lamond, A. I. (2001) Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. J. Cell Sci. 114, 4219-4228
35. Hubbard, M. J. and Cohen, P. (1993) On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem. Sci. 18, 172-177
36. Ceulemans, H., Stalmans, W. and Bollen, M. (2002) Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. Bioessays 24, 371-381
37. Egloff, M. P., Johnson, D. F., Moorhead, G., Cohen, P. T., Cohen, P. and Barford, D. (1997) Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J. 16, 1876-1887
38. Westphal, R. S., Tavalin, S. J., Lin, J. W., Alto, N. M., Fraser, L. D., Langeberg, L. K., Sheng, M. and Scott, J. D. (1999) Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285, 93-96
39. Yan, Z., Hsieh-Wilson, L., Feng, J., Tomizawa, K., Allen, P. B., Fienberg, A. A., Nairn, A. C. and Greengard, P. (1999) Protein phosphatase 1 modulation of neostriatal AMPA channels: recutation by DARPP-32 and spinophilin. Nature Neurosci. 2, 13-17
40. Gorina, S. and Pavletich, N. P. (1996) Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science 274, 1001-1005
41. Schillace, R. V., Vollz, J. W., Sim, A. T., Shenolikar, S. and Scott, J. D. (2001) Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. J. Biol. Chem. 276, 12128-12134
42. Brush, M. H., Weiser, D. C. and Shenolikar, S. (2003) Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1α to the endoplasmic reticulum and promotes dephosphorylation of the α subunit of eukaryotic translation initiation factor 2. Mol. Cell. Biol. 23, 1292-1303
43. Yang, J., Hurley, T. D. and DePaoli-Roach, A. A. (2000) Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the censensus type 1 protein phosphatase-binding motif. J. Biol. Chem. 275, 22635-22644
44. Alto, N., Carlisle Michel, J. J., Dodge, K. L., Langeberg, L. K. and Scott, J. D. (2002) Intra-cellular targeting of protein kinases and phosphatases. Diabetes 51 (Suppl. 3), S385-S388
45. Sim, A. T. and Scott, J. D. (1999) Targeting of PKA, PKc and protein phosphatases to cellular microdomains. Cell Calcium 26, 209-217
46. Steen, R. L., Martins, S. B., Tasken, K. and Collas, P. (2000) Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. J. Cell Biol. 150, 1251-1262
47. Trendelenburg, G., Hummel, M., Riecken, E. O. and Hanski, C. (1996) Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. Biochem. Biophys. Res Commun. 225, 313-319
48. Reinton, N., Collas, P., Haugen, T. B., Skalhegg, B. S., Hansson, V., Jahnsen, T. and Tasken, K. (2000) Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. Dev. Biol. 223, 194-204
49. Witczak, O., Skalhegg, B. S., Keryer, G., Bornens, M., Tasken, K., Jahnsen, T. and Orstavik, S. (1999) Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J. 18, 1858-1868
50. Lin, J. W., Wyszynski1, M., Madhavan, R., Sealock, R., Kim, J. U. and Sheng, M. (1998) Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J Neurosci. 18, 2017-2027
51. Mvumbi, L. and Stalmans, W. (1987) High-affinity binding of glycogen-synthase phosphatase to glycogen particles in the liver. Role of glycogen in the inhibition of synthase phosphatase by phosphorylase a. Biochem. J. 246, 367-374
52. Stälmans, W., Bollen, M. and Mvumbi, L. (1987) Control of glycogen synthesis in health and disease. Diabetes Metab. Rev. 3, 127-161
53. McAvoy, T., Allen, P. B., Obaishi, H., Nakanishi, H., Takai, Y., Greengard, P., Nairn, A. C. and Hemmings, H. C., Jr. (1999) Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. Biochemistry 36, 12943-12949
54. Greengard, P. and Browning, M. D. (1988) Studies of the physiological role of specific neuronal phosphoproteins. Adv. Second Messenger Phosphoprotein Res. 21, 133-146
55. Greengard, P., Allen, P. B. and Nairn, A. C. (1999) Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23, 435-447
56. Greengard, P., Nairn, A. C., Girault, J. A., Ouimet, C. C., Snyder, G. L., Fisone, G., Allen, P. B., Fienberg, A. and Nishi, A. (1998) The DARPP-32/protein phosphatase-1 cascade: a model for signal integration. Brain Res. Rev. 26, 274-284
57. Shenolikar, S. and Nairn, A. C. (1991) Protein phosphatases: recent progress. Adv. Second Messenger Phosphoprotein Res. 23, 1-121
58. Fienberg, A. A. and Greengard, P. (2000) The DARPP-32 knockout mouse. Brain Res. Rev. 31, 313-319
59. Allen, P. B., Hvalby, O., Jensen, V., Errington, M. L., Ramsay, M., Chaudhry, F. A., Bliss, T. V., Storm-Mathisen, J., Morris, R. G., Andersen, P. and Greengard, P. (2000) Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms. J. Neurosci. 20, 3537-3543
60. Brady, M. J. and Saltiel, A. R. (2001) The role of protein phosphatase-1 in insulin action. Recent Prog. Horm. Res. 56, 157-173
61. Browne, G. J., Delibegovic, M., Keppens, S., Stalmans, W. and Cohen, P. T. (2001) The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Biochem. J. 360, 449-459
62. Mayer, R. E., Khew-Goodall, Y., Stone, S. R. and Hemmings, B. A. (1990) Expression and organization of protein phosphatase 2A catalytic subunit genes. Adv. Second Messenger Phosphoprotein Res. 24, 236-241
63. Khew-Goodall, Y., Mayer, R. E., Maurer, F., Stone, S. R. and Hemmings, B. A. (1991) Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. Biochemistry 30, 89-97
64. Erratum (1991) Biochemistry 30, 5328
65. Gotz, J., Probst, A., Ehler, E., Hemmings, B. and Kues, W. (1998) Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα. Proc. Natl. Acad. Sci. U.S.A. 95, 12370-12375
