Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein

Biochemistry

Volumn 44, Issue 18, 2005, Pages 6889-6899

  Dinkova Kostova, Albena T ^a   Holtzclaw, W David ^a   Wakabayashi, Nobunao ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSENSORS; CONFORMATIONS; FLUORESCENCE; INDUCTIVELY COUPLED PLASMA; MONOMERS; ORGANOMETALLICS; STOICHIOMETRY; ZINC COMPOUNDS;

ANTIOXIDANT RESPONSE ELEMENT (ARE); ASSOCIATION CONSTANT; ELECTROPHILES; OXIDANTS;

PROTEINS;

4,4' DITHIODIPYRIDINE; ALANINE; CHELATING AGENT; COBALT; CYSTEINE; METALLOPROTEIN; PROTEIN KEAP1; PROTEINASE ACTIVATED RECEPTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ZINC ION;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL LABELING; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLAME PHOTOMETRY; FLUORESCENCE; GENE CONTROL; HUMAN; HUMAN CELL; HYDROPHOBICITY; METAL BINDING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SENSOR; STOICHIOMETRY; SUBSTITUTION REACTION;

ACUTE-PHASE REACTION; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING, COMPETITIVE; COBALT; CYSTEINE; CYTOPROTECTION; CYTOSKELETAL PROTEINS; DEXAMETHASONE; DIMERIZATION; METALLOPROTEINS; MICE; OXIDANTS; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RESORCINOLS; SULFHYDRYL COMPOUNDS; ZINC;

MURINAE;

EID: 18244377997     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047434h     Document Type: Article

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