-
1
-
-
2442429760
-
'Transcripts of aging'
-
Vijg, J. and Calder, R.B. (2004), 'Transcripts of aging', Trends Genet. Vol. 20, pp. 221-224.
-
(2004)
Trends Genet.
, vol.20
, pp. 221-224
-
-
Vijg, J.1
Calder, R.B.2
-
2
-
-
0035098360
-
'Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice'
-
Weindruch, R., Kayo, T., Lee, C.K. and Prolla, T.A. (2001), 'Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice', J. Nutr. Vol. 131, pp. 918S-923S.
-
(2001)
J. Nutr.
, vol.131
-
-
Weindruch, R.1
Kayo, T.2
Lee, C.K.3
Prolla, T.A.4
-
3
-
-
13944259395
-
'Multiple roads to the aging phenotype: Insights from the molecular dissection of progerias through DNA microarray analysis'
-
Prolla, T.A. (2005), 'Multiple roads to the aging phenotype: insights from the molecular dissection of progerias through DNA microarray analysis', Mech. Ageing Dev. Vol. 126, pp. 461-465.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 461-465
-
-
Prolla, T.A.1
-
4
-
-
21644487750
-
'Microarrays as a tool to investigate the biology of aging: A retrospective and a look to the future'
-
Available at
-
Melov, S. and Hubbard, A. (2004), 'Microarrays as a tool to investigate the biology of aging: A retrospective and a look to the future', Sci. Aging Knowledge Environ. Available at http://sageke.sciencemag.org/cgi/content/full/2004/42/re7.
-
(2004)
Sci. Aging Knowledge Environ
-
-
Melov, S.1
Hubbard, A.2
-
5
-
-
33746336387
-
'Application of high-throughput technologies to aging-related research'
-
Conn, P.M., (Ed.), Elsevier Academic Press, Boston, MA
-
Kaeberlein, M. (2006), 'Application of high-throughput technologies to aging-related research', in Conn, P.M., (Ed.), Handbook of models for human aging, Elsevier Academic Press, Boston, MA.
-
(2006)
Handbook of Models for Human Aging
-
-
Kaeberlein, M.1
-
6
-
-
33746381326
-
'Microarray analysis of gene expression changes in aging'
-
Austad, S.N., (Ed.), Academic Press, Boston, MA
-
Hudson, F.N., Kaeberlein, M., Linford, N. et al. (2005), 'Microarray analysis of gene expression changes in aging', in: Austad, S.N., (Ed.), Handbook of the biology of aging, Academic Press, Boston, MA.
-
(2005)
Handbook of the Biology of Aging
-
-
Hudson, F.N.1
Kaeberlein, M.2
Linford, N.3
-
7
-
-
24944566872
-
'Mass spectrometry in aging research'
-
Schoneich, C. (2005), 'Mass spectrometry in aging research', Mass Spectrom. Rev. Vol. 24, pp. 701-718.
-
(2005)
Mass Spectrom. Rev.
, vol.24
, pp. 701-718
-
-
Schoneich, C.1
-
8
-
-
0037653684
-
'Proteomics in gerontological research'
-
Schoneich, C. (2003), 'Proteomics in gerontological research', Exp Gerontol. Vol. 38, pp. 473-481.
-
(2003)
Exp Gerontol.
, vol.38
, pp. 473-481
-
-
Schoneich, C.1
-
9
-
-
1842732174
-
'Temporal linkage between the phenotypic and genomic responses to caloric restriction'
-
Dhahbi, J.M., Kim, H.J., Mote, P.L. et al. (2004), 'Temporal linkage between the phenotypic and genomic responses to caloric restriction', Proc. Natl. Acad. Sci. USA Vol. 101, pp. 5524-5529.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 5524-5529
-
-
Dhahbi, J.M.1
Kim, H.J.2
Mote, P.L.3
-
10
-
-
21644482166
-
'Aging-related research in the "-omics" age'
-
Available at
-
Kaeberlein, M. (2004), 'Aging-related research in the "-omics" age', Sci. Aging Knowledge Environ. Available at http://sageke.sciencemag.org/ cgi/content/full/2004/42/pe39.
-
(2004)
Sci. Aging Knowledge Environ.
-
-
Kaeberlein, M.1
-
11
-
-
3042755617
-
'Biomarkers of aging: From primitive organisms to humans'
-
Butler, R.N., Sprott, R., Warner, H. et al. (2004), 'Biomarkers of aging: From primitive organisms to humans', J. Gerontol. A Biol. Sci. Med. Sci. Vol. 59, pp. B560-567.
-
(2004)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.59
-
-
Butler, R.N.1
Sprott, R.2
Warner, H.3
-
12
-
-
11144321344
-
'Lessons learned from gene expression profile studies of aging and caloric restriction'
-
Park, S.K. and Prolla, T.A. (2005), 'Lessons learned from gene expression profile studies of aging and caloric restriction', Ageing Res. Rev. Vol. 4, pp. 55-65.
