-
1
-
-
0000424296
-
Development of tolerance to typhoid bacterial pyrogen and its abolition by reticulo-endothelial blockade
-
Beeson, P. B. (1946). Development of tolerance to typhoid bacterial pyrogen and its abolition by reticulo-endothelial blockade. Proc. Soc. Exp. Biol. Med. 61, 248-250.
-
(1946)
Proc. Soc. Exp. Biol. Med.
, vol.61
, pp. 248-250
-
-
Beeson, P.B.1
-
2
-
-
0242666198
-
Phosphorylation of Nrf2S40 by PKC in response to antioxidants leads to the release of Nrf2 from INrf2 but not required for Nrf2 stabilization/ accumulation in the nucleus and transcriptional activation of ARE-mediated NQO1 gene expression
-
10.1074/jbc.M307633200.
-
Bloom, D. A. and Jaiswal, A. K. (2003). Phosphorylation of Nrf2S40 by PKC in response to antioxidants leads to the release of Nrf2 from INrf2 but not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of ARE-mediated NQO1 gene expression. J. Biol. Chem. 10.1074/jbc.M307633200.
-
(2003)
J. Biol. Chem.
-
-
Bloom, D.A.1
Jaiswal, A.K.2
-
3
-
-
0037951567
-
Endotoxin tolerance: Is there a clinical relevance?
-
Cavaillon, J. M., Adrie, C., Fitting, C. and Adib-Conquy, M. (2003). Endotoxin tolerance: is there a clinical relevance? J. Endotoxin Res. 9, 101-107.
-
(2003)
J. Endotoxin Res.
, vol.9
, pp. 101-107
-
-
Cavaillon, J.M.1
Adrie, C.2
Fitting, C.3
Adib-Conquy, M.4
-
4
-
-
13044304201
-
Nrf2 is essential for protection against acute pulmonary injury in mice
-
Chan, K. and Kan, Y. W. (1999). Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. USA 96, 12731-12736.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12731-12736
-
-
Chan, K.1
Kan, Y.W.2
-
5
-
-
0030451213
-
Nrf2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
-
Chan, K., Lu, R., Chang, J. C. and Kan, Y. W. (1996). Nrf2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl. Acad. Sci. USA 93, 13943-13948.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13943-13948
-
-
Chan, K.1
Lu, R.2
Chang, J.C.3
Kan, Y.W.4
-
6
-
-
0035836698
-
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
-
Chan, K., Han, X. D. and Kan, Y. W. (2001). An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. USA 98, 4611-4616.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4611-4616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
7
-
-
0037101768
-
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
-
Chanas, S. A., Jiang, Q., McMahon, M., McWalter, G. K., McLellan, L. I., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moffat, G. J., Itoh, K. et al. (2002). Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem. J. 365, 405-416.
-
(2002)
Biochem. J.
, vol.365
, pp. 405-416
-
-
Chanas, S.A.1
Jiang, Q.2
McMahon, M.3
McWalter, G.K.4
McLellan, L.I.5
Elcombe, C.R.6
Henderson, C.J.7
Wolf, C.R.8
Moffat, G.J.9
Itoh, K.10
-
8
-
-
18844454763
-
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype
-
Devling, T. W., Lindsay, C. D., McLellan, L. I., McMahon, M. and Hayes, J. D. (2005). Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype. Proc. Natl. Acad. Sci. USA 102, 7280-7285.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7280-7285
-
-
Devling, T.W.1
Lindsay, C.D.2
McLellan, L.I.3
McMahon, M.4
Hayes, J.D.5
-
9
-
-
23844553151
-
Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase
-
Dietz, B. M., Kang, Y. H., Liu, G., Eggler, A. L., Yao, P., Chadwick, L. R., Pauli, G. F., Farnsworth, N. R., Mesecar, A. D., van Breemen, R. B. et al. (2005). Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase. Chem. Res. Toxicol. 18, 1296-1305.
-
(2005)
Chem. Res. Toxicol.
