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Volumn 288, Issue 1 51-1, 2005, Pages

Perspective: Emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion

Author keywords

Anaplerosis; Cataplerosis; Citrate oscillations; Insulin release; NADPH; Pyruvate carboxylase; Succinate mechanism

Indexed keywords

2 OXOGLUTARIC ACID; ACETYL COENZYME A; CITRIC ACID; MALONYL COENZYME A; PYRUVATE CARBOXYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINIC ACID;

EID: 11144262144     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00218.2004     Document Type: Review
Times cited : (215)

References (121)
  • 2
    • 0036786434 scopus 로고    scopus 로고
    • Inhibition of glucose- and calcium-induced insulin secretion from beta TC 3 cells by novel inhibitors of protein isoprenylation
    • Amin R, Chen HQ, Tannous M, Gibbs R, and Kowluru A. Inhibition of glucose- and calcium-induced insulin secretion from beta TC3 cells by novel inhibitors of protein isoprenylation. J Pharmacol Exp Ther 303: 82-88, 2002.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 82-88
    • Amin, R.1    Chen, H.Q.2    Tannous, M.3    Gibbs, R.4    Kowluru, A.5
  • 3
    • 0015304430 scopus 로고
    • 6-Aminonicotinamide (6-AN) as a diabetogenic agent. In vitro and in vivo studies in the rat
    • Ammon HP and Steinke J. 6-Aminonicotinamide (6-AN) as a diabetogenic agent. In vitro and in vivo studies in the rat. Diabetes 21: 143-148, 1972.
    • (1972) Diabetes , vol.21 , pp. 143-148
    • Ammon, H.P.1    Steinke, J.2
  • 4
    • 0020471658 scopus 로고
    • The stimulus-secretion coupling of glucose-induced insulin release. Thiol: Disulfide balance in pancreatic islets
    • Anjaneyulu K, Anjaneyulu R, Sener A, and Malaisse WJ. The stimulus-secretion coupling of glucose-induced insulin release. Thiol: disulfide balance in pancreatic islets. Biochimie 64: 29-36, 1982.
    • (1982) Biochimie , vol.64 , pp. 29-36
    • Anjaneyulu, K.1    Anjaneyulu, R.2    Sener, A.3    Malaisse, W.J.4
  • 5
    • 0025918539 scopus 로고
    • 2+ channels and excitation-contraction coupling
    • 2+ channels and excitation-contraction coupling. Curr Opin Cell Biol 3: 671-675, 1991.
    • (1991) Curr Opin Cell Biol , vol.3 , pp. 671-675
    • Ashcroft, F.M.1
  • 6
    • 0346844029 scopus 로고
    • The control of citrate synthesis and breakdown
    • edited by Lowenstein JM. New York: Marcel Dekker
    • Atkinson DE. The control of citrate synthesis and breakdown. In: Citric Acid Cycle: Control and Compartmentation, edited by Lowenstein JM. New York: Marcel Dekker, 1969, p. 137-162.
    • (1969) Citric Acid Cycle: Control and Compartmentation , pp. 137-162
    • Atkinson, D.E.1
  • 8
    • 0037031896 scopus 로고    scopus 로고
    • The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
    • Bertrand G, Ishiyama N, Nenquin M, Ravier MA, and Henquin JC. The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related. J Biol Chem 211: 32883-32891, 2002.
    • (2002) J Biol Chem , vol.211 , pp. 32883-32891
    • Bertrand, G.1    Ishiyama, N.2    Nenquin, M.3    Ravier, M.A.4    Henquin, J.C.5
  • 9
    • 0035145780 scopus 로고    scopus 로고
    • Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
    • Briaud I, Harmon JS, Kelpe CL, Segu VB, and Poitout V. Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50: 315-321, 2001.
    • (2001) Diabetes , vol.50 , pp. 315-321
    • Briaud, I.1    Harmon, J.S.2    Kelpe, C.L.3    Segu, V.B.4    Poitout, V.5
  • 10
    • 0037031846 scopus 로고    scopus 로고
    • Normal thyroid thermogenesis, but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase
    • Brown LJ, Koza RA, Everett C, Reitman ML, Marshall L, Fahien LA, Kozak LP, and MacDonald MJ. Normal thyroid thermogenesis, but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase. J Biol Chem 211: 32892-32898, 2002.
    • (2002) J Biol Chem , vol.211 , pp. 32892-32898
    • Brown, L.J.1    Koza, R.A.2    Everett, C.3    Reitman, M.L.4    Marshall, L.5    Fahien, L.A.6    Kozak, L.P.7    MacDonald, M.J.8
  • 11
    • 0037031946 scopus 로고    scopus 로고
    • Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases
    • Brown LJ, Koza RA, Marshall L, Kozak LP, and MacDonald MJ. Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases. J Biol Chem 211: 32899-32904, 2002.
    • (2002) J Biol Chem , vol.211 , pp. 32899-32904
    • Brown, L.J.1    Koza, R.A.2    Marshall, L.3    Kozak, L.P.4    MacDonald, M.J.5
  • 12
  • 13
    • 0027199057 scopus 로고
    • Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic β-cell line (INS-1)
    • Brun T, Roche E, Kim K, and Prentki M. Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic β-cell line (INS-1). J Biol Chem 268: 18905-18911, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 18905-18911
    • Brun, T.1    Roche, E.2    Kim, K.3    Prentki, M.4
  • 15
    • 0028236988 scopus 로고
    • More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling
    • Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, and McGarry JD. More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling. Diabetes 43: 878-883, 1994.
