Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum

Journal of Biological Chemistry

Volumn 280, Issue 14, 2005, Pages 13554-13559

  Eastman, Richard T ^a   White, John ^a   Hucke, Oliver ^b   Bauer, Kevin ^a   Yokoyama, Kohei ^a   Nallan, Laxman ^a,b   Chakrabarti, Debopam ^c   Verlinde, Christophe L M J ^b   Gelb, Michael H ^a,b   Rathod, Pradipsinh K ^a   Van Voorhis, Wesley C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOCHEMISTRY; BIOLOGICAL MEMBRANES; DATA ACQUISITION; DRUG THERAPY; ENZYME INHIBITION; GENE TRANSFER; MICROORGANISMS; PATHOLOGY;

ANTIMALARIAL AGENTS; EUKARYOPTIC ORGANISMS; PROTEIN FARNESYLTRANSFERASE (PFT); TETRAHYDROQUINOLINE (THQ);

PROTEINS;

BMS 388891; CYSTEINE; PEPTIDE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; QUINOLINE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GENOTYPE; INHIBITION KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; POINT MUTATION; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DRUG RESISTANCE; HUMANS; IMIDAZOLES; MALARIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; POINT MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SUBUNITS; PROTOZOAN PROTEINS; QUINOLINES; SEQUENCE ALIGNMENT;

EID: 20244388655     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413556200     Document Type: Article

References (34)

1. Rathod, P. K. (2001) in Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery (Rosenthal, P. J., ed) Humana Press, Totowa, NJ
2. May, J., and Meyer, C. G. (2003) Trends Parasitol. 19, 432-436
3. White, N. J. (2004) J. Clin. Investig. 113, 1084-1092
4. Buckner, F. S., Eastman, R. T., Nepomuceno-Silva, J. L., Speelmon, E. C., Myler, P. J., Van Voorhis, W. C., and Yokoyama, K. (2002) Mol. Biochem. Parasitol. 122, 181-188
5. Chakrabarti, D., Azam, T., DelVecchio, C., Qiu, L. B., Park, Y., and Allen, C. M. (1998) Mol. Biochem. Parasitol. 94, 175-184
6. Ohkanda, J., Lockman, J. W., Yokoyama, K., Gelb, M. H., Croft, S. L., Kendrick, H., Harrell, M. I., Feagin, J. E., Blaskovich, M. A., Sebti, S. M., and Hamilton, A. D. (2001) Bioorg. Med. Chem. Lett. 11, 761-764
7. Ohkanda, J., Buckner, F. S., Lockman, J. W., Yokoyama, K., Carrico, D., Eastman, R., Luca-Fradley, K., Davies, W., Croft, S. L., Van Voorhis, W. C., Gelb, M. H., Sebti, S. M., and Hamilton, A. D. (2004) J. Med. Chem. 47, 432-445
8. Wiesner, J., Kettler, K., Sakowski, J., Ortmann, R., Katzin, A. M., Kimura, E. A., Silber, K., Klebe, G., Jomaa, H., and Schlitzer, M. (2004) Angew. Chem. Int. Ed. Engl. 43, 251-254
9. Bell, I. M. (2004) J. Med. Chem. 47, 1869-1878
10. Haluska, P., Dy, G. K., and Adjei, A. A. (2002) Eur. J. Cancer 38, 1685-1700
11. Sebti, S. M., and Adjei, A. A. (2004) Semin. Oncol. 31, 28-39
12. Yokoyama, K., Goodwin, G. W., Ghomashchi, F., Glomset, J., and Gelb, M. H. (1992) Biochem. Soc. Trans. 20, 489-494
13. Abrieu, A., Kahana, J. A., Wood, K. W., and Cleveland, D. W. (2000) Cell 102, 817-826
14. Rathod, P. K., McErlean, T., and Lee, P. C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9389-9393
15. Dunten, P., Kammlott, U., Crowther, R., Weber, D., Palermo, R., and Birktoft, J. (1998) Biochemistry 37, 7907-7912
16. Park, H. W., Boduluri, S. R., Moomaw, J. F., Casey, P. J., and Beese, L. S. (1997) Science 275, 1800-1804
17. Reid, T. S., and Beese, L. S. (2004) Biochemistry 43, 6877-6884
18. Long, S. B., Hancock, P. J., Kral, A. M., Hellinga, H. W., and Beese, L. S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 12948-12953
19. Trager, W., and Jensen, J. B. (1976) Science 193, 673-675
20. Rathod, P. K., Khosla, M., Gassis, S., Young, R. D., and Lutz, C. (1994) Antimicrob. Agents Chemother. 38, 2871-2876
21. Desjardins, R. E., Canfield, C. J., Haynes, J. D., and Chulay, J. D. (1979) Antimicrob. Agents Chemother. 16, 710-718
22. Jiang, L., Lee, P. C., White, J., and Rathod, P. K. (2000) Antimicrob. Agents Chemother. 44, 1047-1050
23. Chakrabarti, D., Da Silva, T., Barger, J., Paquette, S., Patel, H., Patterson, S., and Allen, C. M. (2002) J. Biol. Chem. 277, 42066-42073
24. Omer, C. A., Kral, A. M., Diehl, R. E., Prendergast, G. C., Powers, S., Allen, C. M., Gibbs, J. B., and Kohl, N. E. (1993) Biochemistry 32, 5167-5176
25. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
26. Notredame, C., Higgins, D. G., and Heringa, J. (2000) J. Mol. Biol. 302, 205-217
27. Feller, S. E., Gawrisch, K., and MacKerell, A. D., Jr. (2002) J. Am. Chem. Soc. 124, 318-326
28. McMartin, C., and Bohacek, R. S. (1997) J. Comput. Aided Mol. Des. 11, 333-344
29. Ohwada, T., Okamoto, I., Shudo, K., and Yamaguchi, K. (1998) Tetrahedron Lett. 39, 7877-7880
30. Kral, A. M., Diehl, R. E., deSolms, S. J., Williams, T. M., Kohl, N. E., and Omer, C. A. (1997) J. Biol. Chem. 272, 27319-27323
31. Mitsuzawa, H., Esson, K., and Tamanoi, F. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1704-1708
32. Del Villar, K., Urano, J., Guo, L., and Tamanoi, F. (1999) J. Biol. Chem. 274, 27010-27017
33. Jorgensen, W. L., and Severance, D. L. (1990) J. Am. Chem. Soc. 112, 4768-4774
34. Taylor, J. S., Reid, T. S., Terry, K. L., Casey, P. J., and Beese, L. S. (2003) EMBO J. 22, 5963-5974