메뉴 건너뛰기




Volumn 204, Issue 2, 2004, Pages 197-211

RET and neuroendocrine tumors

Author keywords

cAMP; FMTC; FRS2; GDNF; GDNF family receptor ; Lamellidodia; Lipid rafts; Medullary thyroid carcinoma; MEN 2A; MEN 2B; Papillary thyroid carcinoma; Pheochromocytoma; Protein kinase A; Rai; RET; RET PTC; SHC; Signaling pathway; Tyrosine kinase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN RET; PROTEIN TYROSINE KINASE; RAS PROTEIN; SYNAPTOPHYSIN;

EID: 0842330656     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(03)00456-7     Document Type: Article
Times cited : (170)

References (130)
  • 1
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, ret, by DNA rearrangement
    • Takahashi M., Ritz J., Cooper G.M. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell. 42:1985;581-588.
    • (1985) Cell , vol.42 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 2
    • 0023158426 scopus 로고
    • Ret transforming gene encodes a fusion protein homologous to tyrosine kinases
    • Takahashi M., Cooper G.M. Ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol. Cell Biol. 7:1987;1378-1385.
    • (1987) Mol. Cell Biol. , vol.7 , pp. 1378-1385
    • Takahashi, M.1    Cooper, G.M.2
  • 3
    • 0024202787 scopus 로고
    • Structure and expression of the ret transforming gene
    • Takahashi M. Structure and expression of the ret transforming gene. IARC Sci. Publ. 1988;189-197.
    • (1988) IARC Sci. Publ. , pp. 189-197
    • Takahashi, M.1
  • 4
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    • Schuchardt A., D'Agati V., Larsson-Blomberg L., Costantini F., Pachnis V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature. 367:1994;380-383.
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1    D'Agati, V.2    Larsson-Blomberg, L.3    Costantini, F.4    Pachnis, V.5
  • 7
    • 0034764503 scopus 로고    scopus 로고
    • RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons
    • Enomoto H., Crawford P.A., Gorodinsky A., Heuckeroth R.O., Johnson E.M. Jr., Milbrandt J. RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development. 128:2001;3963-3974.
    • (2001) Development , vol.128 , pp. 3963-3974
    • Enomoto, H.1    Crawford, P.A.2    Gorodinsky, A.3    Heuckeroth, R.O.4    Johnson Jr., E.M.5    Milbrandt, J.6
  • 9
    • 0027231568 scopus 로고
    • Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    • Mulligan L.M., Kwok J.B., Healey C.S., Elsdon M.J., Eng C., Gardner E., et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature. 363:1993;458-460.
    • (1993) Nature , vol.363 , pp. 458-460
    • Mulligan, L.M.1    Kwok, J.B.2    Healey, C.S.3    Elsdon, M.J.4    Eng, C.5    Gardner, E.6
  • 11
    • 0028174024 scopus 로고
    • A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
    • Hofstra R.M., Landsvater R.M., Ceccherini I., Stulp R.P., Stelwagen T., Luo Y., et al. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature. 367:1994;375-376.
    • (1994) Nature , vol.367 , pp. 375-376
    • Hofstra, R.M.1    Landsvater, R.M.2    Ceccherini, I.3    Stulp, R.P.4    Stelwagen, T.5    Luo, Y.6
  • 13
    • 0028120882 scopus 로고
    • Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease
    • Romeo G., Ronchetto P., Luo Y., Barone V., Seri M., Ceccherini I., et al. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature. 367:1994;377-378.
    • (1994) Nature , vol.367 , pp. 377-378
    • Romeo, G.1    Ronchetto, P.2    Luo, Y.3    Barone, V.4    Seri, M.5    Ceccherini, I.6
  • 15
    • 0024208663 scopus 로고
    • Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
    • Takahashi M., Buma Y., Iwamoto T., Inaguma Y., Ikeda H., Hiai H. Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. 3:1988;571-578.
    • (1988) Oncogene , vol.3 , pp. 571-578
    • Takahashi, M.1    Buma, Y.2    Iwamoto, T.3    Inaguma, Y.4    Ikeda, H.5    Hiai, H.6
  • 16
    • 0024323273 scopus 로고
    • Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence
    • Takahashi M., Buma Y., Hiai H. Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence. Oncogene. 4:1989;805-806.
    • (1989) Oncogene , vol.4 , pp. 805-806
    • Takahashi, M.1    Buma, Y.2    Hiai, H.3
  • 17
    • 0027407552 scopus 로고
    • CDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily
    • Iwamoto T., Taniguchi M., Asai N., Ohkusu K., Nakashima I., Takahashi M. cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. Oncogene. 8:1993;1087-1091.