66. Sim, A. T., Ratcliffe, E., Mumby, M. C., Villa-Moruzzi, E. and Rostas, J. A. (1994) Differential activities of protein phosphatase types 1 and 2A in cytosolic and particulate fractions from rat forebrain. J. Neurochem. 62, 1552-1559
67. Holst, J., Sim, A. T. and Ludowyke, R. I. (2002) Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells. Mol. Biol. Cell 13, 1083-1098
68. Ludowyke, R. I., Holst, J., Mudge, L. M. and Sim, A. T. (2000) Transient translocation and activation of protein phosphatase 2A during mast cell secretion. J. Biol. Chem. 275, 6144-6152
69. Nunbhakdi-Craig, V., Machleidt, T., Ogris, E., Bellotto, D., White, III, C. L. and Sontag, E. (2002) Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex J. Cell Biol. 158, 967-978
70. Brown, B. M., Carlson, B. L., Zhu, X., Lolley, R. N. and Craft, C. M. (2002) Light-driven translocation of the protein phosphatase 2A complex regulates light/dark dephosphorylation of phosducin and rhodopsin. Biochemistry 41, 13526-13538
71. Hemmings, B. A., Adams-Pearson, C., Maurer, F., Muller, P., Goris, J., Merlevede, W., Holsteenge, J. and Stone, S. R. (1990) α- and β-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry 29, 3166-3173
72. Zhou, J., Pham, H. T., Ruediger, R. and Walter, G. (2003) Characterization of the Aα and Aβ subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction and evolution. Biochem. J 369, 387-398
73. Ruediger, R., Hentz, M., Fait, J., Mumby, M. and Walter, G. (1994) Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. J. Virol. 68, 123-129
74. Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A. and Barford, D. (1999) The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 96, 99-110
75. Li, X. and Virshup, D. M. (2002) Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur. J. Biochem. 269, 546-552
76. Strack, S., Zaucha, J. A., Ebner, F. F., Colbran, R. J. and Wadzinski, B. E. (1998) Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. J. Comp. Neurol. 392, 515-527
77. Strack, S., Ruediger, R., Walter, G., Dagda, R. K., Barwacz, C. A. and Cribbs, J. T. (2002) Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. J. Biol. Chem. 277, 20750-20755
78. Zolnierowicz, S., Van Hoof, C., Andjelkovic, N., Cron, P., Stevens, I., Merlevede, W., Goris, J. and Hemmings, B. A. (1996) The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. Biochem. J. 317, 187-194
79. Virshup, D. M. (2000) Protein phosphatase 2A: a panoply of enzymes. Curr. Opin. Cell Biol. 12, 180-185
80. Zolnierowicz, S. (2000) Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. Biochem. Pharmacol. 60, 1225-1235
81. McCrght, B., Rivers, A. M, Audlin, S. and Virshup, D. M. (1996) The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J. Biol. Chem. 271, 22081-22089
82. Hendrix, P., Mayer-Jackel, R. E., Cron, P., Goris, J., Hofsteenge, J., Merlevede, W. and Hemmings, B. A. (1993) Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. J. Biol. Chem. 268, 15267-15276
83. Voorhoeve, P. M., Hijmans, E. M. and Bernards, R. (1999) Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59 and the retinoblastoma-related p107 protein. Oncogene 18, 515-524
84. Yan, Z., Fedorov, S. A, Mumby, M. C. and Williams, R. S. (2000) PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol. Cell. Biol. 20, 1021-1029
85. Moreno, C. S., Park, S., Nelson, K., Ashby, D., Hubalek, F., Lane, W. S. and Pallas, D. C. (2000) WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J. Biol. Chem. 275, 5257-5263
86. Mumby, M. C. and Walter, G. (1991) Protein phosphatases and DNA tumor viruses: transformation through the back door? Cell Regul. 2, 589-598
87. Chen, J., Martin, B. L. and Brautigan, D. L. (1992) Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257, 1261-1264
88. Lee, J. and Stock, J. (1993) Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase J. Biol. Chem. 268, 19192-19195
89. Xie, H. and Clarke, S. (1994) An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A. Biochem. Biophys. Res. Commun. 203, 1710-1715
90. Xie, H. and Clarke, S. (1994) Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain. J. Biol. Chem. 269, 1981-1984
91. Xie, H. and Clarke, S. (1993) Methyl esterification of C-terminal leucine residues in cytosolic 36-kDa polypeptides of bovine brain. A novel eucaryotic protein carboxyl methylation reaction. J. Biol. Chem. 268, 13364-13371
92. Ogris, E., Gibson, D. M. and Pallas, D. C. (1997) Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen. Oncogene 15, 911-917
93. Guy, G. R., Philp, R. and Tan, Y. H. (1995) Activation of protein kinases and the inactivation of protein phosphatase 2A in tumour necrosis factor and interleukin-1 signal-transduction pathways. Eur. J. Biochem. 229, 503-511
94. Ogris, E., Du, X., Nelson, K. C., Mak, E. K., Yu, X. X., Lane, W. S. and Pallas, D. C. (1999) A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J. Biol. Chem. 274, 14382-14391
95. Wei, H., Ashby, D. G., Moreno, C. S., Ogris, E., Yeong, F. M., Corbett, A. H. and Pallas, D. C. (2001) Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. J. Biol. Chem. 276, 1570-1577
96. Yu, X. X., Du, X., Moreno, C. S., Green, R. E., Ogris, E., Feng, Q., Chou, L., McQuoid, M. J. and Pallas, D. C. (2001) Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Bα regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol. Biol. Cell 12, 185-199