    • (1994) Diabetes , vol.43 , pp. 878-883
    • Chen, S.1    Ogawa, A.2    Ohneda, M.3    Unger, R.H.4    Foster, D.W.5    McGarry, J.D.6
  • 16
    • 0034445329 scopus 로고    scopus 로고
    • Evidence for voltage-gated potassium channel β-subunits with oxidoreductase motifs in human and rodent pancreatic beta cells
    • Chouinard SW, Lu F, Ganetzky B, and MacDonald MJ. Evidence for voltage-gated potassium channel β-subunits with oxidoreductase motifs in human and rodent pancreatic beta cells. Receptors Channels 7: 237-243, 2000.
    • (2000) Receptors Channels , vol.7 , pp. 237-243
    • Chouinard, S.W.1    Lu, F.2    Ganetzky, B.3    MacDonald, M.J.4
  • 18
    • 0033960381 scopus 로고    scopus 로고
    • The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction
    • Corkey BE, Denney JT, Yaney GC, Tornheim K, and Prentki M. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr 130: 299S-304S, 2000.
    • (2000) J Nutr , vol.130
    • Corkey, B.E.1    Denney, J.T.2    Yaney, G.C.3    Tornheim, K.4    Prentki, M.5
  • 19
    • 0024791536 scopus 로고
    • A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic β-cells
    • Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, and Prentki M. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic β-cells. J Biol Chem 264: 21608-21612, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 21608-21612
    • Corkey, B.E.1    Glennon, M.C.2    Chen, K.S.3    Deeney, J.T.4    Matschinsky, F.M.5    Prentki, M.6
  • 21
    • 0025886869 scopus 로고
    • Hexose metabolism in pancreatic islets: Pyruvate carboxylase activity
    • Curi R, Carpinelli AR, and Malaisse WJ. Hexose metabolism in pancreatic islets: pyruvate carboxylase activity. Biochimie 73: 583-586, 1991.
    • (1991) Biochimie , vol.73 , pp. 583-586
    • Curi, R.1    Carpinelli, A.R.2    Malaisse, W.J.3
  • 24
    • 0028006816 scopus 로고
    • Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver
    • Des Rosiers C, Fernandez CA, David F, and Brunengraber H. Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. J Biol Chem 269: 27179-27182, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 27179-27182
    • Des Rosiers, C.1    Fernandez, C.A.2    David, F.3    Brunengraber, H.4
  • 25
    • 0025326250 scopus 로고
    • Activation of glutamate dehydrogenase by leucine and its nonmetabolizable analogue in rat brain synaptosomes
    • Erecinska M and Nelson D. Activation of glutamate dehydrogenase by leucine and its nonmetabolizable analogue in rat brain synaptosomes. J Neurochem 54: 1335-1343, 1990.
    • (1990) J Neurochem , vol.54 , pp. 1335-1343
    • Erecinska, M.1    Nelson, D.2
  • 27
    • 0036724236 scopus 로고    scopus 로고
    • The succinate mechanism of insulin release
    • Fabien LA and MacDonald MJ. The succinate mechanism of insulin release. Diabetes 51: 2669-2676, 2002.
    • (2002) Diabetes , vol.51 , pp. 2669-2676
    • Fabien, L.A.1    MacDonald, M.J.2
  • 28
    • 0023695196 scopus 로고
    • Regulation of insulin release by factors which also modify glutamate dehydrogenase
    • Fahien LA, MacDonald MJ, Kmiotek EH, Mertz RJ, and Fahien CM. Regulation of insulin release by factors which also modify glutamate dehydrogenase. J Biol Chem 263: 13610-13614, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 13610-13614
    • Fahien, L.A.1    MacDonald, M.J.2    Kmiotek, E.H.3    Mertz, R.J.4    Fahien, C.M.5
  • 29
    • 0034072556 scopus 로고    scopus 로고
    • Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: Possible implication of a pyruvate/citrate shuttle in insulin secretion
    • Farfari S, Schulz V, Corkey B, and Prentki M. Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 49: 718-726, 2000.
    • (2000) Diabetes , vol.49 , pp. 718-726
    • Farfari, S.1    Schulz, V.2    Corkey, B.3    Prentki, M.4
  • 30
    • 0036300460 scopus 로고    scopus 로고
    • Critical role for cataplerosis via citrate in glucose-regulated insulin release
    • Flamez D, Berger V, Kruhoffer M, Orntoft T, Pipeleers D, and Schuit FC. Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes 51: 2018-2024, 2002.
    • (2002) Diabetes , vol.51 , pp. 2018-2024
    • Flamez, D.1    Berger, V.2    Kruhoffer, M.3    Orntoft, T.4    Pipeleers, D.5    Schuit, F.C.6
  • 32
    • 0036314998 scopus 로고    scopus 로고
    • Control mechanisms of the oscillations of insulin secretion in vitro and in vivo
    • Gilon P, Ravier MA, Jonas JC, and Henquin JC. Control mechanisms of the oscillations of insulin secretion in vitro and in vivo. Diabetes 51: S144-S151, 2002.