    • (1993) Oncogene , vol.8 , pp. 1087-1091
    • Iwamoto, T.1    Taniguchi, M.2    Asai, N.3    Ohkusu, K.4    Nakashima, I.5    Takahashi, M.6
  • 19
    • 0025164766 scopus 로고
    • Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line
    • Tahira T., Ishizaka Y., Itoh F., Sugimura T., Nagao M. Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. Oncogene. 5:1990;97-102.
    • (1990) Oncogene , vol.5 , pp. 97-102
    • Tahira, T.1    Ishizaka, Y.2    Itoh, F.3    Sugimura, T.4    Nagao, M.5
  • 20
    • 0028862490 scopus 로고
    • Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: A novel C-terminus for RET
    • Myers S.M., Eng C., Ponder B.A., Mulligan L.M. Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: a novel C-terminus for RET. Oncogene. 11:1995;2039-2045.
    • (1995) Oncogene , vol.11 , pp. 2039-2045
    • Myers, S.M.1    Eng, C.2    Ponder, B.A.3    Mulligan, L.M.4
  • 23
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin L.F., Doherty D.H., Lile J.D., Bektesh S., Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260:1993;1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 31
    • 0027374562 scopus 로고
    • Expression of the c-ret proto-oncogene during mouse embryogenesis
    • Pachnis V., Mankoo B., Costantini F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development. 119:1993;1005-1017.
    • (1993) Development , vol.119 , pp. 1005-1017
    • Pachnis, V.1    Mankoo, B.2    Costantini, F.3
  • 32
    • 0028896367 scopus 로고
    • Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues
    • Tsuzuki T., Takahashi M., Asai N., Iwashita T., Matsuyama M., Asai J. Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene. 10:1995;191-198.
    • (1995) Oncogene , vol.10 , pp. 191-198
    • Tsuzuki, T.1    Takahashi, M.2    Asai, N.3    Iwashita, T.4    Matsuyama, M.5    Asai, J.6
  • 33
    • 0030915959 scopus 로고    scopus 로고
    • Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS
    • Trupp M., Belluardo N., Funakoshi H., Ibanez C.F. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17:1997;3554-3567.
    • (1997) J. Neurosci. , vol.17 , pp. 3554-3567
    • Trupp, M.1    Belluardo, N.2    Funakoshi, H.3    Ibanez, C.F.4
  • 34
    • 0032522908 scopus 로고    scopus 로고
    • A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury
    • Bennett D.L., Michael G.J., Ramachandran N., Munson J.B., Averill S., Yan Q., McMahon S.B., Priestley J.V. A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J. Neurosci. 18:1998;3059-3072.
    • (1998) J. Neurosci. , vol.18 , pp. 3059-3072
    • Bennett, D.L.1    Michael, G.J.2    Ramachandran, N.3    Munson, J.B.4    Averill, S.5    Yan, Q.6    McMahon, S.B.7    Priestley, J.V.8
  • 35
    • 0025178894 scopus 로고
    • Specific expression of the ret proto-oncogene in human neuroblastoma cell lines
    • Ikeda I., Ishizaka Y., Tahira T., Suzuki T., Onda M., Sugimura T., Nagao M. Specific expression of the ret proto-oncogene in human neuroblastoma cell lines. Oncogene. 5:1990;1291-1296.
    • (1990) Oncogene , vol.5 , pp. 1291-1296
    • Ikeda, I.1    Ishizaka, Y.2    Tahira, T.3    Suzuki, T.4    Onda, M.5    Sugimura, T.6    Nagao, M.7
  • 36
    • 0025000865 scopus 로고
    • The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas
    • Santoro M., Rosati R., Grieco M., Berlingieri M.T., D'Amato G.L., de Franciscis V., Fusco A. The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas. Oncogene. 5:1990;1595-1598.
    • (1990) Oncogene , vol.5 , pp. 1595-1598
    • Santoro, M.1    Rosati, R.2    Grieco, M.3    Berlingieri, M.T.4    D'Amato, G.L.5    De Franciscis, V.6    Fusco, A.7
  • 37
    • 0026092489 scopus 로고
    • Identification of the ret proto-oncogene products in neuroblastoma and leukemia cells
    • Takahashi M., Buma Y., Taniguchi M. Identification of the ret proto-oncogene products in neuroblastoma and leukemia cells. Oncogene. 6:1991;297-301.
    • (1991) Oncogene , vol.6 , pp. 297-301
    • Takahashi, M.1    Buma, Y.2    Taniguchi, M.3
  • 38
    • 0030065375 scopus 로고    scopus 로고
    • Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts
    • Durbec P.L., Larsson-Blomberg L.B., Schuchardt A., Costantini F., Pachnis V. Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development. 122:1996;349-358.