97. Guo, H., Reddy, S. A. and Damuni, Z. (1993) Purification and characterization of an autophosphorylation-activated protein serine threonine kinase that phosphorylates and inactivates protein phosphatase 2A. J. Biol. Chem. 268, 11193-11198
98. Guo, H. and Damuni, Z. (1993) Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A. Proc. Natl. Acad. Sci. U.S.A. 90, 2500-2504
99. Begum, N. and Ragolia, L. (1996) cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells. J. Biol. Chem. 271, 31166-31171
100. Turowski, P., Fernandez, A., Favre, B., Lamb, N. J. and Hemmings, B. A. (1995) Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression. J. Cell Biol. 129, 397-410
101. Jessus, C., Goris, J., Cayla, X., Hermann, J., Hendrix, P., Ozon, R. and Merlevede, W. (1989) Tubulin and MAP2 regulate the PCSL phosphatase activity. A possible new role for microtubular proteins. Eur. J. Biochem. 180, 15-22
102. Cayla, X., Goris, J., Hermann, J., Jessus, C., Hendrix, P. and Merlevede, W. (1990) Phosphotyrosyl phosphatase activity of the polycation-stimulated protein phosphatases and involvement of dephosphorylation in cell cycle regulation. Adv. Enzyme Regul. 30, 265-285
103. Cayla, X., Goris, J., Hermann, J., Hendrix, P., Ozon, R. and Merlevede, W. (1990) Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes. Biochemistry 29, 658-667
104. Floer, M. and Stock, J. (1994) Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid. Biochem. Biophys. Res. Commun 198, 372-379
105. Dobrowsky, R. T. and Hannun, Y. A. (1993) Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv. Lipid Res. 25, 91-104
106. Dobrowsky, R. T., Kamibayashi, C., Mumby, M. C. and Hannun, Y. A. (1993) Ceramide activates heterotrimeric protein phosphatase 2A. J. Biol. Chem. 268, 15523-15530
107. Chalfant, C. E., Kishikawa, K., Mumby, M. C., Kamibayashi, C., Bielawska, A. and Hannun, Y. A. (1999) Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J. Biol. Chem. 274, 20313-20317
108. Kuno, T., Mukai, H., Ito, A., Chang, C. D., Kishima, K., Saito, N. and Tanaka, C. (1992) Distinct cellular expression of calcineurin Aα and Aβ in rat brain. J. Neurochem. 58, 1643-1651
109. Hubbard, M. J. and Klee, C. B. (1989) Characterization of a high-affinity monoclonal antibody to calcineurin whose epitope defines a new structural domain of calcineurin A. Eur. J. Biochem 185, 411-418
110. Hubbard, M. J. and Klee, C. B. (1989) Functional domain structure of calcineurin A: mapping by limited proteolysis. Biochemistry 28, 1868-1874
111. Hashimoto, Y., Perrino, B. A. and Soderling, T. R. (1990) Identification of an autoinhibitory domain in calcineurin. J. Biol. Chem. 265, 1924-1927
112. Ueki, K., Muramatsu, T. and Kincaid, R. L. (1992) Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). Biochem. Biophys. Res. Commun. 187, 537-543
113. 2+-dependent inactivation of calcineurin in brain. FEES Lett. 374, 237-240
114. 2+ ion regulation of calcineurin by calmodulin and calcineurin B. Biochemistry 33, 6859-6866
115. Erratum (1995) Biochemistry 34, 15880
116. Martin, B. A., Oxhorn, B. C., Rossow, C. R. and Perrino, B. A. (2001) A cluster of basic amino acid residues in calcineurin b participates in the binding of calcineurin to phosphatidylserine vesicles. J. Biochem. (Tokyo) 129, 843-849
117. 2+- and myristoylation-dependent association of calcineurin with phosphatidylserine. J. Biochem. (Tokyo) 129, 835-841
118. Zhu, D., Cardenas, M. E. and Heitman, J. (1995) Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 270, 24831-24838
119. Scott, J. D., Dell'Acqua, M. L., Fraser, I. D., Tavalin, S. J. and Lester, L. B. (2000) Coordination of cAMP signaling events through PKA anchoring. Adv. Pharmacol. 47, 175-207
120. Oliveria, S. F., Gomez, L. L. and Dell'Acqua, M. L. (2003) Imaging kinase-AKAP79-phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J. Cell Biol. 160, 101-112
121. Dell'Acqua, M. L., Dodge, K. L., Tavalin, S. J. and Scott, J. D. (2002) Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J. Biol. Chem. 277, 48796-48802
122. 2+ release channel (ryanodine receptor). J. Biol. Chem. 267, 9474-9477
123. 2+ flux. Cell 83, 463-472
124. 2+ flux. Proc. Natl. Acad. Sci. U.S.A. 92, 1784-1788
125. 2+-triggered cell death. Proc. Natl. Acad. Sci. U.S.A. 99, 9870-9875
126. Lai, M. M., Luo, H. F., Burnett, P. E., Hong, J. J. and Snyder, S. H. (2000) The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. J. Biol. Chem. 275, 34017-34020
127. Kingsbury, T. J. and Cunningham, K. W. (2000) A conserved family of calcineurin regulators. Genes Dev. 14, 1595-1604
128. Fuentes, J. J., Genesca, L., Kingsbury, T. J., Cunningham, K. W., Perez-Riba, M., Estivill, X. and de la Luna, S. (2000) DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet. 9, 1681-1690
129. Miskin, J. E., Abrams, C. C., Goatley, L. C. and Dixon, L. K. (1998) A viral mechanism for inhibition of the cellular phosphatase calcineurin. Science 281, 562-565
130. Sumiyoshi, E., Sugimoto, A. and Yamamoto, M. (2002) Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. J. Cell Sci. 115, 1403-1410
