Farnesyltransferase Inhibitors Inhibit the Growth of Malaria Parasites In Vitro and In Vivo

Angewandte Chemie - International Edition

Volumn 43, Issue 2, 2003, Pages 251-254

  Wiesner, Jochen ^b   Kettler, Katja ^a   Sakowski, Jacek ^a   Ortmann, Regina ^a   Katzin, Alejandro M ^c   Kimura, Emília A ^c   Silber, Katrin ^d   Klebe, Gerhard ^d   Jomaa, Hassan ^b   Schlitzer, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Drug design; Enzyme inhibitors; Farnesyltransferase; Malaria; Medicinal chemistry

Indexed keywords

GROWTH KINETICS; MALARIA CONTROL; PROTEINS;

FARNESYLATION; PARASITES;

ENZYME INHIBITION;

ANTIMALARIAL AGENT; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM;

EID: 9144236861     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351169     Document Type: Article

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