    • (2002) Diabetes , vol.51
    • Gilon, P.1    Ravier, M.A.2    Jonas, J.C.3    Henquin, J.C.4
  • 33
    • 0032787470 scopus 로고    scopus 로고
    • Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: Enzymatic, metabolic and secretory data
    • Giroix MH, Saulnier C, and Portha B. Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data. Diabetologia 42: 965-977, 1999.
    • (1999) Diabetologia , vol.42 , pp. 965-977
    • Giroix, M.H.1    Saulnier, C.2    Portha, B.3
  • 34
    • 0025860494 scopus 로고
    • Multiple abnormalities in insulin response to nonglucose nutrients in neonatally streptozotocin diabetic rats
    • Grill V, Sako Y, Ostenson CG, and Jalkannen P. Multiple abnormalities in insulin response to nonglucose nutrients in neonatally streptozotocin diabetic rats. Endocrinology 128: 2195-2203, 1991.
    • (1991) Endocrinology , vol.128 , pp. 2195-2203
    • Grill, V.1    Sako, Y.2    Ostenson, C.G.3    Jalkannen, P.4
  • 36
    • 0017144760 scopus 로고
    • Comparison of the effects of leucines, non-metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase
    • Gylfe E. Comparison of the effects of leucines, non-metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase. Acta Diabetol 13: 20-24, 1976.
    • (1976) Acta Diabetol , vol.13 , pp. 20-24
    • Gylfe, E.1
  • 40
    • 2642557131 scopus 로고    scopus 로고
    • Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals
    • Hui TY, Sheth SS, Diffley JM, Potter DW, Lusis AJ, Attie AD, and Davis RA. Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. J Biol Chem 279: 24387-24393, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 24387-24393
    • Hui, T.Y.1    Sheth, S.S.2    Diffley, J.M.3    Potter, D.W.4    Lusis, A.J.5    Attie, A.D.6    Davis, R.A.7
  • 42
    • 0014524830 scopus 로고
    • Metabolic control and structure of glycolytic enzymes. 8. Reversal of the dissociation of rabbit muscle pyruvate kinase into unfolded subunits
    • Johnson GS, Kayne MS, and Deal WC Jr. Metabolic control and structure of glycolytic enzymes. 8. Reversal of the dissociation of rabbit muscle pyruvate kinase into unfolded subunits. Biochemistry 8: 2455-2462, 1969.
    • (1969) Biochemistry , vol.8 , pp. 2455-2462
    • Johnson, G.S.1    Kayne, M.S.2    Deal Jr., W.C.3
  • 45
    • 0014603328 scopus 로고
    • Allosteric properties of muscle phosphofructokinase. II. Kinetics of native and thiol-modified enzyme
    • Kemp RG. Allosteric properties of muscle phosphofructokinase. II. Kinetics of native and thiol-modified enzyme. Biochemistry 8: 4490-4496, 1969.
    • (1969) Biochemistry , vol.8 , pp. 4490-4496
    • Kemp, R.G.1
  • 46
    • 13344277277 scopus 로고    scopus 로고
    • Quantifying the carboxylation of pyruvate in pancreatic islets
    • Khan A, Ling ZC, and Landau BR. Quantifying the carboxylation of pyruvate in pancreatic islets. J Biol Chem 271: 2539-2542, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 2539-2542
    • Khan, A.1    Ling, Z.C.2    Landau, B.R.3
  • 47
    • 0141646523 scopus 로고    scopus 로고
    • Novel roles for the rho subfamily of GTP-binding proteins in succinate-induced insulin secretion from βTC3 cells: Further evidence in support of the succinate mechanism of insulin release
    • Kowluru A, Chen HQ, and Tannous M. Novel roles for the rho subfamily of GTP-binding proteins in succinate-induced insulin secretion from βTC3 cells: further evidence in support of the succinate mechanism of insulin release. Endocr Res 29: 363-376, 2003.
    • (2003) Endocr Res , vol.29 , pp. 363-376
    • Kowluru, A.1    Chen, H.Q.2    Tannous, M.3
  • 48
    • 0034751362 scopus 로고    scopus 로고
    • Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase
    • Laclau M, Lu F, and MacDonald MJ. Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase. Mol Cell Biochem 225: 151-160, 2001.
    • (2001) Mol Cell Biochem , vol.225 , pp. 151-160
    • Laclau, M.1    Lu, F.2    MacDonald, M.J.3
  • 49
    • 0014938658 scopus 로고
    • Control of citric acid cycle activity in rat heart mitochondria
    • LaNoue K, Nicklas WJ, and Williamson JR. Control of citric acid cycle activity in rat heart mitochondria. J Biol Chem 245: 102-111, 1970.
    • (1970) J Biol Chem , vol.245 , pp. 102-111
    • LaNoue, K.1    Nicklas, W.J.2    Williamson, J.R.3
  • 50
    • 0042266314 scopus 로고    scopus 로고
    • Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells
    • Laychock SG, Tian Y, and Sessanna SM. Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. Diabetes 52: 1986-1993, 2003.
    • (2003) Diabetes , vol.52 , pp. 1986-1993
    • Laychock, S.G.1    Tian, Y.2    Sessanna, S.M.3
  • 52
    • 0027535853 scopus 로고
    • Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells: Probable involvement of small GTP-binding proteins
    • Li G, Regazzi R, Roche E, and Wollheim CB. Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells: probable involvement of small GTP-binding proteins. Biochem J 289: 379-385, 1993.