131. Zhou, G., Mihindukulasuriya, K. A., MacCorkle-Chosnek, R. A., Van Hooser, A., Hu, M. C., Brinkley, B. R. and Tan, T. H. (2002) Protein phosphatase 4 is involved in tumor necrosis factor-α-induced activation of c-Jun N-terminal kinase. J. Biol. Chem. 277, 6391-6398
132. Reference deleted
133. Wada, T., Miyata, T., Inagi, R., Nangaku, M., Wagatsuma, M., Suzuki, D., Wadzinski, B. E., Okubo, K. and Kurokawa, K. (2001) Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. J. Am. Soc. Nephrol. 12, 2601-2608
134. Chen, J., Peterson, R. T. and Schreiber, S. L. (1998) Alpha 4 associates with protein phosphatases 2A, 4 and 6. Biochem. Biophys. Res. Commun. 247, 827-832
135. Chinkers, M. (2001) Protein phosphatase 5 in signal transduction. Trends Endocrinol. Metab. 12, 28-32
136. Chen, M. X., McPartlin, A. E., Brown, L., Chen, Y. H., Barker, H. M. and Cohen, P. T. (1994) A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J. 13, 4278-4290
137. Ollendorff, V. and Donoghue, D. J. (1997) The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-prornoting complex J. Biol. Chem. 272, 32011-32018
138. Russell, L. C., Whitt, S. R., Chen, M. S. and Chinkers, M. (1999) Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90. J. Biol. Chem. 274, 20060-20063
139. Chen, M. S., Silverstein, A. M., Pratt, W. B. and Chinkers, M. (1996) The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. J. Biol. Chem. 271, 32315-32320
140. Silverstein, A. M., Galigniana, M. D., Chen, M. S., Owens-Grillo, J. K., Chinkers, M. and Pratt, W. B. (1997) Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. J. Biol. Chem. 272, 16224-16230
141. Chinkers, M. (1994) Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Proc. Natl. Acad. Sci. U.S.A. 91, 11075-11079
142. Ollendorff, V. and Donoghue, D. J. (1997) The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. J. Biol. Chem. 272, 32011-32018
143. Chen, M. X. and Cohen, P. T. (1997) Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain. FEBS Lett. 400, 136-140
144. Urban, G., Golden, T., Aragon, I. V., Scammell, J. G., Dean, N. M. and Honkanen, R. E. (2001) Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively. J. Biol Chem. 276, 27638-27646
145. Zhao, S. and Sancar, A. (1997) Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. Photochem. Photobiol. 66, 727-731
146. Eide, E. J., Vielhaber, E. L., Hinz, W. A. and Virshup, D. M. (2002) The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase lepsilon. J. Biol. Chem. 277, 17248-17254
147. Mann, D. J., Dombradi, V. and Cohen, P. T. (1993) Drosophila protein phosphatase V functionally complements a SIT4 mutant in Saccharomyces cerevisiae and its amino-terminal region can confer this complementation to a heterologoos phosphatase catalytic domain. EMBO J. 12, 4833-4842
148. Huang, X. and Honkanen, R. E. (1998) Molecular cloning, expression and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC). J. Biol. Chem. 273, 1462-1468
149. Reference deleted
150. Mann, D. J., Campbell, D. G., McGowan, C. H. and Cohen, P. T. (1992) Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Biochim. Biophys. Acta 1130, 100-104
151. Tong, Y., Quirion, R. and Shen, S. H. (1998) Cloning and characterization of a novel mammalian PP2C isozyme. J. Biol. Chem. 273, 35282-35290
152. Takekawa, M., Maeda, T. and Saito, H. (1998) Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK MAPK pathways. EMBO J. 17, 4744-4752
153. Wenk, J., Trompeter, H. I., Pettrich, K. G., Cohen, P. T., Campbell, D. G. and Mieskes, G. (1992) Molecular cloning and primary structure of a protein phosphatase 2C isoform. FEBS Lett. 297, 135-138
154. Travis, S. M., Berger, H. A. and Welsh, M. J. (1997) Protein phosphatase 2C dephosphorylates and inactivates cystic fibrosis transmembrane conductance regulator. Proc. Natl. Acad. Sci. U.S.A. 94, 11055-11060
155. Travis, S. M. and Welsh, M. J. (1997) PP2Cγ: a human protein phosphatase with a unique acidic domain. FEBS Lett. 412, 415-419
156. Fiscella, M., Zhang, H., Fan, S., Sakaguchi, K., Shen, S., Mercer, W. E., Vande Woude, G. F., O'Connor, P. M. and Appella, E. (1997) Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 94, 6048-6053
157. 2+/calmodulin-dependent protein kinase phosphatase. J. Biochem. (Tokyo) 125, 1022-1028
158. Tamura, S., Kobayashi, T., Ohnishi, M., Chida, N. and Hanada, M. (1998) Structure and function of mammalian protein phosphatase 20 [translation]. Tanpakushitsu Kakusan Koso 43, 959-967 (article in Japanese)
159. Hanada, M., Ninomiya-Tsuji, J., Komaki, K., Ohnishi, M., Katsura, K., Kanamaru, R., Matsumoto, K. and Tamura, S. (2001) Regulation of the TAK1 signaling pathway by protein phosphatase 2C. J. Biol. Chem. 276, 5753-5759
160. Leung-Hagesteijn, C., Mahendra, A., Naruszewicz, I. and Hannigan, G. E. (2001) Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-iinked kinase, ILK1. EMBO J. 20, 2160-2170
161. Koh, C. G., Tan, E. J., Manser, E. and Lim, L. (2002) The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr. Biol. 12, 317-321
162. Hanada, M., Kobayashi, T., Ohnishi, M., Ikeda, S., Wang, H., Katsura, K., Yanagawa, Y., Hiraga, A., Kanamaru, R. and Tamura, S. (1998) Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells. FEBS Lett. 437, 172-176
163. Bevilaqua, L. R. M., Cammarota, M., Dickson, P. W., Sim, A. T. R. and Dunkley, P. R. (2003) Role of PP2C from bovine adrenal chromaffin cells in the dephosphorylation of phosphoserine 40 tyrosine hydroxylase. J. Neurochem. 85, 1368-1375