, vol.18
, pp. 1296-1305
-
-
Dietz, B.M.1
Kang, Y.H.2
Liu, G.3
Eggler, A.L.4
Yao, P.5
Chadwick, L.R.6
Pauli, G.F.7
Farnsworth, N.R.8
Mesecar, A.D.9
Van Breemen, R.B.10
-
10
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M. and Talalay, P. (2002). Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. USA 99, 11908-11913.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
Yamamoto, M.7
Talalay, P.8
-
11
-
-
18244377997
-
Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
-
Dinkova-Kostova, A. T., Holtzclaw, W. D. and Wakabayashi, N. (2005). Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein. Biochemistry 44, 6889-6899.
-
(2005)
Biochemistry
, vol.44
, pp. 6889-6899
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Wakabayashi, N.3
-
12
-
-
22544464124
-
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
-
Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B. and Mesecar, A. D. (2005). Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc. Natl. Acad. Sci. USA 102, 10070-10075.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10070-10075
-
-
Eggler, A.L.1
Liu, G.2
Pezzuto, J.M.3
Van Breemen, R.B.4
Mesecar, A.D.5
-
13
-
-
0035153227
-
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
-
Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T. and Yamamoto, M. (2001). High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci. 59, 169-177.
-
(2001)
Toxicol. Sci.
, vol.59
, pp. 169-177
-
-
Enomoto, A.1
Itoh, K.2
Nagayoshi, E.3
Haruta, J.4
Kimura, T.5
O'Connor, T.6
Harada, T.7
Yamamoto, M.8
-
14
-
-
2342430991
-
Molecular mechanisms of endotoxin tolerance
-
Fan, H. and Cook, J. A. (2004). Molecular mechanisms of endotoxin tolerance. J. Endotoxin Res. 10, 71-84.
-
(2004)
J. Endotoxin Res.
, vol.10
, pp. 71-84
-
-
Fan, H.1
Cook, J.A.2
-
15
-
-
0031712326
-
Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric oxide synthase gene
-
Goldring, C. E., Reveneau, S., Pinard, D. and Jeannin, J. F. (1998). Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric oxide synthase gene. Eur. J. Immunol. 28, 2960-2970.
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 2960-2970
-
-
Goldring, C.E.1
Reveneau, S.2
Pinard, D.3
Jeannin, J.F.4
-
16
-
-
2342613543
-
Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice
-
Goldring, C. E., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., McMahon, M., Hayes, J. D., Itoh, K., Yamamoto, M. et al. (2004). Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice. Hepatology 39, 1267-1276.
-
(2004)
Hepatology
, vol.39
, pp. 1267-1276
-
-
Goldring, C.E.1
Kitteringham, N.R.2
Elsby, R.3
Randle, L.E.4
Clement, Y.N.5
Williams, D.P.6
McMahon, M.7
Hayes, J.D.8
Itoh, K.9
Yamamoto, M.10
-
17
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris, S. L. and Levine, A. J. (2005). The p53 pathway: positive and negative feedback loops. Oncogene 24, 2899-2908.
