Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics

Molecular and Biochemical Parasitology

Volumn 126, Issue 2, 2003, Pages 155-163

  Gelb, Michael H ^a   Van Voorhis, Wesley C ^a   Buckner, Frederick S ^a   Yokoyama, Kohei ^a   Eastman, Richard ^a   Carpenter, Elisabeth P ^c   Panethymitaki, Chrysoula ^b,c   Brown, Katherine A ^c   Smith, Deborah F ^b,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

N Myristoyl transferase; Protein farnesyl transferase; Protein prenylation

Indexed keywords

ANTIFUNGAL AGENT; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; ENZYME INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN N MYRISTOYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; ENZYME INHIBITION; EUKARYOSIS; EUKARYOTIC CELL; HUMAN; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; MALARIA; MYCOSIS; NONHUMAN; PLASMODIUM FALCIPARUM; PRENYLATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTOZOAL INFECTION; REVIEW; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ACYLTRANSFERASES; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTIMALARIALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; PLASMODIUM; PROTEIN CONFORMATION; TRYPANOCIDAL AGENTS; TRYPANOSOMA;

EUKARYOTA; PROTOZOA; TRYPANOSOMATIDAE;

EID: 0345073644     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00282-7     Document Type: Review

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