164. 2+: stimulation by unsaturated fatty acids. FEBS Lett. 437, 229-232
165. Honkanen, R. E. and Golden, T. (2002) Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Curr. Med. Chem. 9, 2055-2075
166. McCluskey, A., Sim, A. T. and Sakoff, J. A. (2002) Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J. Med. Chem. 45, 1151-1175
167. Hardie, D. G., Haystead, T. A. and Sim, A. T. (1991) Use of okadaic acid to inhibit protein phosphatases in intact cells. Methods Enzymol. 201, 469-476
168. Haystead, T. A., Sim, A. T., Carling, D., Honnor, R. C., Tsukitani, Y., Cohen, P. and Hardie, D. G. (1989) Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature (London) 337, 78-81
169. Cohen, P., Holmes, C. F. and Tsukitani, Y. (1990) Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci. 15, 98-102
170. Carmichael, W. W., Beasley, V., Bunner, D. L., Eloff, J. N., Falconer, I., Gorham, P., Harada, K., Krishnamurthy, T., Yu, M. J. and Moore, R. E. (1988) Naming of cyclic heptapeptide toxins of cyanobacteria (blue-green algae). Toxicon 26, 971-973
171. MacKintosh, C., Beattie, K. A., Klumpp, S., Cohen, P. and Codd, G. A. (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264, 187-192
172. Sheppeck, J. E., Gauss, C. M. and Chamberlin, A. R. (1997) Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins. Bioorg. Med. Chem. 5, 1739-1750
173. MacKintosh, C. and Klumpp, S. (1990) Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS Lett. 277, 137-140
174. MacKintosh, C., Beattie, K. A., Klumpp, S., Cohen, P. and Codd, G. A. (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264, 187-192
175. Boger, D. L., Ichikawa, S. and Zhong, W. (2001) Total synthesis of fostriecin (CI-920). J. Am. Chem. Soc. 123, 4161-4167
176. Weinbrenner, C., Baines, C. P., Liu, G. S., Armstrong, S. C., Ganote, C. E., Walsh, A. H., Honkanen, R. E, Cohen, M. V. and Downey, J. M. (1998) Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia. Circulation 98, 899-905
177. Cheng, A., Balczon, R., Zuo, Z., Koons, J S., Walsh, A. H. and Honkanen, R. E. (1998) Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles and the inhibition of serine/threonine protein phosphatase activity. Cancer Res. 58, 3611-3619
178. de Jong, R. S., Mulder, N. H, Uges, D. R., Sleijfer, D. T., Hoppener, F. J., Groen, H. J., Willemse, P. H., van der Graaf, W. T. and de Vries, E. G. (1999) Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Br. J. Cancer 79, 882-887
179. Morimoto, C., Kiyama, A., Kameda, K., Ninomiya, H., Tsujita, T. and Okuda, H. (2000) Mechanism of the stimulatory action of okadaic acid on lipolysis in rat fat cells. J. Lipid Res. 41, 199-204
180. Sumiyoshi, E., Sugimoto, A. and Yamamoto, M. (2002) Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. J. Cell Sci. 115, 1403-1410
181. Muda, M., Worby, C. A., Simonson-Leff, N., Clemens, J. C. and Dixon, J. E. (2002) Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem. J. 366, 73-77
182. Li, X., Scuderi, A., Letsou, A. and Virshup, D. M. (2002) B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol. Cell. Biol. 22, 3674-3684
183. PP2A, associate with and modify the substrate specificity of protein phosphatase 1. J. Biol. Chem. 275, 9209-9214
184. PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. Biochemistry, 35, 6998-7002
185. Li, M., Makkinje, A. and Damuni, Z. (1996) The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J. Biol. Chem. 271, 11059-11062
186. Liu, J., Albers, M. W., Wandless, T. J., Luan, S., Alberg, D. G., Belshaw, P. J., Cohen, P., MacKintosh, C., Klee, C. B. and Schreiber, S. L. (1992) Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry 31, 3896-3901
187. 2+-induced permeability transition in brain mitochondria. Brain Res. 960, 99-111
188. Burgess, T. L. and Kelly, R. B. (1987) Constitutive and regulated secretion of proteins. Annu. Rev. Cell Biol. 3, 243-293
189. 2+ Biophys. J. 67, 2546-2557
190. 2+ dependence of the rate of exocytosis in a synaptic terminal. Nature (London) 371, 513-515
191. Artalejo, C. R., Elhamdani, A. and Palfrey, H. C. (1998) Secretion: dense-core vesicles can kiss-and-run too. Curr. Biol. 8, R62-R65
192. Cousin, M. A. and Robinson, P. J. (2000) Two mechanisms of synaptic vesicle recycling in rat brain nerve terminals. J. Neurochem. 75, 1645-1653
193. Schneider, S. W. (2001) Kiss and run mechanism in exocytosis. J. Membr. Biol. 181, 67-76
194. Storrie, B. and Desjardins, M. (1996) The biogenesis of lysosomes: is it a kiss and run, continuous fusion and fission process? Bioessays 18, 895-903
195. Valtorta, F., Meldolesi, J. and Fesce, R. (2001) Synaptic vesicles: is kissing a matter of competence? Trends Cell Biol. 11, 324-328
196. 2+ concentrations shift the mode of exocytosis to the kiss-and-run mechanism. Nat. Cell Biol. 1, 40-44
197. Stevens, C. F. and Williams, J. H. (2000) "Kiss and run" exocytosis at hippocampal synapses. Proc. Natl. Acad. Sci. U.S.A. 97, 12828-12833
198. Tsuboi, T., Zhao, C., Terakawa, S. and Rutter, G. A. (2000) Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event. Curr. Biol. 10, 1307-1310
199. Taraska, J. W., Perrais, D., Ohara-Imaizumi, M., Nagamatsu, S. and Almers, W. (2003) Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells. Proc. Natl. Acad. Sci. U.S.A. 100, 2070-2075