-
(2005)
Ageing Res. Rev.
, vol.4
, pp. 55-65
-
-
Park, S.K.1
Prolla, T.A.2
-
13
-
-
4043129528
-
'Current status of efforts to measure and modulate the biological rate of aging'
-
Warner, H.R. (2004), 'Current status of efforts to measure and modulate the biological rate of aging', J. Gerontol. A Biol. Sci. Med. Sci. Vol. 59, pp. 692-696.
-
(2004)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.59
, pp. 692-696
-
-
Warner, H.R.1
-
14
-
-
0037396614
-
'Centenarians as a model for healthy aging'
-
Franceschi, C. and Bonafe, M. (2003), 'Centenarians as a model for healthy aging', Biochem. Soc. Trans. Vol. 31, pp. 457-461.
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 457-461
-
-
Franceschi, C.1
Bonafe, M.2
-
15
-
-
0036591671
-
'The genetics of aging'
-
Perls, T., Kunkel, L. and Puca, A. (2002), 'The genetics of aging', Curr. Opin. Genet. Dev. Vol. 12, pp. 362-369.
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 362-369
-
-
Perls, T.1
Kunkel, L.2
Puca, A.3
-
16
-
-
0032961696
-
'Validity of reported age and centenarian prevalence in New England'
-
Perls, T.T., Bochen, K., Freeman, M. et al. (1999), 'Validity of reported age and centenarian prevalence in New England', Age Ageing Vol. 28, pp. 193-197.
-
(1999)
Age Ageing
, vol.28
, pp. 193-197
-
-
Perls, T.T.1
Bochen, K.2
Freeman, M.3
-
17
-
-
0345540639
-
'Centenarians: The older you get, the healthier you have been'
-
Hitt, R., Young-Xu, Y., Silver, M. and Perls, T. (1999), 'Centenarians: The older you get, the healthier you have been', Lancet Vol. 354, p. 652.
-
(1999)
Lancet
, vol.354
, pp. 652
-
-
Hitt, R.1
Young-Xu, Y.2
Silver, M.3
Perls, T.4
-
18
-
-
11144322320
-
'Cancer in the oldest old'
-
Andersen, S.L., Terry, D.F., Wilcox, M.A. et al. (2005), 'Cancer in the oldest old', Mech. Ageing Dev. Vol. 126, pp. 263-267.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 263-267
-
-
Andersen, S.L.1
Terry, D.F.2
Wilcox, M.A.3
-
19
-
-
17944375119
-
'A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4'
-
Puca, A.A., Daly, M.J., Brewster, S.J. et al. (2001), 'A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4', Proc. Natl. Acad. Sci. USA Vol. 98, pp. 10505-10508.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10505-10508
-
-
Puca, A.A.1
Daly, M.J.2
Brewster, S.J.3
-
20
-
-
0344198603
-
'Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan'
-
Geesaman, B.J., Benson, E., Brewster, S.J. et al. (2003), 'Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan', Proc. Natl. Acad. Sci. USA Vol. 100, pp. 14115-14120.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14115-14120
-
-
Geesaman, B.J.1
Benson, E.2
Brewster, S.J.3
-
21
-
-
0028330133
-
'The molecular basis of abetalipoproteinemia'
-
Gregg, R.E. and Wetterau, J.R. (1994), 'The molecular basis of abetalipoproteinemia', Curr. Opin. Lipidol. Vol. 5, pp. 81-86.
-
(1994)
Curr. Opin. Lipidol.
, vol.5
, pp. 81-86
-
-
Gregg, R.E.1
Wetterau, J.R.2
-
22
-
-
23044463691
-
'Mutations in MTP gene in abeta- and hypobeta-lipoproteinemia'
-
Di Leo, E., Lancellotti, S., Penacchioni, J.Y. et al. (2005), 'Mutations in MTP gene in abeta- and hypobeta-lipoproteinemia', Atherosclerosis Vol. 180, pp. 311-318.
-
(2005)
Atherosclerosis
, vol.180
, pp. 311-318
-
-
Di Leo, E.1
Lancellotti, S.2
Penacchioni, J.Y.3
-
23
-
-
0037389642
-
'Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism'
-
Kammerer, S., Burns-Hamuro, L.L., Ma, Y. et al. (2003), 'Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism', Proc. Natl. Acad. Sci. USA Vol. 100, pp. 4066 -4071.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4066-4071
-
-
Kammerer, S.1
Burns-Hamuro, L.L.2
Ma, Y.3
-
24
-
-
0034703217
-
'Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae'
-
Lin, S.J., Defossez, P.A. and Guarente, L. (2000), 'Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae', Science Vol. 289, pp. 2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
25
-
-
0035853552
-
'Regulation of longevity and stress resistance by Sch9 in yeast'
-
Fabrizio, P., Pozza, F., Pletcher, S.D. et al. (2001), 'Regulation of longevity and stress resistance by Sch9 in yeast', Science Vol. 292, pp. 288-290.
