Structure-activity relationships of novel anti-malarial agents: Part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 3, 2003, Pages 361-363

  Wiesner, Jochen ^b,c   Kettler, Katja ^a   Sakowski, Jacek ^a   Ortmann, Regina ^a   Jomaa, Hassan ^c   Schlitzer, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

^c Jomaa Pharmaka GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 NITROBENZOPHENONE; ANTIMALARIAL AGENT; BENZOPHENONE DERIVATIVE; FUNCTIONAL GROUP; KETONE DERIVATIVE; METHYL GROUP; NITRO DERIVATIVE; PHENYLACETIC ACID; UNCLASSIFIED DRUG;

ACYLATION; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ACRYLATES; ANIMALS; ANTIMALARIALS; DRUG RESISTANCE, MULTIPLE; ERYTHROCYTES; FURANS; HUMANS; INDICATORS AND REAGENTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 0037330588     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)01003-X     Document Type: Article

References (13)

1. Sachs J., Malaney P. Nature. 415:2002;680.
2. Ridley R.G. Nature. 415:2002;686.
3. Schlitzer, M. Curr. Pharm. Des. 2002, 8, 1713.
4. Wiesner J., Wißner P., Dahse H.-M., Jomaa H., Schlitzer M. Bioorg. Med. Chem. 9:2001;785.
5. Wiesner J., Mitsch A., Wißner P., Jomaa H., Schlitzer M. Bioorg. Med. Chem. Lett. 11:2001;423.
6. Wiesner J., Kettler K., Jomaa H., Schlitzer M. Bioorg. Med. Chem. Lett. 12:2002;543.
7. Wiesner, J.; Mitsch, A.; Wißner, P.; Krämer, O.; Jomaa, H.; Schlitzer, M. Bioorg. Med. Chem. Lett. 2002, 12, 2681.
8. Kettler, K.; Sakowski, J., Silber, K.; Sattler, I.; Schlitzer, M. Bioorg. Med. Chem. In press.
9. 1H NMR and MS and gave microanalysis within±0.4% of the theoretical values.
10. (a) Desjardins R.E., Canfield C.J., Haynes J.D., Chulay J.D. Antimicrob. Agents Chemother. 16:1979;710.
11. (b) Trager W., Jensen J.B. Science. 193:1976;673.
12. (c) Ancelin M.L., Calas M., Bompart J., Cordina G., Martin D., Bari M.B., Jei T., Druilhe P., Vial H. J. Blood. 91:1998;1.
13. 50 values.