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
18
-
-
24744453945
-
Specific patterns of electrophile adduction trigger keap1 ubiquitination and NRF2 activation
-
Hong, F., Sekhar, K. R., Freeman, M. L. and Liebler, D. C. (2005). Specific patterns of electrophile adduction trigger keap1 ubiquitination and NRF2 activation. J. Biol. Chem. 280, 1768-1775.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 1768-1775
-
-
Hong, F.1
Sekhar, K.R.2
Freeman, M.L.3
Liebler, D.C.4
-
19
-
-
0034685764
-
Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element
-
Hoshino, H., Kobayashi, A., Yoshida, M., Kudo, N., Oyake, T., Motohashi, H., Hayashi, N., Yamamoto, M. and Igarashi, K. (2000). Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element. J. Biol. Chem. 275, 15370-15376.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15370-15376
-
-
Hoshino, H.1
Kobayashi, A.2
Yoshida, M.3
Kudo, N.4
Oyake, T.5
Motohashi, H.6
Hayashi, N.7
Yamamoto, M.8
Igarashi, K.9
-
20
-
-
0037044791
-
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
-
Huang, H. C., Nguyen, T. and Pickett, C. B. (2002). Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J. Biol. Chem. 277, 42769-42774.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42769-42774
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
21
-
-
0034717329
-
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
-
Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S. and Yamamoto, M. (2000). Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J. Biol. Chem. 275, 16023-16029.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16023-16029
-
-
Ishii, T.1
Itoh, K.2
Takahashi, S.3
Sato, H.4
Yanagawa, T.5
Katoh, Y.6
Bannai, S.7
Yamamoto, M.8
-
22
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I. et al. (1997). An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236, 313-322.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
-
23
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D. and Yamamoto, M. (1999). Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13, 76-86.
-
(1999)
Genes Dev.
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
24
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
-
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T. and Yamamoto, M. (2003). Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8, 379-391.
-
(2003)
Genes Cells
, vol.8
, pp. 379-391
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
O'Connor, T.5
Yamamoto, M.6
-
25
-
-
23844475091
-
Nuclear import and export signals in control of Nrf2
-
Jain, A. K., Bloom, D. A. and Jaiswal, A. K. (2005). Nuclear import and export signals in control of Nrf2. J. Biol. Chem. 280, 29158-29168.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29158-29168
-
-
Jain, A.K.1
Bloom, D.A.2
Jaiswal, A.K.3
-
26
-
-
33746020101
-
Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2
-
Kitteringham, N. R., Abdullah, A., Jenkins, R. E., Goldring, C. E. P., Hayes, J. D. and Park, B. K. (2005). Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2. Drug Metab. Rev. 37, 23.
-
(2005)
Drug Metab. Rev.
, vol.37
, pp. 23
-
-
Kitteringham, N.R.1
Abdullah, A.2
Jenkins, R.E.3
Goldring, C.E.P.4
Hayes, J.D.5
Park, B.K.6
-
27
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi, A., Kang, M. I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K. and Yamamoto, M. (2004). Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell. Biol. 24, 7130-7139.
-
(2004)
Mol Cell. Biol.
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
Igarashi, K.7
Yamamoto, M.8
-
29
-
-
1642282736
-
Cellular mechanisms of redox cell signalling: Role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
-
Levonen, A. L., Landar, A., Ramachandran, A., Ceaser, E. K., Dickinson, D. A., Zanoni, G., Morrow, J. D. and Darley-Usmar, V. M. (2004). Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. Biochem. J. 378, 373-382.
-
(2004)
Biochem. J.
, vol.378
, pp. 373-382
-
-
Levonen, A.L.1
Landar, A.2
Ramachandran, A.3
Ceaser, E.K.4
Dickinson, D.A.5
Zanoni, G.6
Morrow, J.D.7
Darley-Usmar, V.M.8
-
30
-
-
23344452360
-
NRF2 possesses a Redox-insensitive nuclear export signal overlapping with the leucine zipper motif
-
Li, W., Jain, M. R., Chen, C., Yue, X., Hebbar, V., Zhou, R. and Kong, A. N. (2005). NRF2 possesses a Redox-insensitive nuclear export signal overlapping with the leucine zipper motif. J. Biol. Chem. 280, 28430-28438.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 28430-28438
-
-
Li, W.1
Jain, M.R.2
Chen, C.3
Yue, X.4
Hebbar, V.5
Zhou, R.6
Kong, A.N.7
-
31
-
-
11144244006
-
Crystal structure of the Kelch domain of human Keap1
-
Li, X., Zhang, D., Hannink, M. and Beamer, L. J. (2004a). Crystal structure of the Kelch domain of human Keap1. J Biol. Chem. 279, 54750-54758.
-
(2004)
J Biol. Chem.