    • (1996) Development , vol.122 , pp. 349-358
    • Durbec, P.L.1    Larsson-Blomberg, L.B.2    Schuchardt, A.3    Costantini, F.4    Pachnis, V.5
  • 39
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • Airaksinen M.S., Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat. Rev. Neurosci. 3:2002;383-394.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 41
    • 0037103913 scopus 로고    scopus 로고
    • RET receptor tyrosine kinase isoforms in kidney function and disease
    • Lee D.C., Chan K.W., Chan S.Y. RET receptor tyrosine kinase isoforms in kidney function and disease. Oncogene. 21:2002;5582-5592.
    • (2002) Oncogene , vol.21 , pp. 5582-5592
    • Lee, D.C.1    Chan, K.W.2    Chan, S.Y.3
  • 45
    • 0029893933 scopus 로고    scopus 로고
    • A mutation at tyrosine 1062 in MEN 2A-Ret and MEN 2B-Ret impairs their transforming activity and association with shc adaptor proteins
    • Asai N., Murakami H., Iwashita T., Takahashi M. A mutation at tyrosine 1062 in MEN 2A-Ret and MEN 2B-Ret impairs their transforming activity and association with shc adaptor proteins. J. Biol. Chem. 271:1996;17644-17649.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17644-17649
    • Asai, N.1    Murakami, H.2    Iwashita, T.3    Takahashi, M.4
  • 48
    • 0031038795 scopus 로고    scopus 로고
    • RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
    • Lorenzo M.J., Gish G.D., Houghton C., Stonehouse T.J., Pawson T., Ponder B.A., Smith D.P. RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2. Oncogene. 14:1997;763-771.
    • (1997) Oncogene , vol.14 , pp. 763-771
    • Lorenzo, M.J.1    Gish, G.D.2    Houghton, C.3    Stonehouse, T.J.4    Pawson, T.5    Ponder, B.A.6    Smith, D.P.7
  • 50
    • 0031924319 scopus 로고    scopus 로고
    • Shc and Enigma are both required for mitogenic signaling by Ret/ptc2
    • Durick K., Gill G.N., Taylor S.S. Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Mol. Cell Biol. 18:1998;2298-2308.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 2298-2308
    • Durick, K.1    Gill, G.N.2    Taylor, S.S.3
  • 51
    • 0028982261 scopus 로고
    • The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10
    • Pandey A., Duan H., Di Fiore P.P., Dixit V.M. The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. J. Biol. Chem. 270:1995;21461-21463.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21461-21463
    • Pandey, A.1    Duan, H.2    Di Fiore, P.P.3    Dixit, V.M.4
  • 52
    • 0032241463 scopus 로고    scopus 로고
    • Signal transduction by the receptor tyrosine kinase Ret
    • van Weering D.H., Bos J.L. Signal transduction by the receptor tyrosine kinase Ret. Recent Results Cancer Res. 154:1998;271-281.
    • (1998) Recent Results Cancer Res. , vol.154 , pp. 271-281
    • Van Weering, D.H.1    Bos, J.L.2
  • 54
    • 0029846514 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase
    • Worby C.A., Vega Q.C., Zhao Y., Chao H.H., Seasholtz A.F., Dixon J.E. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J. Biol. Chem. 271:1996;23619-23622.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23619-23622
    • Worby, C.A.1    Vega, Q.C.2    Zhao, Y.3    Chao, H.H.4    Seasholtz, A.F.5    Dixon, J.E.6
  • 55
    • 0031034813 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation
    • van Weering D.H., Bos J.L. Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation. J. Biol. Chem. 272:1997;249-254.
    • (1997) J. Biol. Chem. , vol.272 , pp. 249-254
    • Van Weering, D.H.1    Bos, J.L.2
  • 56
    • 0032570866 scopus 로고    scopus 로고
    • Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells
    • Xing S., Furminger T.L., Tong Q., Jhiang S.M. Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells. J. Biol. Chem. 273:1998;4909-4914.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4909-4914
    • Xing, S.1    Furminger, T.L.2    Tong, Q.3    Jhiang, S.M.4
  • 58
    • 0033580391 scopus 로고    scopus 로고
    • Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase
    • Murakami H., Iwashita T., Asai N., Iwata Y., Narumiya S., Takahashi M. Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase. Oncogene. 18:1999;1975-1982.