    • (1993) Biochem J , vol.289 , pp. 379-385
    • Li, G.1    Regazzi, R.2    Roche, E.3    Wollheim, C.B.4
  • 54
    • 0026808466 scopus 로고
    • Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells
    • Louis NA and Witters LA. Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells. J Biol Chem 267: 2287-2293, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 2287-2293
    • Louis, N.A.1    Witters, L.A.2
  • 56
    • 0019888328 scopus 로고
    • High content of mitochondrial glycerol 3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide
    • MacDonald MJ. High content of mitochondrial glycerol 3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. J Biol Chem 256: 8287-8290, 1981.
    • (1981) J Biol Chem , vol.256 , pp. 8287-8290
    • MacDonald, M.J.1
  • 57
    • 0020093110 scopus 로고
    • Evidence for the malate-asparate shuttle in pancreatic islets
    • MacDonald MJ. Evidence for the malate-asparate shuttle in pancreatic islets. Arch Biochem Biophys 213: 643-649, 1982.
    • (1982) Arch Biochem Biophys , vol.213 , pp. 643-649
    • MacDonald, M.J.1
  • 58
    • 0027234547 scopus 로고
    • Metabolism of the insulin secretagogue methyl succinate by pancreatic islets
    • MacDonald MJ. Metabolism of the insulin secretagogue methyl succinate by pancreatic islets. Arch Biochem Biophys 300: 201-205, 1993.
    • (1993) Arch Biochem Biophys , vol.300 , pp. 201-205
    • MacDonald, M.J.1
  • 59
    • 0027205593 scopus 로고
    • Estimates of glycolysis, pyruvate (de)carboxylation, pentose phosphate pathway and methyl succinate metabolism in incapacitated pancreatic islets
    • MacDonald MJ. Estimates of glycolysis, pyruvate (de)carboxylation, pentose phosphate pathway and methyl succinate metabolism in incapacitated pancreatic islets. Arch Biochem Biophys 305: 205-214, 1993.
    • (1993) Arch Biochem Biophys , vol.305 , pp. 205-214
    • MacDonald, M.J.1
  • 60
    • 0027686015 scopus 로고
    • Glucose enters mitochondrial metabolism via both carboxylation and decarboxylation of pyruvate in pancreatic islets
    • MacDonald MJ. Glucose enters mitochondrial metabolism via both carboxylation and decarboxylation of pyruvate in pancreatic islets. Metabolism 42: 1229-1231, 1993.
    • (1993) Metabolism , vol.42 , pp. 1229-1231
    • MacDonald, M.J.1
  • 61
    • 0029097424 scopus 로고
    • Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets: Further implication of cytosolic NADPH in insulin secretion
    • MacDonald MJ. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets: further implication of cytosolic NADPH in insulin secretion. J Biol Chem 270: 20051-20058, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 20051-20058
    • MacDonald, M.J.1
  • 62
    • 0029014451 scopus 로고
    • Influence of glucose on pyruvate carboxylase expression in pancreatic islets
    • MacDonald MJ. Influence of glucose on pyruvate carboxylase expression in pancreatic islets. Arch Biochem Biophys 319: 128-132, 1995.
    • (1995) Arch Biochem Biophys , vol.319 , pp. 128-132
    • MacDonald, M.J.1
  • 63
    • 0036326235 scopus 로고    scopus 로고
    • Differences between mouse and rat pancreatic islets: Succinate responsiveness, malic enzyme, and anaplerosis
    • MacDonald MJ. Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis. Am J Physiol Endocrinol Metab 283: E302-E310, 2002.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • MacDonald, M.J.1
  • 64
    • 0037413433 scopus 로고    scopus 로고
    • The export of metabolites from mitochondria and anaplerosis in insulin secretion
    • MacDonald MJ. The export of metabolites from mitochondria and anaplerosis in insulin secretion. Biochim Biophys Acta 1619: 77-88, 2002.
    • (2002) Biochim Biophys Acta , vol.1619 , pp. 77-88
    • MacDonald, M.J.1
  • 65
    • 0041885503 scopus 로고    scopus 로고
    • Export of metabolites from pancreatic islet mitochondria as a means to study anaplerosis in insulin secretion
    • MacDonald MJ. Export of metabolites from pancreatic islet mitochondria as a means to study anaplerosis in insulin secretion. Metabolism 52: 993-998, 2003.
    • (2003) Metabolism , vol.52 , pp. 993-998
    • MacDonald, M.J.1
  • 66
    • 0030840117 scopus 로고    scopus 로고
    • Oscillations in activities of enzymes in pancreatic islet subcellular fractions induced by physiological concentration of effectors
    • MacDonald MJ, Al-Masri H, Jumelle-Laclau M, and Cruz MO. Oscillations in activities of enzymes in pancreatic islet subcellular fractions induced by physiological concentration of effectors. Diabetes 46: 1996-2001, 1997.
    • (1997) Diabetes , vol.46 , pp. 1996-2001
    • MacDonald, M.J.1    Al-Masri, H.2    Jumelle-Laclau, M.3    Cruz, M.O.4
  • 67
    • 0016310157 scopus 로고
    • Failure of 6-aminonicotinamide to inhibit the potentiating effect of leucine and arginine on glucose-induced insulin release in vitro
    • MacDonald MJ, Ammon HPT, Patel TN, and Steinke J. Failure of 6-aminonicotinamide to inhibit the potentiating effect of leucine and arginine on glucose-induced insulin release in vitro. Diabetologia 10: 761-765, 1974.
