Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3- benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity

European Journal of Medicinal Chemistry

Volumn 40, Issue 1, 2005, Pages 93-101

  Kettler, Katja ^a   Wiesner, Jochen ^b   Silber, Katrin ^c   Haebel, Peter ^c   Ortmann, Regina ^a   Sattler, Isabel ^d   Dahse, Hans Martin ^d   Jomaa, Hassan ^b   Klebe, Gerhard ^c   Schlitzer, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Antimalarial activity; Non thiol farnesyltransferase inhibitors; Structure activity relationships

Indexed keywords

BENZOPHENONE; N (4 AMINOACYLAMINO 3 BENZOYLPHENYL) 3 [5 (4 NITROPHENYL) 2 FURYL]ACRYLIC ACID AMIDE; N [2 BENZOYL 4 [3 [5 (4 NITROPHENYL) 2 FURYL]ACRYLOYLAMINO]PHENYL N TERT BUTOXYCARBONYL (4 FLUOROPHENYL)GLYCINAMIDE; N [2 BENZOYL 4 [3 [5 (4 NITROPHENYL) 2 FURYL]ACRYLOYLAMINO]PHENYL] (4 FLUOROPHENYL)GLYCINAMIDE; N [2 BENZOYL 4 [3 [5 (4 NITROPHENYL) 2 FURYL]ACRYLOYLAMINO]PHENYL] (4 TRIFLUOROMETHYLPHENYL)GLYCINAMIDE; N [2 BENZOYL 4 [3 [5 (4 NITROPHENYL) 2 FURYL]ACRYLOYLAMINO]PHENYL] N TERT BUTOXYCARBONYL (4 TRIFLUOROMETHYLPHENYL)GLYCINAMIDE; N [2 BENZOYL 4 [3 [5 (4 NITROPHENYL) 2 FURYL]ACRYLOYLAMINO]PHENYL] N TERT BUTOXYCARBONYLPHENYLGLYCINAMIDE; N [2 BENZOYL 4 [3 [5 (4 NITROPHENYL) 2 FURYL]ACRYLOYLAMINO]PHENYL] PHENYLGLYCINAMIDE; PHENYLACETIC ACID; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; ENZYME INHIBITION;

ACRYLAMIDES; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTIMALARIALS; CELL SURVIVAL; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944428148     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.09.019     Document Type: Article

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