200. Tsuboi, T. and Rutter, G. A. (2003) Multiple forms of 'kiss-and-run' exocytosis revealed by evanescent wave microscopy. Curr. Biol. 13, 563-567
201. Fesce, R. (1999) The kinetics of nerve-evoked quantal secretion. Philos. Trans. R. Soc. London B: Biol. Sci. 354, 319-329
202. Fesce, R. and Meldolesi, J. (1999) Peeping at the vesicle kiss. Nat. Cell Biol. 1, E3-E4
203. Liu, J. P., Sim, A. T. and Robinson, P. J. (1994) Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization. Science 265, 970-973
204. Beaven, M. A. and Baumgartner, R. A. (1996) Downstream signals initiated in mast cells by Fcε RI and other receptors. Curr. Opin. Immunol. 8, 766-772
205. Reference deleted
206. Schulman, E. S. (1993) The role of mast cells in inflammatory responses in the lung. Crit. Rev. Immunol. 13, 35-70
207. Lang, T., Wacker, I., Wunderlich, I., Rohrbach, A., Giese, G., Soldati, T. and Almers, W. (2000) Role of actin cortex in the subplasmalemmal transport of secretory granules in PC-12 cells. Biophys. J. 78, 2863-2877
208. Bastan, R., Peirce, M. J. and Peachell, P. T. (2001) Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung. Eur. J. Pharmacol. 430, 135-141
209. Peirce, M. J., COX, S. E., Munday, M. R. and Peachell, P. T. (1997) Preliminary characterization of the role of protein serine/threonine phosphatases in the regulation of human lung mast cell function. Br. J. Pharmacol. 120, 239-246
210. Kitani, S., Teshima, R., Nonomura, Y., Morita, Y. and Ito, K. (1996) The effect of okadaic acid on histamine release, cell morphology and phosphorylation in rat basophilic leukemia (RBL-2H3) cells, human basophils and rat peritoneal mast cells. Int. Arch. Allergy Immunol 110, 339-347
211. Estevez, M. D., Vieytes, M. R., Louzao, M. C. and Botana, L. M. (1994) Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells. Biochem. Pharmacol. 47, 591-593
212. Taker, M., Mitsui, H. and Endo, K. (1993) Effect of okadaic acid on histamine release from rat peritoneal mast cells activated by anti-IgE. J Pharm. Pharmacol. 45, 750-752
213. Peachell, P. T. and Munday, M. R. (1993) Regulation of human lung mast cell function by phosphatase inhibitors. J. Immunol. 151, 3808-3816
214. 2+ ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors. Cell Biol. Int. 22, 855-865
215. 2+ ionophore. J. Immunol. 143, 2617-2625
216. 2+ ionophore-induced secretion from mast cells correlates with myosin light chain phosphorylation by protein kinase C. J. Immunol. 157, 5130-5138
217. Favre, B., Turowski, P. and Hemmings, B. A. (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid and tautomycin. J. Biol. Chem. 272, 13856-13863
218. Brown, B. M., Carlson, B. L., Zhu, X., Lolley, R. N. and Craft, C. M. (2002) Light-driven translocation of the protein phosphatase 2A complex regulates light/dark dephosphorylation of phosducin and rhodopsin. Biochemistry 41, 13526-13538
219. Nunbhakdi-Craig, V., Machleidt, T., Ogris, E., Bellotto, D., White, III, C. L. and Sontag, E. (2002) Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. J. Cell Biol. 158, 967-978
220. 2+ ionophore-induced secretion from mast cells correlates with myosin light chain phosphorylation by protein kinase C. J. Immunol. 157, 5130-5138
221. 2+ ionophore. J. Immunol. 143, 2617-2625
222. Hansra, G., Bornancin, F., Whelan, R., Hemmings, B. A. and Parker, P. J. (1996) 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer. J. Biol. Chem 271, 32785-32788
223. Ricciareili, R. and Azzi, A. (1998) Regulation of recombinant PKCα activity by protein phosphatase 1 and protein phosphatase 2A. Arch. Biochem. Biophys. 355, 197-200
224. Keranen, L. M., Dutil, E. M. and Newton, A. C. (1995) Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr. Biol. 5, 1394-1403
225. Hansra, G., Bornancin, F., Whelan, R., Hemmings, B. A., and Parker, P. J. (1996) 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer. J. Biol. Chem. 271, 32785-32788
226. Hansra, G., Bornancin, F., Whelan, R., Hemmings, B. A. and Parker, P. J. (1996) 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer. J. Biol. Chem. 271, 32785-32788
227. Choi, O. H., Adelstein, R. S. and Beaven, M. A. (1994) Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C. J. Biol. Chem. 269, 536-541
228. Adelstein, R. S., Beaven, M. A., Bengur, A. R., Kawamoto, S., Ludowyke, R. I., Peleg, I. and Sellers, J. R. (1989) In situ phosphorylation of human platelet and rat basophilic leukemia cell (RBL-2H3) myosin heavy chain and light chain. Adv. Exp. Med. Biol. 255, 289-297
229. Ludowyke, R. I., Peleg, I., Beaven, M. A. and Adelstein, R. S. (1989) Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells. J. Biol. Chem. 264, 12492-12501
230. Choi, O. H., Adelstein, R. S. and Beaven, M. A. (1994) Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C. J. Biol. Chem. 269, 536-541
231. Ludowyke, R, I., Peleg, I., Beaven, M. A. and Adelstein, R. S. (1989) Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells. J. Biol. Chem. 264, 12492-12501
232. Toyoda, H., Nakai, K., Omay, S. B., Shima, H., Nagao, M., Shiku, H. and Nishikawa, M. (1996) Differential association of protein Ser/Thr phosphatase types 1 and 2A with the cytoskeleton upon platelet activation. Thromb. Haemostasis 76, 1053-1062
233. Reference deleted
