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Volumn 8, Issue 1, 2003, Pages 5-17

Growth factor receptors in breast cancer: Potential for therapeutic intervention

Author keywords

Biologic therapy; Breast neoplasm; EGFR; HER2; IGF IR; Monoclonal antibodies; Prognostic markers; Tyrosine kinase inhibitors

Indexed keywords

CANERTINIB; CETUXIMAB; E1A; EPIDERMAL GROWTH FACTOR 2; EPIDERMAL GROWTH FACTOR 3; EPIDERMAL GROWTH FACTOR 4; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; ESTROGEN; ESTROGEN RECEPTOR; GEFITINIB; GROWTH FACTOR RECEPTOR; HUMAN MOUSE ANTIBODY; IMATINIB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY E1A; NEU DIFFERENTIATION FACTOR; PANITUMUMAB; PERTUZUMAB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN; SOMATOMEDIN RECEPTOR; STEM CELL FACTOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 0037285971     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.8-1-5     Document Type: Article
Times cited : (109)

References (157)
  • 2
    • 0031949639 scopus 로고    scopus 로고
    • Update on endocrine therapy for breast cancer
    • Buzdar AU, Hortobagyi G. Update on endocrine therapy for breast cancer. Clin Cancer Res 1998;4:527-534.
    • (1998) Clin Cancer Res , vol.4 , pp. 527-534
    • Buzdar, A.U.1    Hortobagyi, G.2
  • 3
    • 0016000929 scopus 로고
    • Epidermal growth factor: Chemical and biological characterization
    • Cohen S, Taylor JM. Epidermal growth factor: chemical and biological characterization. Recent Prog Horm Res 1974;30:533-550.
    • (1974) Recent Prog Horm Res , vol.30 , pp. 533-550
    • Cohen, S.1    Taylor, J.M.2
  • 4
    • 0015991698 scopus 로고
    • Characterization of the binding protein for epidermal growth factor
    • Taylor JM, Mitchell WM, Cohen S. Characterization of the binding protein for epidermal growth factor. J Biol Chem 1974;249:2188-2194.
    • (1974) J Biol Chem , vol.249 , pp. 2188-2194
    • Taylor, J.M.1    Mitchell, W.M.2    Cohen, S.3
  • 5
    • 0016153702 scopus 로고
    • Characterization of the high molecular weight form of epidermal growth factor
    • Taylor JM, Mitchell WM, Cohen S. Characterization of the high molecular weight form of epidermal growth factor. J Biol Chem 1974;249:3198-3203.
    • (1974) J Biol Chem , vol.249 , pp. 3198-3203
    • Taylor, J.M.1    Mitchell, W.M.2    Cohen, S.3
  • 6
    • 0021281324 scopus 로고
    • Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
    • Downward J, Yarden Y, Mayes E et al. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 1984;307:521-527.
    • (1984) Nature , vol.307 , pp. 521-527
    • Downward, J.1    Yarden, Y.2    Mayes, E.3
  • 7
    • 0021257637 scopus 로고
    • Expression cloning of human EGF receptor complementary DNA: Gene amplification and three related messenger RNA products in A431 cells
    • Lin CR, Chen WS, Kruiger W et al. Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. Science 1984;224:843-848.
    • (1984) Science , vol.224 , pp. 843-848
    • Lin, C.R.1    Chen, W.S.2    Kruiger, W.3
  • 8
    • 0021273420 scopus 로고
    • Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
    • Ullrich A, Coussens L, Hayflick JS et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 1984;309:418-425.
    • (1984) Nature , vol.309 , pp. 418-425
    • Ullrich, A.1    Coussens, L.2    Hayflick, J.S.3
  • 9
    • 0019782605 scopus 로고
    • Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus
    • Cooper JA, Hunter T. Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus. J Cell Biol 1981;91:878-883.
    • (1981) J Cell Biol , vol.91 , pp. 878-883
    • Cooper, J.A.1    Hunter, T.2
  • 10
    • 0019829559 scopus 로고
    • Purified EGF receptor-kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein
    • Chinkers M, Cohen S. Purified EGF receptor-kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein. Nature 1981;290:516-519.
    • (1981) Nature , vol.290 , pp. 516-519
    • Chinkers, M.1    Cohen, S.2
  • 11
    • 0035884231 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
    • Arteaga CL. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 2001;19(suppl 18):32S-40S.
    • (2001) J Clin Oncol , vol.19 , Issue.SUPPL. 18
    • Arteaga, C.L.1
  • 12
    • 0028116305 scopus 로고
    • Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
    • Fan Z, Lu Y, Wu X et al. Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem 1994;269:27595-27602.
    • (1994) J Biol Chem , vol.269 , pp. 27595-27602
    • Fan, Z.1    Lu, Y.2    Wu, X.3
  • 13
    • 0034754136 scopus 로고    scopus 로고
    • Epidermal growth factor receptor biology (IMC-C225)
    • Kim ES, Khuri FR, Herbst RS. Epidermal growth factor receptor biology (IMC-C225). Curr Opin Oncol 2001;13:506-513.
    • (2001) Curr Opin Oncol , vol.13 , pp. 506-513
    • Kim, E.S.1    Khuri, F.R.2    Herbst, R.S.3
  • 14
    • 0032951396 scopus 로고    scopus 로고
    • Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth
    • Tortora G, Caputo R, Pomatico G et al. Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth. Clin Cancer Res 1999;5:875-881.
    • (1999) Clin Cancer Res , vol.5 , pp. 875-881
    • Tortora, G.1    Caputo, R.2    Pomatico, G.3
  • 15
    • 0021363327 scopus 로고
    • Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies
    • Masui H, Kawamoto T, Sato JD et al. Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 1984;44:1002-1007.
    • (1984) Cancer Res , vol.44 , pp. 1002-1007
    • Masui, H.1    Kawamoto, T.2    Sato, J.D.3
  • 16
    • 0034779291 scopus 로고    scopus 로고
    • The EGFR as a target for anticancer therapy - Focus on cetuximab
    • Baselga J. The EGFR as a target for anticancer therapy - focus on cetuximab. Eur J Cancer 2001;37(suppl 4):S16-S22.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 4
    • Baselga, J.1
  • 17
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
    • Herbst RS, Shin DM. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 2002;94:1593-1611.
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 18
    • 0031039315 scopus 로고    scopus 로고
    • Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
    • Mendez MJ, Green LL, Corvalan JR et al. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat Genet 1997;15:146-156.
    • (1997) Nat Genet , vol.15 , pp. 146-156
    • Mendez, M.J.1    Green, L.L.2    Corvalan, J.R.3
  • 19
    • 0036118248 scopus 로고    scopus 로고
    • Therapeutic potential of ABX-EGF: A fully human anti-epidermal growth factor receptor monoclonal antibody for cancer treatment
    • Lynch DH, Yang XD. Therapeutic potential of ABX-EGF: a fully human anti-epidermal growth factor receptor monoclonal antibody for cancer treatment. Semin Oncol 2002;29(suppl 4):47-50.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 4 , pp. 47-50
    • Lynch, D.H.1    Yang, X.D.2
  • 20
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang XD, Jia XC, Corvalan JR et al. Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res 1999;59:1236-1243.