    • (1999) Oncogene , vol.18 , pp. 1975-1982
    • Murakami, H.1    Iwashita, T.2    Asai, N.3    Iwata, Y.4    Narumiya, S.5    Takahashi, M.6
  • 59
    • 0033584474 scopus 로고    scopus 로고
    • Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signaling molecules mediated by ret with the MEN 2B mutation
    • Murakami H., Iwashita T., Asai N., Shimono Y., Iwata Y., Kawai K., Takahashi M. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signaling molecules mediated by ret with the MEN 2B mutation. Biochem. Biophys. Res. Commun. 262:1999;68-75.
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 68-75
    • Murakami, H.1    Iwashita, T.2    Asai, N.3    Shimono, Y.4    Iwata, Y.5    Kawai, K.6    Takahashi, M.7
  • 61
    • 0033597817 scopus 로고    scopus 로고
    • Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
    • Trupp M., Scott R., Whittemore S.R., Ibanez C.F. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J. Biol. Chem. 274:1999;20885-20894.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20885-20894
    • Trupp, M.1    Scott, R.2    Whittemore, S.R.3    Ibanez, C.F.4
  • 62
    • 0033232936 scopus 로고    scopus 로고
    • Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
    • Soler R.M., Dolcet X., Encinas M., Egea J., Bayascas J.R., Comella J.X. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. J. Neurosci. 19:1999;9160-9169.
    • (1999) J. Neurosci. , vol.19 , pp. 9160-9169
    • Soler, R.M.1    Dolcet, X.2    Encinas, M.3    Egea, J.4    Bayascas, J.R.5    Comella, J.X.6
  • 63
    • 0033063448 scopus 로고    scopus 로고
    • Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons
    • Feng L., Wang C.Y., Jiang H., Oho C., Dugich-Djordjevic M., Mei L., Lu B. Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons. Neuroscience. 93:1999;265-273.
    • (1999) Neuroscience , vol.93 , pp. 265-273
    • Feng, L.1    Wang, C.Y.2    Jiang, H.3    Oho, C.4    Dugich-Djordjevic, M.5    Mei, L.6    Lu, B.7
  • 64
    • 0034603172 scopus 로고    scopus 로고
    • Transforming ability of MEN 2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
    • Segouffin-Cariou C., Billaud M. Transforming ability of MEN 2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway. J. Biol. Chem. 275:2000;3568-3576.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3568-3576
    • Segouffin-Cariou, C.1    Billaud, M.2
  • 66
    • 0034671913 scopus 로고    scopus 로고
    • Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
    • Besset V., Scott R.P., Ibanez C.F. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J. Biol. Chem. 275:2000;39159-39166.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39159-39166
    • Besset, V.1    Scott, R.P.2    Ibanez, C.F.3
  • 70
    • 0036788763 scopus 로고    scopus 로고
    • The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway
    • Pelicci G., Troglio F., Bodini A., Melillo R.M., Pettirossi V., Coda L., De Giuseppe A., Santoro M., Pelicci P.G. The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. Mol. Cell Biol. 22:2002;7351-7363.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 7351-7363
    • Pelicci, G.1    Troglio, F.2    Bodini, A.3    Melillo, R.M.4    Pettirossi, V.5    Coda, L.6    De Giuseppe, A.7    Santoro, M.8    Pelicci, P.G.9
  • 71
    • 0029961705 scopus 로고    scopus 로고
    • A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain
    • O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc. Natl Acad. Sci. USA. 93:1996;2729-2734.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 2729-2734
    • O'Bryan, J.P.1    Songyang, Z.2    Cantley, L.3    Der, C.J.4    Pawson, T.5
  • 72
    • 0034520582 scopus 로고    scopus 로고
    • The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons
    • Sakai R., Henderson J.T., O'Bryan J.P., Elia A.J., Saxton T.M., Pawson T. The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron. 28:2000;819-833.
    • (2000) Neuron , vol.28 , pp. 819-833
    • Sakai, R.1    Henderson, J.T.2    O'Bryan, J.P.3    Elia, A.J.4    Saxton, T.M.5    Pawson, T.6
  • 73
    • 0032421354 scopus 로고    scopus 로고
    • Functions of lipid rafts in biological membranes
    • Brown D.A., London E. Functions of lipid rafts in biological membranes. Annu. Rev. Cell. Dev. Biol. 14:1998;111-136.
    • (1998) Annu. Rev. Cell. Dev. Biol. , vol.14 , pp. 111-136
    • Brown, D.A.1    London, E.2
  • 74
    • 0031692336 scopus 로고    scopus 로고
    • The caveolae membrane system
    • Anderson R.G. The caveolae membrane system. Annu. Rev. Biochem. 67:1998;199-225.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 199-225
    • Anderson, R.G.1
  • 75
    • 0035280141 scopus 로고    scopus 로고
    • Secretory granule biogenesis: Rafting to the SNARE
    • Tooze S.A., Martens G.J., Huttner W.B. Secretory granule biogenesis: rafting to the SNARE. Trends Cell Biol. 11:2001;116-122.