-
(2001)
Science
, vol.292
, pp. 288-290
-
-
Fabrizio, P.1
Pozza, F.2
Pletcher, S.D.3
-
26
-
-
27744511769
-
'TOR and Sch9 determine yeast replicative life span in response to nutrients'
-
Kaeberlein, M., Powers, R.W., Steffen, K.K. et al. (2005), 'TOR and Sch9 determine yeast replicative life span in response to nutrients', Science Vol. 310, pp. 1193-1196.
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers, R.W.2
Steffen, K.K.3
-
27
-
-
4544235732
-
'The role of uncoupling protein 1 in the metabolism and adiposity of RII beta-protein kinase A-deficient mice'
-
Nolan, M.A., Sikorski, M.A. and McKnight, G.S. (2004), 'The role of uncoupling protein 1 in the metabolism and adiposity of RII beta-protein kinase A-deficient mice', Mol. Endocrinol. Vol. 18, pp. 2302-2311.
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 2302-2311
-
-
Nolan, M.A.1
Sikorski, M.A.2
McKnight, G.S.3
-
28
-
-
0029737861
-
'Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A'
-
Cummings, D.E., Brandon, E.P., Planas, J.V. et al. (1996), 'Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A', Nature Vol. 382, pp. 622-626.
-
(1996)
Nature
, vol.382
, pp. 622-626
-
-
Cummings, D.E.1
Brandon, E.P.2
Planas, J.V.3
-
29
-
-
15444377729
-
'Deletion of the RIIbeta-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptindeficient ob /ob mouse'
-
Newhall, K.J., Cummings, D.E., Nolan, M.A. and McKnight, G.S. (2005), 'Deletion of the RIIbeta-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptindeficient ob/ ob mouse', Mol. Endocrinol. Vol. 19, pp. 982-991.
-
(2005)
Mol. Endocrinol.
, vol.19
, pp. 982-991
-
-
Newhall, K.J.1
Cummings, D.E.2
Nolan, M.A.3
McKnight, G.S.4
-
30
-
-
2542476271
-
'A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians'
-
Garasto, S., Berardelli, M., DeRango, F. et al. (2004), 'A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians', BMC Med. Genet. Vol. 5, p. 3.
-
(2004)
BMC Med. Genet.
, vol.5
, pp. 3
-
-
Garasto, S.1
Berardelli, M.2
DeRango, F.3
-
31
-
-
25144518559
-
'Contribution of an affect-associated gene to human longevity: Prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians'
-
Gondo, Y., Hirose, N., Arai, Y. et al. (2005), 'Contribution of an affect-associated gene to human longevity: Prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians', Mech. Ageing Dev. Vol. 126, pp. 1178-1184.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 1178-1184
-
-
Gondo, Y.1
Hirose, N.2
Arai, Y.3
-
32
-
-
0028359655
-
'Genetic associations with human longevity at the APOE and ACE loci'
-
Schachter, F., Faure-Delanef, L., Guenot, F. et al. (1994), 'Genetic associations with human longevity at the APOE and ACE loci', Nat. Genet. Vol. 6, pp. 29-32.
-
(1994)
Nat. Genet.
, vol.6
, pp. 29-32
-
-
Schachter, F.1
Faure-Delanef, L.2
Guenot, F.3
-
33
-
-
0142088521
-
'Unique lipoprotein phenotype and genotype associated with exceptional longevity'
-
Barzilai, N., Atzmon, G., Schechter, C. et al. (2003), 'Unique lipoprotein phenotype and genotype associated with exceptional longevity', JAMA Vol. 290, pp. 2030-2040.
-
(2003)
JAMA
, vol.290
, pp. 2030-2040
-
-
Barzilai, N.1
Atzmon, G.2
Schechter, C.3
-
34
-
-
11144316145
-
'Biological evidence for inheritance of exceptional longevity'
-
Atzmon, G., Rincon, M., Rabizadeh, P. and Barzilai, N. (2005), 'Biological evidence for inheritance of exceptional longevity', Mech. Ageing Dev. Vol. 126, pp. 341-345.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 341-345
-
-
Atzmon, G.1
Rincon, M.2
Rabizadeh, P.3
Barzilai, N.4
-
35
-
-
22144477243
-
'Reduced insulin/IGF-1 signalling and human longevity'
-
van Heemst, D., Beekman, M., Mooijaart, S.P. et al. (2005), 'Reduced insulin/IGF-1 signalling and human longevity', Aging Cell Vol. 4, pp. 79-85.