, vol.279
, pp. 54750-54758
-
-
Li, X.1
Zhang, D.2
Hannink, M.3
Beamer, L.J.4
-
32
-
-
19944412632
-
Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1
-
Li, X., Zhang, D., Hannink, M. and Beamer, L. J. (2004b). Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr. D Biol. Crystallogr. 60, 2346-2348.
-
(2004)
Acta Crystallogr. D Biol. Crystallogr.
, vol.60
, pp. 2346-2348
-
-
Li, X.1
Zhang, D.2
Hannink, M.3
Beamer, L.J.4
-
33
-
-
26444562318
-
Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1
-
Liu, G., Eggler, A. L., Dietz, B. M., Mesecar, A. D., Bolton, J. L., Pezzuto, J. M. and van Breemen, R. B. (2005). Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal. Chem. 77, 6407-6414.
-
(2005)
Anal. Chem.
, vol.77
, pp. 6407-6414
-
-
Liu, G.1
Eggler, A.L.2
Dietz, B.M.3
Mesecar, A.D.4
Bolton, J.L.5
Pezzuto, J.M.6
Van Breemen, R.B.7
-
34
-
-
0032080193
-
Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2
-
Martin, F., van Deursen, J. M., Shivdasani, R. A., Jackson, C. W., Troutman, A. G. and Ney, P. A. (1998). Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood 91, 3459-3466.
-
(1998)
Blood
, vol.91
, pp. 3459-3466
-
-
Martin, F.1
Van Deursen, J.M.2
Shivdasani, R.A.3
Jackson, C.W.4
Troutman, A.G.5
Ney, P.A.6
-
35
-
-
0035870298
-
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
-
McMahon, M., Itoh, K., Yamamoto, M., Chanas, S. A., Henderson, C. J., McLellan, L. I., Wolf, C. R., Cavin, C. and Hayes, J. D. (2001). The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 61, 3299-3307.
-
(2001)
Cancer Res.
, vol.61
, pp. 3299-3307
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Chanas, S.A.4
Henderson, C.J.5
McLellan, L.I.6
Wolf, C.R.7
Cavin, C.8
Hayes, J.D.9
-
36
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon, M., Itoh, K., Yamamoto, M. and Hayes, J. D. (2003). Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem. 278, 21592-21600.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
37
-
-
3843104763
-
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
-
McMahon, M., Thomas, N., Itoh, K., Yamamoto, M. and Hayes, J. D. (2004). Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J. Biol. Chem. 279, 31556-31567.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31556-31567
-
-
McMahon, M.1
Thomas, N.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
38
-
-
0034685897
-
Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK
-
Nguyen, T., Huang, H. C. and Pickett, C. B. (2000). Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J. Biol. Chem. 275, 15466-15473.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15466-15473
-
-
Nguyen, T.1
Huang, H.C.2
Pickett, C.B.3
-
39
-
-
33344468962
-
Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1
-
Padmanabhan, B., Scharlock, M., Tong, K. I., Nakamura, Y., Kang, M., Kobayashi, A., Matsumoto, T., Tanaka, A., Yamamoto, M. and Yokoyama, S. (2005). Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61, 153-155.
-
(2005)
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
, vol.61
, pp. 153-155
-
-
Padmanabhan, B.1
Scharlock, M.2
Tong, K.I.3
Nakamura, Y.4
Kang, M.5
Kobayashi, A.6
Matsumoto, T.7
Tanaka, A.8
Yamamoto, M.9
Yokoyama, S.10
-
40
-
-
0037462675
-
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones
-
Pietsch, E. C., Chan, J. Y., Torti, F. M. and Torti, S. V. (2003). Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones. J. Biol. Chem. 278, 2361-2369.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2361-2369
-
-
Pietsch, E.C.1
Chan, J.Y.2
Torti, F.M.3
Torti, S.V.4
-
41
-
-
0025943986
-
The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B
-
Schmitz, M. L. and Baeuerle, P. A. (1991). The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J. 10, 3805-3817.
-
(1991)
EMBO J.
