3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 21, 2006, Pages 7311-7323

  Xie, Aihua ^a   Sivaprakasam, Prasanna ^a   Doerksen, Robert J ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

CoMFA; CoMSIA; Farnesyltransferase inhibitors; Malaria

Indexed keywords

2,5 BISACYLAMINOBENZOPHENONE; 2,5 DIAMINOBENZOPHENONE; ACRYLIC ACID DERIVATIVE; AMIDE; ANTIMALARIAL AGENT; BENZOPHENONE DERIVATIVE; CINNAMIC ACID DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; PHYSICAL CHEMISTRY; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; BENZOPHENONES; ELECTROSTATICS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STATIC ELECTRICITY;

PLASMODIUM FALCIPARUM;

EID: 33748750232     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.041     Document Type: Article

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