-
(2005)
Aging Cell
, vol.4
, pp. 79-85
-
-
van Heemst, D.1
Beekman, M.2
Mooijaart, S.P.3
-
36
-
-
0038637217
-
'Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: Cues for an evolutionarily conserved mechanism oflife span control'
-
Bonafe, M., Barbieri, M., Marchegiani, F. et al. (2003), 'Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: Cues for an evolutionarily conserved mechanism oflife span control', J. Clin. Endocrinol. Metab. Vol. 88, pp. 3299-3304.
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 3299-3304
-
-
Bonafe, M.1
Barbieri, M.2
Marchegiani, F.3
-
37
-
-
3943106903
-
'Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: Genetic background of male centenarians is protective against coronary heart disease'
-
Lio, D., Candore, G., Crivello, A. et al. (2004), 'Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: Genetic background of male centenarians is protective against coronary heart disease', J. Med. Genet. Vol. 41, pp. 790-794.
-
(2004)
J. Med. Genet.
, vol.41
, pp. 790-794
-
-
Lio, D.1
Candore, G.2
Crivello, A.3
-
38
-
-
24944481544
-
'Suppression of aging in mice by the hormone Klotho'
-
Kurosu, H., Yamamoto, M., Clark, J.D. et al. (2005), 'Suppression of aging in mice by the hormone Klotho', Science Vol. 309, pp. 1829-1833.
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
-
39
-
-
14844345016
-
'Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity'
-
Arking, D.E., Atzmon, G., Arking, A. et al. (2005), 'Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity', Circ. Res. Vol. 96, pp. 412-418.
-
(2005)
Circ. Res.
, vol.96
, pp. 412-418
-
-
Arking, D.E.1
Atzmon, G.2
Arking, A.3
-
40
-
-
18244372958
-
'Association of human aging with a functional variant of klotho'
-
Arking, D.E., Krebsova, A., Macek, M. et al. (2002), 'Association of human aging with a functional variant of klotho', Proc. Natl. Acad. Sci. USA Vol. 99, pp. 856-861.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 856-861
-
-
Arking, D.E.1
Krebsova, A.2
Macek, M.3
-
41
-
-
0032539447
-
'Mitochondrial genotype associated with longevity'
-
Tanaka, M., Gong, J.S., Zhang, J. et al. (1998), 'Mitochondrial genotype associated with longevity', Lancet Vol. 351, pp. 185-186.
-
(1998)
Lancet
, vol.351
, pp. 185-186
-
-
Tanaka, M.1
Gong, J.S.2
Zhang, J.3
-
42
-
-
3843062160
-
'Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men'
-
van Rossum, E.F., Feelders, R.A., van den Beld, A.W. et al. (2004), 'Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men', Am. J. Med. Vol. 117, pp. 158 -162.
-
(2004)
Am. J. Med.
, vol.117
, pp. 158-162
-
-
van Rossum, E.F.1
Feelders, R.A.2
van den Beld, A.W.3
-
43
-
-
3242724126
-
'Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity'
-
Barbieri, M., Bonafe, M., Rizzo, M.R. et al. (2004), 'Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity', Exp. Gerontol. Vol. 39, pp. 1095-1100.
-
(2004)
Exp. Gerontol.
, vol.39
, pp. 1095-1100
-
-
Barbieri, M.1
Bonafe, M.2
Rizzo, M.R.3
-
44
-
-
0842305076
-
'Variation in the SHC1 gene and longevity in humans'
-
Mooijaart, S.P., van Heemst, D., Schreuder, J. et al. (2004), 'Variation in the SHC1 gene and longevity in humans', Exp. Gerontol. Vol. 39, pp. 263-268.
-
(2004)
Exp. Gerontol.
, vol.39
, pp. 263-268
-
-
Mooijaart, S.P.1
van Heemst, D.2
Schreuder, J.3
-
45
-
-
10744232772
-
'Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly'
-
Rose, G., Dato, S., Altomare, K. et al. (2003), 'Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly', Exp. Gerontol. Vol. 38, pp. 1065-1070.
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 1065-1070
-
-
Rose, G.1
Dato, S.2
Altomare, K.3
-
46
-
-
13044306003
-
'Gene/ longevity association studies at four autosomal loci (REN, THO, PARR, SOD2)'
-
De Benedictis, G., Carotenuto, L., Carrieri, G. et al. (1998), 'Gene/ longevity association studies at four autosomal loci (REN, THO, PARR, SOD2)', Eur. J. Hum. Genet. Vol. 6, pp. 534-541.
-
(1998)
Eur. J. Hum. Genet.