    • (1974) Diabetologia , vol.10 , pp. 761-765
    • MacDonald, M.J.1    Ammon, H.P.T.2    Patel, T.N.3    Steinke, J.4
  • 68
    • 0021946270 scopus 로고
    • Do pancreatic islets contain significant amounts of phosphoenolpyruvate carboxykinase or ferroactivator activity?
    • MacDonald MJ and Chang CM. Do pancreatic islets contain significant amounts of phosphoenolpyruvate carboxykinase or ferroactivator activity? Diabetes 34: 246-250, 1985.
    • (1985) Diabetes , vol.34 , pp. 246-250
    • MacDonald, M.J.1    Chang, C.M.2
  • 69
    • 0029978571 scopus 로고    scopus 로고
    • Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat
    • MacDonald MJ, Efendic S, and Ostenson CG. Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. Diabetes 45: 886-890, 1996.
    • (1996) Diabetes , vol.45 , pp. 886-890
    • MacDonald, M.J.1    Efendic, S.2    Ostenson, C.G.3
  • 70
    • 0024268017 scopus 로고
    • Glyceraldehyde phosphate and methyl esters of succinic acid
    • Macdonald MJ and Fahien LA. Glyceraldehyde phosphate and methyl esters of succinic acid. Diabetes 37: 997-999, 1988.
    • (1988) Diabetes , vol.37 , pp. 997-999
    • Macdonald, M.J.1    Fahien, L.A.2
  • 71
    • 0025307819 scopus 로고
    • Insulin release in pancreatic islets by a glycolytic and a Krebs cycle intermediate: Contrasting patterns of glyceraldehyde phosphate and succinate
    • MacDonald MJ and Fahien LA. Insulin release in pancreatic islets by a glycolytic and a Krebs cycle intermediate: contrasting patterns of glyceraldehyde phosphate and succinate. Arch Biochem Biophys 279: 104-108, 1990.
    • (1990) Arch Biochem Biophys , vol.279 , pp. 104-108
    • MacDonald, M.J.1    Fahien, L.A.2
  • 72
    • 0034602141 scopus 로고    scopus 로고
    • Glutamate is not a messenger in insulin secretion
    • MacDonald MJ and Fahien LA. Glutamate is not a messenger in insulin secretion. J Biol Chem 275: 34025-34027, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 34025-34027
    • MacDonald, M.J.1    Fahien, L.A.2
  • 73
    • 0346434160 scopus 로고    scopus 로고
    • Citrate oscillates in liver and pancreatic beta cell mitochondria and INS-1 insulinoma cells
    • MacDonald MJ, Fahien LA, Buss JD, Hasan NM, Fallon MJ, and Kendrick MA. Citrate oscillates in liver and pancreatic beta cell mitochondria and INS-1 insulinoma cells. J Biol Chem 278: 51894-51900, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 51894-51900
    • MacDonald, M.J.1    Fahien, L.A.2    Buss, J.D.3    Hasan, N.M.4    Fallon, M.J.5    Kendrick, M.A.6
  • 74
    • 0025094103 scopus 로고
    • Novel effects of insulin secretagogues on capacitation of insulin release and survival of cultured pancreatic islets
    • MacDonald MJ, Fahien LA, McKenzie DI, and Moran SM. Novel effects of insulin secretagogues on capacitation of insulin release and survival of cultured pancreatic islets. Am J Physiol Endocrinol Metab 259: E548-E554, 1990.
    • (1990) Am J Physiol Endocrinol Metab , vol.259
    • MacDonald, M.J.1    Fahien, L.A.2    McKenzie, D.I.3    Moran, S.M.4
  • 75
    • 0024548920 scopus 로고
    • Effects of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets
    • MacDonald MJ, Fahien LA, Mertz RJ, and Rana RS. Effects of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets. Arch Biochem Biophys 269: 400-406, 1989.
    • (1989) Arch Biochem Biophys , vol.269 , pp. 400-406
    • MacDonald, M.J.1    Fahien, L.A.2    Mertz, R.J.3    Rana, R.S.4
  • 76
    • 0025721159 scopus 로고
    • Pyruvate dehydrogenase and pyruvate carboxylase. Sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets
    • MacDonald MJ, Kaysen JH, Moran SM, and Pomije CE. Pyruvate dehydrogenase and pyruvate carboxylase. Sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets. J Biol Chem 266: 22392-22397, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 22392-22397
    • MacDonald, M.J.1    Kaysen, J.H.2    Moran, S.M.3    Pomije, C.E.4
  • 77
    • 0034544579 scopus 로고    scopus 로고
    • +-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle
    • +-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle. Arch Biochem Biophys 384: 143-153, 2000.
    • (2000) Arch Biochem Biophys , vol.384 , pp. 143-153
    • MacDonald, M.J.1    Marshall, L.K.2
  • 78
    • 0034986712 scopus 로고    scopus 로고
    • +-linked glycerol phosphate dehydrogenase: Normal pancreatic beta cell function, but abnormal metabolite pattern in skeletal muscle
    • +-linked glycerol phosphate dehydrogenase: normal pancreatic beta cell function, but abnormal metabolite pattern in skeletal muscle. Mol Cell Biochem 220: 117-125, 2001.
