Inhibition of farnesyltransferase as a strategy for the development of novel anti-malarials

Current Medicinal Chemistry: Anti-Infective Agents

Volumn 4, Issue 3, 2005, Pages 277-286

  Schlitzer, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Farnesyltransferase inhibitors; Malaria; Plasmodium falciparum; Protein prenylation

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ALPHA HYDROXYFARNESYLPHOSPHONIC ACID; ANTIMALARIAL AGENT; ANTISPOROZOAL AGENT; FTI 2148; FTI 2153; FTI 2220; FTI 2277; GERANYLTRANSFERASE 1 INHIBITOR; GGTI 287; GGTI 297; GGTI 298; GLITOXIN; L 741177; L 745631; LIMONENE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SCHL 2171; SCHL 4116; SCHL 4135; SCHL 5189; SCHL 5244; SCHL 6023; SCHL 6103; SCHL 6135; SCHL 898; TIPIFARNIB; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER CELL; CLINICAL TRIAL; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; REVIEW; SEQUENCE ANALYSIS;

EID: 22144438697     PISSN: 15680126     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568012054368137     Document Type: Review

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