, vol.6
, pp. 534-541
-
-
De Benedictis, G.1
Carotenuto, L.2
Carrieri, G.3
-
47
-
-
8544249161
-
'Role of Toll-like receptor 4 in acute myocardial infarction and longevity'
-
Balistreri, C.R., Candore, G., Colonna-Romano, G. et al. (2004), 'Role of Toll-like receptor 4 in acute myocardial infarction and longevity', JAMA Vol. 292, pp. 2339-2340.
-
(2004)
JAMA
, vol.292
, pp. 2339-2340
-
-
Balistreri, C.R.1
Candore, G.2
Colonna-Romano, G.3
-
48
-
-
1842588641
-
'Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls'
-
Gaspari, L., Pedotti, P., Bonafe, M. et al. (2003), 'Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls', Biomarkers Vol. 8, pp. 522-528.
-
(2003)
Biomarkers
, vol.8
, pp. 522-528
-
-
Gaspari, L.1
Pedotti, P.2
Bonafe, M.3
-
49
-
-
12344273381
-
'Variation in the human TP53 gene affects old age survival and cancer mortality'
-
van Heemst, D., Mooijaart, S.P., Beekman, M. et al. (2005), 'Variation in the human TP53 gene affects old age survival and cancer mortality', Exp. Gerontol. Vol. 40, pp. 11-15.
-
(2005)
Exp. Gerontol.
, vol.40
, pp. 11-15
-
-
van Heemst, D.1
Mooijaart, S.P.2
Beekman, M.3
-
50
-
-
33644878267
-
'Allelic variation and human longevity'
-
Available at
-
Nebel, A. and Schreiber, S. (2005), 'Allelic variation and human longevity', Sci. Aging Knowledge Environ. Available at http://sageke.sciencemag.org/cgi/content/full/2005/29/pe23.
-
(2005)
Sci. Aging Knowledge Environ.
-
-
Nebel, A.1
Schreiber, S.2
-
51
-
-
20344389521
-
'No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans'
-
Nebel, A., Croucher, P.J., Stiegeler, R. et al. (2005), 'No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans', Proc. Natl. Acad. Sci. USA Vol. 102, pp. 7906-7909.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7906-7909
-
-
Nebel, A.1
Croucher, P.J.2
Stiegeler, R.3
-
52
-
-
13944283353
-
'A-type nuclear larnins, progerias and other degenerative disorders'
-
Smith, E.D., Kudlow, B.A., Frock, R.L. and Kennedy, B.K. (2005), 'A-type nuclear larnins, progerias and other degenerative disorders', Mech. Ageing Dev. Vol. 126, pp. 447-460.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 447-460
-
-
Smith, E.D.1
Kudlow, B.A.2
Frock, R.L.3
Kennedy, B.K.4
-
53
-
-
0034090075
-
'Extended longevity in Drosophila is consistently associated with a decrease in developmental viability'
-
Buck, S., Vettraino, J., Force, A.G. and Arking, R. (2000), 'Extended longevity in Drosophila is consistently associated with a decrease in developmental viability', J. Gerontol. A Biol. Sci. Med. Sci. Vol. 55, pp. B292-B301.
-
(2000)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.55
-
-
Buck, S.1
Vettraino, J.2
Force, A.G.3
Arking, R.4
-
54
-
-
13944256856
-
'Fitness cost of extended lifespan in Caenorhabditis elegans'
-
Jenkins, N.L., McColl, G. and Lithgow, G.J. (2004), 'Fitness cost of extended lifespan in Caenorhabditis elegans', Proc. Biol. Sci. Vol. 271, pp. 2523-2526.
-
(2004)
Proc. Biol. Sci.
, vol.271
, pp. 2523-2526
-
-
Jenkins, N.L.1
McColl, G.2
Lithgow, G.J.3
-
55
-
-
0031935425
-
'An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans'
-
Tissenbaum, H.A. and Ruvkun, G. (1998), 'An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans', Genetics Vol. 148, pp. 703-717.
-
(1998)
Genetics
, vol.148
, pp. 703-717
-
-
Tissenbaum, H.A.1
Ruvkun, G.2
-
57
-
-
0037198037
-
'AGEID: A database of aging genes and interventions'
-
Kaeberlein, M., Jegalian, B. and McVey, M. (2002), 'AGEID: A database of aging genes and interventions', Mech. Ageing Dev. Vol. 123, pp. 1115-1119.
-
(2002)
Mech. Ageing Dev.
, vol.123
, pp. 1115-1119
-
-
Kaeberlein, M.1
Jegalian, B.2
McVey, M.3
-
58
-
-
0034626747
-
'Genetic pathways that regulate ageing in model organisms'
-
Guarente, L. and Kenyon, C. (2000), 'Genetic pathways that regulate ageing in model organisms', Nature Vol. 408, pp. 255-262.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
59
-
-
13944269223
-
'The plasticity of aging: Insights from long-lived mutants'
-
Kenyon, C. (2005), 'The plasticity of aging: Insights from long-lived mutants', Cell Vol. 120, pp. 449-460.