    • (2001) Mol Cell Biochem , vol.220 , pp. 117-125
    • MacDonald, M.J.1    Marshall, L.K.2
  • 79
    • 0025967980 scopus 로고
    • Glucose regulates leucine-induced insulin release and the expression of the branched chain keto acid dehydrogenase E 1a subunit gene in pancreatic islets
    • MacDonald MJ, McKenzie DI, Kaysen JH, Walker TM, Moran SM, Fahien LA, and Towle HC. Glucose regulates leucine-induced insulin release and the expression of the branched chain keto acid dehydrogenase E1a subunit gene in pancreatic islets. J Biol Chem 266: 1335-1340, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 1335-1340
    • MacDonald, M.J.1    McKenzie, D.I.2    Kaysen, J.H.3    Walker, T.M.4    Moran, S.M.5    Fahien, L.A.6    Towle, H.C.7
  • 80
    • 0026546719 scopus 로고
    • Lack of glyconeogenesis in pancreatic islets: Expression of gluconeogenic enzyme genes in islets
    • MacDonald MJ, McKenzie DI, Walker TM, and Kaysen JH. Lack of glyconeogenesis in pancreatic islets: expression of gluconeogenic enzyme genes in islets. Horm Metab Res 24: 158-160, 1992.
    • (1992) Horm Metab Res , vol.24 , pp. 158-160
    • MacDonald, M.J.1    McKenzie, D.I.2    Walker, T.M.3    Kaysen, J.H.4
  • 81
    • 0029976878 scopus 로고    scopus 로고
    • Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats
    • MacDonald MJ, Tang J, and Polonsky KS. Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes 45: 1626-1630, 1996.
    • (1996) Diabetes , vol.45 , pp. 1626-1630
    • MacDonald, M.J.1    Tang, J.2    Polonsky, K.S.3
  • 82
    • 0037322531 scopus 로고    scopus 로고
    • Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic β-cells
    • MacDonald PE, Salapatek AM, and Wheeler MB. Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic β-cells. J Physiol 546: 647-653, 2003.
    • (2003) J Physiol , vol.546 , pp. 647-653
    • MacDonald, P.E.1    Salapatek, A.M.2    Wheeler, M.B.3
  • 83
    • 0036865991 scopus 로고    scopus 로고
    • Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic β-cells
    • Maechler P. Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic β-cells. Cell Mol Life Sci 59: 1803-18, 2002.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 1803-1818
    • Maechler, P.1
  • 84
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P and Wollheim CB. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402: 685-689, 1999.
    • (1999) Nature , vol.402 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 86
    • 0027408021 scopus 로고
    • Metabolic effects and fate of succinate esters in pancreatic islets
    • Malaisse WJ and Sener A. Metabolic effects and fate of succinate esters in pancreatic islets. Am J Physiol Endocrinol Metab 264: E434-E439, 1993.
    • (1993) Am J Physiol Endocrinol Metab , vol.264
    • Malaisse, W.J.1    Sener, A.2
  • 87
    • 0020317782 scopus 로고
    • The stimulus-secretion coupling of amino acid-induced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets
    • Malaisse-Lagae F, Sener A, Garcia-Morales P, Valverde I, and Malaisse WJ. The stimulus-secretion coupling of amino acid-induced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets. J Biol Chem 257: 3754-3758, 1982.
    • (1982) J Biol Chem , vol.257 , pp. 3754-3758
    • Malaisse-Lagae, F.1    Sener, A.2    Garcia-Morales, P.3    Valverde, I.4    Malaisse, W.J.5
  • 88
    • 0022467904 scopus 로고
    • Pancreatic islet glucose metabolism and regulation of insulin secretion
    • Meglasson MD and Matschinsky FM. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev 2: 163-214, 1986.
    • (1986) Diabetes Metab Rev , vol.2 , pp. 163-214
    • Meglasson, M.D.1    Matschinsky, F.M.2
  • 89
    • 0027364367 scopus 로고
    • Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins
    • Metz SA, Rabaglia M, Stock TB, and Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. Biochem J 295: 31-40, 1993.
    • (1993) Biochem J , vol.295 , pp. 31-40
    • Metz, S.A.1    Rabaglia, M.2    Stock, T.B.3    Kowluru, A.4
  • 90
    • 0035794185 scopus 로고    scopus 로고
    • Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) β-cells
    • Mulder H, Lu D, Finley IVJ, An J, Cohen J, Antinozzi PA, McGarry JD, and Newgard CB. Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) β-cells. J Biol Chem 276: 6479-6484, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 6479-6484
    • Mulder, H.1    Lu, D.2    Finley, I.V.J.3    An, J.4    Cohen, J.5    Antinozzi, P.A.6    McGarry, J.D.7    Newgard, C.B.8
  • 91
    • 0442307716 scopus 로고    scopus 로고
    • Constitutive nitric oxide synthases in rat pancreatic islets: Direct imaging of glucose-induced nitric oxide production in beta-cells
    • Nakada S, Ishikawa T, Yamamoto Y, Kaneko Y, and Nakayama K. Constitutive nitric oxide synthases in rat pancreatic islets: direct imaging of glucose-induced nitric oxide production in beta-cells. Pflügers Arch 447: 305-311, 2003.