    • (1999) Cancer Res , vol.59 , pp. 1236-1243
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3
  • 21
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABXEGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • Yang XD, Jia XC, Corvalan JR et al. Development of ABXEGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol 2001;38:17-23.
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3
  • 22
    • 0036316380 scopus 로고    scopus 로고
    • Potential benefits of the irreversible pan-erbB inhibitor, CI-1033, in the treatment of breast cancer
    • Allen LF, Lenehan PF, Eiseman IA et al. Potential benefits of the irreversible pan-erbB inhibitor, CI-1033, in the treatment of breast cancer. Semin Oncol 2002;29(suppl 11):11-21.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 11 , pp. 11-21
    • Allen, L.F.1    Lenehan, P.F.2    Eiseman, I.A.3
  • 23
    • 0035170259 scopus 로고    scopus 로고
    • Anticancer therapy targeting the ErbB family of receptor tyrosine kinases
    • Slichenmyer WJ, Fry DW. Anticancer therapy targeting the ErbB family of receptor tyrosine kinases. Semin Oncol 2001;28(suppl 16):67-79.
    • (2001) Semin Oncol , vol.28 , Issue.SUPPL. 16 , pp. 67-79
    • Slichenmyer, W.J.1    Fry, D.W.2
  • 24
    • 0034758726 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors-ZD1839 (Iressa)
    • Arteaga CL, Johnson DH. Tyrosine kinase inhibitors-ZD1839 (Iressa). Curr Opin Oncol 2001;13:491-498.
    • (2001) Curr Opin Oncol , vol.13 , pp. 491-498
    • Arteaga, C.L.1    Johnson, D.H.2
  • 25
    • 0035215722 scopus 로고    scopus 로고
    • Selected novel anticancer treatments targeting cell signaling proteins
    • Elsayed YA, Sausville EA. Selected novel anticancer treatments targeting cell signaling proteins. The Oncologist 2001;6:517-537.
    • (2001) The Oncologist , vol.6 , pp. 517-537
    • Elsayed, Y.A.1    Sausville, E.A.2
  • 26
    • 0035023187 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of the orally active selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in healthy volunteers
    • Swaisland H, Laight A, Stafford L et al. Pharmacokinetics and tolerability of the orally active selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in healthy volunteers. Clin Pharmacokinet 2001;40:297-306.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 297-306
    • Swaisland, H.1    Laight, A.2    Stafford, L.3
  • 27
    • 0036569870 scopus 로고    scopus 로고
    • ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
    • Ranson M, Hammond LA, Ferry D et al. ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J Clin Oncol 2002;20:2240-2250.
    • (2002) J Clin Oncol , vol.20 , pp. 2240-2250
    • Ranson, M.1    Hammond, L.A.2    Ferry, D.3
  • 28
    • 0000683712 scopus 로고    scopus 로고
    • Initial results from a phase II trial of ZD1839 (Iressa) as second- and third-line monotherapy for patients with advanced non-small-cell lung cancer (IDEAL 1)
    • Baselga J, Yano S, Giaccone G et al. Initial results from a phase II trial of ZD1839 (Iressa) as second- and third-line monotherapy for patients with advanced non-small-cell lung cancer (IDEAL 1). Clin Cancer Res 2001;7:3780.
    • (2001) Clin Cancer Res , vol.7 , pp. 3780
    • Baselga, J.1    Yano, S.2    Giaccone, G.3
  • 29
    • 0036312252 scopus 로고    scopus 로고
    • HER (erbB) tyrosine kinase inhibitors in the treatment of breast cancer
    • Arteaga CL, Moulder SL, Yakes FM. HER (erbB) tyrosine kinase inhibitors in the treatment of breast cancer. Semin Oncol 2002;29:4-10.
    • (2002) Semin Oncol , vol.29 , pp. 4-10
    • Arteaga, C.L.1    Moulder, S.L.2    Yakes, F.M.3
  • 30
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M, Siu LL, Nemunaitis J et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 2001;19:3267-3279.
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.L.2    Nemunaitis, J.3
  • 31
    • 0035476866 scopus 로고    scopus 로고
    • The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
    • Rusnak DW, Affleck K, Cockerill SG et al. The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Res 2001;61:7196-7203.
    • (2001) Cancer Res , vol.61 , pp. 7196-7203
    • Rusnak, D.W.1    Affleck, K.2    Cockerill, S.G.3
  • 32
    • 0020117514 scopus 로고
    • Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas
    • Padhy LC, Shih C, Cowing D et al. Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas. Cell 1982;28:865-871.
    • (1982) Cell , vol.28 , pp. 865-871
    • Padhy, L.C.1    Shih, C.2    Cowing, D.3
  • 33
    • 0022600388 scopus 로고
    • The neu oncogene encodes an epidermal growth factor receptor-related protein
    • Bargmann CI, Hung MC, Weinberg RA. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 1986;319:226-230.
    • (1986) Nature , vol.319 , pp. 226-230
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 34
    • 0022485548 scopus 로고
    • Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
    • Bargmann CI, Hung MC, Weinberg RA. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 1986;45:649-657.
    • (1986) Cell , vol.45 , pp. 649-657
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 35
    • 0021688634 scopus 로고
    • The neu oncogene: An erb-B-related gene encoding a 185,000-Mr tumour antigen
    • Schechter AL, Stern DF, Vaidyanathan L et al. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature 1984;312:513-516.
    • (1984) Nature , vol.312 , pp. 513-516
    • Schechter, A.L.1    Stern, D.F.2    Vaidyanathan, L.3
  • 36
    • 0022399581 scopus 로고
    • Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
    • Coussens L, Yang-Feng TL, Liao YC et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 1985;230:1132-1139.
    • (1985) Science , vol.230 , pp. 1132-1139
    • Coussens, L.1    Yang-Feng, T.L.2    Liao, Y.C.3
  • 37
    • 0022406444 scopus 로고
    • Amplification of a novel v-erbB-related gene in a human mammary carcinoma
    • King CR, Kraus MH, Aaronson SA. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science 1985;229:974-976.
    • (1985) Science , vol.229 , pp. 974-976
    • King, C.R.1    Kraus, M.H.2    Aaronson, S.A.3
  • 38
    • 0022588467 scopus 로고
    • Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor
    • Yamamoto T, Ikawa S, Akiyama T et al. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 1986;319:230-234.
    • (1986) Nature , vol.319 , pp. 230-234
    • Yamamoto, T.1    Ikawa, S.2    Akiyama, T.3
  • 39
    • 0023196582 scopus 로고
    • erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells
    • Di Fiore PP, Pierce JH, Kraus MH et al. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 1987;237:178-182.