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
60
-
-
27744598238
-
'Genetic approaches to the study of aging'
-
Miller, R.A. (2005), 'Genetic approaches to the study of aging', J. Am. Geriatr. Soc. Vol. 53, pp. S284-S286.
-
(2005)
J. Am. Geriatr. Soc.
, vol.53
-
-
Miller, R.A.1
-
61
-
-
4544256512
-
'Using yeast to discover the fountain of youth'
-
Available at
-
Kaeberlein, M., McVey, M. and Guarente, L. (2001), 'Using yeast to discover the fountain of youth', Sci. Aging Knowledge Environ. Available at http://sageke.sciencemag.org/cgi/conent/full/2001/1/pe1.
-
(2001)
Sci. Aging Knowledge Environ.
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
62
-
-
0037280096
-
'SOD2 functions downstream of Sch9 to extend longevity in yeast'
-
Fabrizio, P., Liou, L.L., Moy, V.N. et al. (2003), 'SOD2 functions downstream of Sch9 to extend longevity in yeast', Genetics Vol. 163, pp. 35-46.
-
(2003)
Genetics
, vol.163
, pp. 35-46
-
-
Fabrizio, P.1
Liou, L.L.2
Moy, V.N.3
-
63
-
-
21144434217
-
'Extension of murine life span by overexpression of catalase targeted to mitochondria'
-
Schriner, S.E., Linford, N.J., Martin, G.M. et al. (2005), 'Extension of murine life span by overexpression of catalase targeted to mitochondria', Science Vol. 308, pp. 1909-1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
-
64
-
-
0027771804
-
'A C. elegans mutant that lives twice as long as wild type'
-
Kenyon, C., Chang, J., Gensch, E. et al. (1993), 'A C. elegans mutant that lives twice as long as wild type', Nature Vol. 366, pp. 461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
-
65
-
-
0030813398
-
'daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans'
-
Kimura, K.D., Tissenbaum, H.A., Liu, Y. and Ruvku, G. (1997), 'daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans', Science Vol. 277, pp. 942-946.
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvku, G.4
-
66
-
-
0035815445
-
'A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function'
-
Tatar, M., Kopelman, A., Epstein, D. et al. (2001), 'A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function', Science Vol. 292, pp. 107-110.
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
-
67
-
-
0347664057
-
'IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice'
-
Holzenberger, M., Dupont, J., Ducos, B. et al. (2003), 'IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice', Nature Vol. 421, pp. 182-187.
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
-
68
-
-
3843142823
-
'Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression'
-
Bluher, M., Patti, M.E., Gesta, S. et al. (2004), 'Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression', J. Biol. Chem, Vol. 279, pp. 31891-31901.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 31891-31901
-
-
Bluher, M.1
Patti, M.E.2
Gesta, S.3
-
69
-
-
0036599352
-
'Regulation of lifespan by histone deacetylase'
-
Chang, K.T. and Min, K.T. (2002), 'Regulation of lifespan by histone deacetylase', Ageing Res. Rev. Vol. 1, pp. 313-326.
-
(2002)
Ageing Res. Rev.
, vol.1
, pp. 313-326
-
-
Chang, K.T.1
Min, K.T.2
-
70
-
-
18744416824
-
'Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction'
-
Rogina, B., Helfand, S.L. and Frankel, S. (2002), 'Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction', Science Vol. 298, p. 1745.
-
(2002)
Science
, vol.298
, pp. 1745
-
-
Rogina, B.1
Helfand, S.L.2
Frankel, S.3
-
71
-
-
10944235398
-
'Large-scale identification in yeast of conserved ageing genes'
-
Kaeberlein, M. and Kennedy, B.K. (2005), 'Large-scale identification in yeast of conserved ageing genes', Mech. Ageing Dev. Vol. 126, pp. 17-21.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 17-21
-
-
Kaeberlein, M.1
Kennedy, B.K.2
-
72
-
-
11144355021
-
'C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span'
-
Hertweck, M., Gobel, C. and Baumeister, R. (2004), 'C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span', Dev. Cell Vol. 6, pp. 577-588.
-
(2004)
Dev. Cell
, vol.6
, pp. 577-588
-
-
Hertweck, M.1
Gobel, C.2
Baumeister, R.3
-
73
-
-
22344443522
-
'A systematic RNAi screen for longevity genes in C. elegatis'
-
Hamilton, B., Dong, Y., Shindo, M. et al. (2005), 'A systematic RNAi screen for longevity genes in C. elegatis', Genes Dev. Vol. 19, pp. 1544-1555.
-
(2005)
Genes Dev.