234. Hultsch, T., Brand, P., Lohmann, S., Saloga, J., Kincaid, R. L. and Knop, J. (1998) Direct evidence that FK506 inhibition of FcεRI-mediated exocytosis from RBL mast cells involves calcineurin. Arch. Dermatol. Res. 290, 258-263
235. + channels. J. Physiol. (Cambridge) 544, 429-445
236. Varadi, A., Ainscow, E. K., Allan, V. J. and Butter, G. A. (2002) Molecular mechanisms involved in secretory vesicle recruitment to the plasma membrane in β-cells. Biochem. Soc. Trans. 30, 328-332
237. Rutter, G. A. (2001) Nutrient-secretion coupling in the pancreatic islet β-cell: recent advances. Mol. Aspects Med. 22, 247-284
238. 2+ signal in pancreatic β cells and inhibition of insulin secretion. Br. J. Pharmacol. 123, 97-105
239. Murphy, L. I. and Jones, P. M (1996) Phosphoserine/threonine phosphatases in rat islets of Langerhans: identification and effect on insulin secretion. Mol. Cell. Endocrinol. 117, 195-202
240. Ratcliff, H. and Jones, P. M. (1993) Effects of okadaic acid on insulin secretion from rat islets of Langerhans. Biochim. Biophys. Acta 1175, 188-191
241. 2+ channels in insulin-secreting cells. Biochem. J. 298, 341-346
242. Ammala, C., Eliasson, L., Bokvist, K., Berggren, P. O., Honkanen, R. E., Sjoholm, A. and Rorsman, P. (1994) Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic β cells. Proc. Natl. Acad. Sci. U.S.A. 91, 4343-4347
243. Krautheim, A., Rustenbeck, I. and Steinfelder, H. J. (1999) Phosphatase inhibitors induce defective hormone secretion in insulin-secreting cells and entry into apoptosis. Exp. Clin. Endocrinol. Diabetes 107, 29-34
244. Mayer, P., Jochum, C., Schatz, H. and Pfeiffer, A. (1994) Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells. Exp. Clin. Endocrinol. 102, 313-319
245. Sjoholm, A., Lehtihet, M., Efanov, A. M., Zaitsev, S. V., Berggren, P. O. and Honkanen, R. E. (2002) Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic β-cells. Endocrinology (Baltimore) 143, 4592-4598
246. i- and insulin-stimulating effect of the non-membrane-permeable phosphatase inhibitor microcystin-LR in intact insulin-secreting cells (RINm5F). Br. J. Pharmacol. 130, 1406-1410
247. Sjoholm, A., Honkanen, R. E. and Berggren, P. O. (1995) Inhibition of serine/threonine protein phosphatases by secretagogues in insulin-secreting cells. Endocrinology (Baltimore) 136, 3391-3397
248. Kowluru, A., Seavey, S. E., Rabaglia, M. E., Nesher, R. and Metz, S. A. (1996) Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion. Endocrinology (Baltimore) 137, 2315-2323
249. 2+-dependent dephosphorylation of kinesin heavy chain on β-granules in pancreatic β-cells. Implications for regulated β-granule transport and insulin exocytosis. J. Biol. Chem. 277, 24232-24242
250. i2 protein-dependent activation of calcineurin in rat pancreatic α-cells J. Biol. Chem. 276, 924-930
251. Renstrom, E., Ding, W. G., Bokvist, K. and Rorsman, P. (1996) Neurotransmitter-induced inhibition of exocytosis in insulin-secreting β-cells by activation of calcineurin. Neuron 17, 513-522
252. Chandrasekar, B. and Mukherjee, S. K. (1988) Effect of prolonged administration of cyclosporin A on (pro)insulin biosynthesis and insulin release by rat islets of Langerhans. Biochem. Pharmacol. 37, 3609-3611
253. 2+- and cyclic adenosine monophosphate-mediated pancreatic amylase secretion. Scand. J. Gastroenterol. 30, 384-391
254. Lester, L. B., Faux, M. C., Nauert, J. B. and Scott, J. D. (2001) Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation. Endocrinology (Baltimore) 142, 1218-1227
255. Redmon, J. B., Olson, L. K., Armstrong, M. B., Greene, M. J. and Robertson, R. P. (1996) Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels and insulin secretion in HIT-T15 cells. J. Clin. Invest. 98, 2786-2793
256. Ebihara, K., Fukunaga, K., Matsumoto, K., Shichiri, M. and Miyamoto, E. (1996) Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6 cells. Endocrinology (Baltimore) 137, 5255-5263
257. 2+-binding proteins calcineurin and calretinin. Histochem. Cell Biol. 108, 133-139
258. Pieribone, V. A., Shupliakov, O., Brodin, L., Hilfiker-Rothenfluh, S., Czernik, A. J. and Greengard, P. (1995) Distinct pools of synaptic vesicles in neurotransmitter release. Nature (London) 375, 493-497
259. Sim, A. T., Ratcliffe, E., Mumby, M. C., Villa-Moruzzi, E. and Rostas, J. A. (1994) Differential activities of protein phosphatase types 1 and 2A in cytosolic and particulate fractions from rat forebrain. J. Neurochem. 62, 1552-1559
260. Ochoa, E. L. and O'Shea, S. M. (1994) Concomitant protein phosphorylation and endogenous acetylcholine release induced by nicotine: dependency on neuronal nicotinic receptors and desensitization. Cell. Mol. Neurobiol. 14, 315-340
261. Abdul-Ghani, M., Kravitz, E. A., Meiri, H. and Rahamimoff, R. (1991) Protein phosphatase inhibitor okadaic acid enhances transmitter release at neuromuscular junctions. Proc. Natl. Acad. Sci. US.A 88, 1803-1807
262. Hingtgen, C. M. and Vasko, M. R. (1994) The phosphatase inhibitor, okadaic acid, increases peptide release from rat sensory neurons in culture. Neurosci. Lett. 178, 135-138
263. Herron, C. E. and Malenka, R. C. (1994) Activity-dependent enhancement of synaptic transmission in hippocampal slices treated with the phosphatase inhibitor calyculin A. J. Neurosci. 14, 6013-6020