    • (1987) Science , vol.237 , pp. 178-182
    • Di Fiore, P.P.1    Pierce, J.H.2    Kraus, M.H.3
  • 40
    • 0026472124 scopus 로고
    • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    • Guy CT, Webster MA, Schaller M et al. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA 1992;89:10578-10582.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10578-10582
    • Guy, C.T.1    Webster, M.A.2    Schaller, M.3
  • 41
    • 0029997433 scopus 로고    scopus 로고
    • Activated neu induces rapid tumor progression
    • Guy CT, Cardiff RD, Muller WJ. Activated neu induces rapid tumor progression. J Biol Chem 1996;271:7673-7678.
    • (1996) J Biol Chem , vol.271 , pp. 7673-7678
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 42
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER2/neu oncogene. Science 1987;235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 44
    • 0025296339 scopus 로고
    • Immunohistochemical study on overexpression of c-erbB-2 protein in human breast cancer: Its correlation with gene amplification and long-term survival of patients
    • Tsuda H, Hirohashi S, Shimosato Y et al. Immunohistochemical study on overexpression of c-erbB-2 protein in human breast cancer: its correlation with gene amplification and long-term survival of patients. Jpn J Cancer Res 1990;81:327-332.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 327-332
    • Tsuda, H.1    Hirohashi, S.2    Shimosato, Y.3
  • 45
    • 0025177290 scopus 로고
    • Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: Prognostic significance of erbB-2 protein overexpression in primary breast cancer
    • Paik S, Hazan R, Fisher ER et al. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. J Clin Oncol 1990;8:103-112.
    • (1990) J Clin Oncol , vol.8 , pp. 103-112
    • Paik, S.1    Hazan, R.2    Fisher, E.R.3
  • 46
    • 0026012037 scopus 로고
    • C-erbB-2 oncoprotein expression in primary and advanced breast cancer
    • Lovekin C, Ellis IO, Locker A et al. C-erbB-2 oncoprotein expression in primary and advanced breast cancer. Br J Cancer 1991;63:439-443.
    • (1991) Br J Cancer , vol.63 , pp. 439-443
    • Lovekin, C.1    Ellis, I.O.2    Locker, A.3
  • 47
    • 0025743925 scopus 로고
    • Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer
    • McCann AH, Dervan PA, O'Regan M et al. Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer. Cancer Res 1991;51:3296-3303.
    • (1991) Cancer Res , vol.51 , pp. 3296-3303
    • McCann, A.H.1    Dervan, P.A.2    O'Regan, M.3
  • 48
    • 0027979311 scopus 로고
    • Elevated erbB-2 oncoprotein levels in preoperative and follow-up serum samples define an aggressive disease course in patients with breast cancer
    • Isola JJ, Holli K, Oksa H et al. Elevated erbB-2 oncoprotein levels in preoperative and follow-up serum samples define an aggressive disease course in patients with breast cancer. Cancer 1994;73:652-658.
    • (1994) Cancer , vol.73 , pp. 652-658
    • Isola, J.J.1    Holli, K.2    Oksa, H.3
  • 49
    • 0028158791 scopus 로고
    • Immunohistochemical study on the expression of c-erbB-2 oncoprotein in breast cancer
    • Horiguchi J, Iino Y, Takei H et al. Immunohistochemical study on the expression of c-erbB-2 oncoprotein in breast cancer. Oncology 1994;51:47-51.
    • (1994) Oncology , vol.51 , pp. 47-51
    • Horiguchi, J.1    Iino, Y.2    Takei, H.3
  • 50
    • 0032538050 scopus 로고    scopus 로고
    • erbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer
    • Thor AD, Berry DA, Budman DR et al. erbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer. J Natl Cancer Inst 1998;90:1346-1360.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1346-1360
    • Thor, A.D.1    Berry, D.A.2    Budman, D.R.3
  • 51
    • 0032538040 scopus 로고    scopus 로고
    • erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer
    • Paik S, Bryant J, Park C et al. erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer. J Natl Cancer Inst 1998;90:1361-1370.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1361-1370
    • Paik, S.1    Bryant, J.2    Park, C.3
  • 52
    • 0003235599 scopus 로고    scopus 로고
    • HER2 overexpression predicts adjuvant tamoxifen (TAM) failure for early breast cancer (EBC): Complete data at 20 yr of the Naples GUN randomized trial
    • Bianco AR, De Laurentiis M, Carlomagno C et al. HER2 overexpression predicts adjuvant tamoxifen (TAM) failure for early breast cancer (EBC): complete data at 20 yr of the Naples GUN randomized trial. Proc Am Soc Clin Oncol 2000;19:289a.
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Bianco, A.R.1    De Laurentiis, M.2    Carlomagno, C.3
  • 53
    • 0033890970 scopus 로고    scopus 로고
    • Expression of erb-B receptors and their ligands in breast cancer: Implications to biological behavior and therapeutic response
    • Bacus SS, Gudkov AV, Esteva FJ et al. Expression of erb-B receptors and their ligands in breast cancer: implications to biological behavior and therapeutic response. Breast Dis 2000;11:63-75.
    • (2000) Breast Dis , vol.11 , pp. 63-75
    • Bacus, S.S.1    Gudkov, A.V.2    Esteva, F.J.3
  • 54
    • 0033674785 scopus 로고    scopus 로고
    • Clinical relevance of HER-2 amplification and overexpression in human cancers
    • Esteva FJ, Pusztai L, Symmans WF et al. Clinical relevance of HER-2 amplification and overexpression in human cancers. Ref Gynecol Obst 2000;7:267-276.
    • (2000) Ref Gynecol Obst , vol.7 , pp. 267-276
    • Esteva, F.J.1    Pusztai, L.2    Symmans, W.F.3
  • 55
    • 0032705268 scopus 로고    scopus 로고
    • Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer
    • Pusztai L, Esteva FJ, Cristofanilli M et al. Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer. Cancer Treat Rev 1999;25:271-277.
    • (1999) Cancer Treat Rev , vol.25 , pp. 271-277
    • Pusztai, L.1    Esteva, F.J.2    Cristofanilli, M.3
  • 56
    • 0025359146 scopus 로고
    • Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues
    • Press MF, Cordon-Cardo C, Slamon DJ. Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene 1990;5:953-962.
    • (1990) Oncogene , vol.5 , pp. 953-962
    • Press, M.F.1    Cordon-Cardo, C.2    Slamon, D.J.3
  • 58
    • 0027283498 scopus 로고
    • Stability of HER-2/neu expression over time and at multiple metastatic sites
    • Niehans GA, Singleton TP, Dykoski D et al. Stability of HER-2/neu expression over time and at multiple metastatic sites. J Natl Cancer Inst 1993;85:1230-1235.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1230-1235
    • Niehans, G.A.1    Singleton, T.P.2    Dykoski, D.3
  • 59
    • 0023430930 scopus 로고
    • Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells
    • Hudziak RM, Schlessinger J, Ullrich A. Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci USA 1987;84:7159-7163.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7159-7163
    • Hudziak, R.M.1    Schlessinger, J.2    Ullrich, A.3
  • 60
    • 0027017679 scopus 로고
    • Anti-p185HER2 monoclonal antibodies: Biological properties and potential for immunotherapy
    • Park JW, Stagg R, Lewis GD et al. Anti-p185HER2 monoclonal antibodies: biological properties and potential for immunotherapy. Cancer Treat Res 1992;61:193-211.