    • (2003) Pflügers Arch , vol.447 , pp. 305-311
    • Nakada, S.1    Ishikawa, T.2    Yamamoto, Y.3    Kaneko, Y.4    Nakayama, K.5
  • 92
    • 0029071517 scopus 로고
    • Metabolic coupling factors in pancreatic β-cell signal transduction
    • Newgard C and McGarry J. Metabolic coupling factors in pancreatic β-cell signal transduction. Annu Rev Biochem 64: 689-719, 1995.
    • (1995) Annu Rev Biochem , vol.64 , pp. 689-719
    • Newgard, C.1    McGarry, J.2
  • 94
    • 0345146921 scopus 로고    scopus 로고
    • Reversible inactivation of α-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status
    • Nulton-Persson AC, Starke DW, Mieyal JJ, and Szweda LI. Reversible inactivation of α-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status. Biochemistry 42: 4235-4242, 2003.
    • (2003) Biochemistry , vol.42 , pp. 4235-4242
    • Nulton-Persson, A.C.1    Starke, D.W.2    Mieyal, J.J.3    Szweda, L.I.4
  • 95
    • 0019884090 scopus 로고
    • Topology of morphologically detectable protein and cholesterol in membranes of polypeptide-secreting cells
    • Orci L, Amherdt M, Montesano R, Vassalli P, and Perrelet A. Topology of morphologically detectable protein and cholesterol in membranes of polypeptide-secreting cells. Philos Trans R Soc Lond B Biol Sci 296: 47-54, 1981.
    • (1981) Philos Trans R Soc Lond B Biol Sci , vol.296 , pp. 47-54
    • Orci, L.1    Amherdt, M.2    Montesano, R.3    Vassalli, P.4    Perrelet, A.5
  • 96
    • 0029932643 scopus 로고    scopus 로고
    • New insights into pancreatic β-cell metabolic signaling in insulin secretion
    • Prentki M. New insights into pancreatic β-cell metabolic signaling in insulin secretion. Eur J Endocrinol 134: 272-286, 1996.
    • (1996) Eur J Endocrinol , vol.134 , pp. 272-286
    • Prentki, M.1
  • 97
    • 0026733643 scopus 로고
    • Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
    • Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, and Corkey BE. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 267: 5802-5803, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 5802-5803
    • Prentki, M.1    Vischer, S.2    Glennon, M.C.3    Regazzi, R.4    Deeney, J.T.5    Corkey, B.E.6
  • 98
    • 0141813781 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    • Rahman SM, Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, and Ntambi J. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci USA 100: 11110-11115, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.100 , pp. 11110-11115
    • Rahman, S.M.1    Dobrzyn, A.2    Dobrzyn, P.3    Lee, S.H.4    Miyazaki, M.5    Ntambi, J.6
  • 99
    • 0037196713 scopus 로고    scopus 로고
    • Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations
    • Ramanadham S, Zhang S, Ma Z, Wohltmann M, Bohrer A, Hsu FF, and Turk J. Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations. Biochim Biophys Acta 1580: 40-56, 2002.
    • (2002) Biochim Biophys Acta , vol.1580 , pp. 40-56
    • Ramanadham, S.1    Zhang, S.2    Ma, Z.3    Wohltmann, M.4    Bohrer, A.5    Hsu, F.F.6    Turk, J.7
  • 100
    • 0022362578 scopus 로고
    • Evidence for glucose-responsive and -unresponsive pools of phospholipid in pancreatic islets
    • Rana RS, Mertz RJ, Kowluru A, Dixon JF, Hokin LE, and MacDonald MJ. Evidence for glucose-responsive and -unresponsive pools of phospholipid in pancreatic islets. J Biol Chem 260: 7861-7867, 1985.
    • (1985) J Biol Chem , vol.260 , pp. 7861-7867
    • Rana, R.S.1    Mertz, R.J.2    Kowluru, A.3    Dixon, J.F.4    Hokin, L.E.5    MacDonald, M.J.6
  • 104
    • 77955093164 scopus 로고
    • Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid
    • Sener A, Malaisse-Lagae F, and Malaisse WJ. Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci USA 78: 5460-5464, 1981.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5460-5464
    • Sener, A.1    Malaisse-Lagae, F.2    Malaisse, W.J.3
  • 105
    • 0036720558 scopus 로고    scopus 로고
    • Oligonucleotide microarray analysis of intact human pancreatic islets: Identification of glucose-responsive genes and a highly regulated TGF beta signaling pathway
    • Shalev A, Pise-Masison CA, Radonovich M, Hoffman SC, Hirshberg B, Brady JN, and Harlan DM. Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGF beta signaling pathway. Endocrinology 148: 3695-3698, 2002.
    • (2002) Endocrinology , vol.148 , pp. 3695-3698
    • Shalev, A.1    Pise-Masison, C.A.2    Radonovich, M.3    Hoffman, S.C.4    Hirshberg, B.5    Brady, J.N.6    Harlan, D.M.7
  • 106
    • 0034029974 scopus 로고    scopus 로고
    • Molecular basis and characterization of the hyperinsulinism (hyperammonemic) syndrome
    • Stanley CA, Fang J, Kutyna K, Hsu BYL, Ming JE, Glaser B, and Poncz M. Molecular basis and characterization of the hyperinsulinism (hyperammonemic) syndrome. Diabetes 49: 667-673, 2000.