, vol.19
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
-
74
-
-
15444371989
-
'JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16'
-
Oh, S.W., Mukhopadhyay, A., Svrzikapa, N. et al. (2005), 'JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16', Proc. Natl. Acad. Sci. USA Vol. 102, pp. 4494-4499.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
-
75
-
-
0033214237
-
'The SIR.2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms'
-
Kaeberlein, M., McVey, M. and Guarente, L. (1999), 'The SIR.2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms', Genes Dev. Vol. 13, pp. 2570-2580.
-
(1999)
Genes Dev.
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
76
-
-
0035826271
-
'Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans'
-
Tissenbaum, H.A. and Guarente, L. (2001), 'Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans', Nature Vol. 410, pp. 227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
77
-
-
8644224064
-
'Sir2 mediates longevity in the fly through a pathway related to calorie restriction'
-
Rogina, B. and Helfand, S.L. (2004), 'Sir2 mediates longevity in the fly through a pathway related to calorie restriction', Proc. Natl. Acad. Sci. USA Vol. 101, pp. 15998-16003.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
78
-
-
19944433088
-
'A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages'
-
Bellizzi, D., Rose, G., Cavalcante, P. et al. (2005), 'A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages', Genomics Vol. 85, pp. 258-263.
-
(2005)
Genomics
, vol.85
, pp. 258-263
-
-
Bellizzi, D.1
Rose, G.2
Cavalcante, P.3
-
79
-
-
0033659765
-
'Targeted neuronal gene expression and longevity in Drosophila'
-
Phillips, J.P., Parkes, T.L. and Hilliker, A.J. (2000), 'Targeted neuronal gene expression and longevity in Drosophila', Exp. Gerontol. Vol. 35, pp. 1157-1164.
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 1157-1164
-
-
Phillips, J.P.1
Parkes, T.L.2
Hilliker, A.J.3
-
80
-
-
30944458446
-
'Extension of chronological life span in yeast by decreased TOR pathway signaling'
-
Powers, 3rd, R.W., Kaeberlein, M., Caldwell, S.D. et al. (2006), 'Extension of chronological life span in yeast by decreased TOR pathway signaling', Genes Dev. Vol. 20, pp. 174-184.
-
(2006)
Genes Dev.
, vol.20
, pp. 174-184
-
-
Powers III, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
-
81
-
-
4544311861
-
'The TOR, pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span'
-
Jia, K., Chen, D. and Riddle, D.L. (2004), 'The TOR, pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span', Development Vol. 131, pp. 3897-3906.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
82
-
-
0642367846
-
'Genetics: Influence of TOR kinase on lifespan in C. elegans'
-
Vellai, T., Takacs-Vellai, K., Zhang, Y. et al. (2003), 'Genetics: Influence of TOR kinase on lifespan in C. elegans', Nature Vol. 426, p. 620.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
-
83
-
-
3042648746
-
'Regulation of lifespan in Drosophila by modulation of genes in the TOP, signaling pathway'
-
Kapahi, P., Zid, B.M., Harper, T. et al. (2004), 'Regulation of lifespan in Drosophila by modulation of genes in the TOP, signaling pathway', Curr. Biol. Vol. 14, pp. 885-890.
-
(2004)
Curr. Biol.
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
-
84
-
-
0023693343
-
'Constitutional genetic markers of aging'
-
Martin, G.M. (1988), 'Constitutional genetic markers of aging', Exp. Gerontol. Vol. 23, pp. 257-270.
-
(1988)
Exp. Gerontol.
, vol.23
, pp. 257-270
-
-
Martin, G.M.1
-
85
-
-
0029768753
-
'A phosphatidyhnositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans'
-
Morris, J.Z., Tissenbaum, H.A. and Ruvkun, G. (1996), 'A phosphatidyhnositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans', Nature Vol. 382, pp. 536-539.
-
(1996)
Nature
, vol.382
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
86
-
-
0023831256
-
'A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility'
-
Friedman, D.B. and Johnson, T.E. (1988), 'A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility', Genetics Vol. 118, pp. 75-86.
-
(1988)
Genetics
, vol.118
, pp. 75-86
-
-
Friedman, D.B.1
Johnson, T.E.2
-
87
-
-
0030657540
-
'daf-16: An HNF-3/forkhead family member that can function to double the life-spin of Caenorhabditis elegans'
-
Lin, K., Dorman, J.B., Rodan, A. and Kenyon, C. (1997), 'daf-16: An HNF-3/forkhead family member that can function to double the life-spin of Caenorhabditis elegans', Science Vol. 278, pp. 1319-1322.
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
88
-
-
0030659557
-
'The Fork head transcription factor DAF-16 transduces; insulin-like metabolic and longevity signals in C. elegans'
-
Ogg, S., Paradis, S., Gottlieb, S. et al. (1997), 'The Fork head transcription factor DAF-16 transduces; insulin-like metabolic and longevity signals in C. elegans', Nature Vol. 389, pp. 994-999.