264. Sim, A. T., Lloyd, H. G., Jarvie, P. E., Morrison, M., Rostas, J. A. and Dunkley, P. R. (1993) Synaptosomal amino acid release: effect of inhibiting protein phosphatases with okadaic acid. Neurosci. Lett. 160, 181-184
265. 2+/calmodulin in the activation of protein phosphatases and in exocytosis of all major transmitters. Eur. J. Pharmacol. 291, 387-398
266. Ogawa, S., Katsuragi, T., Matsuo, K. and Furukawa, T. (1994) Inhibitory effect of okadaic acid on noradrenaline exocytosis from guinea-pig vas deterens. Neurosci. Lett. 178, 144-146
267. Erratum (1994) Neurosci. Lett. 182, 123
268. 3H]GABA release from rat brain synaptosomes. Neurochem. Int. 38, 445-451
269. Vickroy, T. W., Malphurs, W. L. and Carriger, M. L. (1995) Regulation of stimulus-dependent hippocampal acetylcholine release by okadaic acid-sensitive phosphoprotein phosphatases. Neurosci. Lett. 191, 200-204
270. Baldwin, M. L., Rostas, J A. P. and Sim, A. T. R. (2003) Two modes of exocytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B. J. Neurochem. 85, 1190-1199
271. Machado, J. D., Morales, A., Gomez, J. F. and Borges, R. (2001) cAMP modulates exocytotic kinetics and increases quantal size in chromaffin cells. Mol. Pharm. 60, 514-520
272. 2+ channel antagonist on activity- and phosphorylation-enhanced release of acetylcholine at the neuromuscular junction of the frog in vitro. Eur. J. Neurosci. 8, 437-445
273. Erratum (1996) Eur. J. Neurosci. 8, 1315
274. Nichols, R. A., Suplick, G. R. and Brown, J. M. (1994) Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate. J. Biol. Chem. 269, 23817-23823
275. Guatimosim, C., Hull, C., Von Gersdorff, H. and Prado, M. A. (2002) Okadaic acid disrupts synaptic vesicle trafficking in a ribbon-type synapse. J. Neurochem. 82, 1047-1057
276. Dai, Z. and Peng, H. B. (1996) Dynamics of synaptic vesicles in cultured spinal cord neurons in relationship to eynaptogenesis. Mol. Cell Neurosci. 7, 443-452
277. Betz, W. J. and Henkel, A. W. (1994) Okadaic acid disrupts dusters of synaptic vesicles in frog motor nerve terminals. J. Cell Biol. 124, 843-854
278. Greengard, P., Valtorta, F., Czernik, A. J. and Benfenati, F. (1993) Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259, 780-785
279. 2+/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse. Proc. Natl. Acad. Sci. U.S.A. 87, 8257-8261
280. Ceccaldi, P. E., Grohovaz, F., Benfenati, F., Chieregatti, E., Greengard, P. and Valtorta, F. (1995) Dephosphorylated synapsin I anchors synaptic vesicles to actin cytoskeleton: an analysis by videomicroscopy. J. Cell Biol. 128, 905-912
281. Marash, M. and Gerst, J. E. (2001) t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. EMBO J. 20, 411-421
282. Sistiaga, A. and Sanchez-Prieto, J. (2000) Protein phosphatase 1 and 2A inhibitors prolong the switch in the control of glutamate release by group I metabotropic glutamate receptors: characterization of the inhibitory pathway. J. Neurochem. 75, 1566-1574
283. Reference deleted
284. Cousin, M. A. and Robinson, P. J. (2001) The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Trends Neurosci. 24, 659-665
285. Cousin, M. A., Tan, T. C. and Robinson, P. J. (2001) Protein phosphorylation is required for endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin. J. Neurochem. 76, 105-116
286. Robinson, P. J., Liu, J. P., Powell, K. A., Fykse, E. M. and Sudhof, T. C. (1994) Phosphorylation of dynamin I and synaptic-vesicle recycling. Trends Neurosci. 17, 348-353
287. 2+-induced release of catecholamines and neuropeptides. J. Neurochem. 71, 1978-1986
288. Sihra, T. S., Nairn, A. C., Kloppenburg, P., Lin, Z. and Pouzat, C. (1996) A role for calcineurin (protein phosphatase-2B) in the regulation of glutamate release. Biochem. Biophys. Res. Commun. 212, 609-616
289. Wang, S. J. (2002) Interaction between FK506 and isoproterenol in the modulation of glutamate release from cerebrocortical nerve terminals. NeuroReport 13, 983-986
290. 2+-dependent glutamate release in isolated nerve terminals. J. Neurosci. 21, 7944-7963
291. Victor, R. G., Thomas, G. D., Marban, E. and O'Rourke, B. (1995) Presynaptic modulation of cortical synaptic activity by calcineurin. Proc. Natl. Acad. Sci. U.S.A. 92, 6269-6273
292. Lauritsen, J. P., Menne, C., Kastrup, J., Dietrich, J., Odum, N. and Geisler, C. (2000) β2-adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase. Biochim. Biophys. Acta 1497, 297-307
293. Lin, M. J. and Lin-Shiau, S. Y. (1999) Enhanced spontaneous transmitter release at murine motor nerve terminals with cyclosporine. Neuropharmacology 38, 195-198
294. Zhang, W., Li, J. L., Hosaka, M., Janz, R., Shelton, J. M., Albright, G. M., Richardson, J. A., Sudhof, T. C. and Victor, R. G. (2000) Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings. Proc. Natl. Acad. Sci. U.S.A. 97, 9765-9770
295. Holroyd, P., Lang, T., Wenzel, D., De Camilli, P. and Jahn, R. (2002) Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc. Natl. Acad. Sci. U.S.A. 99, 16806-16811
296. Graham, M. E., O'Callaghan, D. W., McMahon, H. T. and Burgoyne, R. D. (2002) Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size. Proc. Natl. Acad. Sci. U.S.A. 99, 7124-7129
297. Lievens, J. C., Woodman, B., Mahal, A. and Bates, G. P. (2002) Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6/2 Huntington's disease transgenic mice. Mol. Cell. Neurosci. 20, 638-648