    • (2000) Diabetes , vol.49 , pp. 667-673
    • Stanley, C.A.1    Fang, J.2    Kutyna, K.3    Hsu, B.Y.L.4    Ming, J.E.5    Glaser, B.6    Poncz, M.7
  • 108
    • 0036868797 scopus 로고    scopus 로고
    • Glucose-stimulated signaling pathways in biphasic insulin secretion
    • Straub SG and Sharp GW. Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev 18: 451-463, 2002.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 451-463
    • Straub, S.G.1    Sharp, G.W.2
  • 109
    • 0036311248 scopus 로고    scopus 로고
    • The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion
    • Straub SG, Yajima H, Komatsu M, Aizawa T, and Sharp GW. The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion. Diabetes 51, Suppl 1: S91-S95, 2002.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Straub, S.G.1    Yajima, H.2    Komatsu, M.3    Aizawa, T.4    Sharp, G.W.5
  • 110
    • 0034709573 scopus 로고    scopus 로고
    • Transcriptional homeostatic control of membrane lipid composition
    • Thewke D, Kramer M, and Sinensky MS. Transcriptional homeostatic control of membrane lipid composition. Biochem Biophys Res Commun 278: 1-4, 2000.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 1-4
    • Thewke, D.1    Kramer, M.2    Sinensky, M.S.3
  • 111
    • 0030756468 scopus 로고    scopus 로고
    • Are metabolic oscillations responsible for normal oscillatory insulin secretion?
    • Tornheim K. Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes 46: 1375-1380, 1997.
    • (1997) Diabetes , vol.46 , pp. 1375-1380
    • Tornheim, K.1
  • 112
    • 0026010045 scopus 로고
    • Modulation by citrate of glycolytic oscillations in skeletal muscle extracts
    • Tornheim K, Andres V, and Schultz V. Modulation by citrate of glycolytic oscillations in skeletal muscle extracts. J Biol Chem 266: 15675-15678, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 15675-15678
    • Tornheim, K.1    Andres, V.2    Schultz, V.3
  • 113
    • 0014010701 scopus 로고
    • Paths of carbon in gluconeogenesis and lipogenesis. 3. The role and regulation of mitochondrial processes involved in supplying precursors of phosphoenolpyruvate
    • Walter P, Paetkau V, and Lardy HA. Paths of carbon in gluconeogenesis and lipogenesis. 3. The role and regulation of mitochondrial processes involved in supplying precursors of phosphoenolpyruvate. J Biol Chem 241: 2523-2532, 1966.
    • (1966) J Biol Chem , vol.241 , pp. 2523-2532
    • Walter, P.1    Paetkau, V.2    Lardy, H.A.3
  • 115
    • 0017754777 scopus 로고
    • Uptake of NADPH by islet secretion granule membranes
    • Watkins DT and Moore M. Uptake of NADPH by islet secretion granule membranes. Endocrinology 100: 1461-1467, 1977.
    • (1977) Endocrinology , vol.100 , pp. 1461-1467
    • Watkins, D.T.1    Moore, M.2
  • 116
    • 0004854859 scopus 로고
    • Regulation of the citric acid cycle in mammalian systems
    • Williamson JR and Cooper MH. Regulation of the citric acid cycle in mammalian systems. FEBS Lett 117, Suppl: K73-K85, 1980.
    • (1980) FEBS Lett , vol.117 , Issue.SUPPL.
    • Williamson, J.R.1    Cooper, M.H.2
  • 117
    • 0036311080 scopus 로고    scopus 로고
    • Beta-cell mitochondria and insulin secretion: Messenger role of nucleotides and metabolites
    • Wollheim CB and Maechler P. Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites. Diabetes 51: S37-S42, 2002.
    • (2002) Diabetes , vol.51
    • Wollheim, C.B.1    Maechler, P.2
  • 118
    • 0141973370 scopus 로고    scopus 로고
    • Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: A study in rat pancreatic islets
    • Yajima H, Komatsu M, Yamada S, Straub SG, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Sharp GW, and Aizawa T. Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets. Diabetes 49: 712-717, 2000.
    • (2000) Diabetes , vol.49 , pp. 712-717
    • Yajima, H.1    Komatsu, M.2    Yamada, S.3    Straub, S.G.4    Kaneko, T.5    Sato, Y.6    Yamauchi, K.7    Hashizume, K.8    Sharp, G.W.9    Aizawa, T.10
  • 119
    • 0344825833 scopus 로고    scopus 로고
    • Nutrient modulation of palmitoylated 24 kDa protein in rat pancreatic islets
    • Yamada S, Komatsu M, Sato Y, Yamauchi K, Aizawa T, and Kojima I. Nutrient modulation of palmitoylated 24 kDa protein in rat pancreatic islets. Endocrinology 144: 5232-5241, 2003.
    • (2003) Endocrinology , vol.144 , pp. 5232-5241
    • Yamada, S.1    Komatsu, M.2    Sato, Y.3    Yamauchi, K.4    Aizawa, T.5    Kojima, I.6
  • 121
    • 0027160176 scopus 로고
    • Comparative effects of monomethylsuccinate and glucose on insulin secretion from perifused rat islets
    • Zawalich WS, Zawalich KC, Cline G, Shulman G, and Rasmussen H. Comparative effects of monomethylsuccinate and glucose on insulin secretion from perifused rat islets. Diabetes 42: 843-850, 1993.
    • (1993) Diabetes , vol.42 , pp. 843-850
    • Zawalich, W.S.1    Zawalich, K.C.2    Cline, G.3    Shulman, G.4    Rasmussen, H.5


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