Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: Kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers

Biochemistry

Volumn 42, Issue 27, 2003, Pages 8232-8239

  Smellie, Melissa ^a   Bose, Deravander S ^b   Thompson, Andrew S ^b   Jenkins, Terence C ^c   Hartley, John A ^a   Thurston, David E ^b,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERS; DNA SEQUENCES; ETHERS;

BINDING SITES;

DNA;

DNA HOMOLOG; MELPHALAN; PLASMID DNA; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE;

ARTICLE; COVALENT BOND; CROSS LINKING; CYTOTOXICITY; DNA CROSS LINKING; DNA SEQUENCE; MOLECULAR INTERACTION; MOLECULAR MODEL; NUCLEOTIDE BINDING SITE; PREDICTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 0037489428     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034313t     Document Type: Article

References (31)

1. Thurston, D. E. (1993) in Molecular Aspects of Anticancer Drug-DNA Interactions (Neidle, S., and Waring, M. J., Eds.) pp 54-88, The Macmillan Press Ltd., London.
2. Puvvada, M. S., Hartley, J. A., Jenkins, T. C., and Thurston, D. E. (1993) Nucleic Acids Res. 21, 3671-3675.
3. Puvvada, M. S., Forrow, S. A., Hartley, J. A., Stephenson, P., Gibson, I., Jenkins, T. C., and Thurston, D. E. (1997) Biochemistry 36, 2478-2484.
4. Thurston, D. E., and Bose, D. S. (1994) Chem. Rev. 94, 433-465.
5. Kamal, A., Rao, M. V., Laxman, N., Ramesh, G., and Reddy, G. S. K. (2002) Curr. Med. Chem.: Anti-Cancer Agents 2, 215-254.
6. Thurston, D. E., Bose, D. S., Howard, P. W., Jenkins, T. C., Leoni, A., Baraldi, P. G., Guiotto, A., Cacciari, B., Kelland, L. R., Foloppe, M. P., and Rault, S. (1999) J. Med. Chem. 42, 1951-1964.
7. Gregson, S. J., Howard, P. W., Barcella, S., Nakamya, A., Jenkins, T. C., Kelland, L. R., and Thurston, D. E. (2000) Bioorg. Med. Chem. Lett. 10, 1849-1851.
8. Gregson, S. J., Howard, P. W., Corcoran, K. E., Barcella, S., Yasin, M. M., Hurst, A. A., Jenkins, T. C., Kelland, L. R., and Thurston, D. E. (2000) Bioorg. Med. Chem. Lett. 10, 1845-1847.
9. Thurston, D. E. (1999) Br. J. Cancer 80, 65-85.
10. Bose, D. S., Thompson, A. S., Ching, J. S., Hartley, J. A., Berardini, M. D., Jenkins, T. C., Neidle, S., Hurley, L. H., and Thurston, D. E. (1992) J. Am. Chem. Soc. 114, 4939-4941.
11. Thurston, D. E., Bose, D. S., Thompson, A. S., Howard, P. W., Leoni, A., Croker, S. J., Jenkins, T. C., Neidle, S., Hartley, J. A., and Hurley, L. H. (1996) J. Org. Chem. 61, 8141-8147.
12. Bose, D. S., Thompson, A. S., Smellie, M., Berardini, M. D., Hartley, J. A., Jenkins, T. C., Neidle, S., and Thurston, D. E. (1992) Chem. Commun., 1518-1520.
13. Smellie, M., Kelland, L. R., Thurston, D. E., Souhami, R. L., and Hartley, J. A. (1994) Br. J. Cancer 70, 48-53.
14. Mountzouris, J. A., Wang, J. J., Thurston, D., and Hurley, L. H. (1994) J. Med. Chem. 37, 3132-3140.
15. Jenkins, T. C., Hurley, L. H., Neidle, S., and Thurston, D. E. (1994) J. Med. Chem. 37, 4529-4537.
16. Adams, L. J., Jenkins, T. C., Banting, L., and Thurston, D. E. (1999) Pharm. Pharmacol. Commun. 5, 555-560.
17. Walton, M. I., Goddard, P., Kelland, L. R., Thurston, D. E., and Harrap, K. R. (1996) Cancer Chemother. Pharmacol. 38, 431-438.
18. Gregson, S. J., Howard, P. W., Corcoran, K. E., Jenkins, T. C., Kelland, L. R., and Thurston, D. E. (2001) Bioorg. Med. Chem. Lett. 11, 2859-2862.
19. Gregson, S. J., Howard, P. W., Hartley, J. A., Brooks, N. A., Adams, L. J., Jenkins, T. C., Kelland, L. R., and Thurston, D. E. (2001) J. Med. Chem. 44, 737-748.
20. Gregson, S. J., Howard, P. W., Jenkins, T. C., Kelland, L. R., and Thurston, D. E. (1999) Chem. Commun., 797-798.
21. Neidle, S., Puvvada, M. S., and Thurston, D. E. (1994) Eur. J. Cancer 30A, 567-568.
22. Neidle, S., and Thurston, D. E. (1994) in New Targets for Cancer Chemotherapy (Kerr, D. J., and Workman, P., Eds.) pp 159-175, CRC Press Ltd., Boca Raton, FL.
23. Woynarowski, J. M., Herzig, M. C., Trevino, A. V., Rodriguez, K. A., Hurley, L., and Hardies, S. C. (2001) Clin. Cancer Res. 7, 705.
24. Woynarowski, J. M. (2002) Biochim. Biophys. Acta 1587, 300-308.
25. Woynarowski, J. M., Hardies, S. C., Trevino, A. V., and Arnett, B. M. (1998) Ann. Oncol. 9, 528.
26. Hartley, J. A., Berardini, M. D., and Souhami, R. L. (1991) Anal. Biochem. 193, 131-134.
27. Schwieters, C. D.; Kuszewski, J. J., Tjandra, N., and Clore, G. M. (2003) J. Magn. Reson. 160, 65-73 (available for academic use from http://nmr.cit.nih.gov/xplor-nih).
28. Adams, L. J., Morris, S. J., Banting, L., Jenkins, T. C., and Thurston, D. E. (1995) Pharm. Sci. 1, 151-154.
29. Nunn, C. M., Jenkins, T. C., and Neidle, S. (1993) Biochemistry 32, 13838-13843.
30. Jenkins, T. C., and Lane, A. N. (1997) Biochim. Biophys. Acta 1350, 189-204.
31. Lane, A. N., Jenkins, T. C., and Frenkiel, T. A. (1997) Biochim. Biophys. Acta 1350, 205-220.