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
-
89
-
-
0042631524
-
'Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16'
-
McElwee, J., Bubb, K. and Thomas, J.H. (2003), 'Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16', Aging Cell Vol. 2, pp. 111-121.
-
(2003)
Aging Cell
, vol.2
, pp. 111-121
-
-
McElwee, J.1
Bubb, K.2
Thomas, J.H.3
-
90
-
-
0042092531
-
'Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans'
-
Murphy, C.T., McCarroll, S.A., Bargmann, C.I. et al. (2003), 'Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans', Nature Vol. 424, pp. 277-283.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
-
91
-
-
0038725897
-
'Genome-wide RNAi screening in Caenorhabditis elegans'
-
Kamath, R.S. and Ahringer, J. (2003), 'Genome-wide RNAi screening in Caenorhabditis elegans', Methods Vol. 30, pp. 313-321.
-
(2003)
Methods
, vol.30
, pp. 313-321
-
-
Kamath, R.S.1
Ahringer, J.2
-
92
-
-
0037448540
-
'Systematic functional analysis of the Caenorhabditis elegans genome using RNAi'
-
Kamath, R.S., Fraser, A.G., Dong, Y. et al. (2003), 'Systematic functional analysis of the Caenorhabditis elegans genome using RNAi', Nature Vol. 421, pp. 231-237.
-
(2003)
Nature
, vol.421
, pp. 231-237
-
-
Kamath, R.S.1
Fraser, A.G.2
Dong, Y.3
-
93
-
-
33645472504
-
'New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen'
-
Hansen, M., Hsu, A.L., Dillin, A. and Kenyon, C. (2005), 'New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen', PLoS Genet. Vol. 1, pp. 119-128.
-
(2005)
PLoS Genet.
, vol.1
, pp. 119-128
-
-
Hansen, M.1
Hsu, A.L.2
Dillin, A.3
Kenyon, C.4
-
94
-
-
0037147103
-
'Rates of behavior and aging specified by mitochondrial function during development'
-
Dillin, A., Hsu, A.L., Arantes-Oliveira, N. et al. (2002), 'Rates of behavior and aging specified by mitochondrial function during development', Science Vol. 298, pp. 2398-2401.
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
-
95
-
-
0037228016
-
'A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity'
-
Lee, S.S., Lee, R.Y., Fraser, A.G. et al. (2003), 'A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity', Nat. Genet. Vol. 33, pp. 40-48.
-
(2003)
Nat. Genet.
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
-
96
-
-
84884674380
-
-
Consortium for the determination of public pathways regulating longevity, University of Washington, Seattle, WA. Available at [cited May 11]
-
Consortium for the determination of public pathways regulating longevity, University of Washington, Seattle, WA. Available at http://www.pathology.washington.edu/research/bioage/ellison. [cited May 11, 2006].
-
(2006)
-
-
-
97
-
-
20444431507
-
'Substrate-specific activation of sirtuins by resveratrol'
-
Kaeberlein, M., McDonagh, T., Heltweg, B. et al. (2005), 'Substrate-specific activation of sirtuins by resveratrol', J. Biol. Chem. Vol. 280, pp. 17038-17045.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
McDonagh, T.2
Heltweg, B.3
-
98
-
-
0004760134
-
'Life span of individual yeast cells'
-
Mortimer, R.K. and Johnston, J.R. (1959), 'Life span of individual yeast cells', Nature Vol. 183, pp. 1751-1752.
-
(1959)
Nature
, vol.183
, pp. 1751-1752
-
-
Mortimer, R.K.1
Johnston, J.R.2
-
99
-
-
0042422247
-
'The chronological life span of Saccharomyces cerevisiae'
-
Fabrizio, P. and Longo, V.D. (2003), 'The chronological life span of Saccharomyces cerevisiae', Aging Cell Vol. 2, pp. 73-81.
-
(2003)
Aging Cell
, vol.2
, pp. 73-81
-
-
Fabrizio, P.1
Longo, V.D.2
-
100
-
-
84882890367
-
'Longevity and aging in the budding yeast'
-
Conn, P.M., (Ed.), Elsevier Academic Press, Boston, MA
-
Kaeberlein, M. (2006), 'Longevity and aging in the budding yeast', in Conn, P.M., (Ed.), Handbook of models for human aging, Elsevier Academic Press, Boston, MA.
-
(2006)
Handbook of Models for Human Aging
-
-
Kaeberlein, M.1
-
101
-
-
0033529707
-
'Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis'
-
Winzeler, E.A., Shoemaker, D.D., Astromoff, A. et al. (1999), 'Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis', Science Vol. 285, pp. 901-906.
-
(1999)
Science
, vol.285
, pp. 901-906
-
-
Winzeler, E.A.1
Shoemaker, D.D.2
Astromoff, A.3
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