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Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 23, 2001, Pages 12948-12953

The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics

(5) Long, Stephen B a Hancock, Paula J b Kral, Astrid M b Hellinga, Homme W a Beese, Lorena S a

a DUKE UNIVERSITY MEDICAL CENTER (United States)

b MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE; PROTEIN FARNESYLTRANSFERASE; TETRAPEPTIDE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME STRUCTURE; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; OLIGOPEPTIDES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 0035818587 PISSN: 00278424 EISSN: None Source Type: Journal
DOI: 10.1073/pnas.241407898 Document Type: Article

Times cited : (107)

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