, vol.10
, pp. 3805-3817
-
-
Schmitz, M.L.1
Baeuerle, P.A.2
-
42
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa, R. K., Mai, K. H., Srisuma, S., Kensler, T. W., Yamamoto, M. and Biswal, S. (2002). Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62, 5196-5203.
-
(2002)
Cancer Res.
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
Kensler, T.W.4
Yamamoto, M.5
Biswal, S.6
-
43
-
-
0036606913
-
Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster
-
Triantafilou, M. and Triantafilou, K. (2002). Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol. 23, 301-304.
-
(2002)
Trends Immunol.
, vol.23
, pp. 301-304
-
-
Triantafilou, M.1
Triantafilou, K.2
-
44
-
-
0028091034
-
Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections
-
van Deuren, M., van der Ven-Jongekrijg, J., Demacker, P. N., Bartelink, A. K., van Dalen, R., Sauerwein, R. W., Gallati, H., Vannice, J. L. and van der Meer, J. W. (1994). Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections. J. Infect. Dis. 169, 157-161.
-
(1994)
J. Infect. Dis.
, vol.169
, pp. 157-161
-
-
Van Deuren, M.1
Van Der Ven-Jongekrijg, J.2
Demacker, P.N.3
Bartelink, A.K.4
Van Dalen, R.5
Sauerwein, R.W.6
Gallati, H.7
Vannice, J.L.8
Van Der Meer, J.W.9
-
45
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., Kotsuji, T., Otsuka, F., Roop, D. R. et al. (2003). Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat. Genet. 35, 238-245.
-
(2003)
Nat. Genet.
, vol.35
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
Motohashi, H.4
Noda, S.5
Takahashi, S.6
Imakado, S.7
Kotsuji, T.8
Otsuka, F.9
Roop, D.R.10
-
46
-
-
1242296811
-
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
-
Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M. I., Kobayashi, A., Yamamoto, M., Kensler, T. W. and Talalay, P. (2004). Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc. Natl. Acad. Sci. USA 101, 2040-2045.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2040-2045
-
-
Wakabayashi, N.1
Dinkova-Kostova, A.T.2
Holtzclaw, W.D.3
Kang, M.I.4
Kobayashi, A.5
Yamamoto, M.6
Kensler, T.W.7
Talalay, P.8
-
47
-
-
0242580049
-
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
-
Zhang, D. D. and Hannink, M. (2003). Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol. Cell. Biol. 23, 8137-8151.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8137-8151
-
-
Zhang, D.D.1
Hannink, M.2
-
48
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
Zhang, D. D., Lo, S. C., Cross, J. V., Templeton, D. J. and Hannink, M. (2004a). Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell. Biol. 24, 10941-10953.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
Lo, S.C.2
Cross, J.V.3
Templeton, D.J.4
Hannink, M.5
-
49
-
-
1342301449
-
Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells
-
Zhang, X., Lu, L., Dixon, C., Wilmer, W., Song, H., Chen, X. and Rovin, B. H. (2004b). Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in human mesangial cells. Kidney Int. 65, 798-810.
-
(2004)
Kidney Int.
, vol.65
, pp. 798-810
-
-
Zhang, X.1
Lu, L.2
Dixon, C.3
Wilmer, W.4
Song, H.5
Chen, X.6
Rovin, B.H.7
-
50
-
-
0034820511
-
The p50-homodimer mechanism in tolerance to LPS
-
Ziegler-Heitbrock, L. (2001). The p50-homodimer mechanism in tolerance to LPS. J. Endotoxin Res. 7, 219-222.
-
(2001)
J. Endotoxin Res.
, vol.7
, pp. 219-222
-
-
Ziegler-Heitbrock, L.1
-
51
-
-
0037183998
-
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
-
Zipper, L. M. and Mulcahy, R. T. (2002). The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm. J. Biol. Chem. 277, 36544-36552.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 36544-36552
-
-
Zipper, L.M.1
Mulcahy, R.T.2
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