    • (2001) Trends Cell Biol. , vol.11 , pp. 116-122
    • Tooze, S.A.1    Martens, G.J.2    Huttner, W.B.3
  • 76
    • 0035826795 scopus 로고    scopus 로고
    • A fluid connection: Cholesterol and Abeta
    • Wolozin B. A fluid connection: cholesterol and Abeta. Proc. Natl Acad. Sci. USA. 98:2001;5371-5373.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5371-5373
    • Wolozin, B.1
  • 78
    • 0033625038 scopus 로고    scopus 로고
    • GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival
    • Tansey M.G., Baloh R.H., Milbrandt J., Johnson E.M. Jr. GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron. 25:2000;611-623.
    • (2000) Neuron , vol.25 , pp. 611-623
    • Tansey, M.G.1    Baloh, R.H.2    Milbrandt, J.3    Johnson Jr., E.M.4
  • 79
    • 0034746376 scopus 로고    scopus 로고
    • Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts
    • Paratcha G., Ledda F., Baars L., Coulpier M., Besset V., Anders J., Scott R., Ibanez C.F. Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. Neuron. 29:2001;171-184.
    • (2001) Neuron , vol.29 , pp. 171-184
    • Paratcha, G.1    Ledda, F.2    Baars, L.3    Coulpier, M.4    Besset, V.5    Anders, J.6    Scott, R.7    Ibanez, C.F.8
  • 80
    • 0029801365 scopus 로고    scopus 로고
    • Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways
    • Engele J., Franke B. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell Tissue Res. 286:1996;235-240.
    • (1996) Cell Tissue Res. , vol.286 , pp. 235-240
    • Engele, J.1    Franke, B.2
  • 81
    • 17344369235 scopus 로고    scopus 로고
    • Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro
    • Hanson M.G. Jr., Shen S., Wiemelt A.P., McMorris F.A., Barres B.A. Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J. Neurosci. 18:1998;7361-7371.
    • (1998) J. Neurosci. , vol.18 , pp. 7361-7371
    • Hanson Jr., M.G.1    Shen, S.2    Wiemelt, A.P.3    McMorris, F.A.4    Barres, B.A.5
  • 82
    • 0032960457 scopus 로고    scopus 로고
    • Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism
    • Cai D., Shen Y., De Bellard M., Tang S., Filbin M.T. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron. 22:1999;89-101.
    • (1999) Neuron , vol.22 , pp. 89-101
    • Cai, D.1    Shen, Y.2    De Bellard, M.3    Tang, S.4    Filbin, M.T.5
  • 83
    • 0030877318 scopus 로고    scopus 로고
    • CAMP-induced switching in turning direction of nerve growth cones
    • Song H.J., Ming G.L., Poo M.M. cAMP-induced switching in turning direction of nerve growth cones. Nature. 388:1997;275-279.
    • (1997) Nature , vol.388 , pp. 275-279
    • Song, H.J.1    Ming, G.L.2    Poo, M.M.3
  • 84
    • 0037166286 scopus 로고    scopus 로고
    • Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase
    • Fukuda T., Kiuchi K., Takahashi M. Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase. J. Biol. Chem. 277:2002;19114-19121.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19114-19121
    • Fukuda, T.1    Kiuchi, K.2    Takahashi, M.3
  • 85
    • 0032403377 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons
    • Krieglstein K., Henheik P., Farkas L., Jaszai J., Galter D., Krohn K., Unsicker K. Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons. J. Neurosci. 18:1998;9822-9834.
    • (1998) J. Neurosci. , vol.18 , pp. 9822-9834
    • Krieglstein, K.1    Henheik, P.2    Farkas, L.3    Jaszai, J.4    Galter, D.5    Krohn, K.6    Unsicker, K.7
  • 86
    • 0033559397 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo
    • Schober A., Hertel R., Arumae U., Farkas L., Jaszai J., Krieglstein K., Saarma M., Unsicker K. Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo. J. Neurosci. 19:1999;2008-2015.
    • (1999) J. Neurosci. , vol.19 , pp. 2008-2015
    • Schober, A.1    Hertel, R.2    Arumae, U.3    Farkas, L.4    Jaszai, J.5    Krieglstein, K.6    Saarma, M.7    Unsicker, K.8
  • 87
    • 0037078123 scopus 로고    scopus 로고
    • TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane
    • Peterziel H., Unsicker K., Krieglstein K. TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane. J. Cell. Biol. 159:2002;157-167.