    • (1992) Cancer Treat Res , vol.61 , pp. 193-211
    • Park, J.W.1    Stagg, R.2    Lewis, G.D.3
  • 61
    • 0028912598 scopus 로고
    • Suppression and promotion of tumor growth by monoclonal antibodies to erbB-2 differentially correlate with cellular uptake
    • Hurwitz E, Stancovski I, Sela M et al. Suppression and promotion of tumor growth by monoclonal antibodies to erbB-2 differentially correlate with cellular uptake. Proc Natl Acad Sci USA 1995;92:3353-3357.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3353-3357
    • Hurwitz, E.1    Stancovski, I.2    Sela, M.3
  • 62
    • 0026685034 scopus 로고
    • Therapy of an animal model of human gastric cancer using a combination of antierbB-2 monoclonal antibodies
    • Kasprzyk PG, Song SU, Di Fiore PP et al. Therapy of an animal model of human gastric cancer using a combination of antierbB-2 monoclonal antibodies. Cancer Res 1992;52:2771-2776.
    • (1992) Cancer Res , vol.52 , pp. 2771-2776
    • Kasprzyk, P.G.1    Song, S.U.2    Di Fiore, P.P.3
  • 63
    • 0027443765 scopus 로고
    • Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth
    • Harwerth IM, Wels W, Schlegel J et al. Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth. Br J Cancer 1993;68:1140-1145.
    • (1993) Br J Cancer , vol.68 , pp. 1140-1145
    • Harwerth, I.M.1    Wels, W.2    Schlegel, J.3
  • 64
    • 0027447698 scopus 로고
    • Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185
    • Xu F, Lupu R, Rodriguez GC et al. Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185. Int J Cancer 1993;53:401-408.
    • (1993) Int J Cancer , vol.53 , pp. 401-408
    • Xu, F.1    Lupu, R.2    Rodriguez, G.C.3
  • 65
    • 0028200221 scopus 로고
    • Antibody to HER2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells
    • Pietras RJ, Fendly BM, Chazin VR et al. Antibody to HER2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene 1994;9:1829-1838.
    • (1994) Oncogene , vol.9 , pp. 1829-1838
    • Pietras, R.J.1    Fendly, B.M.2    Chazin, V.R.3
  • 66
    • 0030870295 scopus 로고    scopus 로고
    • The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells
    • Pegram MD, Finn RS, Arzoo K et al. The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells. Oncogene 1997;15:537-547.
    • (1997) Oncogene , vol.15 , pp. 537-547
    • Pegram, M.D.1    Finn, R.S.2    Arzoo, K.3
  • 67
    • 0029991439 scopus 로고    scopus 로고
    • Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
    • Baselga J, Tripathy D, Mendelsohn J et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 1996;14:737-744.
    • (1996) J Clin Oncol , vol.14 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3
  • 68
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17:2639-2648.
    • (1999) J Clin Oncol , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 69
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-726.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 70
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-792.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 71
    • 0034741923 scopus 로고    scopus 로고
    • Chemotherapy and herceptin for HER2(+) metastatic breast cancer: The best drug?
    • Livingston RB, Esteva FJ. Chemotherapy and herceptin for HER2(+) metastatic breast cancer: the best drug? The Oncologist 2001;6:315-316.
    • (2001) The Oncologist , vol.6 , pp. 315-316
    • Livingston, R.B.1    Esteva, F.J.2
  • 72
    • 0034470522 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy for the treatment of metastatic breast cancer
    • discussion 92-100
    • Fornier M, Esteva FJ, Seidman A. Trastuzumab in combination with chemotherapy for the treatment of metastatic breast cancer. Semin Onco1 2000;27(suppl 11):38-45; discussion 92-100.
    • (2000) Semin Onco1 , vol.27 , Issue.SUPPL. 11 , pp. 38-45
    • Fornier, M.1    Esteva, F.J.2    Seidman, A.3
  • 73
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram MD, Lipton A, Hayes DF et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998;16:2659-2671.
    • (1998) J Clin Oncol , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3
  • 74
    • 0035873815 scopus 로고    scopus 로고
    • Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer wit h analysis of efficacy by HER2 immunophenotype and gene amplification
    • Seidman AD, Fornier M, Esteva FJ et al. Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. J Clin Oncol 2001;19:2587-2595.
    • (2001) J Clin Oncol , vol.19 , pp. 2587-2595
    • Seidman, A.D.1    Fornier, M.2    Esteva, F.J.3
  • 75
    • 0036534121 scopus 로고    scopus 로고
    • Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
    • Esteva FJ, Valero V, Booser D et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:1800-1808.
    • (2002) J Clin Oncol , vol.20 , pp. 1800-1808
    • Esteva, F.J.1    Valero, V.2    Booser, D.3
  • 76
    • 0035873822 scopus 로고    scopus 로고
    • Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer
    • Burstein HJ, Kuter I, Campos SM et al. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol 2001;19:2722-2730.
    • (2001) J Clin Oncol , vol.19 , pp. 2722-2730
    • Burstein, H.J.1    Kuter, I.2    Campos, S.M.3
  • 77
    • 33749089667 scopus 로고    scopus 로고
    • Gemcitabine and trastuzumab for HER-2 positive metastatic breast cancer: Preliminary results of a phase II study
    • O'Shaughnessy JA, Vukelja S, Marsland T et al. Gemcitabine and trastuzumab for HER-2 positive metastatic breast cancer: preliminary results of a phase II study. Breast Cancer Res Treat 2001;69:302a.
    • (2001) Breast Cancer Res Treat , vol.69
    • O'Shaughnessy, J.A.1    Vukelja, S.2    Marsland, T.3
  • 78
    • 0034473393 scopus 로고    scopus 로고
    • Trastuzumab and chemotherapeutics: Drug interactions and synergies
    • Pegram MD, Lopez A, Konecny G et al. Trastuzumab and chemotherapeutics: drug interactions and synergies. Semin Oncol 2000;27(suppl 11):21-25;92-100.
    • (2000) Semin Oncol , vol.27 , Issue.SUPPL. 11 , pp. 21-25
    • Pegram, M.D.1    Lopez, A.2    Konecny, G.3
  • 79
    • 17944383026 scopus 로고    scopus 로고
    • Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples
    • Konecny G, Untch M, Slamon D et al. Drug interactions and cytotoxic effects of paclitaxel in combination with carboplatin, epirubicin, gemcitabine or vinorelbine in breast cancer cell lines and tumor samples. Breast Cancer Res Treat 2001;67:223-233.
    • (2001) Breast Cancer Res Treat , vol.67 , pp. 223-233
    • Konecny, G.1    Untch, M.2    Slamon, D.3
  • 80
    • 0013305364 scopus 로고    scopus 로고
    • Preliminary results of two open-label multicenter pilot phase II trials with Herceptin in combination with docetaxel and platinum salts (cis- or carboplatin) (TCH) as therapy for advanced breast cancer in women with overexpressing HER2/neu
    • Nabholtz JM. Preliminary results of two open-label multicenter pilot phase II trials with Herceptin in combination with docetaxel and platinum salts (cis- or carboplatin) (TCH) as therapy for advanced breast cancer in women with overexpressing HER2/neu. Breast Cancer Res Treat 2000;58:327a.
