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Volumn 68, Issue 13, 2003, Pages 5249-5253

Synthesis of isochrysohermidin - Distamycin hybrids

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROPERTIES;

EID: 0038548108     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo034326c     Document Type: Article
Times cited : (28)

References (41)
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    • For recent examples, see α-Haloacylamides: (a) Cozzi, P.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mongelli, N. Bioorg. Med. Chem. Lett. 2000, 10, 1269. (b) Cozzi, P. Farmaco 2001, 56, 57. (c) Cozzi, P.; Mongelli, N. Curr. Pharm. Des. 1998, 4, 181. (d) Krowicki, K.; Balzarini, J.; De Clerq, E.; Newman, R. A.; Lown, J. W. J. Med. Chem. 1988, 31, 341. (e) Baker, B. F.; Dervan, P. B. J. Am. Chem. Soc. 1985, 107, 8266. Nitrogen mustards: (f) Wang, Y.; Wright, S. C.; Larrick, J. W. Bioorg. Med. Chem. Lett. 2003, 13, 459. (g) Baraldi, P, G.; Romagnoli, R.; Guadix, A. E.; Pineda de la Infantas, M. J.; Gallo, M. A.; Espinosa, A.; Martinez, A.; Bingham, J. P.; Hartley, J. A. J. Med. Chem. 2002, 45, 3630. (h) Cozzi, P. C.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mazzini, S.; Ragg, E. Bioorg. Med. Chem. Lett. 2000, 10, 1653. (i) Xie, G.; Gupta, R.; Lown, J. W. Anti-Cancer Drug Des. 1995, 10, 389. (j) Sigurdsson, S. T.; Rink, S. M.; Hopkins, P. B. J. Am. Chem. Soc. 1993, 115, 12633. (k) Sondhi, S. M.; Praveen-Reddy, B. S.; Lown, J. W. Curr. Med. Chem. 1997, 4, 313.
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    • For recent examples, see α-Haloacylamides: (a) Cozzi, P.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mongelli, N. Bioorg. Med. Chem. Lett. 2000, 10, 1269. (b) Cozzi, P. Farmaco 2001, 56, 57. (c) Cozzi, P.; Mongelli, N. Curr. Pharm. Des. 1998, 4, 181. (d) Krowicki, K.; Balzarini, J.; De Clerq, E.; Newman, R. A.; Lown, J. W. J. Med. Chem. 1988, 31, 341. (e) Baker, B. F.; Dervan, P. B. J. Am. Chem. Soc. 1985, 107, 8266. Nitrogen mustards: (f) Wang, Y.; Wright, S. C.; Larrick, J. W. Bioorg. Med. Chem. Lett. 2003, 13, 459. (g) Baraldi, P, G.; Romagnoli, R.; Guadix, A. E.; Pineda de la Infantas, M. J.; Gallo, M. A.; Espinosa, A.; Martinez, A.; Bingham, J. P.; Hartley, J. A. J. Med. Chem. 2002, 45, 3630. (h) Cozzi, P. C.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mazzini, S.; Ragg, E. Bioorg. Med. Chem. Lett. 2000, 10, 1653. (i) Xie, G.; Gupta, R.; Lown, J. W. Anti-Cancer Drug Des. 1995, 10, 389. (j) Sigurdsson, S. T.; Rink, S. M.; Hopkins, P. B. J. Am. Chem. Soc. 1993, 115, 12633. (k) Sondhi, S. M.; Praveen-Reddy, B. S.; Lown, J. W. Curr. Med. Chem. 1997, 4, 313.
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    • Cozzi, P.C.1    Beria, I.2    Caldarelli, M.3    Capolongo, L.4    Geroni, C.5    Mazzini, S.6    Ragg, E.7
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    • For recent examples, see α-Haloacylamides: (a) Cozzi, P.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mongelli, N. Bioorg. Med. Chem. Lett. 2000, 10, 1269. (b) Cozzi, P. Farmaco 2001, 56, 57. (c) Cozzi, P.; Mongelli, N. Curr. Pharm. Des. 1998, 4, 181. (d) Krowicki, K.; Balzarini, J.; De Clerq, E.; Newman, R. A.; Lown, J. W. J. Med. Chem. 1988, 31, 341. (e) Baker, B. F.; Dervan, P. B. J. Am. Chem. Soc. 1985, 107, 8266. Nitrogen mustards: (f) Wang, Y.; Wright, S. C.; Larrick, J. W. Bioorg. Med. Chem. Lett. 2003, 13, 459. (g) Baraldi, P, G.; Romagnoli, R.; Guadix, A. E.; Pineda de la Infantas, M. J.; Gallo, M. A.; Espinosa, A.; Martinez, A.; Bingham, J. P.; Hartley, J. A. J. Med. Chem. 2002, 45, 3630. (h) Cozzi, P. C.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mazzini, S.; Ragg, E. Bioorg. Med. Chem. Lett. 2000, 10, 1653. (i) Xie, G.; Gupta, R.; Lown, J. W. Anti-Cancer Drug Des. 1995, 10, 389. (j) Sigurdsson, S. T.; Rink, S. M.; Hopkins, P. B. J. Am. Chem. Soc. 1993, 115, 12633. (k) Sondhi, S. M.; Praveen-Reddy, B. S.; Lown, J. W. Curr. Med. Chem. 1997, 4, 313.
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    • For recent examples, see α-Haloacylamides: (a) Cozzi, P.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mongelli, N. Bioorg. Med. Chem. Lett. 2000, 10, 1269. (b) Cozzi, P. Farmaco 2001, 56, 57. (c) Cozzi, P.; Mongelli, N. Curr. Pharm. Des. 1998, 4, 181. (d) Krowicki, K.; Balzarini, J.; De Clerq, E.; Newman, R. A.; Lown, J. W. J. Med. Chem. 1988, 31, 341. (e) Baker, B. F.; Dervan, P. B. J. Am. Chem. Soc. 1985, 107, 8266. Nitrogen mustards: (f) Wang, Y.; Wright, S. C.; Larrick, J. W. Bioorg. Med. Chem. Lett. 2003, 13, 459. (g) Baraldi, P, G.; Romagnoli, R.; Guadix, A. E.; Pineda de la Infantas, M. J.; Gallo, M. A.; Espinosa, A.; Martinez, A.; Bingham, J. P.; Hartley, J. A. J. Med. Chem. 2002, 45, 3630. (h) Cozzi, P. C.; Beria, I.; Caldarelli, M.; Capolongo, L.; Geroni, C.; Mazzini, S.; Ragg, E. Bioorg. Med. Chem. Lett. 2000, 10, 1653. (i) Xie, G.; Gupta, R.; Lown, J. W. Anti-Cancer Drug Des. 1995, 10, 389. (j) Sigurdsson, S. T.; Rink, S. M.; Hopkins, P. B. J. Am. Chem. Soc. 1993, 115, 12633. (k) Sondhi, S. M.; Praveen-Reddy, B. S.; Lown, J. W. Curr. Med. Chem. 1997, 4, 313.
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    • note
    • 50 = 67 (1), 119 (3), 165 (4), >200 (5), and >200 μM (6).
  • 41
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    • note
    • Concentration of resin-bound Rose Bengal was determined according to ref 15 (0.09 mol of Rose Bengal/g of support).


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