    • (2002) J. Cell. Biol. , vol.159 , pp. 157-167
    • Peterziel, H.1    Unsicker, K.2    Krieglstein, K.3
  • 88
    • 0037122878 scopus 로고    scopus 로고
    • NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons
    • Tsui-Pierchala B.A., Milbrandt J., Johnson E.M. Jr. NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons. Neuron. 33:2002;261-273.
    • (2002) Neuron , vol.33 , pp. 261-273
    • Tsui-Pierchala, B.A.1    Milbrandt, J.2    Johnson Jr., E.M.3
  • 89
    • 0034693757 scopus 로고    scopus 로고
    • The RET proto-oncogene in human cancers
    • Jhiang S.M. The RET proto-oncogene in human cancers. Oncogene. 19:2000;5590-5597.
    • (2000) Oncogene , vol.19 , pp. 5590-5597
    • Jhiang, S.M.1
  • 90
    • 0034213402 scopus 로고    scopus 로고
    • Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma
    • Salassidis K., Bruch J., Zitzelsberger H., Lengfelder E., Kellerer A.M., Bauchinger M. Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma. Cancer Res. 60:2000;2786-2789.
    • (2000) Cancer Res. , vol.60 , pp. 2786-2789
    • Salassidis, K.1    Bruch, J.2    Zitzelsberger, H.3    Lengfelder, E.4    Kellerer, A.M.5    Bauchinger, M.6
  • 91
    • 0034671411 scopus 로고    scopus 로고
    • A novel type of RET rearrangement (PTC8) in childhood papillary thyroid carcinomas and characterization of the involved gene (RFG8)
    • Klugbauer S., Jauch A., Lengfelder E., Demidchik E., Rabes H.M. A novel type of RET rearrangement (PTC8) in childhood papillary thyroid carcinomas and characterization of the involved gene (RFG8). Cancer Res. 60:2000;7028-7032.
    • (2000) Cancer Res. , vol.60 , pp. 7028-7032
    • Klugbauer, S.1    Jauch, A.2    Lengfelder, E.3    Demidchik, E.4    Rabes, H.M.5
  • 92
    • 0034849573 scopus 로고    scopus 로고
    • The GDNF/RET signaling pathway and human diseases
    • Takahashi M. The GDNF/RET signaling pathway and human diseases. Cytokine Growth Factor Rev. 12:2001;361-373.
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 361-373
    • Takahashi, M.1
  • 93
    • 0035952364 scopus 로고    scopus 로고
    • Thyroid cancer
    • Gimm O. Thyroid cancer. Cancer Lett. 163:2001;143-156.
    • (2001) Cancer Lett. , vol.163 , pp. 143-156
    • Gimm, O.1
  • 95
    • 85047697611 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1)
    • Baldassarre G., Bruni P., Boccia A., Salvatore G., Melillo R.M., Motti M.L., Napolitano M., Belletti B., Fusco A., Santoro M., Viglietto G. Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1). Oncogene. 21:2002;1739-1749.
    • (2002) Oncogene , vol.21 , pp. 1739-1749
    • Baldassarre, G.1    Bruni, P.2    Boccia, A.3    Salvatore, G.4    Melillo, R.M.5    Motti, M.L.6    Napolitano, M.7    Belletti, B.8    Fusco, A.9    Santoro, M.10    Viglietto, G.11
  • 96
    • 0032894774 scopus 로고    scopus 로고
    • RET proto-oncogene in the development of human cancer
    • Eng C. RET proto-oncogene in the development of human cancer. J. Clin. Oncol. 17:1999;380-393.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 380-393
    • Eng, C.1
  • 97
    • 0028881998 scopus 로고
    • Genotype-phenotype correlation in multiple endocrine neoplasia type 2: Report of the International RET Mutation Consortium
    • Mulligan L.M., Marsh D.J., Robinson B.G., Schuffenecker I., Zedenius J., Lips C.J., et al. Genotype-phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium. J. Intern. Med. 238:1995;343-346.
    • (1995) J. Intern. Med. , vol.238 , pp. 343-346
    • Mulligan, L.M.1    Marsh, D.J.2    Robinson, B.G.3    Schuffenecker, I.4    Zedenius, J.5    Lips, C.J.6
  • 98
    • 4644256817 scopus 로고    scopus 로고
    • The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
    • Eng C., Clayton D., Schuffenecker I., Lenoir G., Cote G., Gagel R.F., et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA. 276:1996;1575-1579.