    • (2000) Breast Cancer Res Treat , vol.58
    • Nabholtz, J.M.1
  • 81
    • 0003257111 scopus 로고    scopus 로고
    • Phase II pilot study of Herceptin combined with Taxotere and carboplatin in metastatic breast cancer patients overexpressing the HER2-neu proto-oncogene: A pilot study of the UCLA Network
    • Slamon DJ, Patel R, Northfelt R et al. Phase II pilot study of Herceptin combined with Taxotere and carboplatin in metastatic breast cancer patients overexpressing the HER2-neu proto-oncogene: a pilot study of the UCLA Network. Proc Am Soc Clin Oncol 2001;20:193a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Slamon, D.J.1    Patel, R.2    Northfelt, R.3
  • 82
    • 0002860255 scopus 로고    scopus 로고
    • Improved survival benefit from Herceptin (trastuzumab) in patients selected by fluorescence in situ hybridization (FISH)
    • Mass RD, Press M, Anderson S et al. Improved survival benefit from Herceptin (trastuzumab) in patients selected by fluorescence in situ hybridization (FISH). Proc Am Soc Clin Oncol 2001;20:85a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Mass, R.D.1    Press, M.2    Anderson, S.3
  • 83
    • 0037024478 scopus 로고    scopus 로고
    • Concordance between local and central laboratory HER2 testing in the breast intergroup trial N9831
    • Roche PC, Suman VJ, Jenkins RB et al. Concordance between local and central laboratory HER2 testing in the breast intergroup trial N9831. J Natl Cancer Inst 2002;94:855-857.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 855-857
    • Roche, P.C.1    Suman, V.J.2    Jenkins, R.B.3
  • 84
    • 0037023986 scopus 로고    scopus 로고
    • Real-world performance of HER2 testing - National Surgical Adjuvant Breast and Bowel Project experience
    • Paik S, Bryant J, Tan-Chiu E et al. Real-world performance of HER2 testing - National Surgical Adjuvant Breast and Bowel Project experience. J Natl Cancer Inst 2002;94:852-854.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 852-854
    • Paik, S.1    Bryant, J.2    Tan-Chiu, E.3
  • 85
    • 0026755810 scopus 로고
    • Recombinant antierbB-2 immunotoxins containing Pseudomonas exotoxin
    • Batra JK, Kasprzyk PG, Bird RE et al. Recombinant antierbB-2 immunotoxins containing Pseudomonas exotoxin. Proc Natl Acad Sci USA 1992;89:5867-5871.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5867-5871
    • Batra, J.K.1    Kasprzyk, P.G.2    Bird, R.E.3
  • 86
    • 0026486446 scopus 로고
    • Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor
    • Wels W, Harwerth IM, Mueller M et al. Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor. Cancer Res 1992;52:6310-6317.
    • (1992) Cancer Res , vol.52 , pp. 6310-6317
    • Wels, W.1    Harwerth, I.M.2    Mueller, M.3
  • 87
    • 0029870563 scopus 로고    scopus 로고
    • The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein
    • King CR, Fischer PH, Rando RF et al. The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein. Semin Cancer Biol 1996;7:79-86.
    • (1996) Semin Cancer Biol , vol.7 , pp. 79-86
    • King, C.R.1    Fischer, P.H.2    Rando, R.F.3
  • 89
    • 0028275863 scopus 로고
    • Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment
    • Reiter Y, Pai LH, Brinkmann U et al. Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment. Cancer Res 1994;54:2714-2718.
    • (1994) Cancer Res , vol.54 , pp. 2714-2718
    • Reiter, Y.1    Pai, L.H.2    Brinkmann, U.3
  • 90
    • 0028791370 scopus 로고
    • Radioimmunotherapy of breast cancer xenografts with monoclonal antibody ICR12 against c-erbB2 p185: Comparison of iodogen and N-succinimidyl 4-methyl-3-(tri-n-butylstannyl) benzoate radioiodination methods
    • Smellie WJ, Dean CJ, Sacks NP et al. Radioimmunotherapy of breast cancer xenografts with monoclonal antibody ICR12 against c-erbB2 p185: comparison of iodogen and N-succinimidyl 4-methyl-3-(tri-n-butylstannyl) benzoate radioiodination methods. Cancer Res 1995;55(suppl 23):5842s-5846s.
    • (1995) Cancer Res , vol.55 , Issue.SUPPL. 23
    • Smellie, W.J.1    Dean, C.J.2    Sacks, N.P.3
  • 91
    • 0027536633 scopus 로고
    • Radioimmunolocalisation in breast cancer using the gene product of c-erbB2 as the target antigen
    • Allan SM, Dean C, Fernando I et al. Radioimmunolocalisation in breast cancer using the gene product of c-erbB2 as the target antigen. Br J Cancer 1993;67:706-712.
    • (1993) Br J Cancer , vol.67 , pp. 706-712
    • Allan, S.M.1    Dean, C.2    Fernando, I.3
  • 92
    • 0027388920 scopus 로고
    • A human tumor xenograft model of therapy with a bispecific monoclonal antibody targeting c-erbB-2 and CD16
    • Weiner LM, Holmes M, Adams GP et al. A human tumor xenograft model of therapy with a bispecific monoclonal antibody targeting c-erbB-2 and CD16. Cancer Res 1993;53:94-100.
    • (1993) Cancer Res , vol.53 , pp. 94-100
    • Weiner, L.M.1    Holmes, M.2    Adams, G.P.3
  • 93
    • 0027272546 scopus 로고
    • Binding and cytotoxicity characteristics of the bispecific murine monoclonal antibody 2B1
    • Weiner LM, Holmes M, Richeson A et al. Binding and cytotoxicity characteristics of the bispecific murine monoclonal antibody 2B1. J Immunol 1993;151:2877-2886.
    • (1993) J Immunol , vol.151 , pp. 2877-2886
    • Weiner, L.M.1    Holmes, M.2    Richeson, A.3
  • 94
    • 0028894462 scopus 로고
    • Bispecific HER2 × CD3 antibodies enhance T-cell cytotoxicity in vitro and localize to HER2-overexpressing xenografts in nude mice
    • Shalaby MR, Carter P, Maneval D et al. Bispecific HER2 × CD3 antibodies enhance T-cell cytotoxicity in vitro and localize to HER2-overexpressing xenografts in nude mice. Clin Immunol Immunopathol 1995;74:185-192.
    • (1995) Clin Immunol Immunopathol , vol.74 , pp. 185-192
    • Shalaby, M.R.1    Carter, P.2    Maneval, D.3
  • 95
    • 0028822836 scopus 로고
    • Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII
    • Weiner LM, Clark JI, Davey M et al. Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII. Cancer Res 1995;55:4586-4593.
