메뉴 건너뛰기




Volumn 22, Issue 5, 2004, Pages 759-761

Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: How do we go from INTACT to impact?

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GEFITINIB; TRASTUZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; QUINAZOLINE DERIVATIVE;

EID: 1542503756     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2004.12.903     Document Type: Editorial
Times cited : (69)

References (20)
  • 1
    • 1542503746 scopus 로고    scopus 로고
    • A phase III clinical trial of Gefitinib, an EGFR inhibitor, in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer (INTACT 1)
    • Giaccone G, Herbst RS, Manegold C, et al: A phase III clinical trial of Gefitinib, an EGFR inhibitor, in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer (INTACT 1). J Clin Oncol 22:777-784, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 2
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in Combination with Paclitaxel and Carboplatin in Chemotherapy-Naive Patients with Advanced Non-Small-Cell Lung Cancer: Results from a Phase III Clinical Trial (INTACT 2)
    • Herbst RS, Giaccone G, Schiller J, et al: Gefitinib in Combination With Paclitaxel and Carboplatin in Chemotherapy-Naive Patients With Advanced Non-Small-Cell Lung Cancer: Results from a Phase III Clinical Trial (INTACT 2). J Clin Oncol 22:785-794, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.3
  • 3
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • Fukuoka M, Yano S, Giaccone G. et al: Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21:2237-2246, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 4
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS, et al: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA 290:2149-2158, 2003
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 5
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, et al: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 6:2053-2063, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 6
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenographs is markedly enhanced by coadministration of ZD1839 (Iressa) an inhibitor of tyrosine kinase
    • Sirotnak FM, Zakowsky MF, Miller VA, et al: Efficacy of cytotoxic agents against human tumor xenographs is markedly enhanced by coadministration of ZD1839 (Iressa) an inhibitor of tyrosine kinase. Clin Cancer Res 6:4885-4892, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowsky, M.F.2    Miller, V.A.3
  • 7
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J: Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 21:2787-2799, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 8
    • 0242668485 scopus 로고    scopus 로고
    • Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving Gefitinib (Iressa, ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2
    • abstr LB-170
    • Bailey LR, Kris M, Wolf M, et al: Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving Gefitinib (Iressa, ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2. Proc Am Assoc Cancer Res 44, 2003 (abstr LB-170)
    • (2003) Proc Am Assoc Cancer Res , pp. 44
    • Bailey, L.R.1    Kris, M.2    Wolf, M.3
  • 9
    • 0037093249 scopus 로고    scopus 로고
    • Influence of unrecognized molecular heterogeneity on randomized clinical trials
    • Betensky RA, Louis DN, Cairncross JG: Influence of unrecognized molecular heterogeneity on randomized clinical trials. J Clin Oncol 20:2495-499, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 2495-2499
    • Betensky, R.A.1    Louis, D.N.2    Cairncross, J.G.3
  • 10
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D, et al: Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 17:2639-2648, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 11
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783-792, 2001
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 12
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D, et al: Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20:719-726, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 13
    • 0003203826 scopus 로고    scopus 로고
    • Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent: Initial results from intergroup trial 0100 (SWOG-8814)
    • abstr 143
    • Albain KS, Green SJ, Ravdin PM, et al: Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent: Initial results from intergroup trial 0100 (SWOG-8814). Proc Am Soc Clin Oncol 21, 2002 (abstr 143)
    • (2002) Proc Am Soc Clin Oncol , pp. 21
    • Albain, K.S.1    Green, S.J.2    Ravdin, P.M.3
  • 14
    • 18844386944 scopus 로고    scopus 로고
    • Pulsatile administration of the EGF receptor inhibitor (Iressa, ZD1839) is significantly more effective that continuosly dosing for sensitizing tumors to Taxol
    • abstr 83
    • Solit DB, She Y, Moasser M, et al: Pulsatile administration of the EGF receptor inhibitor (Iressa, ZD1839) is significantly more effective that continuosly dosing for sensitizing tumors to Taxol. AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics, 2003 (abstr 83)
    • (2003) AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics
    • Solit, D.B.1    She, Y.2    Moasser, M.3
  • 15
    • 0038140033 scopus 로고    scopus 로고
    • Cetuximab (C225) in combination with cisplatin/vinorelbine alone in the first-line treatment of patients with epidermal growth factor (EGFR) positive advanced non-small-cell lung cancer (NSCLC)
    • abstr 2582
    • Gatzemeier U, Rosell R, Ramlau R, et al: Cetuximab (C225) in combination with cisplatin/vinorelbine alone in the first-line treatment of patients with epidermal growth factor (EGFR) positive advanced non-small-cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 22:642, 2003 (abstr 2582)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 642
    • Gatzemeier, U.1    Rosell, R.2    Ramlau, R.3
  • 16
    • 0037862765 scopus 로고    scopus 로고
    • Cetuximab (Erbitux) in combination with irinotecan or as single agent in patients with EGFR-expressing, irinotecan-refractory metastatic colorectal cancer
    • abstr 1012
    • Cunningham D, Humblet Y, Siena S, et al: Cetuximab (Erbitux) in combination with irinotecan or as single agent in patients with EGFR-expressing, irinotecan-refractory metastatic colorectal cancer. Proc Am Soc Clin Oncol 22:252, 2003 (abstr 1012)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 252
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 17
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van't Veer LJ, et al: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347:1999-2009, 2002
    • (2002) N Engl J Med , vol.347 , pp. 1999-2009
    • Van De Vijver, M.J.1    He, Y.D.2    Van't Veer, L.J.3
  • 18
    • 0041301731 scopus 로고    scopus 로고
    • Emerging science: Prospective validation of gene expression profiling-based prediction of complete pathologic response to neoadjuvant paclitaxel/FAC chemotherapy in breast cancer
    • abstr 1
    • Pusztai L, Ayers M, Simmans FW, et al: Emerging science: Prospective validation of gene expression profiling-based prediction of complete pathologic response to neoadjuvant paclitaxel/FAC chemotherapy in breast cancer. Proc Am Soc Clin Oncol 22:1, 2003 (abstr 1)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 1
    • Pusztai, L.1    Ayers, M.2    Simmans, F.W.3
  • 19
    • 0347615106 scopus 로고    scopus 로고
    • A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with advanced tumors
    • abstr 770
    • Tabernero J, RoJo F, Jimenez E, et al: A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with advanced tumors. Proc Am Soc Clin Oncol 22:172, 2003 (abstr 770)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 172
    • Tabernero, J.1    RoJo, F.2    Jimenez, E.3
  • 20
    • 0347910287 scopus 로고    scopus 로고
    • Quantitative gene expression in non-small-cell lung cancer from paraffin-embedded tissue specimens: Predicting response to gefitinib, an EGFR kinase inhibitor
    • abstr 763
    • Natale RB, Shak S, Aronson N, et al: Quantitative gene expression in non-small-cell lung cancer from paraffin-embedded tissue specimens: Predicting response to gefitinib, an EGFR kinase inhibitor. Proc Am Soc Clin Oncol 22:170, 2003 (abstr 763)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 170
    • Natale, R.B.1    Shak, S.2    Aronson, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.