    • (1996) JAMA , vol.276 , pp. 1575-1579
    • Eng, C.1    Clayton, D.2    Schuffenecker, I.3    Lenoir, G.4    Cote, G.5    Gagel, R.F.6
  • 99
    • 0030981891 scopus 로고    scopus 로고
    • A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A
    • Hoppner W., Ritter M.M. A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A. Hum. Mol. Genet. 6:1997;587-590.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 587-590
    • Hoppner, W.1    Ritter, M.M.2
  • 100
    • 0031984908 scopus 로고    scopus 로고
    • Duplication of 9 base pairs in the critical cysteine-rich domain of the RET proto-oncogene causes multiple endocrine neoplasia type 2A
    • Hoppner W., Dralle H., Brabant G. Duplication of 9 base pairs in the critical cysteine-rich domain of the RET proto-oncogene causes multiple endocrine neoplasia type 2A. Hum. Mutat. (Suppl 1):1998;S128-S130.
    • (1998) Hum. Mutat. , Issue.1 SUPPL
    • Hoppner, W.1    Dralle, H.2    Brabant, G.3
  • 102
    • 0033045514 scopus 로고    scopus 로고
    • Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation
    • Miyauchi A., Futami H., Hai N., Yokozawa T., Kuma K., Aoki N., Kosugi S., Sugano K., Yamaguchi K. Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation. Jpn J. Cancer Res. 90:1999;1-5.
    • (1999) Jpn J. Cancer Res. , vol.90 , pp. 1-5
    • Miyauchi, A.1    Futami, H.2    Hai, N.3    Yokozawa, T.4    Kuma, K.5    Aoki, N.6    Kosugi, S.7    Sugano, K.8    Yamaguchi, K.9
  • 104
    • 0028838086 scopus 로고
    • Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
    • Asai N., Iwashita T., Matsuyama M., Takahashi M. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol. Cell Biol. 15:1995;1613-1619.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 1613-1619
    • Asai, N.1    Iwashita, T.2    Matsuyama, M.3    Takahashi, M.4
  • 105
    • 0028914683 scopus 로고
    • Activation of RET as a dominant transforming gene by germline mutations of MEN 2A and MEN 2B
    • Santoro M., Carlomagno F., Romano A., Bottaro D.P., Dathan N.A., Grieco M., et al. Activation of RET as a dominant transforming gene by germline mutations of MEN 2A and MEN 2B. Science. 267:1995;381-383.
    • (1995) Science , vol.267 , pp. 381-383
    • Santoro, M.1    Carlomagno, F.2    Romano, A.3    Bottaro, D.P.4    Dathan, N.A.5    Grieco, M.6
  • 107
    • 0030047832 scopus 로고    scopus 로고
    • Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN 2A or MEN 2B mutation
    • Iwashita T., Asai N., Murakami H., Matsuyama M., Takahashi M. Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN 2A or MEN 2B mutation. Oncogene. 12:1996;481-487.
    • (1996) Oncogene , vol.12 , pp. 481-487
    • Iwashita, T.1    Asai, N.2    Murakami, H.3    Matsuyama, M.4    Takahashi, M.5
  • 109
    • 0030739287 scopus 로고    scopus 로고
    • Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype
    • Ito S., Iwashita T., Asai N., Murakami H., Iwata Y., Sobue G., Takahashi M. Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype. Cancer Res. 57:1997;2870-2872.
    • (1997) Cancer Res. , vol.57 , pp. 2870-2872
    • Ito, S.1    Iwashita, T.2    Asai, N.3    Murakami, H.4    Iwata, Y.5    Sobue, G.6    Takahashi, M.7
  • 111
    • 0033166442 scopus 로고    scopus 로고
    • Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma
    • Iwashita T., Kato M., Murakami H., Asai N., Ishiguro Y., Ito S., Iwata Y., Kawai K., Asai M., Kurokawa K., Kajita H., Takahashi M. Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma. Oncogene. 18:1999;3919-3922.
    • (1999) Oncogene , vol.18 , pp. 3919-3922
    • Iwashita, T.1    Kato, M.2    Murakami, H.3    Asai, N.4    Ishiguro, Y.5    Ito, S.6    Iwata, Y.7    Kawai, K.8    Asai, M.9    Kurokawa, K.10    Kajita, H.11    Takahashi, M.12
  • 112
    • 0031049753 scopus 로고    scopus 로고
    • The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype
    • Carlomagno F., Salvatore G., Cirafici A.M., De Vita G., Melillo R.M., de Franciscis V., Billaud M., Fusco A., Santoro M. The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype. Cancer Res. 57:1997;391-395.