    • (1995) Cancer Res , vol.55 , pp. 4586-4593
    • Weiner, L.M.1    Clark, J.I.2    Davey, M.3
  • 96
    • 0027380135 scopus 로고
    • Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A
    • Yu D, Shi D, Scanlon M et al. Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A. Cancer Res 1993;53:5784-5790.
    • (1993) Cancer Res , vol.53 , pp. 5784-5790
    • Yu, D.1    Shi, D.2    Scanlon, M.3
  • 97
    • 0028823833 scopus 로고
    • Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER2/neu
    • Yu D, Matin A, Xia W et al. Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER2/neu. Oncogene 1995;11:1383-1388.
    • (1995) Oncogene , vol.11 , pp. 1383-1388
    • Yu, D.1    Matin, A.2    Xia, W.3
  • 98
    • 0035879090 scopus 로고    scopus 로고
    • Cationic liposomemediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: A phase I clinical trial
    • Hortobagyi GN, Ueno NT, Xia WY et al. Cationic liposomemediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial. J Clin Oncol 2001;19:3422-3433.
    • (2001) J Clin Oncol , vol.19 , pp. 3422-3433
    • Hortobagyi, G.N.1    Ueno, N.T.2    Xia, W.Y.3
  • 99
    • 0028238218 scopus 로고
    • Reduction of erbB2 gene product in mammary carcinoma cell lines by erbB2 mRNA-specific and tyrosine kinase consensus phosphorothioate antisense oligonucleotides
    • Bertram J, Killian M, Brysch W et al. Reduction of erbB2 gene product in mammary carcinoma cell lines by erbB2 mRNA-specific and tyrosine kinase consensus phosphorothioate antisense oligonucleotides. Biochem Biophys Res Commun 1994;200:661-667.
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 661-667
    • Bertram, J.1    Killian, M.2    Brysch, W.3
  • 100
    • 0028139425 scopus 로고
    • ErbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification
    • Colomer R, Lupu R, Bacus SS et al. ErbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification. Br J Cancer 1994;70:819-825.
    • (1994) Br J Cancer , vol.70 , pp. 819-825
    • Colomer, R.1    Lupu, R.2    Bacus, S.S.3
  • 101
    • 0028701062 scopus 로고
    • Immunity to the HER-2/neu oncogenic protein
    • discussion 207-211
    • Disis ML, Bernhard H, Gralow JR et al. Immunity to the HER-2/neu oncogenic protein. Ciba Found Symp 1994;187:198-207; discussion 207-211.
    • (1994) Ciba Found Symp , vol.187 , pp. 198-207
    • Disis, M.L.1    Bernhard, H.2    Gralow, J.R.3
  • 102
    • 0028330866 scopus 로고
    • In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein
    • Disis ML, Smith JW, Murphy AE et al. In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein. Cancer Res 1994;54:1071-1076.
    • (1994) Cancer Res , vol.54 , pp. 1071-1076
    • Disis, M.L.1    Smith, J.W.2    Murphy, A.E.3
  • 103
    • 0028144438 scopus 로고
    • Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer
    • Disis ML, Calenoff E, McLaughlin G et al. Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res 1994;54:16-20.
    • (1994) Cancer Res , vol.54 , pp. 16-20
    • Disis, M.L.1    Calenoff, E.2    McLaughlin, G.3
  • 104
    • 0028277739 scopus 로고
    • HER2/neu-derived peptides are shared antigens among human nonsmall cell lung cancer and ovarian cancer
    • Yoshino I, Goedegebuure PS, Peoples GE et al. HER2/neu-derived peptides are shared antigens among human nonsmall cell lung cancer and ovarian cancer. Cancer Res 1994;54:3387-3390.
    • (1994) Cancer Res , vol.54 , pp. 3387-3390
    • Yoshino, I.1    Goedegebuure, P.S.2    Peoples, G.E.3
  • 105
    • 0029129132 scopus 로고
    • Shared T cell epitopes in epithelial tumors
    • Peoples GE, Smith RC, Linehan DC et al. Shared T cell epitopes in epithelial tumors. Cell Immunol 1995;164:279-286.
    • (1995) Cell Immunol , vol.164 , pp. 279-286
    • Peoples, G.E.1    Smith, R.C.2    Linehan, D.C.3
  • 106
    • 0036216405 scopus 로고    scopus 로고
    • STI571 (Gleevec™) as a paradigm for cancer therapy
    • Druker BJ. STI571 (Gleevec™) as a paradigm for cancer therapy. Trends Mol Med 2002;8:S14-S18.
    • (2002) Trends Mol Med , vol.8
    • Druker, B.J.1
  • 107
    • 0034868659 scopus 로고    scopus 로고
    • Signal transduction inhibition: Results from phase I clinical trials in chronic myeloid leukemia
    • Druker B. Signal transduction inhibition: results from phase I clinical trials in chronic myeloid leukemia. Semin Hematol 2001;38(suppl 8):9-14.
    • (2001) Semin Hematol , vol.38 , Issue.SUPPL. 8 , pp. 9-14
    • Druker, B.1
  • 108
    • 0036139993 scopus 로고    scopus 로고
    • STI571: A paradigm of new agents for cancer therapeutics
    • Mauro MJ, O'Dwyer M, Heinrich MC et al. STI571: a paradigm of new agents for cancer therapeutics. J Clin Oncol 2002;20:325-334.
    • (2002) J Clin Oncol , vol.20 , pp. 325-334
    • Mauro, M.J.1    O'Dwyer, M.2    Heinrich, M.C.3
  • 109
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H, Sawyers C, Hochhaus A et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002;346:645-652.
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 110
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 111
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    Von Mehren, M.2    Blanke, C.D.3
  • 112
    • 0037103624 scopus 로고    scopus 로고
    • Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    • Apperley JF, Gardembas M, Melo JV et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med 2002;347:481-487.
    • (2002) N Engl J Med , vol.347 , pp. 481-487
    • Apperley, J.F.1    Gardembas, M.2    Melo, J.V.3
  • 113
    • 0036727124 scopus 로고    scopus 로고
    • Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
    • Rubin BP, Schuetze SM, Eary JF et al. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 2002;20:3586-3591.
    • (2002) J Clin Oncol , vol.20 , pp. 3586-3591
    • Rubin, B.P.1    Schuetze, S.M.2    Eary, J.F.3
  • 114
    • 0031133118 scopus 로고    scopus 로고
    • Evidence for a functional kit receptor in melanoma, breast, and lung carcinoma cells
    • DiPaola RS, Kuczynski WI, Onodera K et al. Evidence for a functional kit receptor in melanoma, breast, and lung carcinoma cells. Cancer Gene Therapy 1997;4:176-182.
    • (1997) Cancer Gene Therapy , vol.4 , pp. 176-182
    • DiPaola, R.S.1    Kuczynski, W.I.2    Onodera, K.3
  • 115
    • 0036312255 scopus 로고    scopus 로고
    • The insulin-like growth factor system as a treatment target in breast cancer
    • Yee D. The insulin-like growth factor system as a treatment target in breast cancer. Semin Oncol 2002;29(suppl 11):86-95.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 11 , pp. 86-95
    • Yee, D.1
  • 116
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
    • Hankinson SE, Willett WC, Colditz GA et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998;351:1393-1396.
