Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-polyamide conjugates and 2,2'-PBD dimers

Anti-Cancer Drug Design

Volumn 15, Issue 3, 2000, Pages 225-238

  Reddy, P ^a   Damayanthi, Y ^a   Reddy, N ^a   Lown, J W ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cytotoxicity; DNA; Polyamide; Pyrrolo 2,1 c 1,4 benzodiazepine

Indexed keywords

7 METHOXY 8 [3 [1 METHYL 2 [1 METHYL 2 (3 N,N DIMETHYLAMINOPROPYLAMINOCARBONYL) 4 PYRROLYLAMINOCARBONYL] 4 PYRROLYLAMINOCARBONYL]PROPYLOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPINE 5 DERIVATIVE; 7 METHOXY 8 [3 [1 METHYL 2 [1 METHYL 2 [1 METHYL 2 [1 METHYL 2 (3 N,N DIMETHYLAMINOPROPYLAMINOCARBONYL) 4 PYRROLYLAMINOCARBONYL] 4 PYRROLYLAMINOCARBONYL] 4 PYRROLYLAMINOCARBONYL]PROPYLOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; N 1 [4 (2 [5 OXO 2,3,5,11A TETRAHYDRO 1H BENZO[E]PYRROLO[1,2 C] [1,4]DIAZEPIN 2 YLIDEN]ACETYLAMINO)BUTYL] 2 [10 OXO 1,2,3A,10,10A HEXAHYDROBENZO[E]CYCLOPENTA[B]AZEPIN 2 YLIDEN]ACETAMIDE; POLYAMIDE; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL GROWTH; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; KIDNEY CANCER; MELANOMA; PRIORITY JOURNAL; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, ALKYLATING; BENZODIAZEPINES; CROSS-LINKING REAGENTS; DIMERIZATION; DNA, NEOPLASM; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMAN; NYLONS; PYRROLES; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0033818813     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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