    • (1997) Cancer Res. , vol.57 , pp. 391-395
    • Carlomagno, F.1    Salvatore, G.2    Cirafici, A.M.3    De Vita, G.4    Melillo, R.M.5    De Franciscis, V.6    Billaud, M.7    Fusco, A.8    Santoro, M.9
  • 113
    • 0031720932 scopus 로고    scopus 로고
    • The MEN II syndromes and the role of the ret proto-oncogene
    • Ponder B.A., Smith D. The MEN II syndromes and the role of the ret proto-oncogene. Adv. Cancer Res. 70:1996;179-222.
    • (1996) Adv. Cancer Res. , vol.70 , pp. 179-222
    • Ponder, B.A.1    Smith, D.2
  • 114
    • 0028938721 scopus 로고
    • Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
    • Zhou S., Carraway K.L. III, Eck M.J., Harrison S.C., Feldman R.A., Mohammadi M., et al. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature. 373:1995;536-539.
    • (1995) Nature , vol.373 , pp. 536-539
    • Zhou, S.1    Carraway III, K.L.2    Eck, M.J.3    Harrison, S.C.4    Feldman, R.A.5    Mohammadi, M.6
  • 115
    • 0030663857 scopus 로고    scopus 로고
    • The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck
    • Bocciardi R., Mograbi B., Pasini B., Borrello M.G., Pierotti M.A., Bourget I., Fischer S., Romeo G., Rossi B. The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck. Oncogene. 15:1997;2257-2265.
    • (1997) Oncogene , vol.15 , pp. 2257-2265
    • Bocciardi, R.1    Mograbi, B.2    Pasini, B.3    Borrello, M.G.4    Pierotti, M.A.5    Bourget, I.6    Fischer, S.7    Romeo, G.8    Rossi, B.9
  • 120
    • 24644483719 scopus 로고    scopus 로고
    • Neoplastic disorders affecting multiple endocrine organs
    • E. Braunwald. New York, USA: McGraw-Hill
    • Sherman S.I., Gagel R.F. Neoplastic disorders affecting multiple endocrine organs. Braunwald E. Harrison's Principles of Internal Medicine. 15th ed. 2001;2184-2189 McGraw-Hill, New York, USA.
    • (2001) Harrison's Principles of Internal Medicine 15th Ed. , pp. 2184-2189
    • Sherman, S.I.1    Gagel, R.F.2
  • 121
    • 0028050327 scopus 로고
    • Medullary thyroid carcinoma, genes, and the prevention of cancer
    • Utiger R.D. Medullary thyroid carcinoma, genes, and the prevention of cancer. N. Engl. J. Med. 331:1994;870-871.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 870-871
    • Utiger, R.D.1
  • 123
    • 0028330107 scopus 로고
    • Management of individual tumor syndromes. Medullary thyroid carcinoma and hyperparathyroidism
    • Snow K.J., Boyd A.E. III. Management of individual tumor syndromes. Medullary thyroid carcinoma and hyperparathyroidism. Endocrinol. Metab. Clin. North Am. 23:1994;157-166.
    • (1994) Endocrinol. Metab. Clin. North Am. , vol.23 , pp. 157-166
    • Snow, K.J.1    Boyd III, A.E.2
  • 125
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich M.C., Griffith D.J., Druker B.J., Wait C.L., Ott K.A., Zigler A.J. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 96:2000;925-932.
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 126
    • 0035871874 scopus 로고    scopus 로고
    • ARG tyrosine kinase activity is inhibited by STI571
    • Okuda K., Weisberg E., Gilliland D.G., Griffin J.D. ARG tyrosine kinase activity is inhibited by STI571. Blood. 97:2001;2440-2448.
    • (2001) Blood , vol.97 , pp. 2440-2448
    • Okuda, K.1    Weisberg, E.2    Gilliland, D.G.3    Griffin, J.D.4
  • 127
    • 0036919703 scopus 로고    scopus 로고
    • Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors
    • discussion 966-967
    • Cohen M.S., Hussain H.B., Moley J.F. Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors. Surgery. 132:2002;960-966. discussion 966-967.
    • (2002) Surgery , vol.132 , pp. 960-966
    • Cohen, M.S.1    Hussain, H.B.2    Moley, J.F.3
  • 130
    • 0035426416 scopus 로고    scopus 로고
    • GDNF recruits the signaling crew into lipid rafts
    • Saarma M. GDNF recruits the signaling crew into lipid rafts. Trends Neurosci. 24:2001;427-429.
    • (2001) Trends Neurosci. , vol.24 , pp. 427-429
    • Saarma, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.