    • (1998) Lancet , vol.351 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3
  • 117
    • 0029827295 scopus 로고    scopus 로고
    • Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer
    • Yu H, Levesque MA, Khosravi MJ et al. Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer. Br J Cancer 1996;74:1242-1247.
    • (1996) Br J Cancer , vol.74 , pp. 1242-1247
    • Yu, H.1    Levesque, M.A.2    Khosravi, M.J.3
  • 118
    • 0029934868 scopus 로고    scopus 로고
    • M6P/IGF2 receptor: A candidate breast tumor suppressor gene
    • Hankins GR, De Souza AT, Bentley RC et al. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene 1996;12:2003-2009.
    • (1996) Oncogene , vol.12 , pp. 2003-2009
    • Hankins, G.R.1    De Souza, A.T.2    Bentley, R.C.3
  • 119
    • 0033588086 scopus 로고    scopus 로고
    • Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations
    • Byrd JC, Devi GR, De Souza AT et al. Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations. J Biol Chem 1999;274:24408-24416.
    • (1999) J Biol Chem , vol.274 , pp. 24408-24416
    • Byrd, J.C.1    Devi, G.R.2    De Souza, A.T.3
  • 120
    • 0034788985 scopus 로고    scopus 로고
    • The IGF system and breast cancer
    • Sachdev D, Yee D. The IGF system and breast cancer. Endocr Relat Cancer 2001;8:197-209.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 197-209
    • Sachdev, D.1    Yee, D.2
  • 121
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu YH, Zi XL, Zhao YH et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001;93:1852-1857.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1852-1857
    • Lu, Y.H.1    Zi, X.L.2    Zhao, Y.H.3
  • 122
    • 0034808642 scopus 로고    scopus 로고
    • IGF status is altered by tamoxifen in patients with breast cancer
    • Campbell MJ, Woodside JV, Secker-Walker J et al. IGF status is altered by tamoxifen in patients with breast cancer. Mol Pathol 2001;54:307-310.
    • (2001) Mol Pathol , vol.54 , pp. 307-310
    • Campbell, M.J.1    Woodside, J.V.2    Secker-Walker, J.3
  • 123
    • 0035556312 scopus 로고    scopus 로고
    • Effect of raloxifene on IGF-I and IGFBP-3 in postmenopausal women with breast cancer
    • Torrisi R, Baglietto L, Johansson H et al. Effect of raloxifene on IGF-I and IGFBP-3 in postmenopausal women with breast cancer. Br J Cancer 2001;85:1838-1841.
    • (2001) Br J Cancer , vol.85 , pp. 1838-1841
    • Torrisi, R.1    Baglietto, L.2    Johansson, H.3
  • 124
    • 0033049278 scopus 로고    scopus 로고
    • Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer
    • O'Byrne KJ, Dobbs N, Propper DJ et al. Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer. Br J Cancer 1999;79:1413-1418.
    • (1999) Br J Cancer , vol.79 , pp. 1413-1418
    • O'Byrne, K.J.1    Dobbs, N.2    Propper, D.J.3
  • 125
    • 0033559620 scopus 로고    scopus 로고
    • A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma
    • Ingle JN, Suman VJ, Kardinal CG et al. A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma. Cancer 1999;85:1284-1292.
    • (1999) Cancer , vol.85 , pp. 1284-1292
    • Ingle, J.N.1    Suman, V.J.2    Kardinal, C.G.3
  • 126
    • 0035069931 scopus 로고    scopus 로고
    • Treatment of metastatic breast cancer with somatostatin analogues - A meta-analysis
    • Dolan JT, Miltenburg DM, Granchi TS et al. Treatment of metastatic breast cancer with somatostatin analogues - a meta-analysis. Ann Surg Oncol 2001;8:227-233.
    • (2001) Ann Surg Oncol , vol.8 , pp. 227-233
    • Dolan, J.T.1    Miltenburg, D.M.2    Granchi, T.S.3
  • 127
    • 0036214015 scopus 로고    scopus 로고
    • Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo
    • Chernicky CL, Tan H, Yi L et al. Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo. Mol Pathol 2002;55:102-109.
    • (2002) Mol Pathol , vol.55 , pp. 102-109
    • Chernicky, C.L.1    Tan, H.2    Yi, L.3
  • 128
    • 0020962492 scopus 로고
    • Monoclonal antibodies to receptors for insulin and somatomedin-C
    • Kull Jr FC, Jacobs S, Su YF et al. Monoclonal antibodies to receptors for insulin and somatomedin-C. J Biol Chem 1983;258:6561-6566.
    • (1983) J Biol Chem , vol.258 , pp. 6561-6566
    • Kull F.C., Jr.1    Jacobs, S.2    Su, Y.F.3
  • 129
    • 0024460381 scopus 로고
    • Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice
    • Arteaga CL, Kitten LJ, Coronado EB et al. Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J Clin Invest 1989;84:1418-1423.
    • (1989) J Clin Invest , vol.84 , pp. 1418-1423
    • Arteaga, C.L.1    Kitten, L.J.2    Coronado, E.B.3
  • 130
    • 0024408247 scopus 로고
    • Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor
    • Arteaga CL, Osborne CK. Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor. Cancer Res 1989;49:6237-6241.
    • (1989) Cancer Res , vol.49 , pp. 6237-6241
    • Arteaga, C.L.1    Osborne, C.K.2
  • 131
    • 0027402935 scopus 로고
    • Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)
    • Kato H, Faria TN, Stannard B et al. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J Biol Chem 1993;268:2655-2661.
    • (1993) J Biol Chem , vol.268 , pp. 2655-2661
    • Kato, H.1    Faria, T.N.2    Stannard, B.3
  • 132
    • 0035987995 scopus 로고    scopus 로고
    • Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes
    • Goodwin PJ, Ennis M, Pritchard KI et al. Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes. Breast Cancer Res Treat 2002;74:65-76.
    • (2002) Breast Cancer Res Treat , vol.74 , pp. 65-76
    • Goodwin, P.J.1    Ennis, M.2    Pritchard, K.I.3
  • 133
    • 0036250019 scopus 로고    scopus 로고
    • Expression of C-KIT and HER-2 tyrosine kinase receptors in poor-prognosis breast cancer
    • Palmu S, Soderstrom KO, Quazi K et al. Expression of C-KIT and HER-2 tyrosine kinase receptors in poor-prognosis breast cancer. Anticancer Res 2002;22:411-414.
    • (2002) Anticancer Res , vol.22 , pp. 411-414
    • Palmu, S.1    Soderstrom, K.O.2    Quazi, K.3
  • 134
    • 0033457944 scopus 로고    scopus 로고
    • Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors
    • Hines SJ, Litz JS, Krystal GW. Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors. Breast Cancer Res Treat 1999;58:1-10.
    • (1999) Breast Cancer Res Treat , vol.58 , pp. 1-10
    • Hines, S.J.1    Litz, J.S.2    Krystal, G.W.3
  • 135
    • 0033753971 scopus 로고    scopus 로고
    • Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast
    • Feakins RM, Wells CA, Young KA et al. Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. Hum Pathol 2000;31:1214-1222.
