Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 4, 2004, Pages 901-904

  Masterson, Luke A ^a   Croker, Stephen J ^a   Jenkins, Terence C ^b   Howard, Philip W ^a   Thurston, David E ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

DNA Binding; Gene targeting; PBDs; Pyrrolobenzodiazepines; Sequence selective

Indexed keywords

AMINE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; ISOINDOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG ACTIVITY; DRUG DNA BINDING; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HOLLOW FIBER; HUMAN; HUMAN CELL;

EID: 0842302974     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.017     Document Type: Article

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