    • (2000) Hum Pathol , vol.31 , pp. 1214-1222
    • Feakins, R.M.1    Wells, C.A.2    Young, K.A.3
  • 136
    • 0023225322 scopus 로고
    • Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines
    • Peres R, Betsholtz C, Westermark B et al. Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines. Cancer Res 1987;47:3425-3429.
    • (1987) Cancer Res , vol.47 , pp. 3425-3429
    • Peres, R.1    Betsholtz, C.2    Westermark, B.3
  • 137
    • 0036468926 scopus 로고    scopus 로고
    • Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer
    • Yi B, Williams PJ, Niewolna M et al. Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res 2002;62:917-923.
    • (2002) Cancer Res , vol.62 , pp. 917-923
    • Yi, B.1    Williams, P.J.2    Niewolna, M.3
  • 138
    • 0026571910 scopus 로고
    • The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: A review on 5232 patients
    • Klijn JG, Berns PM, Schmitz PI et al. The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocr Rev 1992;13:3-17.
    • (1992) Endocr Rev , vol.13 , pp. 3-17
    • Klijn, J.G.1    Berns, P.M.2    Schmitz, P.I.3
  • 139
    • 0032532214 scopus 로고    scopus 로고
    • c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer
    • Knowlden JM, Gee JM, Seery LT et al. c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer. Oncogene 1998;17:1949-1957.
    • (1998) Oncogene , vol.17 , pp. 1949-1957
    • Knowlden, J.M.1    Gee, J.M.2    Seery, L.T.3
  • 140
    • 0032718015 scopus 로고    scopus 로고
    • Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo
    • Tang CK, Concepcion XZ, Milan M et al. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. Cancer Res 1999;59:5315-5322.
    • (1999) Cancer Res , vol.59 , pp. 5315-5322
    • Tang, C.K.1    Concepcion, X.Z.2    Milan, M.3
  • 141
    • 0034654554 scopus 로고    scopus 로고
    • Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers
    • Srinivasan R, Gillett CE, Barnes DM et al. Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Res 2000;60:1483-1487.
    • (2000) Cancer Res , vol.60 , pp. 1483-1487
    • Srinivasan, R.1    Gillett, C.E.2    Barnes, D.M.3
  • 142
    • 0034053352 scopus 로고    scopus 로고
    • c-erbB4 protein expression in human breast cancer
    • Kew TY, Bell JA, Pinder SE et al. c-erbB4 protein expression in human breast cancer. Br J Cancer 2000;82:1163-1170.
    • (2000) Br J Cancer , vol.82 , pp. 1163-1170
    • Kew, T.Y.1    Bell, J.A.2    Pinder, S.E.3
  • 143
    • 0033842834 scopus 로고    scopus 로고
    • Crosstalk between the insulin-like growth factors and estrogens in breast cancer
    • Yee D, Lee AV. Crosstalk between the insulin-like growth factors and estrogens in breast cancer. J Mammary Gland Biol Neoplasia 2000;5:107-115.
    • (2000) J Mammary Gland Biol Neoplasia , vol.5 , pp. 107-115
    • Yee, D.1    Lee, A.V.2
  • 145
    • 0027290650 scopus 로고
    • Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
    • Baselga J, Norton L, Masui H et al. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 1993;85:1327-1333.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1327-1333
    • Baselga, J.1    Norton, L.2    Masui, H.3
  • 146
    • 0034987631 scopus 로고    scopus 로고
    • Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex)
    • McClelland RA, Barrow D, Madden TA et al. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinology 2001;142:2776-2788.
    • (2001) Endocrinology , vol.142 , pp. 2776-2788
    • McClelland, R.A.1    Barrow, D.2    Madden, T.A.3
  • 147
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
    • Moulder SL, Yakes FM, Muthuswamy SK et al. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res 2001;61:8887-8895.
    • (2001) Cancer Res , vol.61 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, F.M.2    Muthuswamy, S.K.3
  • 148
    • 0037139374 scopus 로고    scopus 로고
    • ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells
    • Ciardiello F, Caputo R, Borriello G et al. ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells. Int J Cancer 2002;98:463-469.
    • (2002) Int J Cancer , vol.98 , pp. 463-469
    • Ciardiello, F.1    Caputo, R.2    Borriello, G.3
  • 149
    • 0036570203 scopus 로고    scopus 로고
    • ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A, Ogawa S, Kometani T et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res 2002;62:2554-2560.
    • (2002) Cancer Res , vol.62 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.2    Kometani, T.3
  • 150
    • 0036225446 scopus 로고    scopus 로고
    • Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
    • Normanno N, Campiglio M, De Luca A et al. Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Ann Oncol 2002;13:65-72.
    • (2002) Ann Oncol , vol.13 , pp. 65-72
    • Normanno, N.1    Campiglio, M.2    De Luca, A.3
  • 151
    • 0036143027 scopus 로고    scopus 로고
    • Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast
    • Chan KC, Knox WF, Gee JM et al. Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast. Cancer Res 2002;62:122-128.
    • (2002) Cancer Res , vol.62 , pp. 122-128
    • Chan, K.C.1    Knox, W.F.2    Gee, J.M.3
  • 152
    • 0032695910 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
    • Pollack VA, Savage DM, Baker DA et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 1999;291:739-748.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 739-748
    • Pollack, V.A.1    Savage, D.M.2    Baker, D.A.3
  • 153
    • 18444404925 scopus 로고    scopus 로고
    • Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: Implications for cancer therapy
    • Citri A, Alroy I, Lavi S et al. Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy. EMBO J 2002;21:2407-2417.
    • (2002) EMBO J , vol.21 , pp. 2407-2417
    • Citri, A.1    Alroy, I.2    Lavi, S.3
  • 154
    • 0035805596 scopus 로고    scopus 로고
    • Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition
    • Nelson JM, Fry DW. Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition. J Biol Chem 2001;276:14842-14847.
    • (2001) J Biol Chem , vol.276 , pp. 14842-14847
    • Nelson, J.M.1    Fry, D.W.2
  • 155
    • 0034565927 scopus 로고    scopus 로고
    • Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor
    • Rao GS, Murray S, Ethier SP. Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor. Int J Radiat Oncol Biol Phys 2000;48:1519-1528.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 1519-1528
    • Rao, G.S.1    Murray, S.2    Ethier, S.P.3
  • 156
    • 0037089564 scopus 로고    scopus 로고
    • Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol
    • Nahta R, Iglehart JD, Kempkes B et al. Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol. Cancer Res 2002;62:2267-2271.
    • (2002) Cancer Res , vol.62 , pp. 2267-2271
    • Nahta, R.1    Iglehart, J.D.2    Kempkes, B.3
  • 157
    • 19044380618 scopus 로고    scopus 로고
    • Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
    • Agus DB, Akita RW, Fox WD et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2002;2:127-137.
    • (2002) Cancer Cell , vol.2 , pp. 127-137
    • Agus, D.B.1    Akita, R.W.2    Fox, W.D.3


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